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Protein

Protein GPR107

Gene

GPR107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR107
Alternative name(s):
Lung seven transmembrane receptor 1
Gene namesi
Name:GPR107
Synonyms:KIAA1624, LUSTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17830. GPR107.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 263LumenalSequence analysisAdd BLAST224
Transmembranei264 – 284Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini285 – 293CytoplasmicSequence analysis9
Transmembranei294 – 314Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini315 – 337LumenalSequence analysisAdd BLAST23
Transmembranei338 – 358Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini359 – 368CytoplasmicSequence analysis10
Transmembranei369 – 389Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini390 – 402LumenalSequence analysisAdd BLAST13
Transmembranei403 – 423Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini424 – 498CytoplasmicSequence analysisAdd BLAST75
Transmembranei499 – 519Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini520 – 524LumenalSequence analysis5
Transmembranei525 – 544Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini545 – 600CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi182R → A: Abolishes proteolytic cleavage. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000148358.
PharmGKBiPA28854.

Polymorphism and mutation databases

BioMutaiGPR107.
DMDMi68565572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000002134040 – 600Protein GPR107Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 2281 Publication
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ5VW38.
PaxDbiQ5VW38.
PeptideAtlasiQ5VW38.
PRIDEiQ5VW38.

PTM databases

iPTMnetiQ5VW38.
PhosphoSitePlusiQ5VW38.

Expressioni

Gene expression databases

BgeeiENSG00000148358.
CleanExiHS_GPR107.
ExpressionAtlasiQ5VW38. baseline and differential.
GenevisibleiQ5VW38. HS.

Organism-specific databases

HPAiHPA031704.

Interactioni

Protein-protein interaction databases

BioGridi121743. 8 interactors.
IntActiQ5VW38. 2 interactors.
STRINGi9606.ENSP00000361483.

Structurei

3D structure databases

ProteinModelPortaliQ5VW38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOVERGENiHBG056147.
InParanoidiQ5VW38.
OMAiFTRIIAF.
OrthoDBiEOG091G05OJ.
PhylomeDBiQ5VW38.
TreeFamiTF314804.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 2 hits.
PfamiPF06814. Lung_7-TM_R. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV
60 70 80 90 100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS
110 120 130 140 150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD
160 170 180 190 200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN
210 220 230 240 250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN
260 270 280 290 300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA
310 320 330 340 350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL
360 370 380 390 400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW
410 420 430 440 450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA
460 470 480 490 500
GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL
510 520 530 540 550
IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS
560 570 580 590 600
DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV
Length:600
Mass (Da):66,990
Last modified:December 7, 2004 - v1
Checksum:i679D414C0EB9F205
GO
Isoform 2 (identifier: Q5VW38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-483: Missing.

Show »
Length:552
Mass (Da):61,976
Checksum:iC5BD664C167B2230
GO
Isoform 3 (identifier: Q5VW38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-300: MAA → GFH
     301-600: Missing.

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,384
Checksum:i27ED28675ABF911B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250N → D in BAB15408 (PubMed:14702039).Curated1
Sequence conflicti457H → R in BAB13450 (PubMed:10997877).Curated1
Sequence conflicti461Q → R in BAB13450 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030863189A → P.Corresponds to variant rs640343dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014434298 – 300MAA → GFH in isoform 3. 1 Publication3
Alternative sequenceiVSP_014435301 – 600Missing in isoform 3. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_014436436 – 483Missing in isoform 2. 3 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376725 mRNA. Translation: AAK57695.1.
AK026244 mRNA. Translation: BAB15408.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71210.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71211.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12152.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16952.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16953.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12153.1.
CH471090 Genomic DNA. Translation: EAW87924.1.
BC110518 mRNA. Translation: AAI10519.1.
AB046844 mRNA. Translation: BAB13450.1.
AL834359 mRNA. Translation: CAI46205.1. Sequence problems.
CCDSiCCDS35162.1. [Q5VW38-2]
CCDS48041.1. [Q5VW38-1]
RefSeqiNP_001130029.1. NM_001136557.1. [Q5VW38-1]
NP_001130030.1. NM_001136558.1.
NP_066011.2. NM_020960.4. [Q5VW38-2]
UniGeneiHs.512461.

Genome annotation databases

EnsembliENST00000347136; ENSP00000336988; ENSG00000148358. [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358. [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358. [Q5VW38-1]
GeneIDi57720.
KEGGihsa:57720.
UCSCiuc004bzd.3. human. [Q5VW38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376725 mRNA. Translation: AAK57695.1.
AK026244 mRNA. Translation: BAB15408.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71210.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71211.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12152.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16952.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16953.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12153.1.
CH471090 Genomic DNA. Translation: EAW87924.1.
BC110518 mRNA. Translation: AAI10519.1.
AB046844 mRNA. Translation: BAB13450.1.
AL834359 mRNA. Translation: CAI46205.1. Sequence problems.
CCDSiCCDS35162.1. [Q5VW38-2]
CCDS48041.1. [Q5VW38-1]
RefSeqiNP_001130029.1. NM_001136557.1. [Q5VW38-1]
NP_001130030.1. NM_001136558.1.
NP_066011.2. NM_020960.4. [Q5VW38-2]
UniGeneiHs.512461.

3D structure databases

ProteinModelPortaliQ5VW38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121743. 8 interactors.
IntActiQ5VW38. 2 interactors.
STRINGi9606.ENSP00000361483.

PTM databases

iPTMnetiQ5VW38.
PhosphoSitePlusiQ5VW38.

Polymorphism and mutation databases

BioMutaiGPR107.
DMDMi68565572.

Proteomic databases

MaxQBiQ5VW38.
PaxDbiQ5VW38.
PeptideAtlasiQ5VW38.
PRIDEiQ5VW38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347136; ENSP00000336988; ENSG00000148358. [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358. [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358. [Q5VW38-1]
GeneIDi57720.
KEGGihsa:57720.
UCSCiuc004bzd.3. human. [Q5VW38-1]

Organism-specific databases

CTDi57720.
GeneCardsiGPR107.
HGNCiHGNC:17830. GPR107.
HPAiHPA031704.
neXtProtiNX_Q5VW38.
OpenTargetsiENSG00000148358.
PharmGKBiPA28854.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2569. Eukaryota.
ENOG410XQAQ. LUCA.
GeneTreeiENSGT00390000008649.
HOVERGENiHBG056147.
InParanoidiQ5VW38.
OMAiFTRIIAF.
OrthoDBiEOG091G05OJ.
PhylomeDBiQ5VW38.
TreeFamiTF314804.

Miscellaneous databases

ChiTaRSiGPR107. human.
GeneWikiiGPR107.
GenomeRNAii57720.
PROiQ5VW38.

Gene expression databases

BgeeiENSG00000148358.
CleanExiHS_GPR107.
ExpressionAtlasiQ5VW38. baseline and differential.
GenevisibleiQ5VW38. HS.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 2 hits.
PfamiPF06814. Lung_7-TM_R. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP107_HUMAN
AccessioniPrimary (citable) accession number: Q5VW38
Secondary accession number(s): A6NJ53
, Q2TB81, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.