Q5VWK5 (IL23R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-23 receptor
Short name=IL-23 receptor
Short name=IL-23R

Gene names

Name:

IL23R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Ref.1
Subunit structure	Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3. Ref.1
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.1.
Tissue specificity	Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. Ref.1 Ref.2
Post-translational modification	Phosphorylated in response to IL23. Ref.1
Involvement in disease	Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5 Ref.7 Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 2 fibronectin type-III domains.
Sequence caution	The sequence AAH16829.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAH70408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAI22679.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Immunity Inflammatory response Innate immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to Gram-negative bacterium Inferred by curator PubMed 15114670. Source: BHF-UCL inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW interleukin-23-mediated signaling pathway Inferred from direct assay Ref.1. Source: GOC negative regulation of interleukin-10 production Inferred from mutant phenotype PubMed 16751425. Source: BHF-UCL positive regulation of NK T cell activation Inferred by curator PubMed 19088061. Source: BHF-UCL positive regulation of T cell mediated cytotoxicity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T-helper 1 type immune response Inferred from direct assay PubMed 15114670. Source: BHF-UCL positive regulation of T-helper 17 cell lineage commitment Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T-helper 17 type immune response Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of activated T cell proliferation Inferred by curator PubMed 11114383. Source: BHF-UCL positive regulation of activation of JAK2 kinase activity Inferred by curator Ref.1. Source: BHF-UCL positive regulation of defense response to virus by host Inferred from direct assay PubMed 12421946. Source: BHF-UCL positive regulation of granulocyte macrophage colony-stimulating factor production Inferred by curator PubMed 20027291. Source: BHF-UCL positive regulation of interferon-gamma production Inferred from direct assay PubMed 11114383. Source: BHF-UCL positive regulation of interleukin-12 production Inferred from direct assay PubMed 20027291. Source: BHF-UCL positive regulation of interleukin-17 production Inferred by curator PubMed 17888176. Source: BHF-UCL positive regulation of memory T cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of natural killer cell proliferation Inferred by curator PubMed 19088061. Source: BHF-UCL positive regulation of osteoclast differentiation Inferred by curator PubMed 17888176. Source: BHF-UCL positive regulation of tyrosine phosphorylation of Stat3 protein Inferred by curator PubMed 19088061. Source: BHF-UCL positive regulation of tyrosine phosphorylation of Stat4 protein Inferred by curator PubMed 19088061. Source: BHF-UCL positive regulation of tyrosine phosphorylation of Stat5 protein Inferred by curator Ref.1. Source: BHF-UCL regulation of tyrosine phosphorylation of Stat1 protein Inferred by curator Ref.1. Source: BHF-UCL response to interferon-gamma Inferred from direct assay Ref.1. Source: BHF-UCL response to lipopolysaccharide Inferred from direct assay Ref.1. Source: BHF-UCL
Cellular_component	interleukin-23 receptor complex Inferred from direct assay Ref.1. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VWK5-1)

Also known as: IL-23R1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VWK5-2)

Also known as: IL-23R2-F2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 4. No experimental confirmation available.

Isoform 3 (identifier: Q5VWK5-3)

Also known as: IL-23R3-F1;

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: DNRGDIGL → GLKEGSYC
     357-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 5. No experimental confirmation available.

Isoform 4 (identifier: Q5VWK5-4)

Also known as: IL-23R2-F1;

The sequence of this isoform differs from the canonical sequence as follows:
     165-174: LETEEEQQYL → DTFCSRHFQG
     175-629: Missing.

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 2. No experimental confirmation available.

Isoform 5 (identifier: Q5VWK5-5)

Also known as: IL-23R3-F3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.
     366-383: MLSILSLIGIFNRSFRTG → MEFWANSCFHLYRAPYFW

Note: Produced by translation in an alternate frame of the cDNA encoding isoform 3. No experimental confirmation available.

Isoform 6 (identifier: Q5VWK5-6)

Also known as: IL-23R6;

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: Missing.
     256-266: RYKATTNQTWN → MILRPYQPCGT

Note: No experimental confirmation available.

Isoform 7 (identifier: Q5VWK5-7)

Also known as: IL-23R5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-402: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 629	606	Interleukin-23 receptor		PRO_0000268662
Regions
	Topological domain	24 – 355	332	Extracellular Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Topological domain	377 – 629	253	Cytoplasmic Potential
	Domain	124 – 214	91	Fibronectin type-III 1
	Domain	220 – 313	94	Fibronectin type-III 2
Amino acid modifications
	Glycosylation	29	1	N-linked (GlcNAc...); partial Ref.9
	Glycosylation	47	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	81	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	141	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	180	1	N-linked (GlcNAc...) (high mannose) Ref.9
	Glycosylation	232	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	262	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	273	1	N-linked (GlcNAc...); partial Ref.9
Natural variations
	Alternative sequence	1 – 402	402	Missing in isoform 7.		VSP_021990
	Alternative sequence	1 – 365	365	Missing in isoform 5.		VSP_021991
	Alternative sequence	1 – 255	255	Missing in isoform 6.		VSP_021992
	Alternative sequence	1 – 254	254	Missing in isoform 2.		VSP_021993
	Alternative sequence	165 – 174	10	LETEEEQQYL → DTFCSRHFQG in isoform 4.		VSP_021994
	Alternative sequence	175 – 629	455	Missing in isoform 4.		VSP_021995
	Alternative sequence	256 – 266	11	RYKATTNQTWN → MILRPYQPCGT in isoform 6.		VSP_021996
	Alternative sequence	349 – 356	8	DNRGDIGL → GLKEGSYC in isoform 3.		VSP_021997
	Alternative sequence	357 – 629	273	Missing in isoform 3.		VSP_021998
	Alternative sequence	366 – 383	18	MLSIL…SFRTG → MEFWANSCFHLYRAPYFW in isoform 5.		VSP_021999
	Natural variant	3	1	Q → H. Ref.5 Corresponds to variant rs1884444 [ dbSNP | Ensembl ].		VAR_029752
	Natural variant	175	1	T → N. Corresponds to variant rs11465797 [ dbSNP | Ensembl ].		VAR_047955
	Natural variant	310	1	L → P. Ref.1 Ref.2 Ref.4 Ref.5 Ref.8 Corresponds to variant rs7530511 [ dbSNP | Ensembl ].		VAR_029753
	Natural variant	381	1	R → Q Associated with IBD17; has a protective effect against Crohn disease and psoriasis. Ref.5 Ref.6 Ref.7 Ref.8 Corresponds to variant rs11209026 [ dbSNP | Ensembl ].		VAR_029754
Experimental info
	Sequence conflict	46	1	M → T in AAY18346. Ref.2
	Sequence conflict	133	1	C → R in AAY18348. Ref.2
	Sequence conflict	302	1	R → G in AAY18348. Ref.2
	Sequence conflict	475	1	V → A in AAY18347. Ref.2
	Sequence conflict	481	1	N → D in AAY18347. Ref.2
	Sequence conflict	581	1	S → R in AAY18349. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (IL-23R1) [UniParc]. Last modified November 2, 2010. Version 3. Checksum: AC63C89E81AABF05	FASTA	629	71,722
	10 20 30 40 50 60 MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ 70 80 90 100 110 120 PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS 130 140 150 160 170 180 SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSLETEEE QQYLTSSYIN 190 200 210 220 230 240 ISTDSLQGGK KYLVWVQAAN ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII 250 260 270 280 290 300 YWDSQTTIEK VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG 310 320 330 340 350 360 KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN RGDIGLLLGM 370 380 390 400 410 420 IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI PNMKNSNVVK MLQENSELMN 430 440 450 460 470 480 NNSSEQVLYV DPMITEIKEI FIPEHKPTDY KKENTGPLET RDYPQNSLFD NTTVVYIPDL 490 500 510 520 530 540 NTGYKPQISN FLPEGSHLSN NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL 550 560 570 580 590 600 SNTIFLGELS LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI 610 620 VNEELPSINT YFPQNILESH FNRISLLEK
	Isoform 2 (IL-23R2-F2) [UniParc]. Checksum: F6436B1432AD56A9	FASTA	375	42,822
	10 20 30 40 50 60 MRYKATTNQT WNVKEFDTNF TYVQQSEFYL EPNIKYVFQV RCQETGKRYW QPWSSLFFHK 70 80 90 100 110 120 TPETVPQVTS KAFQHDTWNS GLTVASISTG HLTSDNRGDI GLLLGMIVFA VMLSILSLIG 130 140 150 160 170 180 IFNRSFRTGI KRRILLLIPK WLYEDIPNMK NSNVVKMLQE NSELMNNNSS EQVLYVDPMI 190 200 210 220 230 240 TEIKEIFIPE HKPTDYKKEN TGPLETRDYP QNSLFDNTTV VYIPDLNTGY KPQISNFLPE 250 260 270 280 290 300 GSHLSNNNEI TSLTLKPPVD SLDSGNNPRL QKHPNFAFSV SSVNSLSNTI FLGELSLILN 310 320 330 340 350 360 QGECSSPDIQ NSVEEETTML LENDSPSETI PEQTLLPDEF VSCLGIVNEE LPSINTYFPQ 370 NILESHFNRI SLLEK
	Isoform 3 (IL-23R3-F1) [UniParc]. Checksum: D9A98F0E8F380490	FASTA	356	40,859
	10 20 30 40 50 60 MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ 70 80 90 100 110 120 PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS 130 140 150 160 170 180 SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSLETEEE QQYLTSSYIN 190 200 210 220 230 240 ISTDSLQGGK KYLVWVQAAN ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII 250 260 270 280 290 300 YWDSQTTIEK VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG 310 320 330 340 350 KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSGL KEGSYC
	Isoform 4 (IL-23R2-F1) [UniParc]. Checksum: 2F45099F46F673A5	FASTA	174	20,068
	10 20 30 40 50 60 MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ 70 80 90 100 110 120 PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS 130 140 150 160 170 SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSDTFCSR HFQG
	Isoform 5 (IL-23R3-F3) [UniParc]. Checksum: 1695194600E3DABF	FASTA	264	30,278
	10 20 30 40 50 60 MEFWANSCFH LYRAPYFWIK RRILLLIPKW LYEDIPNMKN SNVVKMLQEN SELMNNNSSE 70 80 90 100 110 120 QVLYVDPMIT EIKEIFIPEH KPTDYKKENT GPLETRDYPQ NSLFDNTTVV YIPDLNTGYK 130 140 150 160 170 180 PQISNFLPEG SHLSNNNEIT SLTLKPPVDS LDSGNNPRLQ KHPNFAFSVS SVNSLSNTIF 190 200 210 220 230 240 LGELSLILNQ GECSSPDIQN SVEEETTMLL ENDSPSETIP EQTLLPDEFV SCLGIVNEEL 250 260 PSINTYFPQN ILESHFNRIS LLEK
	Isoform 6 (IL-23R6) [UniParc]. Checksum: FCB35A2F849DA5F7	FASTA	374	42,587
	10 20 30 40 50 60 MILRPYQPCG TVKEFDTNFT YVQQSEFYLE PNIKYVFQVR CQETGKRYWQ PWSSLFFHKT 70 80 90 100 110 120 PETVPQVTSK AFQHDTWNSG LTVASISTGH LTSDNRGDIG LLLGMIVFAV MLSILSLIGI 130 140 150 160 170 180 FNRSFRTGIK RRILLLIPKW LYEDIPNMKN SNVVKMLQEN SELMNNNSSE QVLYVDPMIT 190 200 210 220 230 240 EIKEIFIPEH KPTDYKKENT GPLETRDYPQ NSLFDNTTVV YIPDLNTGYK PQISNFLPEG 250 260 270 280 290 300 SHLSNNNEIT SLTLKPPVDS LDSGNNPRLQ KHPNFAFSVS SVNSLSNTIF LGELSLILNQ 310 320 330 340 350 360 GECSSPDIQN SVEEETTMLL ENDSPSETIP EQTLLPDEFV SCLGIVNEEL PSINTYFPQN 370 ILESHFNRIS LLEK
	Isoform 7 (IL-23R5) [UniParc]. Checksum: 43A70A48046FA1F2	FASTA	227	25,551
	10 20 30 40 50 60 MKNSNVVKML QENSELMNNN SSEQVLYVDP MITEIKEIFI PEHKPTDYKK ENTGPLETRD 70 80 90 100 110 120 YPQNSLFDNT TVVYIPDLNT GYKPQISNFL PEGSHLSNNN EITSLTLKPP VDSLDSGNNP 130 140 150 160 170 180 RLQKHPNFAF SVSSVNSLSN TIFLGELSLI LNQGECSSPD IQNSVEEETT MLLENDSPSE 190 200 210 220 TIPEQTLLPD EFVSCLGIVN EELPSINTYF PQNILESHFN RISLLEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R." Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M. , Kastelein R.A., de Waal Malefyt R., Moore K.W. J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH IL23; IL12RB1; JAK2 AND STAT3, PHOSPHORYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT PRO-310. Tissue: Natural killer cell and T-cell.
[2]	"Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells." Zhang X.-Y., Zhang H.-J., Zhang Y., Fu Y.-J., He J., Zhu L.-P., Wang S.-H., Liu L. Immunogenetics 57:934-943(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [MRNA] OF 37-629 (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY, VARIANT PRO-310. Tissue: Bone marrow.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANT PRO-310. Tissue: Bone marrow and Skin.
[5]	"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene." Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., Steinhart A.H., Abraham C., Regueiro M., Griffiths A., Dassopoulos T., Bitton A., Yang H., Targan S., Datta L.W., Kistner E.O., Schumm L.P., Lee A.T. , Gregersen P.K., Barmada M.M., Rotter J.I., Nicolae D.L., Cho J.H. Science 314:1461-1463(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN IBD17, VARIANTS HIS-3; PRO-310 AND GLN-381.
[6]	"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis." Capon F., Di Meglio P., Szaub J., Prescott N.J., Dunster C., Baumber L., Timms K., Gutin A., Abkevic V., Burden A.D., Lanchbury J., Barker J.N., Trembath R.C., Nestle F.O. Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN PSORIASIS, VARIANT GLN-381.
[7]	"Genome-wide association study for Crohn's disease in the Quebec founder population identifies multiple validated disease loci." Raelson J.V., Little R.D., Ruether A., Fournier H., Paquin B., Van Eerdewegh P., Bradley W.E.C., Croteau P., Nguyen-Huu Q., Segal J., Debrus S., Allard R., Rosenstiel P., Franke A., Jacobs G., Nikolaus S., Vidal J.-M., Szego P. , Laplante N., Clark H.F., Paulussen R.J., Hooper J.W., Keith T.P., Belouchi A., Schreiber S. Proc. Natl. Acad. Sci. U.S.A. 104:14747-14752(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN IBD17, VARIANT GLN-381.
[8]	"Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis." Huffmeier U., Lascorz J., Bohm B., Lohmann J., Wendler J., Mossner R., Reich K., Traupe H., Kurrat W., Burkhardt H., Reis A. J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION WITH PSORIASIS, VARIANTS PRO-310 AND GLN-381.
[9]	"Glycosylation analysis of interleukin-23 receptor: elucidation of glycosylation sites and characterization of attached glycan structures." Zhao J., Liu Y.H., Reichert P., Pflanz S., Pramanik B. J. Mass Spectrom. 45:1416-1425(2010) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-29; ASN-47; ASN-81; ASN-141; ASN-180; ASN-232; ASN-262 AND ASN-273.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF461422 mRNA. Translation: AAM44229.1. AY937250 mRNA. Translation: AAY18345.1. AY937251 mRNA. Translation: AAY18346.1. AY937252 mRNA. Translation: AAY18347.1. AY937253 mRNA. Translation: AAY18348.1. AY937254 mRNA. Translation: AAY18349.1. AY937255 mRNA. Translation: AAY18350.1. AL389925, AL109843 Genomic DNA. Translation: CAH70406.1. AL389925, AL109843 Genomic DNA. Translation: CAH70408.1. Different initiation. AL109843, AL389925 Genomic DNA. Translation: CAI22678.1. AL109843, AL389925 Genomic DNA. Translation: CAI22679.1. Different initiation. BC016829 mRNA. Translation: AAH16829.1. Different initiation. BC040720 mRNA. Translation: AAH40720.1.
IPI	IPI00303045. IPI00479853. IPI00815647. IPI00816048. IPI00816154. IPI00816175. IPI00816507.
RefSeq	NP_653302.2. NM_144701.2.
UniGene	Hs.677426.
3D structure databases
ProteinModelPortal	Q5VWK5.
SMR	Q5VWK5. Positions 28-318.
ModBase	Search...
PTM databases
PhosphoSite	Q5VWK5.
Polymorphism databases
DMDM	311033431.
Proteomic databases
PaxDb	Q5VWK5.
PRIDE	Q5VWK5.
Protocols and materials databases
DNASU	149233.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000347310; ENSP00000321345; ENSG00000162594. ENST00000371002; ENSP00000360041; ENSG00000162594. ENST00000395227; ENSP00000378652; ENSG00000162594.
GeneID	149233.
KEGG	hsa:149233.
UCSC	uc001ddo.3. human. uc001dds.3. human. uc001ddt.3. human. uc010opk.2. human. uc010opw.2. human.
Organism-specific databases
CTD	149233.
GeneCards	GC01P067632.
H-InvDB	HIX0023553.
HGNC	HGNC:19100. IL23R.
MIM	605606. phenotype. 607562. gene. 612261. phenotype.
neXtProt	NX_Q5VWK5.
Orphanet	117. Behcet disease. 206. Crohn disease. 771. Ulcerative colitis.
PharmGKB	PA134935109.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41959.
HOVERGEN	HBG081787.
InParanoid	Q5VWK5.
KO	K05065.
OMA	RCQETGK.
OrthoDB	EOG42FSH7.
PhylomeDB	Q5VWK5.
Enzyme and pathway databases
Pathway_Interaction_DB	il23pathway. IL23-mediated signaling events.
SignaLink	Q5VWK5.
Gene expression databases
ArrayExpress	Q5VWK5.
Bgee	Q5VWK5.
Genevestigator	Q5VWK5.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
SMART	SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	149233.
NextBio	86105.
SOURCE	Search...

Entry information

Entry name

IL23R_HUMAN

Accession

Primary (citable) accession number: Q5VWK5
Secondary accession number(s): C9JGX4 , Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6, Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 2, 2010
Last modified:	May 29, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.