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Q5VW38

- GP107_HUMAN

UniProt

Q5VW38 - GP107_HUMAN

Protein

Protein GPR107

Gene

GPR107

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GPR107
    Alternative name(s):
    Lung seven transmembrane receptor 1
    Gene namesi
    Name:GPR107
    Synonyms:KIAA1624, LUSTR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:17830. GPR107.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28854.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 600561Protein GPR107PRO_0000021340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ5VW38.
    PaxDbiQ5VW38.
    PRIDEiQ5VW38.

    PTM databases

    PhosphoSiteiQ5VW38.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VW38.
    BgeeiQ5VW38.
    CleanExiHS_GPR107.
    GenevestigatoriQ5VW38.

    Organism-specific databases

    HPAiHPA031704.

    Interactioni

    Protein-protein interaction databases

    BioGridi121743. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VW38.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei525 – 54420Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LU7TM family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG294185.
    HOVERGENiHBG056147.
    InParanoidiQ5VW38.
    OMAiGVMENMK.
    PhylomeDBiQ5VW38.
    TreeFamiTF314804.

    Family and domain databases

    InterProiIPR009637. TM_rcpt_euk.
    [Graphical view]
    PANTHERiPTHR21229. PTHR21229. 1 hit.
    PfamiPF06814. Lung_7-TM_R. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VW38-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALAPVGSP ASRGPRLAAG LRLLPMLGLL QLLAEPGLGR VHHLALKDDV    50
    RHKVHLNTFG FFKDGYMVVN VSSLSLNEPE DKDVTIGFSL DRTKNDGFSS 100
    YLDEDVNYCI LKKQSVSVTL LILDISRSEV RVKSPPEAGT QLPKIIFSRD 150
    EKVLGQSQEP NVNPASAGNQ TQKTQDGGKS KRSTVDSKAM GEKSFSVHNN 200
    GGAVSFQFFF NISTDDQEGL YSLYFHKCLG KELPSDKFTF SLDIEITEKN 250
    PDSYLSAGEI PLPKLYISMA FFFFLSGTIW IHILRKRRND VFKIHWLMAA 300
    LPFTKSLSLV FHAIDYHYIS SQGFPIEGWA VVYYITHLLK GALLFITIAL 350
    IGTGWAFIKH ILSDKDKKIF MIVIPLQVLA NVAYIIIEST EEGTTEYGLW 400
    KDSLFLVDLL CCGAILFPVV WSIRHLQEAS ATDGKGDSMG PLQQRANLRA 450
    GSRIESHHFA QADLELLASS CPPASVSQRA GITAAINLAK LKLFRHYYVL 500
    IVCYIYFTRI IAFLLKLAVP FQWKWLYQLL DETATLVFFV LTGYKFRPAS 550
    DNPYLQLSQE EEDLEMESVV TTSGVMESMK KVKKVTNGSV EPQGEWEGAV 600
    Length:600
    Mass (Da):66,990
    Last modified:December 7, 2004 - v1
    Checksum:i679D414C0EB9F205
    GO
    Isoform 2 (identifier: Q5VW38-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         436-483: Missing.

    Show »
    Length:552
    Mass (Da):61,976
    Checksum:iC5BD664C167B2230
    GO
    Isoform 3 (identifier: Q5VW38-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         298-300: MAA → GFH
         301-600: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:300
    Mass (Da):33,384
    Checksum:i27ED28675ABF911B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501N → D in BAB15408. (PubMed:14702039)Curated
    Sequence conflicti457 – 4571H → R in BAB13450. (PubMed:10997877)Curated
    Sequence conflicti461 – 4611Q → R in BAB13450. (PubMed:10997877)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti189 – 1891A → P.
    Corresponds to variant rs640343 [ dbSNP | Ensembl ].
    VAR_030863

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei298 – 3003MAA → GFH in isoform 3. 1 PublicationVSP_014434
    Alternative sequencei301 – 600300Missing in isoform 3. 1 PublicationVSP_014435Add
    BLAST
    Alternative sequencei436 – 48348Missing in isoform 2. 3 PublicationsVSP_014436Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF376725 mRNA. Translation: AAK57695.1.
    AK026244 mRNA. Translation: BAB15408.1.
    AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71210.1.
    AL392105, AL136141, AL360004 Genomic DNA. Translation: CAH71211.1.
    AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12152.1.
    AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16952.1.
    AL360004, AL136141, AL392105 Genomic DNA. Translation: CAI16953.1.
    AL136141, AL360004, AL392105 Genomic DNA. Translation: CAI12153.1.
    CH471090 Genomic DNA. Translation: EAW87924.1.
    BC110518 mRNA. Translation: AAI10519.1.
    AB046844 mRNA. Translation: BAB13450.1.
    AL834359 mRNA. Translation: CAI46205.1. Sequence problems.
    CCDSiCCDS35162.1. [Q5VW38-2]
    CCDS48041.1. [Q5VW38-1]
    RefSeqiNP_001130029.1. NM_001136557.1. [Q5VW38-1]
    NP_001130030.1. NM_001136558.1.
    NP_066011.2. NM_020960.4. [Q5VW38-2]
    UniGeneiHs.512461.

    Genome annotation databases

    EnsembliENST00000347136; ENSP00000336988; ENSG00000148358. [Q5VW38-2]
    ENST00000372406; ENSP00000361483; ENSG00000148358. [Q5VW38-1]
    GeneIDi57720.
    KEGGihsa:57720.
    UCSCiuc004bzb.2. human. [Q5VW38-2]
    uc004bze.2. human. [Q5VW38-1]

    Polymorphism databases

    DMDMi68565572.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF376725 mRNA. Translation: AAK57695.1 .
    AK026244 mRNA. Translation: BAB15408.1 .
    AL392105 , AL136141 , AL360004 Genomic DNA. Translation: CAH71210.1 .
    AL392105 , AL136141 , AL360004 Genomic DNA. Translation: CAH71211.1 .
    AL136141 , AL360004 , AL392105 Genomic DNA. Translation: CAI12152.1 .
    AL360004 , AL136141 , AL392105 Genomic DNA. Translation: CAI16952.1 .
    AL360004 , AL136141 , AL392105 Genomic DNA. Translation: CAI16953.1 .
    AL136141 , AL360004 , AL392105 Genomic DNA. Translation: CAI12153.1 .
    CH471090 Genomic DNA. Translation: EAW87924.1 .
    BC110518 mRNA. Translation: AAI10519.1 .
    AB046844 mRNA. Translation: BAB13450.1 .
    AL834359 mRNA. Translation: CAI46205.1 . Sequence problems.
    CCDSi CCDS35162.1. [Q5VW38-2 ]
    CCDS48041.1. [Q5VW38-1 ]
    RefSeqi NP_001130029.1. NM_001136557.1. [Q5VW38-1 ]
    NP_001130030.1. NM_001136558.1.
    NP_066011.2. NM_020960.4. [Q5VW38-2 ]
    UniGenei Hs.512461.

    3D structure databases

    ProteinModelPortali Q5VW38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121743. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 651.

    PTM databases

    PhosphoSitei Q5VW38.

    Polymorphism databases

    DMDMi 68565572.

    Proteomic databases

    MaxQBi Q5VW38.
    PaxDbi Q5VW38.
    PRIDEi Q5VW38.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347136 ; ENSP00000336988 ; ENSG00000148358 . [Q5VW38-2 ]
    ENST00000372406 ; ENSP00000361483 ; ENSG00000148358 . [Q5VW38-1 ]
    GeneIDi 57720.
    KEGGi hsa:57720.
    UCSCi uc004bzb.2. human. [Q5VW38-2 ]
    uc004bze.2. human. [Q5VW38-1 ]

    Organism-specific databases

    CTDi 57720.
    GeneCardsi GC09P132815.
    HGNCi HGNC:17830. GPR107.
    HPAi HPA031704.
    neXtProti NX_Q5VW38.
    PharmGKBi PA28854.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294185.
    HOVERGENi HBG056147.
    InParanoidi Q5VW38.
    OMAi GVMENMK.
    PhylomeDBi Q5VW38.
    TreeFami TF314804.

    Miscellaneous databases

    ChiTaRSi GPR107. human.
    GeneWikii GPR107.
    GenomeRNAii 57720.
    NextBioi 64658.
    PROi Q5VW38.

    Gene expression databases

    ArrayExpressi Q5VW38.
    Bgeei Q5VW38.
    CleanExi HS_GPR107.
    Genevestigatori Q5VW38.

    Family and domain databases

    InterProi IPR009637. TM_rcpt_euk.
    [Graphical view ]
    PANTHERi PTHR21229. PTHR21229. 1 hit.
    Pfami PF06814. Lung_7-TM_R. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel putative G protein-coupled receptors cloned from lung."
      Edgar A.J., Polak J.M.
      J. Anat. 200:202-202(2002)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Small intestine.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-600 (ISOFORM 1).
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-600 (ISOFORM 2).
      Tissue: Lymph node.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGP107_HUMAN
    AccessioniPrimary (citable) accession number: Q5VW38
    Secondary accession number(s): A6NJ53
    , Q2TB81, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3