Q5VWQ8 (DAB2P_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disabled homolog 2-interacting protein
Short name=DAB2 interaction protein
Short name=DAB2-interacting protein

Alternative name(s):
ASK-interacting protein 1

Gene names

Name:	DAB2IP
Synonyms:	AF9Q34, AIP1, KIAA1743

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a Ras GTPase-activating protein By similarity. Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene. Ref.8
Subunit structure	Interacts with MAP3K5, preferentially with its 'Ser-966' dephosphorylated form. On plasma membrane, exists in an inactive form complexed with TNFR1. In response to TNF, dissociates from TNFR1 complex, tranlocates to cytoplasm and forms part of an intracellular signaling complex comprising TRADD, RALBP1, TRAF2 and MAP3K5. Binding to MAP3K5 is induced by TNF. Interacts with DAB1 and DAB2 By similarity. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Ref.8 Ref.9 Ref.10
Subcellular location	Membrane. Cytoplasm. Note: Translocates to the cytoplasm in response to TNF. Ref.9 Ref.10
Tissue specificity	Low expression in prostate. Down-regulated in prostate cancer. Ref.1
Domain	The C2 and Ras-GAP domains are required for the interaction with MAP3K5.
Involvement in disease	A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain.
Sequence similarities	Contains 1 C2 domain. Contains 1 PH domain. Contains 1 Ras-GAP domain.
Sequence caution	The sequence CAH72155.3 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Tumor suppressor
Domain	Coiled coil
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of JUN kinase activity Inferred from direct assay Ref.8. Source: BHF-UCL cellular protein catabolic process Inferred from direct assay PubMed 17389591. Source: UniProtKB cellular response to epidermal growth factor stimulus Inferred from sequence or structural similarity PubMed 11812785. Source: BHF-UCL cellular response to tumor necrosis factor Inferred from direct assay PubMed 17389591. Source: UniProtKB intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from sequence or structural similarity PubMed 18281285. Source: BHF-UCL negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 17389591. Source: UniProtKB negative regulation of MAP kinase activity Inferred from direct assay Ref.8. Source: BHF-UCL negative regulation of NF-kappaB transcription factor activity Inferred from mutant phenotype PubMed 20154697. Source: BHF-UCL negative regulation of Ras GTPase activity Inferred from mutant phenotype PubMed 20154697. Source: BHF-UCL negative regulation of Ras protein signal transduction Inferred by curator PubMed 20154697. Source: BHF-UCL negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 20080667. Source: BHF-UCL negative regulation of catenin import into nucleus Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of epidermal growth factor receptor signaling pathway Inferred from sequence or structural similarity PubMed 11812785. Source: BHF-UCL negative regulation of epithelial cell migration Traceable author statement PubMed 20080667. Source: BHF-UCL negative regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 20154697. Source: BHF-UCL negative regulation of epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 20080667. Source: BHF-UCL negative regulation of fibroblast proliferation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.9. Source: BHF-UCL positive regulation of JNK cascade Inferred from direct assay PubMed 17389591. Source: UniProtKB positive regulation of apoptotic process Inferred from direct assay PubMed 17389591. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17389591. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.9. Source: BHF-UCL intrinsic to internal side of plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	14-3-3 protein binding Inferred from direct assay PubMed 17389591. Source: BHF-UCL Ras GTPase activator activity Inferred from sequence or structural similarity. Source: BHF-UCL phospholipid binding Inferred from electronic annotation. Source: InterPro protein phosphatase 2A binding Inferred from direct assay PubMed 20080667. Source: BHF-UCL signaling adaptor activity Inferred from direct assay PubMed 20080667. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VWQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on EST data.

Isoform 2 (identifier: Q5VWQ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Isoform 3 (identifier: Q5VWQ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-193: Missing.
     1158-1189: RYSMQARNGISPTNPTKLQITENGEFRNSSNC → SMH

Isoform 4 (identifier: Q5VWQ8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.
     1158-1189: RYSMQARNGISPTNPTKLQITENGEFRNSSNC → SMH

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1189	1189	Disabled homolog 2-interacting protein		PRO_0000252407
Regions
	Domain	101 – 202	102	PH
	Domain	200 – 295	96	C2
	Domain	371 – 563	193	Ras-GAP
	Coiled coil	1026 – 1159	134	Potential
	Compositional bias	8 – 52	45	Arg-rich
	Compositional bias	112 – 117	6	Poly-Ala
	Compositional bias	867 – 870	4	Poly-Ala
	Compositional bias	903 – 948	46	Pro-rich
Sites
	Site	172 – 173	2	Breakpoint for translocation to form MLL-DAB2IP
Amino acid modifications
	Modified residue	702	1	Phosphoserine By similarity
	Modified residue	978	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	1 – 193	193	Missing in isoform 3.		VSP_020952
	Alternative sequence	1 – 124	124	Missing in isoform 2 and isoform 4.		VSP_020953
	Alternative sequence	1158 – 1189	32	RYSMQ…NSSNC → SMH in isoform 3 and isoform 4.		VSP_020954
	Natural variant	59	1	S → F. Corresponds to variant rs7027492 [ dbSNP | Ensembl ].		VAR_056858
Experimental info
	Mutagenesis	228 – 230	3	KKK → AAA: No effect on binding to MAP3K5. Ref.8
	Mutagenesis	281 – 284	4	KKKK → AAAA: Significantly reduced binding to MAP3K5. Ref.8
	Mutagenesis	413	1	R → L: No effect on binding to MAP3K5. Ref.8
	Sequence conflict	482	1	I → T in AAM00371. Ref.1
	Sequence conflict	921	1	P → S in AAM00371. Ref.1
	Sequence conflict	1091 – 1092	2	QQ → HE in AAM00371. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 7494FF05AACF3320	FASTA	1,189	131,625
	10 20 30 40 50 60 MSAGGSARKS TGRSSYYYRL LRRPRLQRQR SRSRSRTRPA RESPQERPGS RRSLPGSLSE 70 80 90 100 110 120 KSPSMEPSAA TPFRVTGFLS RRLKGSIKRT KSQPKLDRNH SFRHILPGFR SAAAAAADNE 130 140 150 160 170 180 RSHLMPRLKE SRSHESLLSP SSAVEALDLS MEEEVVIKPV HSSILGQDYC FEVTTSSGSK 190 200 210 220 230 240 CFSCRSAAER DKWMENLRRA VHPNKDNSRR VEHILKLWVI EAKDLPAKKK YLCELCLDDV 250 260 270 280 290 300 LYARTTGKLK TDNVFWGEHF EFHNLPPLRT VTVHLYRETD KKKKKERNSY LGLVSLPAAS 310 320 330 340 350 360 VAGRQFVEKW YPVVTPNPKG GKGPGPMIRI KARYQTITIL PMEMYKEFAE HITNHYLGLC 370 380 390 400 410 420 AALEPILSAK TKEEMASALV HILQSTGKVK DFLTDLMMSE VDRCGDNEHL IFRENTLATK 430 440 450 460 470 480 AIEEYLKLVG QKYLQDALGE FIKALYESDE NCEVDPSKCS AADLPEHQGN LKMCCELAFC 490 500 510 520 530 540 KIINSYCVFP RELKEVFASW RQECSSRGRP DISERLISAS LFLRFLCPAI MSPSLFNLLQ 550 560 570 580 590 600 EYPDDRTART LTLIAKVTQN LANFAKFGSK EEYMSFMNQF LEHEWTNMQR FLLEISNPET 610 620 630 640 650 660 LSNTAGFEGY IDLGRELSSL HSLLWEAVSQ LEQSIVSKLG PLPRILRDVH TALSTPGSGQ 670 680 690 700 710 720 LPGTNDLAST PGSGSSSISA GLQKMVIEND LSGLIDFTRL PSPTPENKDL FFVTRSSGVQ 730 740 750 760 770 780 PSPARSSSYS EANEPDLQMA NGGKSLSMVD LQDARTLDGE AGSPAGPDVL PTDGQAAAAQ 790 800 810 820 830 840 LVAGWPARAT PVNLAGLATV RRAGQTPTTP GTSEGAPGRP QLLAPLSFQN PVYQMAAGLP 850 860 870 880 890 900 LSPRGLGDSG SEGHSSLSSH SNSEELAAAA KLGSFSTAAE ELARRPGELA RRQMSLTEKG 910 920 930 940 950 960 GQPTVPRQNS AGPQRRIDQP PPPPPPPPPA PRGRTPPNLL STLQYPRPSS GTLASASPDW 970 980 990 1000 1010 1020 VGPSTRLRQQ SSSSKGDSPE LKPRAVHKQG PSPVSPNALD RTAAWLLTMN AQLLEDEGLG 1030 1040 1050 1060 1070 1080 PDPPHRDRLR SKDELSQAEK DLAVLQDKLR ISTKKLEEYE TLFKCQEETT QKLVLEYQAR 1090 1100 1110 1120 1130 1140 LEEGEERLRR QQEDKDIQMK GIISRLMSVE EELKKDHAEM QAAVDSKQKI IDAQEKRIAS 1150 1160 1170 1180 LDAANARLMS ALTQLKERYS MQARNGISPT NPTKLQITEN GEFRNSSNC
	Isoform 2 [UniParc]. Checksum: 4787F41F02108AA3	FASTA	1,065	117,651
	10 20 30 40 50 60 MPRLKESRSH ESLLSPSSAV EALDLSMEEE VVIKPVHSSI LGQDYCFEVT TSSGSKCFSC 70 80 90 100 110 120 RSAAERDKWM ENLRRAVHPN KDNSRRVEHI LKLWVIEAKD LPAKKKYLCE LCLDDVLYAR 130 140 150 160 170 180 TTGKLKTDNV FWGEHFEFHN LPPLRTVTVH LYRETDKKKK KERNSYLGLV SLPAASVAGR 190 200 210 220 230 240 QFVEKWYPVV TPNPKGGKGP GPMIRIKARY QTITILPMEM YKEFAEHITN HYLGLCAALE 250 260 270 280 290 300 PILSAKTKEE MASALVHILQ STGKVKDFLT DLMMSEVDRC GDNEHLIFRE NTLATKAIEE 310 320 330 340 350 360 YLKLVGQKYL QDALGEFIKA LYESDENCEV DPSKCSAADL PEHQGNLKMC CELAFCKIIN 370 380 390 400 410 420 SYCVFPRELK EVFASWRQEC SSRGRPDISE RLISASLFLR FLCPAIMSPS LFNLLQEYPD 430 440 450 460 470 480 DRTARTLTLI AKVTQNLANF AKFGSKEEYM SFMNQFLEHE WTNMQRFLLE ISNPETLSNT 490 500 510 520 530 540 AGFEGYIDLG RELSSLHSLL WEAVSQLEQS IVSKLGPLPR ILRDVHTALS TPGSGQLPGT 550 560 570 580 590 600 NDLASTPGSG SSSISAGLQK MVIENDLSGL IDFTRLPSPT PENKDLFFVT RSSGVQPSPA 610 620 630 640 650 660 RSSSYSEANE PDLQMANGGK SLSMVDLQDA RTLDGEAGSP AGPDVLPTDG QAAAAQLVAG 670 680 690 700 710 720 WPARATPVNL AGLATVRRAG QTPTTPGTSE GAPGRPQLLA PLSFQNPVYQ MAAGLPLSPR 730 740 750 760 770 780 GLGDSGSEGH SSLSSHSNSE ELAAAAKLGS FSTAAEELAR RPGELARRQM SLTEKGGQPT 790 800 810 820 830 840 VPRQNSAGPQ RRIDQPPPPP PPPPPAPRGR TPPNLLSTLQ YPRPSSGTLA SASPDWVGPS 850 860 870 880 890 900 TRLRQQSSSS KGDSPELKPR AVHKQGPSPV SPNALDRTAA WLLTMNAQLL EDEGLGPDPP 910 920 930 940 950 960 HRDRLRSKDE LSQAEKDLAV LQDKLRISTK KLEEYETLFK CQEETTQKLV LEYQARLEEG 970 980 990 1000 1010 1020 EERLRRQQED KDIQMKGIIS RLMSVEEELK KDHAEMQAAV DSKQKIIDAQ EKRIASLDAA 1030 1040 1050 1060 NARLMSALTQ LKERYSMQAR NGISPTNPTK LQITENGEFR NSSNC
	Isoform 3 [UniParc]. Checksum: E69CEB1FB00A2219	FASTA	967	106,764
	10 20 30 40 50 60 MENLRRAVHP NKDNSRRVEH ILKLWVIEAK DLPAKKKYLC ELCLDDVLYA RTTGKLKTDN 70 80 90 100 110 120 VFWGEHFEFH NLPPLRTVTV HLYRETDKKK KKERNSYLGL VSLPAASVAG RQFVEKWYPV 130 140 150 160 170 180 VTPNPKGGKG PGPMIRIKAR YQTITILPME MYKEFAEHIT NHYLGLCAAL EPILSAKTKE 190 200 210 220 230 240 EMASALVHIL QSTGKVKDFL TDLMMSEVDR CGDNEHLIFR ENTLATKAIE EYLKLVGQKY 250 260 270 280 290 300 LQDALGEFIK ALYESDENCE VDPSKCSAAD LPEHQGNLKM CCELAFCKII NSYCVFPREL 310 320 330 340 350 360 KEVFASWRQE CSSRGRPDIS ERLISASLFL RFLCPAIMSP SLFNLLQEYP DDRTARTLTL 370 380 390 400 410 420 IAKVTQNLAN FAKFGSKEEY MSFMNQFLEH EWTNMQRFLL EISNPETLSN TAGFEGYIDL 430 440 450 460 470 480 GRELSSLHSL LWEAVSQLEQ SIVSKLGPLP RILRDVHTAL STPGSGQLPG TNDLASTPGS 490 500 510 520 530 540 GSSSISAGLQ KMVIENDLSG LIDFTRLPSP TPENKDLFFV TRSSGVQPSP ARSSSYSEAN 550 560 570 580 590 600 EPDLQMANGG KSLSMVDLQD ARTLDGEAGS PAGPDVLPTD GQAAAAQLVA GWPARATPVN 610 620 630 640 650 660 LAGLATVRRA GQTPTTPGTS EGAPGRPQLL APLSFQNPVY QMAAGLPLSP RGLGDSGSEG 670 680 690 700 710 720 HSSLSSHSNS EELAAAAKLG SFSTAAEELA RRPGELARRQ MSLTEKGGQP TVPRQNSAGP 730 740 750 760 770 780 QRRIDQPPPP PPPPPPAPRG RTPPNLLSTL QYPRPSSGTL ASASPDWVGP STRLRQQSSS 790 800 810 820 830 840 SKGDSPELKP RAVHKQGPSP VSPNALDRTA AWLLTMNAQL LEDEGLGPDP PHRDRLRSKD 850 860 870 880 890 900 ELSQAEKDLA VLQDKLRIST KKLEEYETLF KCQEETTQKL VLEYQARLEE GEERLRRQQE 910 920 930 940 950 960 DKDIQMKGII SRLMSVEEEL KKDHAEMQAA VDSKQKIIDA QEKRIASLDA ANARLMSALT QLKESMH
	Isoform 4 [UniParc]. Checksum: 1B07D8D3B9DEA76A	FASTA	1,036	114,410
	10 20 30 40 50 60 MPRLKESRSH ESLLSPSSAV EALDLSMEEE VVIKPVHSSI LGQDYCFEVT TSSGSKCFSC 70 80 90 100 110 120 RSAAERDKWM ENLRRAVHPN KDNSRRVEHI LKLWVIEAKD LPAKKKYLCE LCLDDVLYAR 130 140 150 160 170 180 TTGKLKTDNV FWGEHFEFHN LPPLRTVTVH LYRETDKKKK KERNSYLGLV SLPAASVAGR 190 200 210 220 230 240 QFVEKWYPVV TPNPKGGKGP GPMIRIKARY QTITILPMEM YKEFAEHITN HYLGLCAALE 250 260 270 280 290 300 PILSAKTKEE MASALVHILQ STGKVKDFLT DLMMSEVDRC GDNEHLIFRE NTLATKAIEE 310 320 330 340 350 360 YLKLVGQKYL QDALGEFIKA LYESDENCEV DPSKCSAADL PEHQGNLKMC CELAFCKIIN 370 380 390 400 410 420 SYCVFPRELK EVFASWRQEC SSRGRPDISE RLISASLFLR FLCPAIMSPS LFNLLQEYPD 430 440 450 460 470 480 DRTARTLTLI AKVTQNLANF AKFGSKEEYM SFMNQFLEHE WTNMQRFLLE ISNPETLSNT 490 500 510 520 530 540 AGFEGYIDLG RELSSLHSLL WEAVSQLEQS IVSKLGPLPR ILRDVHTALS TPGSGQLPGT 550 560 570 580 590 600 NDLASTPGSG SSSISAGLQK MVIENDLSGL IDFTRLPSPT PENKDLFFVT RSSGVQPSPA 610 620 630 640 650 660 RSSSYSEANE PDLQMANGGK SLSMVDLQDA RTLDGEAGSP AGPDVLPTDG QAAAAQLVAG 670 680 690 700 710 720 WPARATPVNL AGLATVRRAG QTPTTPGTSE GAPGRPQLLA PLSFQNPVYQ MAAGLPLSPR 730 740 750 760 770 780 GLGDSGSEGH SSLSSHSNSE ELAAAAKLGS FSTAAEELAR RPGELARRQM SLTEKGGQPT 790 800 810 820 830 840 VPRQNSAGPQ RRIDQPPPPP PPPPPAPRGR TPPNLLSTLQ YPRPSSGTLA SASPDWVGPS 850 860 870 880 890 900 TRLRQQSSSS KGDSPELKPR AVHKQGPSPV SPNALDRTAA WLLTMNAQLL EDEGLGPDPP 910 920 930 940 950 960 HRDRLRSKDE LSQAEKDLAV LQDKLRISTK KLEEYETLFK CQEETTQKLV LEYQARLEEG 970 980 990 1000 1010 1020 EERLRRQQED KDIQMKGIIS RLMSVEEELK KDHAEMQAAV DSKQKIIDAQ EKRIASLDAA 1030 NARLMSALTQ LKESMH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization." Chen H., Pong R.-C., Wang Z., Hsieh J.-T. Genomics 79:573-581(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[2]	"Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia." von Bergh A.R.M., Wijers P.M., Groot A.J., van Zelderen-Bhola S., Falkenburg J.H.F., Kluin P.M., Schuuring E. Genes Chromosomes Cancer 39:324-334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION WITH MLL.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[8]	"AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3." Zhang R., He X., Liu W., Lu M., Hsieh J.-T., Min W. J. Clin. Invest. 111:1933-1943(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MAP3K5, MUTAGENESIS OF 228-LYS--LYS-230; 281-LYS--LYS-284 AND ARG-413.
[9]	"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation." Zhang H., Zhang R., Luo Y., D'Alessio A., Pober J.S., Min W. J. Biol. Chem. 279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TNFR1; MAP3K5; TRADD; RALBP1 AND TRAF2.
[10]	"Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation." Li X., Zhang R., Luo D., Park S.-J., Wang Q., Kim Y., Min W. J. Biol. Chem. 280:15061-15070(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HIPK1, SUBCELLULAR LOCATION.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-978, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF367051 mRNA. Translation: AAM00371.1. AY032952 mRNA. Translation: AAK50336.1. AB051530 mRNA. Translation: BAB21834.2. AL365274 Genomic DNA. Translation: CAH72155.3. Sequence problems. AL365274 Genomic DNA. Translation: CAQ10385.1. AL365274 Genomic DNA. Translation: CAH72158.1. CH471090 Genomic DNA. Translation: EAW87503.1. BC146762 mRNA. Translation: AAI46763.1.
IPI	IPI00045600. IPI00646394. IPI00789361. IPI00914911.
RefSeq	NP_115941.2. NM_032552.2. NP_619723.1. NM_138709.1.
UniGene	Hs.522378.
3D structure databases
HSSP	HSSP built from PDB template 1NF1 based on UniProtKB P21359.
ProteinModelPortal	Q5VWQ8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5VWQ8. 1 interaction.
MINT	MINT-268247.
STRING	9606.ENSP00000259371.
PTM databases
PhosphoSite	Q5VWQ8.
Polymorphism databases
DMDM	116247768.
Proteomic databases
PaxDb	Q5VWQ8.
PRIDE	Q5VWQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309989; ENSP00000310827; ENSG00000136848. ENST00000408936; ENSP00000386183; ENSG00000136848.
GeneID	153090.
KEGG	hsa:153090.
UCSC	uc004bln.3. human.
Organism-specific databases
CTD	153090.
GeneCards	GC09P124329.
HGNC	HGNC:17294. DAB2IP.
HPA	HPA036977.
MIM	609205. gene.
neXtProt	NX_Q5VWQ8.
PharmGKB	PA27133.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245428.
HOVERGEN	HBG006492.
InParanoid	Q5VWQ8.
OMA	CAALEPI.
OrthoDB	EOG473PQJ.
Gene expression databases
ArrayExpress	Q5VWQ8.
Bgee	Q5VWQ8.
CleanEx	HS_DAB2IP.
Genevestigator	Q5VWQ8.
GermOnline	ENSG00000136848. Homo sapiens.
Family and domain databases
Gene3D	1.10.506.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR021887. DUF3498. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR001936. RasGAP. IPR023152. RasGAP_CS. IPR008936. Rho_GTPase_activation_prot. [Graphical view]
Pfam	PF00168. C2. 1 hit. PF12004. DUF3498. 1 hit. PF00616. RasGAP. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00233. PH. 1 hit. SM00323. RasGAP. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50004. C2. False negative. PS50003. PH_DOMAIN. 1 hit. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DAB2IP. human.
GenomeRNAi	153090.
NextBio	87071.
SOURCE	Search...

Entry information

Entry name

DAB2P_HUMAN

Accession

Primary (citable) accession number: Q5VWQ8
Secondary accession number(s): A6H8V2 , A6NHI9, B0QZB1, Q8TDL2, Q96SE1, Q9C0C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.