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Q5VW38

- GP107_HUMAN

UniProt

Q5VW38 - GP107_HUMAN

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Protein

Protein GPR107

Gene

GPR107

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GPR107
Alternative name(s):
Lung seven transmembrane receptor 1
Gene namesi
Name:GPR107
Synonyms:KIAA1624, LUSTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:17830. GPR107.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 600561Protein GPR107PRO_0000021340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5VW38.
PaxDbiQ5VW38.
PRIDEiQ5VW38.

PTM databases

PhosphoSiteiQ5VW38.

Expressioni

Gene expression databases

BgeeiQ5VW38.
CleanExiHS_GPR107.
ExpressionAtlasiQ5VW38. baseline and differential.
GenevestigatoriQ5VW38.

Organism-specific databases

HPAiHPA031704.

Interactioni

Protein-protein interaction databases

BioGridi121743. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5VW38.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei264 – 28421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei369 – 38921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei499 – 51921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei525 – 54420Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294185.
GeneTreeiENSGT00390000008649.
HOVERGENiHBG056147.
InParanoidiQ5VW38.
OMAiGVMENMK.
PhylomeDBiQ5VW38.
TreeFamiTF314804.

Family and domain databases

InterProiIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV
60 70 80 90 100
RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS
110 120 130 140 150
YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD
160 170 180 190 200
EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN
210 220 230 240 250
GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN
260 270 280 290 300
PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA
310 320 330 340 350
LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL
360 370 380 390 400
IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW
410 420 430 440 450
KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA
460 470 480 490 500
GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL
510 520 530 540 550
IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS
560 570 580 590 600
DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV
Length:600
Mass (Da):66,990
Last modified:December 7, 2004 - v1
Checksum:i679D414C0EB9F205
GO
Isoform 2 (identifier: Q5VW38-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-483: Missing.

Show »
Length:552
Mass (Da):61,976
Checksum:iC5BD664C167B2230
GO
Isoform 3 (identifier: Q5VW38-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-300: MAA → GFH
     301-600: Missing.

Note: No experimental confirmation available.

Show »
Length:300
Mass (Da):33,384
Checksum:i27ED28675ABF911B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501N → D in BAB15408. (PubMed:14702039)Curated
Sequence conflicti457 – 4571H → R in BAB13450. (PubMed:10997877)Curated
Sequence conflicti461 – 4611Q → R in BAB13450. (PubMed:10997877)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891A → P.
Corresponds to variant rs640343 [ dbSNP | Ensembl ].
VAR_030863

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei298 – 3003MAA → GFH in isoform 3. 1 PublicationVSP_014434
Alternative sequencei301 – 600300Missing in isoform 3. 1 PublicationVSP_014435Add
BLAST
Alternative sequencei436 – 48348Missing in isoform 2. 3 PublicationsVSP_014436Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF376725 mRNA. Translation: AAK57695.1.
AK026244 mRNA. Translation: BAB15408.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71210.1.
AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71211.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12152.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16952.1.
AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16953.1.
AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12153.1.
CH471090 Genomic DNA. Translation: EAW87924.1.
BC110518 mRNA. Translation: AAI10519.1.
AB046844 mRNA. Translation: BAB13450.1.
AL834359 mRNA. Translation: CAI46205.1. Sequence problems.
CCDSiCCDS35162.1. [Q5VW38-2]
CCDS48041.1. [Q5VW38-1]
RefSeqiNP_001130029.1. NM_001136557.1. [Q5VW38-1]
NP_001130030.1. NM_001136558.1.
NP_066011.2. NM_020960.4. [Q5VW38-2]
UniGeneiHs.512461.

Genome annotation databases

EnsembliENST00000347136; ENSP00000336988; ENSG00000148358. [Q5VW38-2]
ENST00000372406; ENSP00000361483; ENSG00000148358. [Q5VW38-1]
ENST00000610997; ENSP00000483750; ENSG00000148358. [Q5VW38-1]
GeneIDi57720.
KEGGihsa:57720.
UCSCiuc004bzb.2. human. [Q5VW38-2]
uc004bze.2. human. [Q5VW38-1]

Polymorphism databases

DMDMi68565572.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF376725 mRNA. Translation: AAK57695.1 .
AK026244 mRNA. Translation: BAB15408.1 .
AL392105 , AL136141 , AL360004 Genomic DNA. Translation: CAH71210.1 .
AL392105 , AL136141 , AL360004 Genomic DNA. Translation: CAH71211.1 .
AL136141 , AL360004 , AL392105 Genomic DNA. Translation: CAI12152.1 .
AL360004 , AL136141 , AL392105 Genomic DNA. Translation: CAI16952.1 .
AL360004 , AL136141 , AL392105 Genomic DNA. Translation: CAI16953.1 .
AL136141 , AL360004 , AL392105 Genomic DNA. Translation: CAI12153.1 .
CH471090 Genomic DNA. Translation: EAW87924.1 .
BC110518 mRNA. Translation: AAI10519.1 .
AB046844 mRNA. Translation: BAB13450.1 .
AL834359 mRNA. Translation: CAI46205.1 . Sequence problems.
CCDSi CCDS35162.1. [Q5VW38-2 ]
CCDS48041.1. [Q5VW38-1 ]
RefSeqi NP_001130029.1. NM_001136557.1. [Q5VW38-1 ]
NP_001130030.1. NM_001136558.1.
NP_066011.2. NM_020960.4. [Q5VW38-2 ]
UniGenei Hs.512461.

3D structure databases

ProteinModelPortali Q5VW38.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121743. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi 651.

PTM databases

PhosphoSitei Q5VW38.

Polymorphism databases

DMDMi 68565572.

Proteomic databases

MaxQBi Q5VW38.
PaxDbi Q5VW38.
PRIDEi Q5VW38.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347136 ; ENSP00000336988 ; ENSG00000148358 . [Q5VW38-2 ]
ENST00000372406 ; ENSP00000361483 ; ENSG00000148358 . [Q5VW38-1 ]
ENST00000610997 ; ENSP00000483750 ; ENSG00000148358 . [Q5VW38-1 ]
GeneIDi 57720.
KEGGi hsa:57720.
UCSCi uc004bzb.2. human. [Q5VW38-2 ]
uc004bze.2. human. [Q5VW38-1 ]

Organism-specific databases

CTDi 57720.
GeneCardsi GC09P132815.
HGNCi HGNC:17830. GPR107.
HPAi HPA031704.
neXtProti NX_Q5VW38.
PharmGKBi PA28854.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294185.
GeneTreei ENSGT00390000008649.
HOVERGENi HBG056147.
InParanoidi Q5VW38.
OMAi GVMENMK.
PhylomeDBi Q5VW38.
TreeFami TF314804.

Miscellaneous databases

ChiTaRSi GPR107. human.
GeneWikii GPR107.
GenomeRNAii 57720.
NextBioi 64658.
PROi Q5VW38.

Gene expression databases

Bgeei Q5VW38.
CleanExi HS_GPR107.
ExpressionAtlasi Q5VW38. baseline and differential.
Genevestigatori Q5VW38.

Family and domain databases

InterProi IPR009637. TM_rcpt_euk.
[Graphical view ]
PANTHERi PTHR21229. PTHR21229. 1 hit.
Pfami PF06814. Lung_7-TM_R. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel putative G protein-coupled receptors cloned from lung."
    Edgar A.J., Polak J.M.
    J. Anat. 200:202-202(2002)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Small intestine.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-600 (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-600 (ISOFORM 2).
    Tissue: Lymph node.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGP107_HUMAN
AccessioniPrimary (citable) accession number: Q5VW38
Secondary accession number(s): A6NJ53
, Q2TB81, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3