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Protein
Submitted name:

26S proteasome non-ATPase regulatory subunit 4

Gene

PSMD4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome non-ATPase regulatory subunit 4Imported
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_bImported
Gene namesi
Name:PSMD4Imported
ORF Names:hCG_1741224Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159352.15
HGNCiHGNC:9561 PSMD4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159352

PTM / Processingi

Proteomic databases

MaxQBiQ5VWC4
PeptideAtlasiQ5VWC4

Expressioni

Gene expression databases

BgeeiENSG00000159352

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5VWC4, 3 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 188VWFAInterPro annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili117 – 137Sequence analysisAdd BLAST21
Coiled coili221 – 241Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2884 Eukaryota
COG5148 LUCA
GeneTreeiENSGT00530000064050
HOGENOMiHOG000165630
HOVERGENiHBG000425
OMAiMGGKGPE
OrthoDBiEOG091G0A6L

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR027040 Proteasome_su_Rpn10
IPR003903 UIM_dom
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR10223:SF6 PTHR10223:SF6, 1 hit
PfamiView protein in Pfam
PF02809 UIM, 2 hits
PF13519 VWA_2, 1 hit
SMARTiView protein in SMART
SM00726 UIM, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50330 UIM, 2 hits
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5VWC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG
60 70 80 90 100
LITLANDCEV LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR
110 120 130 140 150
QGKNHKMRII AFVGSPVEDN EKDLVKLAKR LKKEKVNVDI INFGEEEVNT
160 170 180 190 200
EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA DALISSPILA GEGGAMLGLG
210 220 230 240 250
ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA ASAAEAGIAT
260 270 280 290 300
TGTEGERDSD DALLKMTISQ QEFGRTGLPD LSSMTEEEQI AYAMQMSLQG
310 320 330 340 350
AEFGQAESAD IDASSAMDTS EPAKEEDDYD VMQDPEFLQS VLENLPGVDP
360 370 380
NNEAIRNAMG SLASQATKDG KKDKKEEDKK
Length:380
Mass (Da):41,079
Last modified:December 7, 2004 - v1
Checksum:i349CEDC533705229
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391069 Genomic DNA No translation available.
AL592424 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53456.1
RefSeqiNP_001317621.1, NM_001330692.1
UniGeneiHs.505059

Genome annotation databases

EnsembliENST00000368881; ENSP00000357876; ENSG00000159352
GeneIDi5710
UCSCiuc057kts.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5VWC4_HUMAN
AccessioniPrimary (citable) accession number: Q5VWC4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health