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Q5VWQ0

- RSBN1_HUMAN

UniProt

Q5VWQ0 - RSBN1_HUMAN

Protein

Round spermatid basic protein 1

Gene

RSBN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Round spermatid basic protein 1
    Gene namesi
    Name:RSBN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25642. RSBN1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869532.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 802802Round spermatid basic protein 1PRO_0000299412Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei81 – 811Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by PKA.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5VWQ0.
    PaxDbiQ5VWQ0.
    PRIDEiQ5VWQ0.

    PTM databases

    PhosphoSiteiQ5VWQ0.

    Expressioni

    Gene expression databases

    BgeeiQ5VWQ0.
    CleanExiHS_RSBN1.
    GenevestigatoriQ5VWQ0.

    Organism-specific databases

    HPAiHPA042124.
    HPA049484.

    Interactioni

    Protein-protein interaction databases

    BioGridi120094. 5 interactions.
    IntActiQ5VWQ0. 2 interactions.
    STRINGi9606.ENSP00000261441.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VWQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi252 – 26312Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi103 – 16563Pro-richAdd
    BLAST
    Compositional biasi114 – 1174Poly-Arg
    Compositional biasi185 – 19713His-richAdd
    BLAST
    Compositional biasi252 – 26110Poly-Lys

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG306264.
    HOGENOMiHOG000043117.
    HOVERGENiHBG094904.
    InParanoidiQ5VWQ0.
    OMAiDLKHKDK.
    OrthoDBiEOG7HTHGN.
    PhylomeDBiQ5VWQ0.
    TreeFamiTF323256.

    Family and domain databases

    InterProiIPR026306. RSBN1.
    [Graphical view]
    PANTHERiPTHR13354. PTHR13354. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VWQ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA    50
    AQVGAVRVVR AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR 100
    GRPSQEPPLA PPHRRRRSRQ HPGPLPPTNA APTVPGPVEP LLLPPPPPPS 150
    LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA AGPKHKGHKE RHKHHHHRGP 200
    DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN GKTQRADDFV 250
    LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS 300
    TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL 350
    KTGTKFSNFI HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF 400
    SENEKNAAYY ALAIVHGAAA YLPDFLDYFA FNFPNTPVKM EILGKKDIET 450
    TTISNFHTQV NRTYCCGTYR AGPMRQISLV GAVDEEVGDY FPEFLDMLEE 500
    SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP TADMPKSPFK 550
    RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV 600
    LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV 650
    DEAKLNQMRR EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR 700
    LKQYHPVVEA TQNTESNSNM DCGLTGKREL EVDSQCVRIK TESEEACTEI 750
    QLLTTASSSF PPASELNLQQ DQKTQPIPVL KVESRLDSDQ QHNLQEHSTT 800
    SV 802
    Length:802
    Mass (Da):90,072
    Last modified:September 1, 2009 - v2
    Checksum:i78F229AB6A0FABD1
    GO
    Isoform 4 (identifier: Q5VWQ0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         460-802: Missing.

    Show »
    Length:459
    Mass (Da):50,802
    Checksum:i9B1EA055DF7807A1
    GO

    Sequence cautioni

    The sequence CAH10493.1 differs from that shown. Reason: Aberrant splicing.
    The sequence AAH26155.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA92075.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB13974.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH10493.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAH72507.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI19067.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 402GP → SG in AAH26155. (PubMed:15489334)Curated
    Sequence conflicti106 – 1061E → G in BAF85241. (PubMed:14702039)Curated
    Sequence conflicti120 – 1201Q → R in BAA92075. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei460 – 802343Missing in isoform 4. 1 PublicationVSP_027656Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002082 mRNA. Translation: BAA92075.1. Different initiation.
    AK292552 mRNA. Translation: BAF85241.1.
    AK022166 mRNA. Translation: BAB13974.1. Different initiation.
    AL365321, AL137856 Genomic DNA. Translation: CAH72507.1. Different initiation.
    AL137856, AL365321 Genomic DNA. Translation: CAI19067.1. Different initiation.
    BC026155 mRNA. Translation: AAH26155.1. Different initiation.
    CR627402 mRNA. Translation: CAH10493.1. Sequence problems.
    CCDSiCCDS862.1. [Q5VWQ0-1]
    RefSeqiNP_060834.2. NM_018364.3. [Q5VWQ0-1]
    UniGeneiHs.486285.

    Genome annotation databases

    EnsembliENST00000261441; ENSP00000261441; ENSG00000081019. [Q5VWQ0-1]
    GeneIDi54665.
    KEGGihsa:54665.
    UCSCiuc001edq.3. human. [Q5VWQ0-1]

    Polymorphism databases

    DMDMi257050986.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002082 mRNA. Translation: BAA92075.1 . Different initiation.
    AK292552 mRNA. Translation: BAF85241.1 .
    AK022166 mRNA. Translation: BAB13974.1 . Different initiation.
    AL365321 , AL137856 Genomic DNA. Translation: CAH72507.1 . Different initiation.
    AL137856 , AL365321 Genomic DNA. Translation: CAI19067.1 . Different initiation.
    BC026155 mRNA. Translation: AAH26155.1 . Different initiation.
    CR627402 mRNA. Translation: CAH10493.1 . Sequence problems.
    CCDSi CCDS862.1. [Q5VWQ0-1 ]
    RefSeqi NP_060834.2. NM_018364.3. [Q5VWQ0-1 ]
    UniGenei Hs.486285.

    3D structure databases

    ProteinModelPortali Q5VWQ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120094. 5 interactions.
    IntActi Q5VWQ0. 2 interactions.
    STRINGi 9606.ENSP00000261441.

    PTM databases

    PhosphoSitei Q5VWQ0.

    Polymorphism databases

    DMDMi 257050986.

    Proteomic databases

    MaxQBi Q5VWQ0.
    PaxDbi Q5VWQ0.
    PRIDEi Q5VWQ0.

    Protocols and materials databases

    DNASUi 54665.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261441 ; ENSP00000261441 ; ENSG00000081019 . [Q5VWQ0-1 ]
    GeneIDi 54665.
    KEGGi hsa:54665.
    UCSCi uc001edq.3. human. [Q5VWQ0-1 ]

    Organism-specific databases

    CTDi 54665.
    GeneCardsi GC01M114304.
    H-InvDB HIX0000902.
    HGNCi HGNC:25642. RSBN1.
    HPAi HPA042124.
    HPA049484.
    MIMi 615858. gene.
    neXtProti NX_Q5VWQ0.
    PharmGKBi PA134869532.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306264.
    HOGENOMi HOG000043117.
    HOVERGENi HBG094904.
    InParanoidi Q5VWQ0.
    OMAi DLKHKDK.
    OrthoDBi EOG7HTHGN.
    PhylomeDBi Q5VWQ0.
    TreeFami TF323256.

    Miscellaneous databases

    GenomeRNAii 54665.
    NextBioi 57216.
    PROi Q5VWQ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5VWQ0.
    CleanExi HS_RSBN1.
    Genevestigatori Q5VWQ0.

    Family and domain databases

    InterProi IPR026306. RSBN1.
    [Graphical view ]
    PANTHERi PTHR13354. PTHR13354. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo and Placenta.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-802 (ISOFORM 4).
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-802 (ISOFORM 1).
      Tissue: Liver tumor.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRSBN1_HUMAN
    AccessioniPrimary (citable) accession number: Q5VWQ0
    Secondary accession number(s): A8K937
    , Q6AI21, Q8TC33, Q9HA80, Q9NUP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3