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Protein

PRAME family member 18

Gene

PRAMEF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 18Curated
Gene namesi
Name:PRAMEF18Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30693. PRAMEF18.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148195.

Polymorphism and mutation databases

BioMutaiPRAMEF18.
DMDMi74747420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479PRAME family member 18PRO_0000290163Add
BLAST

Proteomic databases

PaxDbiQ5VWM3.
PRIDEiQ5VWM3.

Expressioni

Gene expression databases

CleanExiHS_PRAMEF18.

Organism-specific databases

HPAiHPA057423.

Structurei

3D structure databases

ProteinModelPortaliQ5VWM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 3824LRR 1Sequence analysisAdd
BLAST
Repeati231 – 25424LRR 2Sequence analysisAdd
BLAST
Repeati293 – 31523LRR 3Sequence analysisAdd
BLAST
Repeati319 – 34224LRR 4Sequence analysisAdd
BLAST
Repeati391 – 41424LRR 5Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PRAME family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IUJ0. Eukaryota.
ENOG4110PY0. LUCA.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiQ5VWM3.
OrthoDBiEOG7TF7DQ.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VWM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPPLF VEAFTSRRCE
60 70 80 90 100
VLKVMVQAWP FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL
110 120 130 140 150
QVLEMRDVDE NFWTIWSGAR LLSCSPEAMS KRQTVEDCPR TGEKQPLKVF
160 170 180 190 200
MDVCLKEKFM DEDLSFFSGW VQHRRGSVHL CCTKVVNYSM SILNFRNILE
210 220 230 240 250
TVYPDSIQVL EIWNMCWLCM IVEFSRYLSQ MRNLRKLFIS DGCRYLLSSD
260 270 280 290 300
SQEQLVAEFS SVLLRLENLQ MLYVRRVCFF RGHLDQLIRC LRSPLETLAL
310 320 330 340 350
TYGFLEEEDL KCLPRYPSLS QLKQLNLSHG ALRFIRLEPL RALLEKVAAT
360 370 380 390 400
LQTLFLVDCG IGYSKLRVIL PALSRCSNLT TFCFHGNDTS MDALKDLLRH
410 420 430 440 450
TGRLSNLSLE TYPAPRESLD NRGRVILELL TPLQAELMRI LREVREPKRI
460 470
FFGPVSCPCC GTSPTEQLES NFCLWGRPA
Length:479
Mass (Da):55,334
Last modified:January 20, 2016 - v2
Checksum:iB65477B0D5E3B8DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA. No translation available.
AL365443 Genomic DNA. Translation: CAH71446.1.
RefSeqiNP_001093320.2. NM_001099850.2.

Genome annotation databases

GeneIDi391003.
KEGGihsa:391003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244216 Genomic DNA. No translation available.
AL365443 Genomic DNA. Translation: CAH71446.1.
RefSeqiNP_001093320.2. NM_001099850.2.

3D structure databases

ProteinModelPortaliQ5VWM3.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiPRAMEF18.
DMDMi74747420.

Proteomic databases

PaxDbiQ5VWM3.
PRIDEiQ5VWM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi391003.
KEGGihsa:391003.

Organism-specific databases

CTDi391003.
GeneCardsiPRAMEF18.
HGNCiHGNC:30693. PRAMEF18.
HPAiHPA057423.
neXtProtiNX_Q5VWM3.
PharmGKBiPA145148195.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUJ0. Eukaryota.
ENOG4110PY0. LUCA.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiQ5VWM3.
OrthoDBiEOG7TF7DQ.
TreeFamiTF332708.

Miscellaneous databases

NextBioi104237.
PROiQ5VWM3.

Gene expression databases

CleanExiHS_PRAMEF18.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRA18_HUMAN
AccessioniPrimary (citable) accession number: Q5VWM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 20, 2016
Last modified: May 11, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.