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Protein

Sorting nexin-30

Gene

SNX30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-30
Gene namesi
Name:SNX30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23685. SNX30.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi401548.
OpenTargetsiENSG00000148158.
PharmGKBiPA142670889.

Polymorphism and mutation databases

BioMutaiSNX30.
DMDMi74747407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845331 – 437Sorting nexin-30Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphothreonineBy similarity1
Modified residuei40PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VWJ9.
MaxQBiQ5VWJ9.
PaxDbiQ5VWJ9.
PeptideAtlasiQ5VWJ9.
PRIDEiQ5VWJ9.

PTM databases

iPTMnetiQ5VWJ9.
PhosphoSitePlusiQ5VWJ9.

Expressioni

Gene expression databases

BgeeiENSG00000148158.
CleanExiHS_SNX30.
ExpressionAtlasiQ5VWJ9. baseline and differential.
GenevisibleiQ5VWJ9. HS.

Organism-specific databases

HPAiHPA019346.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SNX4O952192EBI-8099676,EBI-724909

Protein-protein interaction databases

BioGridi135142. 4 interactors.
IntActiQ5VWJ9. 3 interactors.
MINTiMINT-4827005.
STRINGi9606.ENSP00000363349.

Structurei

3D structure databases

ProteinModelPortaliQ5VWJ9.
SMRiQ5VWJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 210PXPROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00840000129805.
HOGENOMiHOG000010283.
HOVERGENiHBG009723.
InParanoidiQ5VWJ9.
KOiK17921.
OMAiKQEDRTP.
OrthoDBiEOG091G08JS.
PhylomeDBiQ5VWJ9.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR004148. BAR_dom.
IPR001683. Phox.
IPR028649. SNX30.
[Graphical view]
PANTHERiPTHR10555:SF123. PTHR10555:SF123. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VWJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPPKALP STGPHSLRDM PHPLAGSSSE EAVGGDSTPS PDLLMARSFG
60 70 80 90 100
DKDLILPNGG TPAGTSSPAS SSSLLNRLQL DDDIDGETRD LFVIVDDPKK
110 120 130 140 150
HVCTMETYIT YRITTKSTRV EFDLPEYSVR RRYQDFDWLR SKLEESQPTH
160 170 180 190 200
LIPPLPEKFV VKGVVDRFSE EFVETRRKAL DKFLKRITDH PVLSFNEHFN
210 220 230 240 250
IFLTAKDLNA YKKQGIALLT RMGESVKHVT GGYKLRTRPL EFAAIGDYLD
260 270 280 290 300
TFALKLGTID RIAQRIIKEE IEYLVELREY GPVYSTWSAL EGELAEPLEG
310 320 330 340 350
VSACIGNCST ALEELTDDMT EDFLPVLREY ILYSDSMKSV LKKRDQVQAE
360 370 380 390 400
YEAKLEAVAL RKEDRPKVPA DVEKCQDRME CFNADLKADM ERWQNNKRQD
410 420 430
FRQLLMGMAD KNIQYYEKCL MAWESIIPLL QEKQEAK
Length:437
Mass (Da):49,677
Last modified:December 7, 2004 - v1
Checksum:i32496ED341C5E9A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03177183D → H.Corresponds to variant rs2796036dbSNPEnsembl.1
Natural variantiVAR_052483125P → A.Corresponds to variant rs10117709dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390067, AL139041, AL360235 Genomic DNA. Translation: CAH71937.1.
AL360235, AL139041, AL390067 Genomic DNA. Translation: CAI41353.1.
AL139041, AL360235, AL390067 Genomic DNA. Translation: CAI95198.1.
CCDSiCCDS43865.1.
RefSeqiNP_001013012.1. NM_001012994.1.
UniGeneiHs.522350.

Genome annotation databases

EnsembliENST00000374232; ENSP00000363349; ENSG00000148158.
GeneIDi401548.
KEGGihsa:401548.
UCSCiuc004bgj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390067, AL139041, AL360235 Genomic DNA. Translation: CAH71937.1.
AL360235, AL139041, AL390067 Genomic DNA. Translation: CAI41353.1.
AL139041, AL360235, AL390067 Genomic DNA. Translation: CAI95198.1.
CCDSiCCDS43865.1.
RefSeqiNP_001013012.1. NM_001012994.1.
UniGeneiHs.522350.

3D structure databases

ProteinModelPortaliQ5VWJ9.
SMRiQ5VWJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135142. 4 interactors.
IntActiQ5VWJ9. 3 interactors.
MINTiMINT-4827005.
STRINGi9606.ENSP00000363349.

PTM databases

iPTMnetiQ5VWJ9.
PhosphoSitePlusiQ5VWJ9.

Polymorphism and mutation databases

BioMutaiSNX30.
DMDMi74747407.

Proteomic databases

EPDiQ5VWJ9.
MaxQBiQ5VWJ9.
PaxDbiQ5VWJ9.
PeptideAtlasiQ5VWJ9.
PRIDEiQ5VWJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374232; ENSP00000363349; ENSG00000148158.
GeneIDi401548.
KEGGihsa:401548.
UCSCiuc004bgj.5. human.

Organism-specific databases

CTDi401548.
DisGeNETi401548.
GeneCardsiSNX30.
H-InvDBHIX0008296.
HGNCiHGNC:23685. SNX30.
HPAiHPA019346.
neXtProtiNX_Q5VWJ9.
OpenTargetsiENSG00000148158.
PharmGKBiPA142670889.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00840000129805.
HOGENOMiHOG000010283.
HOVERGENiHBG009723.
InParanoidiQ5VWJ9.
KOiK17921.
OMAiKQEDRTP.
OrthoDBiEOG091G08JS.
PhylomeDBiQ5VWJ9.
TreeFamiTF328543.

Miscellaneous databases

ChiTaRSiSNX30. human.
GenomeRNAii401548.
PROiQ5VWJ9.

Gene expression databases

BgeeiENSG00000148158.
CleanExiHS_SNX30.
ExpressionAtlasiQ5VWJ9. baseline and differential.
GenevisibleiQ5VWJ9. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR004148. BAR_dom.
IPR001683. Phox.
IPR028649. SNX30.
[Graphical view]
PANTHERiPTHR10555:SF123. PTHR10555:SF123. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX30_HUMAN
AccessioniPrimary (citable) accession number: Q5VWJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.