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Q5VWM4 (PRAM8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PRAME family member 8
Gene names
Name:PRAMEF8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PRAME family.

Contains 2 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474PRAME family member 8
PRO_0000156982

Regions

Repeat318 – 34124LRR 1
Repeat347 – 37428LRR 2

Sequences

Sequence LengthMass (Da)Tools
Q5VWM4 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: BBE3C9336F8922C9

FASTA47453,669
        10         20         30         40         50         60 
MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE TLKTMVQAWP 

        70         80         90        100        110        120 
FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL QVLDLRNVDE NFCDIFSGAT 

       130        140        150        160        170        180 
ASFPEALSQK QTADNCPGTG RQQPFMVFID LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC 

       190        200        210        220        230        240 
QELQVFGMPI HSIIEVLNMV ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI 

       250        260        270        280        290        300 
RASACIPPDN KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT 

       310        320        330        340        350        360 
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL QTLDLEDCGI 

       370        380        390        400        410        420 
MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT VGLSKLSLEL YPAPLESYDT 

       430        440        450        460        470 
QGALCWGRFA ELGAELMKTL RDLRQPKIIV FCTVPCPRCG IRASYDLEPS HCLC 

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References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL365443 Genomic DNA. Translation: CAH71450.1.
RefSeqNP_001012276.1. NM_001012276.2.

3D structure databases

ProteinModelPortalQ5VWM4.
SMRQ5VWM4. Positions 202-456.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74756937.

Proteomic databases

PaxDbQ5VWM4.
PRIDEQ5VWM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357367; ENSP00000349931; ENSG00000182330.
GeneID391002.
KEGGhsa:391002.
UCSCuc001aup.3. human.

Organism-specific databases

CTD391002.
GeneCardsGC01M013386.
HGNCHGNC:24074. PRAMEF8.
HPAHPA049887.
neXtProtNX_Q5VWM4.
PharmGKBPA142671145.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG120841.
HOVERGENHBG006326.
InParanoidQ5VWM4.
OMARASACIT.
OrthoDBEOG7KSX88.
TreeFamTF332708.

Gene expression databases

CleanExHS_PRAMEF8.
GenevestigatorQ5VWM4.

Family and domain databases

InterProIPR026292. PRAME/Leu_rich_rep-con_p14.
IPR026271. PRAME_family.
[Graphical view]
PANTHERPTHR14224. PTHR14224. 1 hit.
PIRSFPIRSF038286. PRAME. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi391002.
NextBio104233.
PROQ5VWM4.

Entry information

Entry namePRAM8_HUMAN
AccessionPrimary (citable) accession number: Q5VWM4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: March 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM