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Protein

Focadhesin

Gene

FOCAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential tumor suppressor in gliomas.By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Focadhesin
Gene namesi
Name:FOCAD
Synonyms:KIAA1797
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23377. FOCAD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Transmembranei1036 – 1056HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • focal adhesion Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54914.
PharmGKBiPA134934777.

Polymorphism and mutation databases

BioMutaiFOCAD.
DMDMi74747342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144571 – 1801FocadhesinAdd BLAST1801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei819N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5VW36.
MaxQBiQ5VW36.
PaxDbiQ5VW36.
PeptideAtlasiQ5VW36.
PRIDEiQ5VW36.

PTM databases

iPTMnetiQ5VW36.
PhosphoSitePlusiQ5VW36.

Expressioni

Tissue specificityi

Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000188352.
CleanExiHS_KIAA1797.
ExpressionAtlasiQ5VW36. baseline and differential.
GenevisibleiQ5VW36. HS.

Organism-specific databases

HPAiHPA055015.

Interactioni

Subunit structurei

Interacts with VCL.1 Publication

Protein-protein interaction databases

BioGridi120256. 10 interactors.
IntActiQ5VW36. 6 interactors.
MINTiMINT-8247615.
STRINGi9606.ENSP00000344307.

Structurei

3D structure databases

ProteinModelPortaliQ5VW36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II1D. Eukaryota.
ENOG410YIIU. LUCA.
HOVERGENiHBG095600.
InParanoidiQ5VW36.
OrthoDBiEOG091G00F3.
PhylomeDBiQ5VW36.
TreeFamiTF323261.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR022542. DUF3730.
IPR021392. Focadhesin.
[Graphical view]
PfamiPF12530. DUF3730. 1 hit.
PF11229. Focadhesin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5VW36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDIRKRFE FPNSLIQSQA VGHLIAAVLK ENGFSEKIHQ STNQTPALNL
60 70 80 90 100
LWEKCCSDNV VVRTACCEGL VALVAQDHAE FSYVLNGILN LIPSTRNTHG
110 120 130 140 150
LIKAIMHLLQ MQALKEGQGG EKNIQSIYTI RNHPHPLITV LEHRPDCWPV
160 170 180 190 200
FLQQLTAFFQ QCPERLEVSC IQIMAPFLWY LYCEPSQLQE YAKLRLALLK
210 220 230 240 250
VLLQPQVLCD KDQPSILEQQ ILQLCCDIVP CLQVKDLIQT TEAMMFIEEV
260 270 280 290 300
CLSLLRHPVF WKIQLTQMSL QLLCVSEVSL KITGECSSSI HLLEHSVELL
310 320 330 340 350
KEDFPVELVI IGIALLLLQT PASQQKPILN LALKLLSVTE DQKIPKSSLL
360 370 380 390 400
LVMPILQILS STALEDCISV DEEGPSRQQL ALNLLEMIQQ ECYRDDHQKL
410 420 430 440 450
SYKLVCPVTS MYGTIFTAWR ILEVMTDSSA ASDWLASVES LLPITAVIPA
460 470 480 490 500
PAFLLLAHLL VEDKGQNLHQ ILKVTTELAQ ADSSQVPNLI PVLMFKLGRP
510 520 530 540 550
LEPILYNDIL YTLPKLGVHK VCIGQILRII QLLGTTPRLR AVTLRLLTSL
560 570 580 590 600
WEKQDRVYPE LQRFMAVSDV PSLSVGKEVQ WEKLIAKAAS IRDICKQRPY
610 620 630 640 650
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA
660 670 680 690 700
LSPKLSCDTR PLILKTLSEL FSLVPSLTVN TTEYENFKVQ VLSFLWTHTQ
710 720 730 740 750
NKDPIVANAA YRSLANFTAG EHTILHLPEK IRPEIPIPEE LDDDEDVEDV
760 770 780 790 800
DLSVPGSCYL KLLSLTPPLV LPALEEFFTS LVKQEMVNMP RGIYHSALKG
810 820 830 840 850
GARSDQGKTV AGIPNFILKM YETNKQPGLK PGLAGGMLFC YDVSMYQSKD
860 870 880 890 900
GKPLNRLMAS RGRSFKQTSL ALVHEVHIQL SEWHRAIFLP QAWLAYMNRA
910 920 930 940 950
YHAILQGRLG ELELQLKHGK EEPEEVQYKK STAWLWVRDM LTDEITKAAA
960 970 980 990 1000
KESPVVKGNA LLALSSLAVV VSRHEASLSS DSDGLLEVQP NFLSMKEWVS
1010 1020 1030 1040 1050
MVLDTLLVIV DSHYQPRGQL LSWFYYKSYS GENTASAIAR SAAATALSLL
1060 1070 1080 1090 1100
VPVFIISCKE KVEEILNMLT ARLPGKPSAD ESQAVQIHMG LALGMFLSRL
1110 1120 1130 1140 1150
CEEKLSDISG QEMNLLLMKS LDALENCCFD TSLEYNTGCI LGVGLVLSLM
1160 1170 1180 1190 1200
SHSSQMQSRV HVAALLRKLS AHVDDSGSQS RTFQEVLAYT LSCVCTSAFS
1210 1220 1230 1240 1250
AGIIEATEAE DVMNKLRLLV ENSQQTSGFA LALGNIVHGL SVCGHGKAED
1260 1270 1280 1290 1300
LGSKLLPAWI RIVLTEGTPT MLCLAALHGM VALVGSEGDV MQLKSEAIQT
1310 1320 1330 1340 1350
SHFQGRLNEV IRTLTQVISV SGVIGLQSNA VWLLGHLHLS TLSSSQSRAS
1360 1370 1380 1390 1400
VPTDYSYLPE SSFIGAAIGF FITGGKKGPE SVPPSLLKVV MKPIATVGES
1410 1420 1430 1440 1450
YQYPPVNWAA LLSPLMRLNF GEEIQQLCLE IMVTQAQSSQ NAAALLGLWV
1460 1470 1480 1490 1500
TPPLIHSLSL NTKRYLLISA PLWIKHISDE QILGFVENLM VAVFKAASPL
1510 1520 1530 1540 1550
GSPELCPSAL HGLSQAMKLP SPAHHLWSLL SEATGKIFDL LPNKIRRKDL
1560 1570 1580 1590 1600
ELYISIAKCL LEMTDDDANR IAQVTKSNIE KAAFVKLYLV SQGRFPLVNL
1610 1620 1630 1640 1650
TDMLSVAVQH REKEVLAWMI LHSLYQARIV SHANTGVLKR MEWLLELMGY
1660 1670 1680 1690 1700
IRNVAYQSTS FHNTALDKAL DFFLLIFATA VVAWADHTAP LLLGLSASWL
1710 1720 1730 1740 1750
PWHQENGPAG PVPSFLGRSP MHRVTLQEVL TLLPNSMALL LQKEPWKEQT
1760 1770 1780 1790 1800
QKFIDWLFSI MESPKEALSA QSRDLLKATL LSLRVLPEFK KKAVWTRAYG

W
Length:1,801
Mass (Da):200,072
Last modified:December 7, 2004 - v1
Checksum:iD9E96037C621FB80
GO

Sequence cautioni

The sequence BAA91129 differs from that shown. Reason: Frameshift at position 261.Curated
The sequence BAA91129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD18787 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481A → V in AAN17740 (Ref. 1) Curated1
Sequence conflicti481A → V in BAB71203 (PubMed:14702039).Curated1
Sequence conflicti1430E → D in AAH01246 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037877166L → S.Corresponds to variant rs10511687dbSNPEnsembl.1
Natural variantiVAR_037878234V → I.Corresponds to variant rs10441706dbSNPEnsembl.1
Natural variantiVAR_037879523I → V.Corresponds to variant rs17832431dbSNPEnsembl.1
Natural variantiVAR_037880718T → S.4 PublicationsCorresponds to variant rs7875872dbSNPEnsembl.1
Natural variantiVAR_049528721E → K.Corresponds to variant rs10964742dbSNPEnsembl.1
Natural variantiVAR_0612511373T → A.1 PublicationCorresponds to variant rs3206852dbSNPEnsembl.1
Natural variantiVAR_0378811373T → P.Corresponds to variant rs3206852dbSNPEnsembl.1
Natural variantiVAR_0612521373T → S.Corresponds to variant rs3206852dbSNPEnsembl.1
Natural variantiVAR_0378821668K → E.4 PublicationsCorresponds to variant rs4977881dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139834 mRNA. Translation: AAN17740.1.
AL392163, AL445624, AL662879 Genomic DNA. Translation: CAH73851.1.
AK000382 mRNA. Translation: BAA91129.1. Frameshift.
AK056522 mRNA. Translation: BAB71203.1.
AK172818 mRNA. Translation: BAD18787.1. Different initiation.
AB058700 mRNA. Translation: BAB47426.1.
CH471071 Genomic DNA. Translation: EAW58627.1.
CH471071 Genomic DNA. Translation: EAW58628.1.
CH471071 Genomic DNA. Translation: EAW58629.1.
BC001246 mRNA. Translation: AAH01246.2.
CCDSiCCDS34993.1.
RefSeqiNP_060264.4. NM_017794.4.
XP_005251551.2. XM_005251494.3.
UniGeneiHs.136247.

Genome annotation databases

EnsembliENST00000338382; ENSP00000344307; ENSG00000188352.
ENST00000380249; ENSP00000369599; ENSG00000188352.
GeneIDi54914.
KEGGihsa:54914.
UCSCiuc003zog.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139834 mRNA. Translation: AAN17740.1.
AL392163, AL445624, AL662879 Genomic DNA. Translation: CAH73851.1.
AK000382 mRNA. Translation: BAA91129.1. Frameshift.
AK056522 mRNA. Translation: BAB71203.1.
AK172818 mRNA. Translation: BAD18787.1. Different initiation.
AB058700 mRNA. Translation: BAB47426.1.
CH471071 Genomic DNA. Translation: EAW58627.1.
CH471071 Genomic DNA. Translation: EAW58628.1.
CH471071 Genomic DNA. Translation: EAW58629.1.
BC001246 mRNA. Translation: AAH01246.2.
CCDSiCCDS34993.1.
RefSeqiNP_060264.4. NM_017794.4.
XP_005251551.2. XM_005251494.3.
UniGeneiHs.136247.

3D structure databases

ProteinModelPortaliQ5VW36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120256. 10 interactors.
IntActiQ5VW36. 6 interactors.
MINTiMINT-8247615.
STRINGi9606.ENSP00000344307.

PTM databases

iPTMnetiQ5VW36.
PhosphoSitePlusiQ5VW36.

Polymorphism and mutation databases

BioMutaiFOCAD.
DMDMi74747342.

Proteomic databases

EPDiQ5VW36.
MaxQBiQ5VW36.
PaxDbiQ5VW36.
PeptideAtlasiQ5VW36.
PRIDEiQ5VW36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338382; ENSP00000344307; ENSG00000188352.
ENST00000380249; ENSP00000369599; ENSG00000188352.
GeneIDi54914.
KEGGihsa:54914.
UCSCiuc003zog.2. human.

Organism-specific databases

CTDi54914.
DisGeNETi54914.
GeneCardsiFOCAD.
HGNCiHGNC:23377. FOCAD.
HPAiHPA055015.
MIMi614606. gene.
neXtProtiNX_Q5VW36.
PharmGKBiPA134934777.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1D. Eukaryota.
ENOG410YIIU. LUCA.
HOVERGENiHBG095600.
InParanoidiQ5VW36.
OrthoDBiEOG091G00F3.
PhylomeDBiQ5VW36.
TreeFamiTF323261.

Miscellaneous databases

ChiTaRSiFOCAD. human.
GeneWikiiKIAA1797.
GenomeRNAii54914.
PROiQ5VW36.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188352.
CleanExiHS_KIAA1797.
ExpressionAtlasiQ5VW36. baseline and differential.
GenevisibleiQ5VW36. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR022542. DUF3730.
IPR021392. Focadhesin.
[Graphical view]
PfamiPF12530. DUF3730. 1 hit.
PF11229. Focadhesin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFOCAD_HUMAN
AccessioniPrimary (citable) accession number: Q5VW36
Secondary accession number(s): D3DRJ9
, Q6ZME1, Q8IZG0, Q96JM8, Q96MS9, Q9BVF3, Q9NX87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.