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Protein

Transcription elongation regulator 1-like protein

Gene

TCERG1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation regulator 1-like protein
Gene namesi
Name:TCERG1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176769.9
HGNCiHGNC:23533 TCERG1L
neXtProtiNX_Q5VWI1

Pathology & Biotechi

Organism-specific databases

DisGeNETi256536
OpenTargetsiENSG00000176769
PharmGKBiPA134864258

Polymorphism and mutation databases

BioMutaiTCERG1L
DMDMi172045963

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128721 – 586Transcription elongation regulator 1-like proteinAdd BLAST586

Proteomic databases

EPDiQ5VWI1
MaxQBiQ5VWI1
PaxDbiQ5VWI1
PeptideAtlasiQ5VWI1
PRIDEiQ5VWI1

PTM databases

iPTMnetiQ5VWI1
PhosphoSitePlusiQ5VWI1

Expressioni

Gene expression databases

BgeeiENSG00000176769
CleanExiHS_TCERG1L
GenevisibleiQ5VWI1 HS

Interactioni

Protein-protein interaction databases

BioGridi129171, 1 interactor
STRINGi9606.ENSP00000357631

Structurei

3D structure databases

ProteinModelPortaliQ5VWI1
SMRiQ5VWI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 181WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini339 – 372WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini450 – 503FF 1Add BLAST54
Domaini515 – 570FF 2Add BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 105Poly-Ala6
Compositional biasi237 – 247Poly-AlaAdd BLAST11

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0155 Eukaryota
ENOG410XPZW LUCA
GeneTreeiENSGT00910000144189
HOGENOMiHOG000154533
HOVERGENiHBG108553
InParanoidiQ5VWI1
OMAiIDKRIPN
OrthoDBiEOG091G0I5O
PhylomeDBiQ5VWI1
TreeFamiTF317748

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di1.10.10.440, 2 hits
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF01846 FF, 2 hits
SMARTiView protein in SMART
SM00441 FF, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
SSF81698 SSF81698, 2 hits
PROSITEiView protein in PROSITE
PS51676 FF, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VWI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAGARFQRR RRQLQQQQPR RRQPLLWPMD AEPPPPPPWV WMVPGSAGLL
60 70 80 90 100
RLSAGVVVPP VLLASAPPPA APLLPGLPGW PAPSEPVLPL LPLPSAPDSA
110 120 130 140 150
AAAAAHPFPA LHGQWLFGGH SPSLGLPPSS TVELVPVFPH LCPSALATPI
160 170 180 190 200
GKSWIDKRIP NCKIFFNNSF ALDSTWIHPE ESRFFHGHEK PRLLANQVAV
210 220 230 240 250
SLSRPAPASR PLPTVVLAPQ PIPGGCHNSL KVTSSPAIAI ATAAAAAMVS
260 270 280 290 300
VDPENLRGPS PSSVQPRHFL TLAPIKIPLR TSPVSDTRTE RGRVARPPAL
310 320 330 340 350
MLRAQKSRDG DKEDKEPPPM LGGGEDSTAR GNRPVASTPV PGSPWCVVWT
360 370 380 390 400
GDDRVFFFNP TMHLSVWEKP MDLKDRGDLN RIIEDPPHKR KLEAPATDNS
410 420 430 440 450
DGSSSEDNRE DQDVKTKRNR TEGCGSPKPE EAKREDKGTR TPPPQILLPL
460 470 480 490 500
EERVTHFRDM LLERGVSAFS TWEKELHKIV FDPRYLLLNS EERKQIFEQF
510 520 530 540 550
VKTRIKEEYK EKKSKLLLAK EEFKKLLEES KVSPRTTFKE FAEKYGRDQR
560 570 580
FRLVQKRKDQ EHFFNQFILI LKKRDKENRL RLRKMR
Length:586
Mass (Da):65,660
Last modified:February 26, 2008 - v2
Checksum:i473F0274B5C8BE5A
GO

Sequence cautioni

The sequence AAH42951 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH93639 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI01536 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Q → R in AAH93639 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037601339P → Q1 PublicationCorresponds to variant dbSNP:rs17857275Ensembl.1
Natural variantiVAR_037602437K → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037603529E → K1 PublicationCorresponds to variant dbSNP:rs17857276Ensembl.1
Natural variantiVAR_037604566Q → K1 PublicationCorresponds to variant dbSNP:rs17854242Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067746 Genomic DNA No translation available.
AL390203 Genomic DNA No translation available.
BC042951 mRNA Translation: AAH42951.1 Different initiation.
BC093639 mRNA Translation: AAH93639.1 Different initiation.
BC101535 mRNA Translation: AAI01536.1 Different initiation.
CCDSiCCDS7662.2
RefSeqiNP_777597.2, NM_174937.3
UniGeneiHs.126575

Genome annotation databases

EnsembliENST00000368642; ENSP00000357631; ENSG00000176769
GeneIDi256536
KEGGihsa:256536
UCSCiuc001lkp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCRGL_HUMAN
AccessioniPrimary (citable) accession number: Q5VWI1
Secondary accession number(s): Q5VWI2, Q86XM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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