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Protein

PRAME family member 8

Gene

PRAMEF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. negative regulation of apoptotic process Source: InterPro
  2. negative regulation of cell differentiation Source: InterPro
  3. negative regulation of retinoic acid receptor signaling pathway Source: InterPro
  4. negative regulation of transcription, DNA-templated Source: InterPro
  5. positive regulation of cell proliferation Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 8
Gene namesi
Name:PRAMEF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24074. PRAMEF8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474PRAME family member 8PRO_0000156982Add
BLAST

Proteomic databases

PaxDbiQ5VWM4.
PRIDEiQ5VWM4.

Expressioni

Gene expression databases

CleanExiHS_PRAMEF8.
GenevestigatoriQ5VWM4.

Organism-specific databases

HPAiHPA049887.
HPA051704.

Interactioni

Protein-protein interaction databases

BioGridi133762. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5VWM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati318 – 34124LRR 1Add
BLAST
Repeati347 – 37428LRR 2Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family.Curated
Contains 2 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG120841.
HOVERGENiHBG006326.
InParanoidiQ5VWM4.
OMAiCHELKIS.
OrthoDBiEOG7KSX88.
PhylomeDBiQ5VWM4.
TreeFamiTF332708.

Family and domain databases

InterProiIPR026292. PRAME/Leu_rich_rep-con_p14.
IPR026271. PRAME_family.
[Graphical view]
PANTHERiPTHR14224. PTHR14224. 1 hit.
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRAPPRLL ELARQRLLRD QALAISTMEE LPRELFPTLF MEAFSRRRCE
60 70 80 90 100
TLKTMVQAWP FTRLPLGSLM KSPHLESLKS VLEGVDVLLT QEVRPRQSKL
110 120 130 140 150
QVLDLRNVDE NFCDIFSGAT ASFPEALSQK QTADNCPGTG RQQPFMVFID
160 170 180 190 200
LCLKNRTLDE CLTHLLEWGK QRKGLLHVCC QELQVFGMPI HSIIEVLNMV
210 220 230 240 250
ELDCIQEVEV CCPWELSTLV KFAPYLGQMR NLRKLVLFNI RASACIPPDN
260 270 280 290 300
KGQFIARFTS QFLKLDYFQN LSMHSVSFLE GHLDQLLRCL QASLEMVVMT
310 320 330 340 350
DCLLSESDLK HLSWCPSIRQ LKELDLRGVT LTHFSPEPLT GLLEQVVATL
360 370 380 390 400
QTLDLEDCGI MDSQLSAILP VLSRCSQLST FSFCGNLISM AALENLLRHT
410 420 430 440 450
VGLSKLSLEL YPAPLESYDT QGALCWGRFA ELGAELMKTL RDLRQPKIIV
460 470
FCTVPCPRCG IRASYDLEPS HCLC
Length:474
Mass (Da):53,669
Last modified:December 7, 2004 - v1
Checksum:iBBE3C9336F8922C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365443 Genomic DNA. Translation: CAH71450.1.
UniGeneiHs.553832.

Genome annotation databases

EnsembliENST00000357367; ENSP00000349931; ENSG00000182330.
UCSCiuc001aup.3. human.

Polymorphism databases

DMDMi74756937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365443 Genomic DNA. Translation: CAH71450.1.
UniGeneiHs.553832.

3D structure databases

ProteinModelPortaliQ5VWM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133762. 1 interaction.

Polymorphism databases

DMDMi74756937.

Proteomic databases

PaxDbiQ5VWM4.
PRIDEiQ5VWM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357367; ENSP00000349931; ENSG00000182330.
UCSCiuc001aup.3. human.

Organism-specific databases

GeneCardsiGC01M013386.
HGNCiHGNC:24074. PRAMEF8.
HPAiHPA049887.
HPA051704.
neXtProtiNX_Q5VWM4.
PharmGKBiPA142671145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG120841.
HOVERGENiHBG006326.
InParanoidiQ5VWM4.
OMAiCHELKIS.
OrthoDBiEOG7KSX88.
PhylomeDBiQ5VWM4.
TreeFamiTF332708.

Miscellaneous databases

GenomeRNAii391002.
NextBioi104233.
PROiQ5VWM4.

Gene expression databases

CleanExiHS_PRAMEF8.
GenevestigatoriQ5VWM4.

Family and domain databases

InterProiIPR026292. PRAME/Leu_rich_rep-con_p14.
IPR026271. PRAME_family.
[Graphical view]
PANTHERiPTHR14224. PTHR14224. 1 hit.
PIRSFiPIRSF038286. PRAME. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRAM8_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: March 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.