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Q5VW38 (GP107_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GPR107
Alternative name(s):
Lung seven transmembrane receptor 1
Gene names
Name:GPR107
Synonyms:KIAA1624, LUSTR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the LU7TM family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VW38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VW38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     436-483: Missing.
Isoform 3 (identifier: Q5VW38-3)

The sequence of this isoform differs from the canonical sequence as follows:
     298-300: MAA → GFH
     301-600: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 Potential
Chain40 – 600561Protein GPR107
PRO_0000021340

Regions

Transmembrane264 – 28421Helical; Name=1; Potential
Transmembrane294 – 31421Helical; Name=2; Potential
Transmembrane338 – 35821Helical; Name=3; Potential
Transmembrane369 – 38921Helical; Name=4; Potential
Transmembrane403 – 42321Helical; Name=5; Potential
Transmembrane499 – 51921Helical; Name=6; Potential
Transmembrane525 – 54420Helical; Name=7; Potential

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence298 – 3003MAA → GFH in isoform 3.
VSP_014434
Alternative sequence301 – 600300Missing in isoform 3.
VSP_014435
Alternative sequence436 – 48348Missing in isoform 2.
VSP_014436
Natural variant1891A → P.
Corresponds to variant rs640343 [ dbSNP | Ensembl ].
VAR_030863

Experimental info

Sequence conflict2501N → D in BAB15408. Ref.2
Sequence conflict4571H → R in BAB13450. Ref.6
Sequence conflict4611Q → R in BAB13450. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 679D414C0EB9F205

FASTA60066,990
        10         20         30         40         50         60 
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV RHKVHLNTFG 

        70         80         90        100        110        120 
FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS YLDEDVNYCI LKKQSVSVTL 

       130        140        150        160        170        180 
LILDISRSEV RVKSPPEAGT QLPKIIFSRD EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS 

       190        200        210        220        230        240 
KRSTVDSKAM GEKSFSVHNN GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF 

       250        260        270        280        290        300 
SLDIEITEKN PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA 

       310        320        330        340        350        360 
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL IGTGWAFIKH 

       370        380        390        400        410        420 
ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW KDSLFLVDLL CCGAILFPVV 

       430        440        450        460        470        480 
WSIRHLQEAS ATDGKGDSMG PLQQRANLRA GSRIESHHFA QADLELLASS CPPASVSQRA 

       490        500        510        520        530        540 
GITAAINLAK LKLFRHYYVL IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV 

       550        560        570        580        590        600 
LTGYKFRPAS DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV 

« Hide

Isoform 2 [UniParc].

Checksum: C5BD664C167B2230
Show »

FASTA55261,976
Isoform 3 [UniParc].

Checksum: 27ED28675ABF911B
Show »

FASTA30033,384

References

« Hide 'large scale' references
[1]"Novel putative G protein-coupled receptors cloned from lung."
Edgar A.J., Polak J.M.
J. Anat. 200:202-202(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Small intestine.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-600 (ISOFORM 1).
Tissue: Brain.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-600 (ISOFORM 2).
Tissue: Lymph node.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF376725 mRNA. Translation: AAK57695.1.
AK026244 mRNA. Translation: BAB15408.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71210.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71211.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12152.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16952.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16953.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12153.1.
CH471090 Genomic DNA. Translation: EAW87924.1.
BC110518 mRNA. Translation: AAI10519.1.
AB046844 mRNA. Translation: BAB13450.1.
AL834359 mRNA. Translation: CAI46205.1. Sequence problems.
CCDSCCDS35162.1. [Q5VW38-2]
CCDS48041.1. [Q5VW38-1]
RefSeqNP_001130029.1. NM_001136557.1. [Q5VW38-1]
NP_001130030.1. NM_001136558.1.
NP_066011.2. NM_020960.4. [Q5VW38-2]
UniGeneHs.512461.

3D structure databases

ProteinModelPortalQ5VW38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121743. 1 interaction.

Chemistry

GuidetoPHARMACOLOGY651.

PTM databases

PhosphoSiteQ5VW38.

Polymorphism databases

DMDM68565572.

Proteomic databases

MaxQBQ5VW38.
PaxDbQ5VW38.
PRIDEQ5VW38.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000347136; ENSP00000336988; ENSG00000148358. [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358. [Q5VW38-1]
ENST00000594046; ENSP00000472756; ENSG00000269797. [Q5VW38-1]
ENST00000594105; ENSP00000469056; ENSG00000269797. [Q5VW38-2]
GeneID57720.
KEGGhsa:57720.
UCSCuc004bzb.2. human. [Q5VW38-2]
uc004bze.2. human. [Q5VW38-1]

Organism-specific databases

CTD57720.
GeneCardsGC09P132815.
HGNCHGNC:17830. GPR107.
HPAHPA031704.
neXtProtNX_Q5VW38.
PharmGKBPA28854.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG294185.
HOVERGENHBG056147.
InParanoidQ5VW38.
OMAGVMENMK.
PhylomeDBQ5VW38.
TreeFamTF314804.

Gene expression databases

ArrayExpressQ5VW38.
BgeeQ5VW38.
CleanExHS_GPR107.
GenevestigatorQ5VW38.

Family and domain databases

InterProIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERPTHR21229. PTHR21229. 1 hit.
PfamPF06814. Lung_7-TM_R. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR107. human.
GeneWikiGPR107.
GenomeRNAi57720.
NextBio64658.
PROQ5VW38.

Entry information

Entry nameGP107_HUMAN
AccessionPrimary (citable) accession number: Q5VW38
Secondary accession number(s): A6NJ53 expand/collapse secondary AC list , Q2TB81, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM