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Protein
Submitted name:

26S proteasome non-ATPase regulatory subunit 4

Gene

PSMD4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome non-ATPase regulatory subunit 4Imported
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_bImported
Gene namesi
Name:PSMD4Imported
ORF Names:hCG_1741224Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9561. PSMD4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ProteasomeImported

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159352.

PTM / Processingi

Proteomic databases

EPDiQ5VWC4.
MaxQBiQ5VWC4.
PeptideAtlasiQ5VWC4.
PRIDEiQ5VWC4.

Expressioni

Gene expression databases

BgeeiENSG00000159352.
ExpressionAtlasiQ5VWC4. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ5VWC4. 3 interactors.
STRINGi9606.ENSP00000357879.

Structurei

3D structure databases

ProteinModelPortaliQ5VWC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 188VWFAInterPro annotationAdd BLAST184

Phylogenomic databases

eggNOGiKOG2884. Eukaryota.
COG5148. LUCA.
GeneTreeiENSGT00530000064050.
HOGENOMiHOG000165630.
HOVERGENiHBG000425.
OMAiDETNAPM.
OrthoDBiEOG091G0A6L.
PhylomeDBiQ5VWC4.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR027040. Proteasome_su_Rpn10.
IPR003903. UIM_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10223. PTHR10223. 1 hit.
PfamiPF02809. UIM. 2 hits.
PF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50330. UIM. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VWC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG
60 70 80 90 100
LITLANDCEV LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR
110 120 130 140 150
QGKNHKMRII AFVGSPVEDN EKDLVKLAKR LKKEKVNVDI INFGEEEVNT
160 170 180 190 200
EKLTAFVNTL NGKDGTGSHL VTVPPGPSLA DALISSPILA GEGGAMLGLG
210 220 230 240 250
ASDFEFGVDP SADPELALAL RVSMEEQRQR QEEEARRAAA ASAAEAGIAT
260 270 280 290 300
TGTEGERDSD DALLKMTISQ QEFGRTGLPD LSSMTEEEQI AYAMQMSLQG
310 320 330 340 350
AEFGQAESAD IDASSAMDTS EPAKEEDDYD VMQDPEFLQS VLENLPGVDP
360 370 380
NNEAIRNAMG SLASQATKDG KKDKKEEDKK
Length:380
Mass (Da):41,079
Last modified:December 7, 2004 - v1
Checksum:i349CEDC533705229
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391069 Genomic DNA. No translation available.
AL592424 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53456.1.
RefSeqiNP_001317621.1. NM_001330692.1.
UniGeneiHs.505059.

Genome annotation databases

EnsembliENST00000368881; ENSP00000357876; ENSG00000159352.
GeneIDi5710.
UCSCiuc057kts.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391069 Genomic DNA. No translation available.
AL592424 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53456.1.
RefSeqiNP_001317621.1. NM_001330692.1.
UniGeneiHs.505059.

3D structure databases

ProteinModelPortaliQ5VWC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5VWC4. 3 interactors.
STRINGi9606.ENSP00000357879.

Proteomic databases

EPDiQ5VWC4.
MaxQBiQ5VWC4.
PeptideAtlasiQ5VWC4.
PRIDEiQ5VWC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368881; ENSP00000357876; ENSG00000159352.
GeneIDi5710.
UCSCiuc057kts.1. human.

Organism-specific databases

CTDi5710.
HGNCiHGNC:9561. PSMD4.
OpenTargetsiENSG00000159352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2884. Eukaryota.
COG5148. LUCA.
GeneTreeiENSGT00530000064050.
HOGENOMiHOG000165630.
HOVERGENiHBG000425.
OMAiDETNAPM.
OrthoDBiEOG091G0A6L.
PhylomeDBiQ5VWC4.

Miscellaneous databases

ChiTaRSiPSMD4. human.
GenomeRNAii5710.

Gene expression databases

BgeeiENSG00000159352.
ExpressionAtlasiQ5VWC4. baseline and differential.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR027040. Proteasome_su_Rpn10.
IPR003903. UIM_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10223. PTHR10223. 1 hit.
PfamiPF02809. UIM. 2 hits.
PF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50330. UIM. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5VWC4_HUMAN
AccessioniPrimary (citable) accession number: Q5VWC4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.