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Protein

Transcription elongation regulator 1-like protein

Gene

TCERG1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation regulator 1-like protein
Gene namesi
Name:TCERG1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23533. TCERG1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864258.

Polymorphism and mutation databases

BioMutaiTCERG1L.
DMDMi172045963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Transcription elongation regulator 1-like proteinPRO_0000312872Add
BLAST

Proteomic databases

EPDiQ5VWI1.
PaxDbiQ5VWI1.
PeptideAtlasiQ5VWI1.
PRIDEiQ5VWI1.

PTM databases

iPTMnetiQ5VWI1.
PhosphoSiteiQ5VWI1.

Expressioni

Gene expression databases

BgeeiQ5VWI1.
CleanExiHS_TCERG1L.
GenevisibleiQ5VWI1. HS.

Interactioni

Protein-protein interaction databases

BioGridi129171. 1 interaction.
STRINGi9606.ENSP00000357631.

Structurei

3D structure databases

ProteinModelPortaliQ5VWI1.
SMRiQ5VWI1. Positions 153-181, 324-390, 450-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 18134WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini339 – 37234WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini450 – 50354FF 1Add
BLAST
Domaini515 – 57056FF 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 1056Poly-Ala
Compositional biasi237 – 24711Poly-AlaAdd
BLAST

Sequence similaritiesi

Contains 2 FF domains.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0155. Eukaryota.
ENOG410XPZW. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000154533.
HOVERGENiHBG108553.
InParanoidiQ5VWI1.
OMAiIDKRIPN.
OrthoDBiEOG7DC24V.
PhylomeDBiQ5VWI1.
TreeFamiTF317748.

Family and domain databases

Gene3Di1.10.10.440. 2 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 2 hits.
PROSITEiPS51676. FF. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VWI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAGARFQRR RRQLQQQQPR RRQPLLWPMD AEPPPPPPWV WMVPGSAGLL
60 70 80 90 100
RLSAGVVVPP VLLASAPPPA APLLPGLPGW PAPSEPVLPL LPLPSAPDSA
110 120 130 140 150
AAAAAHPFPA LHGQWLFGGH SPSLGLPPSS TVELVPVFPH LCPSALATPI
160 170 180 190 200
GKSWIDKRIP NCKIFFNNSF ALDSTWIHPE ESRFFHGHEK PRLLANQVAV
210 220 230 240 250
SLSRPAPASR PLPTVVLAPQ PIPGGCHNSL KVTSSPAIAI ATAAAAAMVS
260 270 280 290 300
VDPENLRGPS PSSVQPRHFL TLAPIKIPLR TSPVSDTRTE RGRVARPPAL
310 320 330 340 350
MLRAQKSRDG DKEDKEPPPM LGGGEDSTAR GNRPVASTPV PGSPWCVVWT
360 370 380 390 400
GDDRVFFFNP TMHLSVWEKP MDLKDRGDLN RIIEDPPHKR KLEAPATDNS
410 420 430 440 450
DGSSSEDNRE DQDVKTKRNR TEGCGSPKPE EAKREDKGTR TPPPQILLPL
460 470 480 490 500
EERVTHFRDM LLERGVSAFS TWEKELHKIV FDPRYLLLNS EERKQIFEQF
510 520 530 540 550
VKTRIKEEYK EKKSKLLLAK EEFKKLLEES KVSPRTTFKE FAEKYGRDQR
560 570 580
FRLVQKRKDQ EHFFNQFILI LKKRDKENRL RLRKMR
Length:586
Mass (Da):65,660
Last modified:February 26, 2008 - v2
Checksum:i473F0274B5C8BE5A
GO

Sequence cautioni

The sequence AAH42951.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH93639.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI01536.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231Q → R in AAH93639 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti339 – 3391P → Q.1 Publication
Corresponds to variant rs17857275 [ dbSNP | Ensembl ].
VAR_037601
Natural varianti437 – 4371K → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_037602
Natural varianti529 – 5291E → K.1 Publication
Corresponds to variant rs17857276 [ dbSNP | Ensembl ].
VAR_037603
Natural varianti566 – 5661Q → K.1 Publication
Corresponds to variant rs17854242 [ dbSNP | Ensembl ].
VAR_037604

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390203, AC067746 Genomic DNA. Translation: CAH74038.2.
BC042951 mRNA. Translation: AAH42951.1. Different initiation.
BC093639 mRNA. Translation: AAH93639.1. Different initiation.
BC101535 mRNA. Translation: AAI01536.1. Different initiation.
CCDSiCCDS7662.2.
RefSeqiNP_777597.2. NM_174937.3.
UniGeneiHs.126575.

Genome annotation databases

EnsembliENST00000368642; ENSP00000357631; ENSG00000176769.
GeneIDi256536.
KEGGihsa:256536.
UCSCiuc001lkp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL390203, AC067746 Genomic DNA. Translation: CAH74038.2.
BC042951 mRNA. Translation: AAH42951.1. Different initiation.
BC093639 mRNA. Translation: AAH93639.1. Different initiation.
BC101535 mRNA. Translation: AAI01536.1. Different initiation.
CCDSiCCDS7662.2.
RefSeqiNP_777597.2. NM_174937.3.
UniGeneiHs.126575.

3D structure databases

ProteinModelPortaliQ5VWI1.
SMRiQ5VWI1. Positions 153-181, 324-390, 450-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129171. 1 interaction.
STRINGi9606.ENSP00000357631.

PTM databases

iPTMnetiQ5VWI1.
PhosphoSiteiQ5VWI1.

Polymorphism and mutation databases

BioMutaiTCERG1L.
DMDMi172045963.

Proteomic databases

EPDiQ5VWI1.
PaxDbiQ5VWI1.
PeptideAtlasiQ5VWI1.
PRIDEiQ5VWI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368642; ENSP00000357631; ENSG00000176769.
GeneIDi256536.
KEGGihsa:256536.
UCSCiuc001lkp.4. human.

Organism-specific databases

CTDi256536.
GeneCardsiTCERG1L.
H-InvDBHIX0009316.
HGNCiHGNC:23533. TCERG1L.
neXtProtiNX_Q5VWI1.
PharmGKBiPA134864258.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0155. Eukaryota.
ENOG410XPZW. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000154533.
HOVERGENiHBG108553.
InParanoidiQ5VWI1.
OMAiIDKRIPN.
OrthoDBiEOG7DC24V.
PhylomeDBiQ5VWI1.
TreeFamiTF317748.

Miscellaneous databases

GenomeRNAii256536.
PROiQ5VWI1.

Gene expression databases

BgeeiQ5VWI1.
CleanExiHS_TCERG1L.
GenevisibleiQ5VWI1. HS.

Family and domain databases

Gene3Di1.10.10.440. 2 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
SSF81698. SSF81698. 2 hits.
PROSITEiPS51676. FF. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-339; LYS-529 AND LYS-566.
    Tissue: Brain cortex and Hippocampus.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-437.

Entry informationi

Entry nameiTCRGL_HUMAN
AccessioniPrimary (citable) accession number: Q5VWI1
Secondary accession number(s): Q5VWI2, Q86XM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.