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Q5VW36

- FOCAD_HUMAN

UniProt

Q5VW36 - FOCAD_HUMAN

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Protein
Focadhesin
Gene
FOCAD, KIAA1797
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Potential tumor suppressor in gliomas By similarity.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Focadhesin
Gene namesi
Name:FOCAD
Synonyms:KIAA1797
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23377. FOCAD.

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Cell junctionfocal adhesion
Note: Colocalizes with VCL in astrocytes.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei404 – 42421Helical; Reviewed prediction
Add
BLAST
Transmembranei441 – 46121Helical; Reviewed prediction
Add
BLAST
Transmembranei1036 – 105621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. focal adhesion Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18011801Focadhesin
PRO_0000314457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei819 – 8191N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ5VW36.
PaxDbiQ5VW36.
PRIDEiQ5VW36.

PTM databases

PhosphoSiteiQ5VW36.

Expressioni

Tissue specificityi

Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines.2 Publications

Gene expression databases

BgeeiQ5VW36.
CleanExiHS_KIAA1797.
GenevestigatoriQ5VW36.

Organism-specific databases

HPAiHPA055015.

Interactioni

Subunit structurei

Interacts with VCL.1 Publication

Protein-protein interaction databases

BioGridi120256. 4 interactions.
IntActiQ5VW36. 1 interaction.
MINTiMINT-8247615.

Structurei

3D structure databases

ProteinModelPortaliQ5VW36.
SMRiQ5VW36. Positions 690-716.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG27815.
HOVERGENiHBG095600.
InParanoidiQ5VW36.
OMAiSPKLSCD.
OrthoDBiEOG7N0C3T.
PhylomeDBiQ5VW36.
TreeFamiTF323261.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR021392. DUF3028.
IPR022542. DUF3730.
[Graphical view]
PfamiPF11229. DUF3028. 1 hit.
PF12530. DUF3730. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5VW36-1 [UniParc]FASTAAdd to Basket

« Hide

MSDDIRKRFE FPNSLIQSQA VGHLIAAVLK ENGFSEKIHQ STNQTPALNL     50
LWEKCCSDNV VVRTACCEGL VALVAQDHAE FSYVLNGILN LIPSTRNTHG 100
LIKAIMHLLQ MQALKEGQGG EKNIQSIYTI RNHPHPLITV LEHRPDCWPV 150
FLQQLTAFFQ QCPERLEVSC IQIMAPFLWY LYCEPSQLQE YAKLRLALLK 200
VLLQPQVLCD KDQPSILEQQ ILQLCCDIVP CLQVKDLIQT TEAMMFIEEV 250
CLSLLRHPVF WKIQLTQMSL QLLCVSEVSL KITGECSSSI HLLEHSVELL 300
KEDFPVELVI IGIALLLLQT PASQQKPILN LALKLLSVTE DQKIPKSSLL 350
LVMPILQILS STALEDCISV DEEGPSRQQL ALNLLEMIQQ ECYRDDHQKL 400
SYKLVCPVTS MYGTIFTAWR ILEVMTDSSA ASDWLASVES LLPITAVIPA 450
PAFLLLAHLL VEDKGQNLHQ ILKVTTELAQ ADSSQVPNLI PVLMFKLGRP 500
LEPILYNDIL YTLPKLGVHK VCIGQILRII QLLGTTPRLR AVTLRLLTSL 550
WEKQDRVYPE LQRFMAVSDV PSLSVGKEVQ WEKLIAKAAS IRDICKQRPY 600
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA 650
LSPKLSCDTR PLILKTLSEL FSLVPSLTVN TTEYENFKVQ VLSFLWTHTQ 700
NKDPIVANAA YRSLANFTAG EHTILHLPEK IRPEIPIPEE LDDDEDVEDV 750
DLSVPGSCYL KLLSLTPPLV LPALEEFFTS LVKQEMVNMP RGIYHSALKG 800
GARSDQGKTV AGIPNFILKM YETNKQPGLK PGLAGGMLFC YDVSMYQSKD 850
GKPLNRLMAS RGRSFKQTSL ALVHEVHIQL SEWHRAIFLP QAWLAYMNRA 900
YHAILQGRLG ELELQLKHGK EEPEEVQYKK STAWLWVRDM LTDEITKAAA 950
KESPVVKGNA LLALSSLAVV VSRHEASLSS DSDGLLEVQP NFLSMKEWVS 1000
MVLDTLLVIV DSHYQPRGQL LSWFYYKSYS GENTASAIAR SAAATALSLL 1050
VPVFIISCKE KVEEILNMLT ARLPGKPSAD ESQAVQIHMG LALGMFLSRL 1100
CEEKLSDISG QEMNLLLMKS LDALENCCFD TSLEYNTGCI LGVGLVLSLM 1150
SHSSQMQSRV HVAALLRKLS AHVDDSGSQS RTFQEVLAYT LSCVCTSAFS 1200
AGIIEATEAE DVMNKLRLLV ENSQQTSGFA LALGNIVHGL SVCGHGKAED 1250
LGSKLLPAWI RIVLTEGTPT MLCLAALHGM VALVGSEGDV MQLKSEAIQT 1300
SHFQGRLNEV IRTLTQVISV SGVIGLQSNA VWLLGHLHLS TLSSSQSRAS 1350
VPTDYSYLPE SSFIGAAIGF FITGGKKGPE SVPPSLLKVV MKPIATVGES 1400
YQYPPVNWAA LLSPLMRLNF GEEIQQLCLE IMVTQAQSSQ NAAALLGLWV 1450
TPPLIHSLSL NTKRYLLISA PLWIKHISDE QILGFVENLM VAVFKAASPL 1500
GSPELCPSAL HGLSQAMKLP SPAHHLWSLL SEATGKIFDL LPNKIRRKDL 1550
ELYISIAKCL LEMTDDDANR IAQVTKSNIE KAAFVKLYLV SQGRFPLVNL 1600
TDMLSVAVQH REKEVLAWMI LHSLYQARIV SHANTGVLKR MEWLLELMGY 1650
IRNVAYQSTS FHNTALDKAL DFFLLIFATA VVAWADHTAP LLLGLSASWL 1700
PWHQENGPAG PVPSFLGRSP MHRVTLQEVL TLLPNSMALL LQKEPWKEQT 1750
QKFIDWLFSI MESPKEALSA QSRDLLKATL LSLRVLPEFK KKAVWTRAYG 1800
W 1801
Length:1,801
Mass (Da):200,072
Last modified:December 7, 2004 - v1
Checksum:iD9E96037C621FB80
GO

Sequence cautioni

The sequence BAA91129.1 differs from that shown. Reason: Frameshift at position 261.
The sequence BAA91129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAD18787.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661L → S.
Corresponds to variant rs10511687 [ dbSNP | Ensembl ].
VAR_037877
Natural varianti234 – 2341V → I.
Corresponds to variant rs10441706 [ dbSNP | Ensembl ].
VAR_037878
Natural varianti523 – 5231I → V.
Corresponds to variant rs17832431 [ dbSNP | Ensembl ].
VAR_037879
Natural varianti718 – 7181T → S.4 Publications
Corresponds to variant rs7875872 [ dbSNP | Ensembl ].
VAR_037880
Natural varianti721 – 7211E → K.
Corresponds to variant rs10964742 [ dbSNP | Ensembl ].
VAR_049528
Natural varianti1373 – 13731T → A.1 Publication
Corresponds to variant rs3206852 [ dbSNP | Ensembl ].
VAR_061251
Natural varianti1373 – 13731T → P.
Corresponds to variant rs3206852 [ dbSNP | Ensembl ].
VAR_037881
Natural varianti1373 – 13731T → S.
Corresponds to variant rs3206852 [ dbSNP | Ensembl ].
VAR_061252
Natural varianti1668 – 16681K → E.4 Publications
Corresponds to variant rs4977881 [ dbSNP | Ensembl ].
VAR_037882

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti481 – 4811A → V in AAN17740. 1 Publication
Sequence conflicti481 – 4811A → V in BAB71203. 1 Publication
Sequence conflicti1430 – 14301E → D in AAH01246. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY139834 mRNA. Translation: AAN17740.1.
AL392163, AL445624, AL662879 Genomic DNA. Translation: CAH73851.1.
AK000382 mRNA. Translation: BAA91129.1. Frameshift.
AK056522 mRNA. Translation: BAB71203.1.
AK172818 mRNA. Translation: BAD18787.1. Different initiation.
AB058700 mRNA. Translation: BAB47426.1.
CH471071 Genomic DNA. Translation: EAW58627.1.
CH471071 Genomic DNA. Translation: EAW58628.1.
CH471071 Genomic DNA. Translation: EAW58629.1.
BC001246 mRNA. Translation: AAH01246.2.
CCDSiCCDS34993.1.
RefSeqiNP_060264.4. NM_017794.4.
XP_005251551.2. XM_005251494.2.
UniGeneiHs.136247.

Genome annotation databases

EnsembliENST00000338382; ENSP00000344307; ENSG00000188352.
ENST00000380249; ENSP00000369599; ENSG00000188352.
GeneIDi54914.
KEGGihsa:54914.
UCSCiuc003zog.1. human.

Polymorphism databases

DMDMi74747342.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY139834 mRNA. Translation: AAN17740.1 .
AL392163 , AL445624 , AL662879 Genomic DNA. Translation: CAH73851.1 .
AK000382 mRNA. Translation: BAA91129.1 . Frameshift.
AK056522 mRNA. Translation: BAB71203.1 .
AK172818 mRNA. Translation: BAD18787.1 . Different initiation.
AB058700 mRNA. Translation: BAB47426.1 .
CH471071 Genomic DNA. Translation: EAW58627.1 .
CH471071 Genomic DNA. Translation: EAW58628.1 .
CH471071 Genomic DNA. Translation: EAW58629.1 .
BC001246 mRNA. Translation: AAH01246.2 .
CCDSi CCDS34993.1.
RefSeqi NP_060264.4. NM_017794.4.
XP_005251551.2. XM_005251494.2.
UniGenei Hs.136247.

3D structure databases

ProteinModelPortali Q5VW36.
SMRi Q5VW36. Positions 690-716.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120256. 4 interactions.
IntActi Q5VW36. 1 interaction.
MINTi MINT-8247615.

PTM databases

PhosphoSitei Q5VW36.

Polymorphism databases

DMDMi 74747342.

Proteomic databases

MaxQBi Q5VW36.
PaxDbi Q5VW36.
PRIDEi Q5VW36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338382 ; ENSP00000344307 ; ENSG00000188352 .
ENST00000380249 ; ENSP00000369599 ; ENSG00000188352 .
GeneIDi 54914.
KEGGi hsa:54914.
UCSCi uc003zog.1. human.

Organism-specific databases

CTDi 54914.
GeneCardsi GC09P020659.
HGNCi HGNC:23377. FOCAD.
HPAi HPA055015.
MIMi 614606. gene.
neXtProti NX_Q5VW36.
PharmGKBi PA134934777.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27815.
HOVERGENi HBG095600.
InParanoidi Q5VW36.
OMAi SPKLSCD.
OrthoDBi EOG7N0C3T.
PhylomeDBi Q5VW36.
TreeFami TF323261.

Miscellaneous databases

GeneWikii KIAA1797.
GenomeRNAii 54914.
NextBioi 57970.
PROi Q5VW36.
SOURCEi Search...

Gene expression databases

Bgeei Q5VW36.
CleanExi HS_KIAA1797.
Genevestigatori Q5VW36.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR021392. DUF3028.
IPR022542. DUF3730.
[Graphical view ]
Pfami PF11229. DUF3028. 1 hit.
PF12530. DUF3730. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Chen L., Yu L.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-718 AND GLU-1668.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-718.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-915 AND 1305-1801, VARIANTS SER-718; ALA-1373 AND GLU-1668.
    Tissue: Endothelial cell, Hepatoma and Teratocarcinoma.
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 521-1801, VARIANTS SER-718 AND GLU-1668.
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1300-1801, VARIANT GLU-1668.
    Tissue: Choriocarcinoma.
  7. "L1 antisense promoter drives tissue-specific transcription of human genes."
    Matlik K., Redik K., Speek M.
    J. Biomed. Biotechnol. 2006:71753-71753(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-819, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: TISSUE SPECIFICITY, INTERACTION WITH VCL, FUNCTION.

Entry informationi

Entry nameiFOCAD_HUMAN
AccessioniPrimary (citable) accession number: Q5VW36
Secondary accession number(s): D3DRJ9
, Q6ZME1, Q8IZG0, Q96JM8, Q96MS9, Q9BVF3, Q9NX87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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