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Q5VW36 (FOCAD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Focadhesin
Gene names
Name:FOCAD
Synonyms:KIAA1797
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1801 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential tumor suppressor in gliomas By similarity. Ref.10

Subunit structure

Interacts with VCL. Ref.10

Subcellular location

Membrane; Multi-pass membrane protein Potential. Cell junctionfocal adhesion. Note: Colocalizes with VCL in astrocytes.

Tissue specificity

Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines. Ref.7 Ref.10

Sequence caution

The sequence BAA91129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA91129.1 differs from that shown. Reason: Frameshift at position 261.

The sequence BAD18787.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCell junction
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentfocal adhesion

Inferred from direct assay Ref.10. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18011801Focadhesin
PRO_0000314457

Regions

Transmembrane404 – 42421Helical; Potential
Transmembrane441 – 46121Helical; Potential
Transmembrane1036 – 105621Helical; Potential

Amino acid modifications

Modified residue8191N6-acetyllysine Ref.8

Natural variations

Natural variant1661L → S.
Corresponds to variant rs10511687 [ dbSNP | Ensembl ].
VAR_037877
Natural variant2341V → I.
Corresponds to variant rs10441706 [ dbSNP | Ensembl ].
VAR_037878
Natural variant5231I → V.
Corresponds to variant rs17832431 [ dbSNP | Ensembl ].
VAR_037879
Natural variant7181T → S. Ref.1 Ref.3 Ref.4 Ref.5
Corresponds to variant rs7875872 [ dbSNP | Ensembl ].
VAR_037880
Natural variant7211E → K.
Corresponds to variant rs10964742 [ dbSNP | Ensembl ].
VAR_049528
Natural variant13731T → A. Ref.4
Corresponds to variant rs3206852 [ dbSNP | Ensembl ].
VAR_061251
Natural variant13731T → P.
Corresponds to variant rs3206852 [ dbSNP | Ensembl ].
VAR_037881
Natural variant13731T → S.
Corresponds to variant rs3206852 [ dbSNP | Ensembl ].
VAR_061252
Natural variant16681K → E. Ref.1 Ref.4 Ref.5 Ref.6
Corresponds to variant rs4977881 [ dbSNP | Ensembl ].
VAR_037882

Experimental info

Sequence conflict4811A → V in AAN17740. Ref.1
Sequence conflict4811A → V in BAB71203. Ref.4
Sequence conflict14301E → D in AAH01246. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q5VW36 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: D9E96037C621FB80

FASTA1,801200,072
        10         20         30         40         50         60 
MSDDIRKRFE FPNSLIQSQA VGHLIAAVLK ENGFSEKIHQ STNQTPALNL LWEKCCSDNV 

        70         80         90        100        110        120 
VVRTACCEGL VALVAQDHAE FSYVLNGILN LIPSTRNTHG LIKAIMHLLQ MQALKEGQGG 

       130        140        150        160        170        180 
EKNIQSIYTI RNHPHPLITV LEHRPDCWPV FLQQLTAFFQ QCPERLEVSC IQIMAPFLWY 

       190        200        210        220        230        240 
LYCEPSQLQE YAKLRLALLK VLLQPQVLCD KDQPSILEQQ ILQLCCDIVP CLQVKDLIQT 

       250        260        270        280        290        300 
TEAMMFIEEV CLSLLRHPVF WKIQLTQMSL QLLCVSEVSL KITGECSSSI HLLEHSVELL 

       310        320        330        340        350        360 
KEDFPVELVI IGIALLLLQT PASQQKPILN LALKLLSVTE DQKIPKSSLL LVMPILQILS 

       370        380        390        400        410        420 
STALEDCISV DEEGPSRQQL ALNLLEMIQQ ECYRDDHQKL SYKLVCPVTS MYGTIFTAWR 

       430        440        450        460        470        480 
ILEVMTDSSA ASDWLASVES LLPITAVIPA PAFLLLAHLL VEDKGQNLHQ ILKVTTELAQ 

       490        500        510        520        530        540 
ADSSQVPNLI PVLMFKLGRP LEPILYNDIL YTLPKLGVHK VCIGQILRII QLLGTTPRLR 

       550        560        570        580        590        600 
AVTLRLLTSL WEKQDRVYPE LQRFMAVSDV PSLSVGKEVQ WEKLIAKAAS IRDICKQRPY 

       610        620        630        640        650        660 
QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA LSPKLSCDTR 

       670        680        690        700        710        720 
PLILKTLSEL FSLVPSLTVN TTEYENFKVQ VLSFLWTHTQ NKDPIVANAA YRSLANFTAG 

       730        740        750        760        770        780 
EHTILHLPEK IRPEIPIPEE LDDDEDVEDV DLSVPGSCYL KLLSLTPPLV LPALEEFFTS 

       790        800        810        820        830        840 
LVKQEMVNMP RGIYHSALKG GARSDQGKTV AGIPNFILKM YETNKQPGLK PGLAGGMLFC 

       850        860        870        880        890        900 
YDVSMYQSKD GKPLNRLMAS RGRSFKQTSL ALVHEVHIQL SEWHRAIFLP QAWLAYMNRA 

       910        920        930        940        950        960 
YHAILQGRLG ELELQLKHGK EEPEEVQYKK STAWLWVRDM LTDEITKAAA KESPVVKGNA 

       970        980        990       1000       1010       1020 
LLALSSLAVV VSRHEASLSS DSDGLLEVQP NFLSMKEWVS MVLDTLLVIV DSHYQPRGQL 

      1030       1040       1050       1060       1070       1080 
LSWFYYKSYS GENTASAIAR SAAATALSLL VPVFIISCKE KVEEILNMLT ARLPGKPSAD 

      1090       1100       1110       1120       1130       1140 
ESQAVQIHMG LALGMFLSRL CEEKLSDISG QEMNLLLMKS LDALENCCFD TSLEYNTGCI 

      1150       1160       1170       1180       1190       1200 
LGVGLVLSLM SHSSQMQSRV HVAALLRKLS AHVDDSGSQS RTFQEVLAYT LSCVCTSAFS 

      1210       1220       1230       1240       1250       1260 
AGIIEATEAE DVMNKLRLLV ENSQQTSGFA LALGNIVHGL SVCGHGKAED LGSKLLPAWI 

      1270       1280       1290       1300       1310       1320 
RIVLTEGTPT MLCLAALHGM VALVGSEGDV MQLKSEAIQT SHFQGRLNEV IRTLTQVISV 

      1330       1340       1350       1360       1370       1380 
SGVIGLQSNA VWLLGHLHLS TLSSSQSRAS VPTDYSYLPE SSFIGAAIGF FITGGKKGPE 

      1390       1400       1410       1420       1430       1440 
SVPPSLLKVV MKPIATVGES YQYPPVNWAA LLSPLMRLNF GEEIQQLCLE IMVTQAQSSQ 

      1450       1460       1470       1480       1490       1500 
NAAALLGLWV TPPLIHSLSL NTKRYLLISA PLWIKHISDE QILGFVENLM VAVFKAASPL 

      1510       1520       1530       1540       1550       1560 
GSPELCPSAL HGLSQAMKLP SPAHHLWSLL SEATGKIFDL LPNKIRRKDL ELYISIAKCL 

      1570       1580       1590       1600       1610       1620 
LEMTDDDANR IAQVTKSNIE KAAFVKLYLV SQGRFPLVNL TDMLSVAVQH REKEVLAWMI 

      1630       1640       1650       1660       1670       1680 
LHSLYQARIV SHANTGVLKR MEWLLELMGY IRNVAYQSTS FHNTALDKAL DFFLLIFATA 

      1690       1700       1710       1720       1730       1740 
VVAWADHTAP LLLGLSASWL PWHQENGPAG PVPSFLGRSP MHRVTLQEVL TLLPNSMALL 

      1750       1760       1770       1780       1790       1800 
LQKEPWKEQT QKFIDWLFSI MESPKEALSA QSRDLLKATL LSLRVLPEFK KKAVWTRAYG 


W 

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References

« Hide 'large scale' references
[1]Guo J.H., Chen L., Yu L.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-718 AND GLU-1668.
Tissue: Brain.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-718.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-915 AND 1305-1801, VARIANTS SER-718; ALA-1373 AND GLU-1668.
Tissue: Endothelial cell, Hepatoma and Teratocarcinoma.
[5]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 521-1801, VARIANTS SER-718 AND GLU-1668.
Tissue: Brain.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1300-1801, VARIANT GLU-1668.
Tissue: Choriocarcinoma.
[7]"L1 antisense promoter drives tissue-specific transcription of human genes."
Matlik K., Redik K., Speek M.
J. Biomed. Biotechnol. 2006:71753-71753(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-819, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas."
Brockschmidt A., Trost D., Peterziel H., Zimmermann K., Ehrler M., Grassmann H., Pfenning P.N., Waha A., Wohlleber D., Brockschmidt F.F., Jugold M., Hoischen A., Kalla C., Waha A., Seifert G., Knolle P.A., Latz E., Hans V.H. expand/collapse author list , Wick W., Pfeifer A., Angel P., Weber R.G.
Brain 135:1027-1041(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH VCL, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY139834 mRNA. Translation: AAN17740.1.
AL392163, AL445624, AL662879 Genomic DNA. Translation: CAH73851.1.
AK000382 mRNA. Translation: BAA91129.1. Frameshift.
AK056522 mRNA. Translation: BAB71203.1.
AK172818 mRNA. Translation: BAD18787.1. Different initiation.
AB058700 mRNA. Translation: BAB47426.1.
CH471071 Genomic DNA. Translation: EAW58627.1.
CH471071 Genomic DNA. Translation: EAW58628.1.
CH471071 Genomic DNA. Translation: EAW58629.1.
BC001246 mRNA. Translation: AAH01246.2.
RefSeqNP_060264.3. NM_017794.3.
XP_005251551.2. XM_005251494.2.
UniGeneHs.136247.

3D structure databases

ProteinModelPortalQ5VW36.
SMRQ5VW36. Positions 690-716.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120256. 4 interactions.
IntActQ5VW36. 1 interaction.
MINTMINT-8247615.

PTM databases

PhosphoSiteQ5VW36.

Polymorphism databases

DMDM74747342.

Proteomic databases

PaxDbQ5VW36.
PRIDEQ5VW36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338382; ENSP00000344307; ENSG00000188352.
ENST00000380249; ENSP00000369599; ENSG00000188352.
GeneID54914.
KEGGhsa:54914.
UCSCuc003zog.1. human.

Organism-specific databases

CTD54914.
GeneCardsGC09P020659.
HGNCHGNC:23377. FOCAD.
HPAHPA055015.
MIM614606. gene.
neXtProtNX_Q5VW36.
PharmGKBPA134934777.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG27815.
HOVERGENHBG095600.
InParanoidQ5VW36.
OMASPKLSCD.
OrthoDBEOG7N0C3T.
PhylomeDBQ5VW36.
TreeFamTF323261.

Gene expression databases

BgeeQ5VW36.
CleanExHS_KIAA1797.
GenevestigatorQ5VW36.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR021392. DUF3028.
IPR022542. DUF3730.
[Graphical view]
PfamPF11229. DUF3028. 1 hit.
PF12530. DUF3730. 2 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
ProtoNetSearch...

Other

GeneWikiKIAA1797.
GenomeRNAi54914.
NextBio57970.
PROQ5VW36.
SOURCESearch...

Entry information

Entry nameFOCAD_HUMAN
AccessionPrimary (citable) accession number: Q5VW36
Secondary accession number(s): D3DRJ9 expand/collapse secondary AC list , Q6ZME1, Q8IZG0, Q96JM8, Q96MS9, Q9BVF3, Q9NX87
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM