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Q5VWM4

- PRAM8_HUMAN

UniProt

Q5VWM4 - PRAM8_HUMAN

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Protein
PRAME family member 8
Gene
PRAMEF8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. negative regulation of apoptotic process Source: InterPro
  2. negative regulation of cell differentiation Source: InterPro
  3. negative regulation of retinoic acid receptor signaling pathway Source: InterPro
  4. negative regulation of transcription, DNA-templated Source: InterPro
  5. positive regulation of cell proliferation Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 8
Gene namesi
Name:PRAMEF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24074. PRAMEF8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474PRAME family member 8
PRO_0000156982Add
BLAST

Proteomic databases

PaxDbiQ5VWM4.
PRIDEiQ5VWM4.

Expressioni

Gene expression databases

CleanExiHS_PRAMEF8.
GenevestigatoriQ5VWM4.

Organism-specific databases

HPAiHPA049887.

Structurei

3D structure databases

ProteinModelPortaliQ5VWM4.
SMRiQ5VWM4. Positions 257-409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati318 – 34124LRR 1
Add
BLAST
Repeati347 – 37428LRR 2
Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG120841.
HOVERGENiHBG006326.
InParanoidiQ5VWM4.
OMAiCHELKIS.
OrthoDBiEOG7KSX88.
PhylomeDBiQ5VWM4.
TreeFamiTF332708.

Family and domain databases

InterProiIPR026292. PRAME/Leu_rich_rep-con_p14.
IPR026271. PRAME_family.
[Graphical view]
PANTHERiPTHR14224. PTHR14224. 1 hit.
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VWM4-1 [UniParc]FASTAAdd to Basket

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MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE    50
TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL 100
QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID 150
LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC QELQVFGMPI HSIIEVLNMV 200
ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN 250
KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT 300
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL 350
QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT 400
VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMKTL RDLRQPKIIV 450
FCTVPCPRCG IRASYDLEPS HCLC 474
Length:474
Mass (Da):53,669
Last modified:December 7, 2004 - v1
Checksum:iBBE3C9336F8922C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL365443 Genomic DNA. Translation: CAH71450.1.
UniGeneiHs.553832.

Genome annotation databases

EnsembliENST00000357367; ENSP00000349931; ENSG00000182330.
KEGGihsa:391002.
UCSCiuc001aup.3. human.

Polymorphism databases

DMDMi74756937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL365443 Genomic DNA. Translation: CAH71450.1 .
UniGenei Hs.553832.

3D structure databases

ProteinModelPortali Q5VWM4.
SMRi Q5VWM4. Positions 257-409.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74756937.

Proteomic databases

PaxDbi Q5VWM4.
PRIDEi Q5VWM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357367 ; ENSP00000349931 ; ENSG00000182330 .
KEGGi hsa:391002.
UCSCi uc001aup.3. human.

Organism-specific databases

CTDi 391002.
GeneCardsi GC01M013386.
HGNCi HGNC:24074. PRAMEF8.
HPAi HPA049887.
neXtProti NX_Q5VWM4.
PharmGKBi PA142671145.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG120841.
HOVERGENi HBG006326.
InParanoidi Q5VWM4.
OMAi CHELKIS.
OrthoDBi EOG7KSX88.
PhylomeDBi Q5VWM4.
TreeFami TF332708.

Miscellaneous databases

GenomeRNAii 391002.
NextBioi 104233.
PROi Q5VWM4.

Gene expression databases

CleanExi HS_PRAMEF8.
Genevestigatori Q5VWM4.

Family and domain databases

InterProi IPR026292. PRAME/Leu_rich_rep-con_p14.
IPR026271. PRAME_family.
[Graphical view ]
PANTHERi PTHR14224. PTHR14224. 1 hit.
PIRSFi PIRSF038286. PRAME. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRAM8_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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