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Protein

PRAME family member 8

Gene

PRAMEF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 8Imported
Gene namesi
Name:PRAMEF8Imported
Synonyms:PRAMEF24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24074. PRAMEF8.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182330.
PharmGKBiPA142671145.

Polymorphism and mutation databases

BioMutaiPRAMEF8.
DMDMi74756937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569821 – 474PRAME family member 8Add BLAST474

Proteomic databases

PaxDbiQ5VWM4.
PRIDEiQ5VWM4.

PTM databases

iPTMnetiQ5VWM4.
PhosphoSitePlusiQ5VWM4.

Expressioni

Gene expression databases

CleanExiHS_PRAMEF8.

Organism-specific databases

HPAiHPA049887.
HPA051704.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349931.

Structurei

3D structure databases

ProteinModelPortaliQ5VWM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 122LRR 1; degenerateBy similarityAdd BLAST26
Repeati177 – 201LRR 2; degenerateBy similarityAdd BLAST25
Repeati202 – 228LRR 3; degenerateBy similarityAdd BLAST27
Repeati229 – 264LRR 4; degenerateBy similarityAdd BLAST36
Repeati265 – 290LRR 5By similarityAdd BLAST26
Repeati291 – 322LRR 6By similarityAdd BLAST32
Repeati323 – 341LRR 7By similarityAdd BLAST19
Repeati347 – 374LRR 8By similarityAdd BLAST28
Repeati375 – 399LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KFA8. Eukaryota.
ENOG411141V. LUCA.
GeneTreeiENSGT00760000119028.
HOVERGENiHBG006326.
InParanoidiQ5VWM4.
OMAiPRTICIS.
OrthoDBiEOG091G05PP.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR026271. PRAME_family.
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE
60 70 80 90 100
TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL
110 120 130 140 150
QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID
160 170 180 190 200
LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC KELQVFGMPI HSIIEVLNMV
210 220 230 240 250
ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN
260 270 280 290 300
KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT
310 320 330 340 350
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL
360 370 380 390 400
QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT
410 420 430 440 450
VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMNTL RDLRQPKIIV
460 470
FCTVPCPRCG IRASYDLEPS HCLC
Length:474
Mass (Da):53,655
Last modified:April 1, 2015 - v2
Checksum:i73F5231BC6EB3B29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA. No translation available.
BC144565 mRNA. Translation: AAI44566.1.
CCDSiCCDS72709.1.
RefSeqiNP_001012276.2. NM_001012276.3.
XP_016856758.1. XM_017001269.1.
UniGeneiHs.553832.

Genome annotation databases

EnsembliENST00000357367; ENSP00000349931; ENSG00000182330.
ENST00000611408; ENSP00000478860; ENSG00000278021.
ENST00000614831; ENSP00000484204; ENSG00000182330.
ENST00000616484; ENSP00000480509; ENSG00000278021.
ENST00000621519; ENSP00000484753; ENSG00000182330.
ENST00000631760; ENSP00000488367; ENSG00000282583.
ENST00000632222; ENSP00000488892; ENSG00000282583.
ENST00000632952; ENSP00000488817; ENSG00000282583.
ENST00000636073; ENSP00000490581; ENSG00000283387.
ENST00000637866; ENSP00000490715; ENSG00000283387.
ENST00000637989; ENSP00000490790; ENSG00000283387.
GeneIDi391002.
KEGGihsa:391002.
UCSCiuc031tpu.2. human.
uc031tpv.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRAM8_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM4
Secondary accession number(s): A6NMC2, B7ZMI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 1, 2015
Last modified: July 5, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families