Q5VW36 (FOCAD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Focadhesin

Gene names

Name:	FOCAD
Synonyms:	KIAA1797

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1801 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential tumor suppressor in gliomas By similarity. Ref.10
Subunit structure	Interacts with VCL. Ref.10
Subcellular location	Membrane; Multi-pass membrane protein Potential. Cell junction › focal adhesion. Note: Colocalizes with VCL in astrocytes.
Tissue specificity	Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines. Ref.7 Ref.10
Sequence caution	The sequence BAA91129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91129.1 differs from that shown. Reason: Frameshift at position 261. The sequence BAD18787.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell junction Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	focal adhesion Inferred from direct assay Ref.10. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1801	1801	Focadhesin		PRO_0000314457
Regions
	Transmembrane	404 – 424	21	Helical; Potential
	Transmembrane	441 – 461	21	Helical; Potential
	Transmembrane	1036 – 1056	21	Helical; Potential
Amino acid modifications
	Modified residue	819	1	N6-acetyllysine Ref.8
Natural variations
	Natural variant	166	1	L → S. Corresponds to variant rs10511687 [ dbSNP | Ensembl ].		VAR_037877
	Natural variant	234	1	V → I. Corresponds to variant rs10441706 [ dbSNP | Ensembl ].		VAR_037878
	Natural variant	523	1	I → V. Corresponds to variant rs17832431 [ dbSNP | Ensembl ].		VAR_037879
	Natural variant	718	1	T → S. Ref.1 Ref.3 Ref.4 Ref.5 Corresponds to variant rs7875872 [ dbSNP | Ensembl ].		VAR_037880
	Natural variant	721	1	E → K. Corresponds to variant rs10964742 [ dbSNP | Ensembl ].		VAR_049528
	Natural variant	1373	1	T → A. Ref.4 Corresponds to variant rs3206852 [ dbSNP | Ensembl ].		VAR_061251
	Natural variant	1373	1	T → P. Corresponds to variant rs3206852 [ dbSNP | Ensembl ].		VAR_037881
	Natural variant	1373	1	T → S. Corresponds to variant rs3206852 [ dbSNP | Ensembl ].		VAR_061252
	Natural variant	1668	1	K → E. Ref.1 Ref.4 Ref.5 Ref.6 Corresponds to variant rs4977881 [ dbSNP | Ensembl ].		VAR_037882
Experimental info
	Sequence conflict	481	1	A → V in AAN17740. Ref.1
	Sequence conflict	481	1	A → V in BAB71203. Ref.4
	Sequence conflict	1430	1	E → D in AAH01246. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q5VW36 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: D9E96037C621FB80	FASTA	1,801	200,072
	10 20 30 40 50 60 MSDDIRKRFE FPNSLIQSQA VGHLIAAVLK ENGFSEKIHQ STNQTPALNL LWEKCCSDNV 70 80 90 100 110 120 VVRTACCEGL VALVAQDHAE FSYVLNGILN LIPSTRNTHG LIKAIMHLLQ MQALKEGQGG 130 140 150 160 170 180 EKNIQSIYTI RNHPHPLITV LEHRPDCWPV FLQQLTAFFQ QCPERLEVSC IQIMAPFLWY 190 200 210 220 230 240 LYCEPSQLQE YAKLRLALLK VLLQPQVLCD KDQPSILEQQ ILQLCCDIVP CLQVKDLIQT 250 260 270 280 290 300 TEAMMFIEEV CLSLLRHPVF WKIQLTQMSL QLLCVSEVSL KITGECSSSI HLLEHSVELL 310 320 330 340 350 360 KEDFPVELVI IGIALLLLQT PASQQKPILN LALKLLSVTE DQKIPKSSLL LVMPILQILS 370 380 390 400 410 420 STALEDCISV DEEGPSRQQL ALNLLEMIQQ ECYRDDHQKL SYKLVCPVTS MYGTIFTAWR 430 440 450 460 470 480 ILEVMTDSSA ASDWLASVES LLPITAVIPA PAFLLLAHLL VEDKGQNLHQ ILKVTTELAQ 490 500 510 520 530 540 ADSSQVPNLI PVLMFKLGRP LEPILYNDIL YTLPKLGVHK VCIGQILRII QLLGTTPRLR 550 560 570 580 590 600 AVTLRLLTSL WEKQDRVYPE LQRFMAVSDV PSLSVGKEVQ WEKLIAKAAS IRDICKQRPY 610 620 630 640 650 660 QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA LSPKLSCDTR 670 680 690 700 710 720 PLILKTLSEL FSLVPSLTVN TTEYENFKVQ VLSFLWTHTQ NKDPIVANAA YRSLANFTAG 730 740 750 760 770 780 EHTILHLPEK IRPEIPIPEE LDDDEDVEDV DLSVPGSCYL KLLSLTPPLV LPALEEFFTS 790 800 810 820 830 840 LVKQEMVNMP RGIYHSALKG GARSDQGKTV AGIPNFILKM YETNKQPGLK PGLAGGMLFC 850 860 870 880 890 900 YDVSMYQSKD GKPLNRLMAS RGRSFKQTSL ALVHEVHIQL SEWHRAIFLP QAWLAYMNRA 910 920 930 940 950 960 YHAILQGRLG ELELQLKHGK EEPEEVQYKK STAWLWVRDM LTDEITKAAA KESPVVKGNA 970 980 990 1000 1010 1020 LLALSSLAVV VSRHEASLSS DSDGLLEVQP NFLSMKEWVS MVLDTLLVIV DSHYQPRGQL 1030 1040 1050 1060 1070 1080 LSWFYYKSYS GENTASAIAR SAAATALSLL VPVFIISCKE KVEEILNMLT ARLPGKPSAD 1090 1100 1110 1120 1130 1140 ESQAVQIHMG LALGMFLSRL CEEKLSDISG QEMNLLLMKS LDALENCCFD TSLEYNTGCI 1150 1160 1170 1180 1190 1200 LGVGLVLSLM SHSSQMQSRV HVAALLRKLS AHVDDSGSQS RTFQEVLAYT LSCVCTSAFS 1210 1220 1230 1240 1250 1260 AGIIEATEAE DVMNKLRLLV ENSQQTSGFA LALGNIVHGL SVCGHGKAED LGSKLLPAWI 1270 1280 1290 1300 1310 1320 RIVLTEGTPT MLCLAALHGM VALVGSEGDV MQLKSEAIQT SHFQGRLNEV IRTLTQVISV 1330 1340 1350 1360 1370 1380 SGVIGLQSNA VWLLGHLHLS TLSSSQSRAS VPTDYSYLPE SSFIGAAIGF FITGGKKGPE 1390 1400 1410 1420 1430 1440 SVPPSLLKVV MKPIATVGES YQYPPVNWAA LLSPLMRLNF GEEIQQLCLE IMVTQAQSSQ 1450 1460 1470 1480 1490 1500 NAAALLGLWV TPPLIHSLSL NTKRYLLISA PLWIKHISDE QILGFVENLM VAVFKAASPL 1510 1520 1530 1540 1550 1560 GSPELCPSAL HGLSQAMKLP SPAHHLWSLL SEATGKIFDL LPNKIRRKDL ELYISIAKCL 1570 1580 1590 1600 1610 1620 LEMTDDDANR IAQVTKSNIE KAAFVKLYLV SQGRFPLVNL TDMLSVAVQH REKEVLAWMI 1630 1640 1650 1660 1670 1680 LHSLYQARIV SHANTGVLKR MEWLLELMGY IRNVAYQSTS FHNTALDKAL DFFLLIFATA 1690 1700 1710 1720 1730 1740 VVAWADHTAP LLLGLSASWL PWHQENGPAG PVPSFLGRSP MHRVTLQEVL TLLPNSMALL 1750 1760 1770 1780 1790 1800 LQKEPWKEQT QKFIDWLFSI MESPKEALSA QSRDLLKATL LSLRVLPEFK KKAVWTRAYG W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Guo J.H., Chen L., Yu L. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-718 AND GLU-1668. Tissue: Brain.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-718.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-915 AND 1305-1801, VARIANTS SER-718; ALA-1373 AND GLU-1668. Tissue: Endothelial cell, Hepatoma and Teratocarcinoma.
[5]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 521-1801, VARIANTS SER-718 AND GLU-1668. Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1300-1801, VARIANT GLU-1668. Tissue: Choriocarcinoma.
[7]	"L1 antisense promoter drives tissue-specific transcription of human genes." Matlik K., Redik K., Speek M. J. Biomed. Biotechnol. 2006:71753-71753(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-819, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas." Brockschmidt A., Trost D., Peterziel H., Zimmermann K., Ehrler M., Grassmann H., Pfenning P.N., Waha A., Wohlleber D., Brockschmidt F.F., Jugold M., Hoischen A., Kalla C., Waha A., Seifert G., Knolle P.A., Latz E., Hans V.H. , Wick W., Pfeifer A., Angel P., Weber R.G. Brain 135:1027-1041(2012) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH VCL, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY139834 mRNA. Translation: AAN17740.1. AL392163, AL445624, AL662879 Genomic DNA. Translation: CAH73851.1. AK000382 mRNA. Translation: BAA91129.1. Frameshift. AK056522 mRNA. Translation: BAB71203.1. AK172818 mRNA. Translation: BAD18787.1. Different initiation. AB058700 mRNA. Translation: BAB47426.1. CH471071 Genomic DNA. Translation: EAW58627.1. CH471071 Genomic DNA. Translation: EAW58628.1. CH471071 Genomic DNA. Translation: EAW58629.1. BC001246 mRNA. Translation: AAH01246.2.
IPI	IPI00748360.
RefSeq	NP_060264.3. NM_017794.3.
UniGene	Hs.136247.
3D structure databases
ProteinModelPortal	Q5VW36.
ModBase	Search...
PTM databases
PhosphoSite	Q5VW36.
Polymorphism databases
DMDM	74747342.
Proteomic databases
PaxDb	Q5VW36.
PRIDE	Q5VW36.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338382; ENSP00000344307; ENSG00000188352. ENST00000380249; ENSP00000369599; ENSG00000188352.
GeneID	54914.
KEGG	hsa:54914.
UCSC	uc003zog.1. human.
Organism-specific databases
CTD	54914.
GeneCards	GC09P020659.
HGNC	HGNC:23377. FOCAD.
HPA	HPA055015.
MIM	614606. gene.
neXtProt	NX_Q5VW36.
PharmGKB	PA134934777.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG27815.
HOVERGEN	HBG095600.
InParanoid	Q5VW36.
OMA	SCDTRPL.
OrthoDB	EOG4WWRHQ.
Gene expression databases
Bgee	Q5VW36.
CleanEx	HS_KIAA1797.
Genevestigator	Q5VW36.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR021392. DUF3028. IPR022542. DUF3730. [Graphical view]
Pfam	PF11229. DUF3028. 1 hit. PF12530. DUF3730. 2 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	54914.
NextBio	57970.
SOURCE	Search...

Entry information

Entry name

FOCAD_HUMAN

Accession

Primary (citable) accession number: Q5VW36
Secondary accession number(s): D3DRJ9 , Q6ZME1, Q8IZG0, Q96JM8, Q96MS9, Q9BVF3, Q9NX87

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.