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Q5VWK5

- IL23R_HUMAN

UniProt

Q5VWK5 - IL23R_HUMAN

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Protein
Interleukin-23 receptor
Gene
IL23R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.1 Publication

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: BHF-UCL
  2. inflammatory response Source: UniProtKB-KW
  3. interleukin-23-mediated signaling pathway Source: GOC
  4. negative regulation of interleukin-10 production Source: BHF-UCL
  5. positive regulation of NK T cell activation Source: BHF-UCL
  6. positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
  7. positive regulation of T cell proliferation Source: BHF-UCL
  8. positive regulation of T-helper 1 type immune response Source: BHF-UCL
  9. positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
  10. positive regulation of T-helper 17 type immune response Source: BHF-UCL
  11. positive regulation of activated T cell proliferation Source: BHF-UCL
  12. positive regulation of activation of JAK2 kinase activity Source: BHF-UCL
  13. positive regulation of defense response to virus by host Source: BHF-UCL
  14. positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
  15. positive regulation of interferon-gamma production Source: BHF-UCL
  16. positive regulation of interleukin-12 production Source: BHF-UCL
  17. positive regulation of interleukin-17 production Source: BHF-UCL
  18. positive regulation of memory T cell differentiation Source: BHF-UCL
  19. positive regulation of natural killer cell proliferation Source: BHF-UCL
  20. positive regulation of osteoclast differentiation Source: BHF-UCL
  21. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  22. positive regulation of tyrosine phosphorylation of Stat4 protein Source: BHF-UCL
  23. positive regulation of tyrosine phosphorylation of Stat5 protein Source: BHF-UCL
  24. regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
  25. response to interferon-gamma Source: BHF-UCL
  26. response to lipopolysaccharide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

SignaLinkiQ5VWK5.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 receptor
Short name:
IL-23 receptor
Short name:
IL-23R
Gene namesi
Name:IL23R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19100. IL23R.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 355332Extracellular Reviewed prediction
Add
BLAST
Transmembranei356 – 37621Helical; Reviewed prediction
Add
BLAST
Topological domaini377 – 629253Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. interleukin-23 receptor complex Source: BHF-UCL
  2. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti381 – 3811R → Q Associated with IBD17; has a protective effect against Crohn disease and psoriasis. 4 Publications
Corresponds to variant rs11209026 [ dbSNP | Ensembl ].
VAR_029754
Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi605606. phenotype.
612261. phenotype.
Orphaneti117. Behcet disease.
206. Crohn disease.
771. Ulcerative colitis.
PharmGKBiPA134935109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 629606Interleukin-23 receptor
PRO_0000268662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...); partial1 Publication
Glycosylationi47 – 471N-linked (GlcNAc...)1 Publication
Glycosylationi81 – 811N-linked (GlcNAc...)1 Publication
Glycosylationi141 – 1411N-linked (GlcNAc...)1 Publication
Glycosylationi180 – 1801N-linked (GlcNAc...) (high mannose)1 Publication
Glycosylationi232 – 2321N-linked (GlcNAc...)1 Publication
Glycosylationi262 – 2621N-linked (GlcNAc...)1 Publication
Glycosylationi273 – 2731N-linked (GlcNAc...); partial1 Publication

Post-translational modificationi

Phosphorylated in response to IL23.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5VWK5.
PRIDEiQ5VWK5.

PTM databases

PhosphoSiteiQ5VWK5.

Expressioni

Tissue specificityi

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.2 Publications

Gene expression databases

ArrayExpressiQ5VWK5.
BgeeiQ5VWK5.
GenevestigatoriQ5VWK5.

Organism-specific databases

HPAiHPA056427.

Interactioni

Subunit structurei

Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.1 Publication

Protein-protein interaction databases

BioGridi127199. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5VWK5.
SMRiQ5VWK5. Positions 76-308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 21791Fibronectin type-III 1
Add
BLAST
Domaini219 – 318100Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41959.
HOVERGENiHBG081787.
InParanoidiQ5VWK5.
KOiK05065.
OMAiDEFVSCL.
OrthoDBiEOG7C2R0N.
PhylomeDBiQ5VWK5.
TreeFamiTF335930.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VWK5-1) [UniParc]FASTAAdd to Basket

Also known as: IL-23R1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI    50
YCQAAIKNCQ PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY 100
CTAECPKHFQ ETLICGKDIS SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK 150
LTYIDTKYVV HVKSLETEEE QQYLTSSYIN ISTDSLQGGK KYLVWVQAAN 200
ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII YWDSQTTIEK 250
VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG 300
KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN 350
RGDIGLLLGM IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI 400
PNMKNSNVVK MLQENSELMN NNSSEQVLYV DPMITEIKEI FIPEHKPTDY 450
KKENTGPLET RDYPQNSLFD NTTVVYIPDL NTGYKPQISN FLPEGSHLSN 500
NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL SNTIFLGELS 550
LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI 600
VNEELPSINT YFPQNILESH FNRISLLEK 629
Length:629
Mass (Da):71,722
Last modified:November 2, 2010 - v3
Checksum:iAC63C89E81AABF05
GO
Isoform 2 (identifier: Q5VWK5-2) [UniParc]FASTAAdd to Basket

Also known as: IL-23R2-F2

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 4. No experimental confirmation available.

Show »
Length:375
Mass (Da):42,822
Checksum:iF6436B1432AD56A9
GO
Isoform 3 (identifier: Q5VWK5-3) [UniParc]FASTAAdd to Basket

Also known as: IL-23R3-F1

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: DNRGDIGL → GLKEGSYC
     357-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 5. No experimental confirmation available.

Show »
Length:356
Mass (Da):40,859
Checksum:iD9A98F0E8F380490
GO
Isoform 4 (identifier: Q5VWK5-4) [UniParc]FASTAAdd to Basket

Also known as: IL-23R2-F1

The sequence of this isoform differs from the canonical sequence as follows:
     165-174: LETEEEQQYL → DTFCSRHFQG
     175-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 2. No experimental confirmation available.

Show »
Length:174
Mass (Da):20,068
Checksum:i2F45099F46F673A5
GO
Isoform 5 (identifier: Q5VWK5-5) [UniParc]FASTAAdd to Basket

Also known as: IL-23R3-F3

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.
     366-383: MLSILSLIGIFNRSFRTG → MEFWANSCFHLYRAPYFW

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 3. No experimental confirmation available.

Show »
Length:264
Mass (Da):30,278
Checksum:i1695194600E3DABF
GO
Isoform 6 (identifier: Q5VWK5-6) [UniParc]FASTAAdd to Basket

Also known as: IL-23R6

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-266: RYKATTNQTWN → MILRPYQPCGT

Note: No experimental confirmation available.

Show »
Length:374
Mass (Da):42,587
Checksum:iFCB35A2F849DA5F7
GO
Isoform 7 (identifier: Q5VWK5-7) [UniParc]FASTAAdd to Basket

Also known as: IL-23R5

The sequence of this isoform differs from the canonical sequence as follows:
     1-402: Missing.

Note: No experimental confirmation available.

Show »
Length:227
Mass (Da):25,551
Checksum:i43A70A48046FA1F2
GO

Sequence cautioni

The sequence AAH16829.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAH70408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAI22679.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31Q → H.1 Publication
Corresponds to variant rs1884444 [ dbSNP | Ensembl ].
VAR_029752
Natural varianti175 – 1751T → N.
Corresponds to variant rs11465797 [ dbSNP | Ensembl ].
VAR_047955
Natural varianti310 – 3101L → P.5 Publications
Corresponds to variant rs7530511 [ dbSNP | Ensembl ].
VAR_029753
Natural varianti381 – 3811R → Q Associated with IBD17; has a protective effect against Crohn disease and psoriasis. 4 Publications
Corresponds to variant rs11209026 [ dbSNP | Ensembl ].
VAR_029754

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 402402Missing in isoform 7.
VSP_021990Add
BLAST
Alternative sequencei1 – 365365Missing in isoform 5.
VSP_021991Add
BLAST
Alternative sequencei1 – 255255Missing in isoform 6.
VSP_021992Add
BLAST
Alternative sequencei1 – 254254Missing in isoform 2.
VSP_021993Add
BLAST
Alternative sequencei165 – 17410LETEEEQQYL → DTFCSRHFQG in isoform 4.
VSP_021994
Alternative sequencei175 – 629455Missing in isoform 4.
VSP_021995Add
BLAST
Alternative sequencei256 – 26611RYKATTNQTWN → MILRPYQPCGT in isoform 6.
VSP_021996Add
BLAST
Alternative sequencei349 – 3568DNRGDIGL → GLKEGSYC in isoform 3.
VSP_021997
Alternative sequencei357 – 629273Missing in isoform 3.
VSP_021998Add
BLAST
Alternative sequencei366 – 38318MLSIL…SFRTG → MEFWANSCFHLYRAPYFW in isoform 5.
VSP_021999Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461M → T in AAY18346. 1 Publication
Sequence conflicti133 – 1331C → R in AAY18348. 1 Publication
Sequence conflicti302 – 3021R → G in AAY18348. 1 Publication
Sequence conflicti475 – 4751V → A in AAY18347. 1 Publication
Sequence conflicti481 – 4811N → D in AAY18347. 1 Publication
Sequence conflicti581 – 5811S → R in AAY18349. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461422 mRNA. Translation: AAM44229.1.
AY937250 mRNA. Translation: AAY18345.1.
AY937251 mRNA. Translation: AAY18346.1.
AY937252 mRNA. Translation: AAY18347.1.
AY937253 mRNA. Translation: AAY18348.1.
AY937254 mRNA. Translation: AAY18349.1.
AY937255 mRNA. Translation: AAY18350.1.
AL389925, AL109843 Genomic DNA. Translation: CAH70406.1.
AL389925, AL109843 Genomic DNA. Translation: CAH70408.1. Different initiation.
AL109843, AL389925 Genomic DNA. Translation: CAI22678.1.
AL109843, AL389925 Genomic DNA. Translation: CAI22679.1. Different initiation.
BC016829 mRNA. Translation: AAH16829.1. Different initiation.
BC040720 mRNA. Translation: AAH40720.1.
CCDSiCCDS637.1. [Q5VWK5-1]
RefSeqiNP_653302.2. NM_144701.2. [Q5VWK5-1]
XP_005270573.1. XM_005270516.1. [Q5VWK5-2]
XP_005270574.1. XM_005270517.1. [Q5VWK5-6]
UniGeneiHs.677426.

Genome annotation databases

EnsembliENST00000347310; ENSP00000321345; ENSG00000162594. [Q5VWK5-1]
ENST00000371002; ENSP00000360041; ENSG00000162594. [Q5VWK5-3]
ENST00000395227; ENSP00000378652; ENSG00000162594. [Q5VWK5-6]
GeneIDi149233.
KEGGihsa:149233.
UCSCiuc001ddo.3. human. [Q5VWK5-1]
uc001dds.3. human. [Q5VWK5-6]
uc001ddt.3. human. [Q5VWK5-7]
uc010opk.2. human. [Q5VWK5-3]
uc010opw.2. human. [Q5VWK5-5]

Polymorphism databases

DMDMi311033431.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF461422 mRNA. Translation: AAM44229.1 .
AY937250 mRNA. Translation: AAY18345.1 .
AY937251 mRNA. Translation: AAY18346.1 .
AY937252 mRNA. Translation: AAY18347.1 .
AY937253 mRNA. Translation: AAY18348.1 .
AY937254 mRNA. Translation: AAY18349.1 .
AY937255 mRNA. Translation: AAY18350.1 .
AL389925 , AL109843 Genomic DNA. Translation: CAH70406.1 .
AL389925 , AL109843 Genomic DNA. Translation: CAH70408.1 . Different initiation.
AL109843 , AL389925 Genomic DNA. Translation: CAI22678.1 .
AL109843 , AL389925 Genomic DNA. Translation: CAI22679.1 . Different initiation.
BC016829 mRNA. Translation: AAH16829.1 . Different initiation.
BC040720 mRNA. Translation: AAH40720.1 .
CCDSi CCDS637.1. [Q5VWK5-1 ]
RefSeqi NP_653302.2. NM_144701.2. [Q5VWK5-1 ]
XP_005270573.1. XM_005270516.1. [Q5VWK5-2 ]
XP_005270574.1. XM_005270517.1. [Q5VWK5-6 ]
UniGenei Hs.677426.

3D structure databases

ProteinModelPortali Q5VWK5.
SMRi Q5VWK5. Positions 76-308.
ModBasei Search...

Protein-protein interaction databases

BioGridi 127199. 2 interactions.

PTM databases

PhosphoSitei Q5VWK5.

Polymorphism databases

DMDMi 311033431.

Proteomic databases

PaxDbi Q5VWK5.
PRIDEi Q5VWK5.

Protocols and materials databases

DNASUi 149233.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347310 ; ENSP00000321345 ; ENSG00000162594 . [Q5VWK5-1 ]
ENST00000371002 ; ENSP00000360041 ; ENSG00000162594 . [Q5VWK5-3 ]
ENST00000395227 ; ENSP00000378652 ; ENSG00000162594 . [Q5VWK5-6 ]
GeneIDi 149233.
KEGGi hsa:149233.
UCSCi uc001ddo.3. human. [Q5VWK5-1 ]
uc001dds.3. human. [Q5VWK5-6 ]
uc001ddt.3. human. [Q5VWK5-7 ]
uc010opk.2. human. [Q5VWK5-3 ]
uc010opw.2. human. [Q5VWK5-5 ]

Organism-specific databases

CTDi 149233.
GeneCardsi GC01P067632.
H-InvDB HIX0023553.
HGNCi HGNC:19100. IL23R.
HPAi HPA056427.
MIMi 605606. phenotype.
607562. gene.
612261. phenotype.
neXtProti NX_Q5VWK5.
Orphaneti 117. Behcet disease.
206. Crohn disease.
771. Ulcerative colitis.
PharmGKBi PA134935109.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41959.
HOVERGENi HBG081787.
InParanoidi Q5VWK5.
KOi K05065.
OMAi DEFVSCL.
OrthoDBi EOG7C2R0N.
PhylomeDBi Q5VWK5.
TreeFami TF335930.

Enzyme and pathway databases

SignaLinki Q5VWK5.

Miscellaneous databases

GeneWikii Interleukin-23_receptor.
GenomeRNAii 149233.
NextBioi 86105.
PROi Q5VWK5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5VWK5.
Bgeei Q5VWK5.
Genevestigatori Q5VWK5.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH IL23; IL12RB1; JAK2 AND STAT3, PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT PRO-310.
    Tissue: Natural killer cell and T-cell.
  2. "Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells."
    Zhang X.-Y., Zhang H.-J., Zhang Y., Fu Y.-J., He J., Zhu L.-P., Wang S.-H., Liu L.
    Immunogenetics 57:934-943(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [MRNA] OF 37-629 (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY, VARIANT PRO-310.
    Tissue: Bone marrow.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANT PRO-310.
    Tissue: Bone marrow and Skin.
  5. Cited for: INVOLVEMENT IN IBD17, VARIANTS HIS-3; PRO-310 AND GLN-381.
  6. "Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."
    Capon F., Di Meglio P., Szaub J., Prescott N.J., Dunster C., Baumber L., Timms K., Gutin A., Abkevic V., Burden A.D., Lanchbury J., Barker J.N., Trembath R.C., Nestle F.O.
    Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PSORIASIS, VARIANT GLN-381.
  7. Cited for: INVOLVEMENT IN IBD17, VARIANT GLN-381.
  8. "Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."
    Huffmeier U., Lascorz J., Bohm B., Lohmann J., Wendler J., Mossner R., Reich K., Traupe H., Kurrat W., Burkhardt H., Reis A.
    J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH PSORIASIS, VARIANTS PRO-310 AND GLN-381.
  9. "Glycosylation analysis of interleukin-23 receptor: elucidation of glycosylation sites and characterization of attached glycan structures."
    Zhao J., Liu Y.H., Reichert P., Pflanz S., Pramanik B.
    J. Mass Spectrom. 45:1416-1425(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-29; ASN-47; ASN-81; ASN-141; ASN-180; ASN-232; ASN-262 AND ASN-273.

Entry informationi

Entry nameiIL23R_HUMAN
AccessioniPrimary (citable) accession number: Q5VWK5
Secondary accession number(s): C9JGX4
, Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6, Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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