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Q5VWK5 (IL23R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-23 receptor

Short name=IL-23 receptor
Short name=IL-23R
Gene names
Name:IL23R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Ref.1

Subunit structure

Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3. Ref.1

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.1.

Tissue specificity

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. Ref.1 Ref.2

Post-translational modification

Phosphorylated in response to IL23. Ref.1

Involvement in disease

Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5 Ref.7

Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Contains 2 fibronectin type-III domains.

Sequence caution

The sequence AAH16829.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAH70408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAI22679.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processImmunity
Inflammatory response
Innate immunity
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to Gram-negative bacterium

Inferred by curator PubMed 15114670. Source: BHF-UCL

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-23-mediated signaling pathway

Inferred from direct assay Ref.1. Source: GOC

negative regulation of interleukin-10 production

Inferred from mutant phenotype PubMed 16751425. Source: BHF-UCL

positive regulation of NK T cell activation

Inferred by curator PubMed 19088061. Source: BHF-UCL

positive regulation of T cell mediated cytotoxicity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell proliferation

Inferred by curator Ref.1. Source: BHF-UCL

positive regulation of T-helper 1 type immune response

Inferred from direct assay PubMed 15114670. Source: BHF-UCL

positive regulation of T-helper 17 cell lineage commitment

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T-helper 17 type immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of activated T cell proliferation

Inferred by curator PubMed 11114383. Source: BHF-UCL

positive regulation of activation of JAK2 kinase activity

Inferred by curator Ref.1. Source: BHF-UCL

positive regulation of defense response to virus by host

Inferred from direct assay PubMed 12421946. Source: BHF-UCL

positive regulation of granulocyte macrophage colony-stimulating factor production

Inferred by curator PubMed 20027291. Source: BHF-UCL

positive regulation of interferon-gamma production

Inferred from direct assay PubMed 11114383. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from direct assay PubMed 20027291. Source: BHF-UCL

positive regulation of interleukin-17 production

Inferred by curator PubMed 17888176. Source: BHF-UCL

positive regulation of memory T cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of natural killer cell proliferation

Inferred by curator PubMed 19088061. Source: BHF-UCL

positive regulation of osteoclast differentiation

Inferred by curator PubMed 17888176. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred by curator PubMed 19088061. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat4 protein

Inferred by curator PubMed 19088061. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat5 protein

Inferred by curator Ref.1. Source: BHF-UCL

regulation of tyrosine phosphorylation of Stat1 protein

Inferred by curator Ref.1. Source: BHF-UCL

response to interferon-gamma

Inferred from direct assay Ref.1. Source: BHF-UCL

response to lipopolysaccharide

Inferred from direct assay Ref.1. Source: BHF-UCL

   Cellular_componentinterleukin-23 receptor complex

Inferred from direct assay Ref.1. Source: BHF-UCL

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VWK5-1)

Also known as: IL-23R1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VWK5-2)

Also known as: IL-23R2-F2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
Note: Produced by translation in an alternate frame of the cDNA encoding isoform 4. No experimental confirmation available.
Isoform 3 (identifier: Q5VWK5-3)

Also known as: IL-23R3-F1;

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: DNRGDIGL → GLKEGSYC
     357-629: Missing.
Note: Produced by translation in an alternate frame of the cDNA encoding isoform 5. No experimental confirmation available.
Isoform 4 (identifier: Q5VWK5-4)

Also known as: IL-23R2-F1;

The sequence of this isoform differs from the canonical sequence as follows:
     165-174: LETEEEQQYL → DTFCSRHFQG
     175-629: Missing.
Note: Produced by translation in an alternate frame of the cDNA encoding isoform 2. No experimental confirmation available.
Isoform 5 (identifier: Q5VWK5-5)

Also known as: IL-23R3-F3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.
     366-383: MLSILSLIGIFNRSFRTG → MEFWANSCFHLYRAPYFW
Note: Produced by translation in an alternate frame of the cDNA encoding isoform 3. No experimental confirmation available.
Isoform 6 (identifier: Q5VWK5-6)

Also known as: IL-23R6;

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-266: RYKATTNQTWN → MILRPYQPCGT
Note: No experimental confirmation available.
Isoform 7 (identifier: Q5VWK5-7)

Also known as: IL-23R5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-402: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 629606Interleukin-23 receptor
PRO_0000268662

Regions

Topological domain24 – 355332Extracellular Potential
Transmembrane356 – 37621Helical; Potential
Topological domain377 – 629253Cytoplasmic Potential
Domain127 – 21791Fibronectin type-III 1
Domain219 – 318100Fibronectin type-III 2

Amino acid modifications

Glycosylation291N-linked (GlcNAc...); partial Ref.9
Glycosylation471N-linked (GlcNAc...) Ref.9
Glycosylation811N-linked (GlcNAc...) Ref.9
Glycosylation1411N-linked (GlcNAc...) Ref.9
Glycosylation1801N-linked (GlcNAc...) (high mannose) Ref.9
Glycosylation2321N-linked (GlcNAc...) Ref.9
Glycosylation2621N-linked (GlcNAc...) Ref.9
Glycosylation2731N-linked (GlcNAc...); partial Ref.9

Natural variations

Alternative sequence1 – 402402Missing in isoform 7.
VSP_021990
Alternative sequence1 – 365365Missing in isoform 5.
VSP_021991
Alternative sequence1 – 255255Missing in isoform 6.
VSP_021992
Alternative sequence1 – 254254Missing in isoform 2.
VSP_021993
Alternative sequence165 – 17410LETEEEQQYL → DTFCSRHFQG in isoform 4.
VSP_021994
Alternative sequence175 – 629455Missing in isoform 4.
VSP_021995
Alternative sequence256 – 26611RYKATTNQTWN → MILRPYQPCGT in isoform 6.
VSP_021996
Alternative sequence349 – 3568DNRGDIGL → GLKEGSYC in isoform 3.
VSP_021997
Alternative sequence357 – 629273Missing in isoform 3.
VSP_021998
Alternative sequence366 – 38318MLSIL…SFRTG → MEFWANSCFHLYRAPYFW in isoform 5.
VSP_021999
Natural variant31Q → H. Ref.5
Corresponds to variant rs1884444 [ dbSNP | Ensembl ].
VAR_029752
Natural variant1751T → N.
Corresponds to variant rs11465797 [ dbSNP | Ensembl ].
VAR_047955
Natural variant3101L → P. Ref.1 Ref.2 Ref.4 Ref.5 Ref.8
Corresponds to variant rs7530511 [ dbSNP | Ensembl ].
VAR_029753
Natural variant3811R → Q Associated with IBD17; has a protective effect against Crohn disease and psoriasis. Ref.5 Ref.6 Ref.7 Ref.8
Corresponds to variant rs11209026 [ dbSNP | Ensembl ].
VAR_029754

Experimental info

Sequence conflict461M → T in AAY18346. Ref.2
Sequence conflict1331C → R in AAY18348. Ref.2
Sequence conflict3021R → G in AAY18348. Ref.2
Sequence conflict4751V → A in AAY18347. Ref.2
Sequence conflict4811N → D in AAY18347. Ref.2
Sequence conflict5811S → R in AAY18349. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (IL-23R1) [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: AC63C89E81AABF05

FASTA62971,722
        10         20         30         40         50         60 
MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ 

        70         80         90        100        110        120 
PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS 

       130        140        150        160        170        180 
SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSLETEEE QQYLTSSYIN 

       190        200        210        220        230        240 
ISTDSLQGGK KYLVWVQAAN ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII 

       250        260        270        280        290        300 
YWDSQTTIEK VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG 

       310        320        330        340        350        360 
KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN RGDIGLLLGM 

       370        380        390        400        410        420 
IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI PNMKNSNVVK MLQENSELMN 

       430        440        450        460        470        480 
NNSSEQVLYV DPMITEIKEI FIPEHKPTDY KKENTGPLET RDYPQNSLFD NTTVVYIPDL 

       490        500        510        520        530        540 
NTGYKPQISN FLPEGSHLSN NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL 

       550        560        570        580        590        600 
SNTIFLGELS LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI 

       610        620 
VNEELPSINT YFPQNILESH FNRISLLEK 

« Hide

Isoform 2 (IL-23R2-F2) [UniParc].

Checksum: F6436B1432AD56A9
Show »

FASTA37542,822
Isoform 3 (IL-23R3-F1) [UniParc].

Checksum: D9A98F0E8F380490
Show »

FASTA35640,859
Isoform 4 (IL-23R2-F1) [UniParc].

Checksum: 2F45099F46F673A5
Show »

FASTA17420,068
Isoform 5 (IL-23R3-F3) [UniParc].

Checksum: 1695194600E3DABF
Show »

FASTA26430,278
Isoform 6 (IL-23R6) [UniParc].

Checksum: FCB35A2F849DA5F7
Show »

FASTA37442,587
Isoform 7 (IL-23R5) [UniParc].

Checksum: 43A70A48046FA1F2
Show »

FASTA22725,551

References

« Hide 'large scale' references
[1]"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M. expand/collapse author list , Kastelein R.A., de Waal Malefyt R., Moore K.W.
J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH IL23; IL12RB1; JAK2 AND STAT3, PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT PRO-310.
Tissue: Natural killer cell and T-cell.
[2]"Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells."
Zhang X.-Y., Zhang H.-J., Zhang Y., Fu Y.-J., He J., Zhu L.-P., Wang S.-H., Liu L.
Immunogenetics 57:934-943(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [MRNA] OF 37-629 (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY, VARIANT PRO-310.
Tissue: Bone marrow.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANT PRO-310.
Tissue: Bone marrow and Skin.
[5]"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene."
Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., Steinhart A.H., Abraham C., Regueiro M., Griffiths A., Dassopoulos T., Bitton A., Yang H., Targan S., Datta L.W., Kistner E.O., Schumm L.P., Lee A.T. expand/collapse author list , Gregersen P.K., Barmada M.M., Rotter J.I., Nicolae D.L., Cho J.H.
Science 314:1461-1463(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN IBD17, VARIANTS HIS-3; PRO-310 AND GLN-381.
[6]"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."
Capon F., Di Meglio P., Szaub J., Prescott N.J., Dunster C., Baumber L., Timms K., Gutin A., Abkevic V., Burden A.D., Lanchbury J., Barker J.N., Trembath R.C., Nestle F.O.
Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN PSORIASIS, VARIANT GLN-381.
[7]"Genome-wide association study for Crohn's disease in the Quebec founder population identifies multiple validated disease loci."
Raelson J.V., Little R.D., Ruether A., Fournier H., Paquin B., Van Eerdewegh P., Bradley W.E.C., Croteau P., Nguyen-Huu Q., Segal J., Debrus S., Allard R., Rosenstiel P., Franke A., Jacobs G., Nikolaus S., Vidal J.-M., Szego P. expand/collapse author list , Laplante N., Clark H.F., Paulussen R.J., Hooper J.W., Keith T.P., Belouchi A., Schreiber S.
Proc. Natl. Acad. Sci. U.S.A. 104:14747-14752(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN IBD17, VARIANT GLN-381.
[8]"Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."
Huffmeier U., Lascorz J., Bohm B., Lohmann J., Wendler J., Mossner R., Reich K., Traupe H., Kurrat W., Burkhardt H., Reis A.
J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH PSORIASIS, VARIANTS PRO-310 AND GLN-381.
[9]"Glycosylation analysis of interleukin-23 receptor: elucidation of glycosylation sites and characterization of attached glycan structures."
Zhao J., Liu Y.H., Reichert P., Pflanz S., Pramanik B.
J. Mass Spectrom. 45:1416-1425(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-29; ASN-47; ASN-81; ASN-141; ASN-180; ASN-232; ASN-262 AND ASN-273.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF461422 mRNA. Translation: AAM44229.1.
AY937250 mRNA. Translation: AAY18345.1.
AY937251 mRNA. Translation: AAY18346.1.
AY937252 mRNA. Translation: AAY18347.1.
AY937253 mRNA. Translation: AAY18348.1.
AY937254 mRNA. Translation: AAY18349.1.
AY937255 mRNA. Translation: AAY18350.1.
AL389925, AL109843 Genomic DNA. Translation: CAH70406.1.
AL389925, AL109843 Genomic DNA. Translation: CAH70408.1. Different initiation.
AL109843, AL389925 Genomic DNA. Translation: CAI22678.1.
AL109843, AL389925 Genomic DNA. Translation: CAI22679.1. Different initiation.
BC016829 mRNA. Translation: AAH16829.1. Different initiation.
BC040720 mRNA. Translation: AAH40720.1.
RefSeqNP_653302.2. NM_144701.2.
XP_005270573.1. XM_005270516.1.
XP_005270574.1. XM_005270517.1.
UniGeneHs.677426.

3D structure databases

ProteinModelPortalQ5VWK5.
SMRQ5VWK5. Positions 28-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127199. 2 interactions.

PTM databases

PhosphoSiteQ5VWK5.

Polymorphism databases

DMDM311033431.

Proteomic databases

PaxDbQ5VWK5.
PRIDEQ5VWK5.

Protocols and materials databases

DNASU149233.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000347310; ENSP00000321345; ENSG00000162594. [Q5VWK5-1]
ENST00000371002; ENSP00000360041; ENSG00000162594. [Q5VWK5-3]
ENST00000395227; ENSP00000378652; ENSG00000162594. [Q5VWK5-6]
GeneID149233.
KEGGhsa:149233.
UCSCuc001ddo.3. human. [Q5VWK5-1]
uc001dds.3. human. [Q5VWK5-6]
uc001ddt.3. human. [Q5VWK5-7]
uc010opk.2. human. [Q5VWK5-3]
uc010opw.2. human. [Q5VWK5-5]

Organism-specific databases

CTD149233.
GeneCardsGC01P067632.
H-InvDBHIX0023553.
HGNCHGNC:19100. IL23R.
HPAHPA056427.
MIM605606. phenotype.
607562. gene.
612261. phenotype.
neXtProtNX_Q5VWK5.
Orphanet117. Behcet disease.
206. Crohn disease.
771. Ulcerative colitis.
PharmGKBPA134935109.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41959.
HOVERGENHBG081787.
InParanoidQ5VWK5.
KOK05065.
OMADEFVSCL.
OrthoDBEOG7C2R0N.
PhylomeDBQ5VWK5.
TreeFamTF335930.

Enzyme and pathway databases

SignaLinkQ5VWK5.

Gene expression databases

ArrayExpressQ5VWK5.
BgeeQ5VWK5.
GenevestigatorQ5VWK5.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin-23_receptor.
GenomeRNAi149233.
NextBio86105.
PROQ5VWK5.
SOURCESearch...

Entry information

Entry nameIL23R_HUMAN
AccessionPrimary (citable) accession number: Q5VWK5
Secondary accession number(s): C9JGX4 expand/collapse secondary AC list , Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6, Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM