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Protein

Putative nucleotidyltransferase FAM46C

Gene

FAM46C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.1 Publication
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nucleotidyltransferase FAM46CCurated (EC:2.7.7.-1 Publication)
Gene namesi
Name:FAM46CImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183508.4.
HGNCiHGNC:24712. FAM46C.

Pathology & Biotechi

Organism-specific databases

DisGeNETi54855.
OpenTargetsiENSG00000183508.
PharmGKBiPA134955264.

Polymorphism and mutation databases

BioMutaiFAM46C.
DMDMi117940143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599331 – 391Putative nucleotidyltransferase FAM46CAdd BLAST391

Proteomic databases

PaxDbiQ5VWP2.
PeptideAtlasiQ5VWP2.
PRIDEiQ5VWP2.

PTM databases

iPTMnetiQ5VWP2.
PhosphoSitePlusiQ5VWP2.

Expressioni

Inductioni

By type I interferons.1 Publication

Gene expression databases

BgeeiENSG00000183508.
CleanExiHS_FAM46C.
GenevisibleiQ5VWP2. HS.

Organism-specific databases

HPAiHPA054049.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOXF2Q9BQY43EBI-741787,EBI-372094

Protein-protein interaction databases

BioGridi120205. 8 interactors.
IntActiQ5VWP2. 6 interactors.
MINTiMINT-1471126.
STRINGi9606.ENSP00000358458.

Structurei

3D structure databases

ProteinModelPortaliQ5VWP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM46 family.Curated

Phylogenomic databases

eggNOGiKOG3852. Eukaryota.
ENOG410XTG4. LUCA.
GeneTreeiENSGT00500000044785.
HOGENOMiHOG000234733.
HOVERGENiHBG057969.
InParanoidiQ5VWP2.
OMAiFFYDCSS.
OrthoDBiEOG091G06T9.
PhylomeDBiQ5VWP2.
TreeFamiTF315239.

Family and domain databases

InterProiView protein in InterPro
IPR012937. DUF1693.
PfamiView protein in Pfam
PF07984. NTP_transf_7. 1 hit.
SMARTiView protein in SMART
SM01153. DUF1693. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VWP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD
60 70 80 90 100
IVQTVRSRLE EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP
110 120 130 140 150
TEAEFQLVRD VVLCSLLNFL PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD
160 170 180 190 200
RWSLISLSNK NGKNVELKFV DSIRRQFEFS VDSFQIILDS LLFFYDCSNN
210 220 230 240 250
PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR GGGLLKYSNL
260 270 280 290 300
LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE
310 320 330 340 350
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA
360 370 380 390
TNVTCYYQPA PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N
Length:391
Mass (Da):44,944
Last modified:August 30, 2005 - v1
Checksum:i1B73C6688284F8AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150D → V in BAA91010 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06013267H → Q. Corresponds to variant dbSNP:rs1630312Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000209 mRNA. Translation: BAA91010.1.
AL365331 Genomic DNA. No translation available.
BC036516 mRNA. Translation: AAH36516.3.
BC131726 mRNA. Translation: AAI31727.1.
CCDSiCCDS896.1.
RefSeqiNP_060179.2. NM_017709.3.
UniGeneiHs.356216.

Genome annotation databases

EnsembliENST00000369448; ENSP00000358458; ENSG00000183508.
GeneIDi54855.
KEGGihsa:54855.
UCSCiuc001ehe.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFA46C_HUMAN
AccessioniPrimary (citable) accession number: Q5VWP2
Secondary accession number(s): A3KMG2, Q8NE25, Q9NXK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: August 30, 2005
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families