Q5VWM1 (PRA16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PRAME family member 16

Gene names

Name:

PRAMEF16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the PRAME family. Contains 2 LRR (leucine-rich) repeats.

Ontologies

Keywords
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of apoptotic process Inferred from electronic annotation. Source: InterPro negative regulation of cell differentiation Inferred from electronic annotation. Source: InterPro negative regulation of retinoic acid receptor signaling pathway Inferred from electronic annotation. Source: InterPro negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	PRAME family member 16		PRO_0000290165
Regions
	Repeat	319 – 342	24	LRR 1
	Repeat	348 – 375	28	LRR 2

Sequences

	Sequence		Length	Mass (Da)
	Q5VWM1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 02C5476C477A806B	FASTA	474	54,838
	10 20 30 40 50 60 MSLQSPSRLL ELAGQSLLRN QFLTIFILDE LPREVFPLMF MEASSMRHFE ALKLMVQAWP 70 80 90 100 110 120 FLRLPLGSLM KTPHLETLQA VLKGLDTLLA QKLRPRRWKL QVLDLRDVDG NFWTIWSGAR 130 140 150 160 170 180 ALSCSPEAMR KRQTVEDYPR TGEHQPLKVF IDLCQKESTL DECLSYLCRW IHYRRGLVHL 190 200 210 220 230 240 CCNKVQNYSM PTSSFRNLLK RVYPDSIQEL EIKRKCSLNK TGKFAPYLSQ MSNLRKLFLA 250 260 270 280 290 300 FGYDDELYVS GQQQFVPDLD CPFLCLYYPQ MLYIRKISNI KEHLEHLLRC LKNPLGTFIF 310 320 330 340 350 360 CHAYLADQDM ECLSQYPSLS QLKELHLIHI LMWTTNLEPL GALLEKVAAT LEILTLKDCQ 370 380 390 400 410 420 IQDSQLRVLL PALSRCSQLT TFYFRGNETS TNALKDLLCH TGGLSKLGLE LYPAPLECLD 430 440 450 460 470 NRGHVNWEIL APIRAELMCT LREVRQPKRI FFGPIPCPSC GSWPSEKVDF HLCS

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL365443 Genomic DNA. Translation: CAH71445.1.
IPI	IPI00642000.
RefSeq	NP_001038945.1. NM_001045480.1.
UniGene	Hs.684629.
3D structure databases
ProteinModelPortal	Q5VWM1.
ModBase	Search...
PTM databases
PhosphoSite	Q5VWM1.
Polymorphism databases
DMDM	74747419.
Proteomic databases
PaxDb	Q5VWM1.
PRIDE	Q5VWM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376121; ENSP00000365289; ENSG00000204488.
GeneID	654348.
KEGG	hsa:654348.
UCSC	uc001aux.3. human.
Organism-specific databases
CTD	654348.
GeneCards	GC01P013495.
HGNC	HGNC:25767. PRAMEF16.
neXtProt	NX_Q5VWM1.
PharmGKB	PA145148186.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70296.
HOGENOM	HOG000231112.
HOVERGEN	HBG006326.
InParanoid	Q5VWM1.
OMA	MANHINE.
OrthoDB	EOG4VQ9P3.
Gene expression databases
Genevestigator	Q5VWM1.
Family and domain databases
InterPro	IPR026292. PRAME/Leu_rich_rep-con_p14. IPR026271. PRAME_family. [Graphical view]
PANTHER	PTHR14224. PTHR14224. 1 hit.
PIRSF	PIRSF038286. PRAME. 1 hit.
ProtoNet	Search...
Other
NextBio	123893.

Entry information

Entry name

PRA16_HUMAN

Accession

Primary (citable) accession number: Q5VWM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.