Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5VWM4

- PRAM8_HUMAN

UniProt

Q5VWM4 - PRAM8_HUMAN

Protein

PRAME family member 8

Gene

PRAMEF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. negative regulation of apoptotic process Source: InterPro
    2. negative regulation of cell differentiation Source: InterPro
    3. negative regulation of retinoic acid receptor signaling pathway Source: InterPro
    4. negative regulation of transcription, DNA-templated Source: InterPro
    5. positive regulation of cell proliferation Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PRAME family member 8
    Gene namesi
    Name:PRAMEF8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24074. PRAMEF8.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671145.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474PRAME family member 8PRO_0000156982Add
    BLAST

    Proteomic databases

    PaxDbiQ5VWM4.
    PRIDEiQ5VWM4.

    Expressioni

    Gene expression databases

    CleanExiHS_PRAMEF8.
    GenevestigatoriQ5VWM4.

    Organism-specific databases

    HPAiHPA049887.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VWM4.
    SMRiQ5VWM4. Positions 257-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati318 – 34124LRR 1Add
    BLAST
    Repeati347 – 37428LRR 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the PRAME family.Curated
    Contains 2 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG120841.
    HOVERGENiHBG006326.
    InParanoidiQ5VWM4.
    OMAiCHELKIS.
    OrthoDBiEOG7KSX88.
    PhylomeDBiQ5VWM4.
    TreeFamiTF332708.

    Family and domain databases

    InterProiIPR026292. PRAME/Leu_rich_rep-con_p14.
    IPR026271. PRAME_family.
    [Graphical view]
    PANTHERiPTHR14224. PTHR14224. 1 hit.
    PIRSFiPIRSF038286. PRAME. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5VWM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE    50
    TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL 100
    QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID 150
    LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC QELQVFGMPI HSIIEVLNMV 200
    ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN 250
    KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT 300
    DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL 350
    QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT 400
    VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMKTL RDLRQPKIIV 450
    FCTVPCPRCG IRASYDLEPS HCLC 474
    Length:474
    Mass (Da):53,669
    Last modified:December 7, 2004 - v1
    Checksum:iBBE3C9336F8922C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL365443 Genomic DNA. Translation: CAH71450.1.
    UniGeneiHs.553832.

    Genome annotation databases

    EnsembliENST00000357367; ENSP00000349931; ENSG00000182330.
    KEGGihsa:391002.
    UCSCiuc001aup.3. human.

    Polymorphism databases

    DMDMi74756937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL365443 Genomic DNA. Translation: CAH71450.1 .
    UniGenei Hs.553832.

    3D structure databases

    ProteinModelPortali Q5VWM4.
    SMRi Q5VWM4. Positions 257-409.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74756937.

    Proteomic databases

    PaxDbi Q5VWM4.
    PRIDEi Q5VWM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357367 ; ENSP00000349931 ; ENSG00000182330 .
    KEGGi hsa:391002.
    UCSCi uc001aup.3. human.

    Organism-specific databases

    GeneCardsi GC01M013386.
    HGNCi HGNC:24074. PRAMEF8.
    HPAi HPA049887.
    neXtProti NX_Q5VWM4.
    PharmGKBi PA142671145.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG120841.
    HOVERGENi HBG006326.
    InParanoidi Q5VWM4.
    OMAi CHELKIS.
    OrthoDBi EOG7KSX88.
    PhylomeDBi Q5VWM4.
    TreeFami TF332708.

    Miscellaneous databases

    GenomeRNAii 391002.
    NextBioi 104233.
    PROi Q5VWM4.

    Gene expression databases

    CleanExi HS_PRAMEF8.
    Genevestigatori Q5VWM4.

    Family and domain databases

    InterProi IPR026292. PRAME/Leu_rich_rep-con_p14.
    IPR026271. PRAME_family.
    [Graphical view ]
    PANTHERi PTHR14224. PTHR14224. 1 hit.
    PIRSFi PIRSF038286. PRAME. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPRAM8_HUMAN
    AccessioniPrimary (citable) accession number: Q5VWM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3