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Protein

BRO1 domain-containing protein BROX

Gene

BROX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BRO1 domain-containing protein BROX
Alternative name(s):
BRO1 domain- and CAAX motif-containing protein
Gene namesi
Name:BROX
Synonyms:BROFTI, C1orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26512. BROX.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672509.

Polymorphism and mutation databases

DMDMi74747339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408BRO1 domain-containing protein BROXPRO_0000304612Add
BLAST
Propeptidei409 – 4113Removed in mature formCuratedPRO_0000396736

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831N6-acetyllysineCombined sources
Modified residuei408 – 4081Cysteine methyl esterCurated
Lipidationi408 – 4081S-farnesyl cysteine2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ5VW32.
MaxQBiQ5VW32.
PaxDbiQ5VW32.
PeptideAtlasiQ5VW32.
PRIDEiQ5VW32.

PTM databases

iPTMnetiQ5VW32.
PhosphoSiteiQ5VW32.
SwissPalmiQ5VW32.

Expressioni

Gene expression databases

BgeeiENSG00000162819.
CleanExiHS_C1orf58.
ExpressionAtlasiQ5VW32. baseline and differential.
GenevisibleiQ5VW32. HS.

Organism-specific databases

HPAiHPA031445.

Interactioni

Subunit structurei

Interacts with CHMP4B.1 Publication

Protein-protein interaction databases

BioGridi127145. 10 interactions.
DIPiDIP-59406N.
IntActiQ5VW32. 1 interaction.
STRINGi9606.ENSP00000343742.

Structurei

Secondary structure

1
411
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 233Combined sources
Helixi27 – 4620Combined sources
Helixi54 – 6815Combined sources
Helixi69 – 713Combined sources
Beta strandi75 – 817Combined sources
Turni83 – 864Combined sources
Beta strandi90 – 923Combined sources
Beta strandi95 – 973Combined sources
Beta strandi102 – 1054Combined sources
Helixi107 – 13024Combined sources
Helixi137 – 16024Combined sources
Helixi162 – 1643Combined sources
Beta strandi173 – 1764Combined sources
Helixi177 – 20125Combined sources
Helixi206 – 22722Combined sources
Helixi232 – 26332Combined sources
Helixi267 – 29226Combined sources
Beta strandi298 – 3014Combined sources
Helixi303 – 3053Combined sources
Helixi307 – 32923Combined sources
Beta strandi347 – 3493Combined sources
Helixi367 – 3715Combined sources
Helixi375 – 3773Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R9MX-ray1.95A2-374[»]
3ULYX-ray2.60A2-408[»]
3UM0X-ray3.10A2-408[»]
3UM1X-ray2.71A/D2-377[»]
3UM2X-ray2.59A/D2-377[»]
3UM3X-ray3.80A2-411[»]
3ZXPX-ray2.50A/B/C1-401[»]
ProteinModelPortaliQ5VW32.
SMRiQ5VW32. Positions 2-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 408319BRO1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BROX family.Curated
Contains 1 BRO1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEDQ. Eukaryota.
ENOG410ZHPX. LUCA.
GeneTreeiENSGT00390000006681.
HOGENOMiHOG000007224.
HOVERGENiHBG107541.
InParanoidiQ5VW32.
OMAiEAKDVHR.
OrthoDBiEOG091G0E9F.
PhylomeDBiQ5VW32.
TreeFamiTF314743.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
InterProiIPR004328. BRO1_dom.
[Graphical view]
PfamiPF03097. BRO1. 1 hit.
[Graphical view]
SMARTiSM01041. BRO1. 1 hit.
[Graphical view]
PROSITEiPS51180. BRO1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VW32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHWFHRNPL KATAPVSFNY YGVVTGPSAS KICNDLRSSR ARLLELFTDL
60 70 80 90 100
SCNPEMMKNA ADSYFSLLQG FINSLDESTQ ESKLRYIQNF KWTDTLQGQV
110 120 130 140 150
PSAQQDAVFE LISMGFNVAL WYTKYASRLA GKENITEDEA KEVHRSLKIA
160 170 180 190 200
AGIFKHLKES HLPKLITPAE KGRDLESRLI EAYVIQCQAE AQEVTIARAI
210 220 230 240 250
ELKHAPGLIA ALAYETANFY QKADHTLSSL EPAYSAKWRK YLHLKMCFYT
260 270 280 290 300
AYAYCYHGET LLASDKCGEA IRSLQEAEKL YAKAEALCKE YGETKGPGPT
310 320 330 340 350
VKPSGHLFFR KLGNLVKNTL EKCQRENGFI YFQKIPTEAP QLELKANYGL
360 370 380 390 400
VEPIPFEFPP TSVQWTPETL AAFDLTKRPK DDSTKPKPEE EVKPVKEPDI
410
KPQKDTGCYI S
Length:411
Mass (Da):46,476
Last modified:December 7, 2004 - v1
Checksum:i6ED03F79BE1514C6
GO
Isoform 2 (identifier: Q5VW32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-134: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):42,872
Checksum:iD089C76DDBFE7DFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351I → T in BAF56045 (PubMed:18190528).Curated
Sequence conflicti335 – 3351I → T in BAB71331 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 13432Missing in isoform 2. 2 PublicationsVSP_055551Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB276123 mRNA. Translation: BAF56045.1.
AK056983 mRNA. Translation: BAB71331.1.
AK315930 mRNA. Translation: BAH14301.1.
AL392172 Genomic DNA. Translation: CAH73932.1.
CH471100 Genomic DNA. Translation: EAW93265.1.
BC113635 mRNA. Translation: AAI13636.1.
BC113637 mRNA. Translation: AAI13638.1.
BC143811 mRNA. Translation: AAI43812.1.
CCDSiCCDS1534.1. [Q5VW32-1]
CCDS73037.1. [Q5VW32-2]
RefSeqiNP_001275508.1. NM_001288579.1. [Q5VW32-2]
NP_001275509.1. NM_001288580.1. [Q5VW32-2]
NP_001275510.1. NM_001288581.1.
NP_653296.2. NM_144695.3. [Q5VW32-1]
XP_005273122.2. XM_005273065.2. [Q5VW32-1]
XP_011507516.1. XM_011509214.2. [Q5VW32-1]
UniGeneiHs.534965.
Hs.552608.
Hs.600844.

Genome annotation databases

EnsembliENST00000340934; ENSP00000343742; ENSG00000162819. [Q5VW32-1]
ENST00000539697; ENSP00000441080; ENSG00000162819. [Q5VW32-2]
ENST00000612948; ENSP00000478496; ENSG00000162819. [Q5VW32-2]
GeneIDi148362.
KEGGihsa:148362.
UCSCiuc001hns.2. human. [Q5VW32-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB276123 mRNA. Translation: BAF56045.1.
AK056983 mRNA. Translation: BAB71331.1.
AK315930 mRNA. Translation: BAH14301.1.
AL392172 Genomic DNA. Translation: CAH73932.1.
CH471100 Genomic DNA. Translation: EAW93265.1.
BC113635 mRNA. Translation: AAI13636.1.
BC113637 mRNA. Translation: AAI13638.1.
BC143811 mRNA. Translation: AAI43812.1.
CCDSiCCDS1534.1. [Q5VW32-1]
CCDS73037.1. [Q5VW32-2]
RefSeqiNP_001275508.1. NM_001288579.1. [Q5VW32-2]
NP_001275509.1. NM_001288580.1. [Q5VW32-2]
NP_001275510.1. NM_001288581.1.
NP_653296.2. NM_144695.3. [Q5VW32-1]
XP_005273122.2. XM_005273065.2. [Q5VW32-1]
XP_011507516.1. XM_011509214.2. [Q5VW32-1]
UniGeneiHs.534965.
Hs.552608.
Hs.600844.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R9MX-ray1.95A2-374[»]
3ULYX-ray2.60A2-408[»]
3UM0X-ray3.10A2-408[»]
3UM1X-ray2.71A/D2-377[»]
3UM2X-ray2.59A/D2-377[»]
3UM3X-ray3.80A2-411[»]
3ZXPX-ray2.50A/B/C1-401[»]
ProteinModelPortaliQ5VW32.
SMRiQ5VW32. Positions 2-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127145. 10 interactions.
DIPiDIP-59406N.
IntActiQ5VW32. 1 interaction.
STRINGi9606.ENSP00000343742.

PTM databases

iPTMnetiQ5VW32.
PhosphoSiteiQ5VW32.
SwissPalmiQ5VW32.

Polymorphism and mutation databases

DMDMi74747339.

Proteomic databases

EPDiQ5VW32.
MaxQBiQ5VW32.
PaxDbiQ5VW32.
PeptideAtlasiQ5VW32.
PRIDEiQ5VW32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340934; ENSP00000343742; ENSG00000162819. [Q5VW32-1]
ENST00000539697; ENSP00000441080; ENSG00000162819. [Q5VW32-2]
ENST00000612948; ENSP00000478496; ENSG00000162819. [Q5VW32-2]
GeneIDi148362.
KEGGihsa:148362.
UCSCiuc001hns.2. human. [Q5VW32-1]

Organism-specific databases

CTDi148362.
GeneCardsiBROX.
H-InvDBHIX0001617.
HIX0001618.
HGNCiHGNC:26512. BROX.
HPAiHPA031445.
neXtProtiNX_Q5VW32.
PharmGKBiPA142672509.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEDQ. Eukaryota.
ENOG410ZHPX. LUCA.
GeneTreeiENSGT00390000006681.
HOGENOMiHOG000007224.
HOVERGENiHBG107541.
InParanoidiQ5VW32.
OMAiEAKDVHR.
OrthoDBiEOG091G0E9F.
PhylomeDBiQ5VW32.
TreeFamiTF314743.

Miscellaneous databases

ChiTaRSiBROX. human.
GenomeRNAii148362.
PROiQ5VW32.

Gene expression databases

BgeeiENSG00000162819.
CleanExiHS_C1orf58.
ExpressionAtlasiQ5VW32. baseline and differential.
GenevisibleiQ5VW32. HS.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
InterProiIPR004328. BRO1_dom.
[Graphical view]
PfamiPF03097. BRO1. 1 hit.
[Graphical view]
SMARTiSM01041. BRO1. 1 hit.
[Graphical view]
PROSITEiPS51180. BRO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBROX_HUMAN
AccessioniPrimary (citable) accession number: Q5VW32
Secondary accession number(s): B7Z9G5, Q96MG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.