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Q5VWQ0

- RSBN1_HUMAN

UniProt

Q5VWQ0 - RSBN1_HUMAN

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Protein

Round spermatid basic protein 1

Gene

RSBN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Round spermatid basic protein 1
Gene namesi
Name:RSBN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25642. RSBN1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Round spermatid basic protein 1PRO_0000299412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by PKA.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5VWQ0.
PaxDbiQ5VWQ0.
PRIDEiQ5VWQ0.

PTM databases

PhosphoSiteiQ5VWQ0.

Expressioni

Gene expression databases

BgeeiQ5VWQ0.
CleanExiHS_RSBN1.
GenevestigatoriQ5VWQ0.

Organism-specific databases

HPAiHPA042124.
HPA049484.

Interactioni

Protein-protein interaction databases

BioGridi120094. 10 interactions.
IntActiQ5VWQ0. 2 interactions.
STRINGi9606.ENSP00000261441.

Structurei

3D structure databases

ProteinModelPortaliQ5VWQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi252 – 26312Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi103 – 16563Pro-richAdd
BLAST
Compositional biasi114 – 1174Poly-Arg
Compositional biasi185 – 19713His-richAdd
BLAST
Compositional biasi252 – 26110Poly-Lys

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG306264.
GeneTreeiENSGT00390000001969.
HOGENOMiHOG000043117.
HOVERGENiHBG094904.
InParanoidiQ5VWQ0.
OMAiDLKHKDK.
OrthoDBiEOG7HTHGN.
PhylomeDBiQ5VWQ0.
TreeFamiTF323256.

Family and domain databases

InterProiIPR026306. RSBN1.
[Graphical view]
PANTHERiPTHR13354. PTHR13354. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VWQ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA
60 70 80 90 100
AQVGAVRVVR AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR
110 120 130 140 150
GRPSQEPPLA PPHRRRRSRQ HPGPLPPTNA APTVPGPVEP LLLPPPPPPS
160 170 180 190 200
LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA AGPKHKGHKE RHKHHHHRGP
210 220 230 240 250
DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN GKTQRADDFV
260 270 280 290 300
LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS
310 320 330 340 350
TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL
360 370 380 390 400
KTGTKFSNFI HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF
410 420 430 440 450
SENEKNAAYY ALAIVHGAAA YLPDFLDYFA FNFPNTPVKM EILGKKDIET
460 470 480 490 500
TTISNFHTQV NRTYCCGTYR AGPMRQISLV GAVDEEVGDY FPEFLDMLEE
510 520 530 540 550
SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP TADMPKSPFK
560 570 580 590 600
RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
610 620 630 640 650
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV
660 670 680 690 700
DEAKLNQMRR EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR
710 720 730 740 750
LKQYHPVVEA TQNTESNSNM DCGLTGKREL EVDSQCVRIK TESEEACTEI
760 770 780 790 800
QLLTTASSSF PPASELNLQQ DQKTQPIPVL KVESRLDSDQ QHNLQEHSTT

SV
Length:802
Mass (Da):90,072
Last modified:September 1, 2009 - v2
Checksum:i78F229AB6A0FABD1
GO
Isoform 4 (identifier: Q5VWQ0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     460-802: Missing.

Show »
Length:459
Mass (Da):50,802
Checksum:i9B1EA055DF7807A1
GO

Sequence cautioni

The sequence CAH10493.1 differs from that shown. Reason: Aberrant splicing.
The sequence AAH26155.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA92075.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB13974.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH10493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAH72507.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI19067.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 402GP → SG in AAH26155. (PubMed:15489334)Curated
Sequence conflicti106 – 1061E → G in BAF85241. (PubMed:14702039)Curated
Sequence conflicti120 – 1201Q → R in BAA92075. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei460 – 802343Missing in isoform 4. 1 PublicationVSP_027656Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002082 mRNA. Translation: BAA92075.1. Different initiation.
AK292552 mRNA. Translation: BAF85241.1.
AK022166 mRNA. Translation: BAB13974.1. Different initiation.
AL365321, AL137856 Genomic DNA. Translation: CAH72507.1. Different initiation.
AL137856, AL365321 Genomic DNA. Translation: CAI19067.1. Different initiation.
BC026155 mRNA. Translation: AAH26155.1. Different initiation.
CR627402 mRNA. Translation: CAH10493.1. Sequence problems.
CCDSiCCDS862.1. [Q5VWQ0-1]
RefSeqiNP_060834.2. NM_018364.3. [Q5VWQ0-1]
UniGeneiHs.486285.

Genome annotation databases

EnsembliENST00000261441; ENSP00000261441; ENSG00000081019. [Q5VWQ0-1]
ENST00000476412; ENSP00000433256; ENSG00000081019.
ENST00000612242; ENSP00000479490; ENSG00000081019. [Q5VWQ0-1]
ENST00000616024; ENSP00000478459; ENSG00000081019.
GeneIDi54665.
KEGGihsa:54665.
UCSCiuc001edq.3. human. [Q5VWQ0-1]

Polymorphism databases

DMDMi257050986.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002082 mRNA. Translation: BAA92075.1 . Different initiation.
AK292552 mRNA. Translation: BAF85241.1 .
AK022166 mRNA. Translation: BAB13974.1 . Different initiation.
AL365321 , AL137856 Genomic DNA. Translation: CAH72507.1 . Different initiation.
AL137856 , AL365321 Genomic DNA. Translation: CAI19067.1 . Different initiation.
BC026155 mRNA. Translation: AAH26155.1 . Different initiation.
CR627402 mRNA. Translation: CAH10493.1 . Sequence problems.
CCDSi CCDS862.1. [Q5VWQ0-1 ]
RefSeqi NP_060834.2. NM_018364.3. [Q5VWQ0-1 ]
UniGenei Hs.486285.

3D structure databases

ProteinModelPortali Q5VWQ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120094. 10 interactions.
IntActi Q5VWQ0. 2 interactions.
STRINGi 9606.ENSP00000261441.

PTM databases

PhosphoSitei Q5VWQ0.

Polymorphism databases

DMDMi 257050986.

Proteomic databases

MaxQBi Q5VWQ0.
PaxDbi Q5VWQ0.
PRIDEi Q5VWQ0.

Protocols and materials databases

DNASUi 54665.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261441 ; ENSP00000261441 ; ENSG00000081019 . [Q5VWQ0-1 ]
ENST00000476412 ; ENSP00000433256 ; ENSG00000081019 .
ENST00000612242 ; ENSP00000479490 ; ENSG00000081019 . [Q5VWQ0-1 ]
ENST00000616024 ; ENSP00000478459 ; ENSG00000081019 .
GeneIDi 54665.
KEGGi hsa:54665.
UCSCi uc001edq.3. human. [Q5VWQ0-1 ]

Organism-specific databases

CTDi 54665.
GeneCardsi GC01M114304.
H-InvDB HIX0000902.
HGNCi HGNC:25642. RSBN1.
HPAi HPA042124.
HPA049484.
MIMi 615858. gene.
neXtProti NX_Q5VWQ0.
PharmGKBi PA134869532.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306264.
GeneTreei ENSGT00390000001969.
HOGENOMi HOG000043117.
HOVERGENi HBG094904.
InParanoidi Q5VWQ0.
OMAi DLKHKDK.
OrthoDBi EOG7HTHGN.
PhylomeDBi Q5VWQ0.
TreeFami TF323256.

Miscellaneous databases

GenomeRNAii 54665.
NextBioi 57216.
PROi Q5VWQ0.
SOURCEi Search...

Gene expression databases

Bgeei Q5VWQ0.
CleanExi HS_RSBN1.
Genevestigatori Q5VWQ0.

Family and domain databases

InterProi IPR026306. RSBN1.
[Graphical view ]
PANTHERi PTHR13354. PTHR13354. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo and Placenta.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-802 (ISOFORM 4).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-802 (ISOFORM 1).
    Tissue: Liver tumor.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRSBN1_HUMAN
AccessioniPrimary (citable) accession number: Q5VWQ0
Secondary accession number(s): A8K937
, Q6AI21, Q8TC33, Q9HA80, Q9NUP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3