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Protein

Transcription elongation regulator 1-like protein

Gene

TCERG1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation regulator 1-like protein
Gene namesi
Name:TCERG1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176769.9.
HGNCiHGNC:23533. TCERG1L.

Pathology & Biotechi

Organism-specific databases

DisGeNETi256536.
OpenTargetsiENSG00000176769.
PharmGKBiPA134864258.

Polymorphism and mutation databases

BioMutaiTCERG1L.
DMDMi172045963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128721 – 586Transcription elongation regulator 1-like proteinAdd BLAST586

Proteomic databases

EPDiQ5VWI1.
MaxQBiQ5VWI1.
PaxDbiQ5VWI1.
PeptideAtlasiQ5VWI1.
PRIDEiQ5VWI1.

PTM databases

iPTMnetiQ5VWI1.
PhosphoSitePlusiQ5VWI1.

Expressioni

Gene expression databases

BgeeiENSG00000176769.
CleanExiHS_TCERG1L.
GenevisibleiQ5VWI1. HS.

Interactioni

Protein-protein interaction databases

BioGridi129171. 1 interactor.
STRINGi9606.ENSP00000357631.

Structurei

3D structure databases

ProteinModelPortaliQ5VWI1.
SMRiQ5VWI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 181WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini339 – 372WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini450 – 503FF 1Add BLAST54
Domaini515 – 570FF 2Add BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 105Poly-Ala6
Compositional biasi237 – 247Poly-AlaAdd BLAST11

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0155. Eukaryota.
ENOG410XPZW. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000154533.
HOVERGENiHBG108553.
InParanoidiQ5VWI1.
OMAiIDKRIPN.
OrthoDBiEOG091G0I5O.
PhylomeDBiQ5VWI1.
TreeFamiTF317748.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR002713. FF_domain.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF01846. FF. 2 hits.
SMARTiView protein in SMART
SM00441. FF. 2 hits.
SM00456. WW. 1 hit.
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 2 hits.
PROSITEiView protein in PROSITE
PS51676. FF. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VWI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAGARFQRR RRQLQQQQPR RRQPLLWPMD AEPPPPPPWV WMVPGSAGLL
60 70 80 90 100
RLSAGVVVPP VLLASAPPPA APLLPGLPGW PAPSEPVLPL LPLPSAPDSA
110 120 130 140 150
AAAAAHPFPA LHGQWLFGGH SPSLGLPPSS TVELVPVFPH LCPSALATPI
160 170 180 190 200
GKSWIDKRIP NCKIFFNNSF ALDSTWIHPE ESRFFHGHEK PRLLANQVAV
210 220 230 240 250
SLSRPAPASR PLPTVVLAPQ PIPGGCHNSL KVTSSPAIAI ATAAAAAMVS
260 270 280 290 300
VDPENLRGPS PSSVQPRHFL TLAPIKIPLR TSPVSDTRTE RGRVARPPAL
310 320 330 340 350
MLRAQKSRDG DKEDKEPPPM LGGGEDSTAR GNRPVASTPV PGSPWCVVWT
360 370 380 390 400
GDDRVFFFNP TMHLSVWEKP MDLKDRGDLN RIIEDPPHKR KLEAPATDNS
410 420 430 440 450
DGSSSEDNRE DQDVKTKRNR TEGCGSPKPE EAKREDKGTR TPPPQILLPL
460 470 480 490 500
EERVTHFRDM LLERGVSAFS TWEKELHKIV FDPRYLLLNS EERKQIFEQF
510 520 530 540 550
VKTRIKEEYK EKKSKLLLAK EEFKKLLEES KVSPRTTFKE FAEKYGRDQR
560 570 580
FRLVQKRKDQ EHFFNQFILI LKKRDKENRL RLRKMR
Length:586
Mass (Da):65,660
Last modified:February 26, 2008 - v2
Checksum:i473F0274B5C8BE5A
GO

Sequence cautioni

The sequence AAH42951 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH93639 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI01536 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Q → R in AAH93639 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037601339P → Q1 PublicationCorresponds to variant dbSNP:rs17857275Ensembl.1
Natural variantiVAR_037602437K → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037603529E → K1 PublicationCorresponds to variant dbSNP:rs17857276Ensembl.1
Natural variantiVAR_037604566Q → K1 PublicationCorresponds to variant dbSNP:rs17854242Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390203, AC067746 Genomic DNA. Translation: CAH74038.2.
BC042951 mRNA. Translation: AAH42951.1. Different initiation.
BC093639 mRNA. Translation: AAH93639.1. Different initiation.
BC101535 mRNA. Translation: AAI01536.1. Different initiation.
CCDSiCCDS7662.2.
RefSeqiNP_777597.2. NM_174937.3.
UniGeneiHs.126575.

Genome annotation databases

EnsembliENST00000368642; ENSP00000357631; ENSG00000176769.
GeneIDi256536.
KEGGihsa:256536.
UCSCiuc001lkp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCRGL_HUMAN
AccessioniPrimary (citable) accession number: Q5VWI1
Secondary accession number(s): Q5VWI2, Q86XM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations