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Protein

BRO1 domain-containing protein BROX

Gene

BROX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BRO1 domain-containing protein BROX
Alternative name(s):
BRO1 domain- and CAAX motif-containing protein
Gene namesi
Name:BROX
Synonyms:BROFTI, C1orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26512. BROX.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162819.
PharmGKBiPA142672509.

Polymorphism and mutation databases

DMDMi74747339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003046121 – 408BRO1 domain-containing protein BROXAdd BLAST408
PropeptideiPRO_0000396736409 – 411Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283N6-acetyllysineCombined sources1
Modified residuei408Cysteine methyl esterCurated1
Lipidationi408S-farnesyl cysteine2 Publications1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ5VW32.
MaxQBiQ5VW32.
PaxDbiQ5VW32.
PeptideAtlasiQ5VW32.
PRIDEiQ5VW32.

PTM databases

iPTMnetiQ5VW32.
PhosphoSitePlusiQ5VW32.
SwissPalmiQ5VW32.

Expressioni

Gene expression databases

BgeeiENSG00000162819.
CleanExiHS_C1orf58.
ExpressionAtlasiQ5VW32. baseline and differential.
GenevisibleiQ5VW32. HS.

Organism-specific databases

HPAiHPA031445.

Interactioni

Subunit structurei

Interacts with CHMP4B.1 Publication

Protein-protein interaction databases

BioGridi127145. 10 interactors.
DIPiDIP-59406N.
IntActiQ5VW32. 1 interactor.
STRINGi9606.ENSP00000343742.

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 23Combined sources3
Helixi27 – 46Combined sources20
Helixi54 – 68Combined sources15
Helixi69 – 71Combined sources3
Beta strandi75 – 81Combined sources7
Turni83 – 86Combined sources4
Beta strandi90 – 92Combined sources3
Beta strandi95 – 97Combined sources3
Beta strandi102 – 105Combined sources4
Helixi107 – 130Combined sources24
Helixi137 – 160Combined sources24
Helixi162 – 164Combined sources3
Beta strandi173 – 176Combined sources4
Helixi177 – 201Combined sources25
Helixi206 – 227Combined sources22
Helixi232 – 263Combined sources32
Helixi267 – 292Combined sources26
Beta strandi298 – 301Combined sources4
Helixi303 – 305Combined sources3
Helixi307 – 329Combined sources23
Beta strandi347 – 349Combined sources3
Helixi367 – 371Combined sources5
Helixi375 – 377Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R9MX-ray1.95A2-374[»]
3ULYX-ray2.60A2-408[»]
3UM0X-ray3.10A2-408[»]
3UM1X-ray2.71A/D2-377[»]
3UM2X-ray2.59A/D2-377[»]
3UM3X-ray3.80A2-411[»]
3ZXPX-ray2.50A/B/C1-401[»]
ProteinModelPortaliQ5VW32.
SMRiQ5VW32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 408BRO1PROSITE-ProRule annotationAdd BLAST319

Sequence similaritiesi

Belongs to the BROX family.Curated
Contains 1 BRO1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEDQ. Eukaryota.
ENOG410ZHPX. LUCA.
GeneTreeiENSGT00390000006681.
HOGENOMiHOG000007224.
HOVERGENiHBG107541.
InParanoidiQ5VW32.
OMAiEAKDVHR.
OrthoDBiEOG091G0E9F.
PhylomeDBiQ5VW32.
TreeFamiTF314743.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
InterProiIPR004328. BRO1_dom.
[Graphical view]
PfamiPF03097. BRO1. 1 hit.
[Graphical view]
SMARTiSM01041. BRO1. 1 hit.
[Graphical view]
PROSITEiPS51180. BRO1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VW32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHWFHRNPL KATAPVSFNY YGVVTGPSAS KICNDLRSSR ARLLELFTDL
60 70 80 90 100
SCNPEMMKNA ADSYFSLLQG FINSLDESTQ ESKLRYIQNF KWTDTLQGQV
110 120 130 140 150
PSAQQDAVFE LISMGFNVAL WYTKYASRLA GKENITEDEA KEVHRSLKIA
160 170 180 190 200
AGIFKHLKES HLPKLITPAE KGRDLESRLI EAYVIQCQAE AQEVTIARAI
210 220 230 240 250
ELKHAPGLIA ALAYETANFY QKADHTLSSL EPAYSAKWRK YLHLKMCFYT
260 270 280 290 300
AYAYCYHGET LLASDKCGEA IRSLQEAEKL YAKAEALCKE YGETKGPGPT
310 320 330 340 350
VKPSGHLFFR KLGNLVKNTL EKCQRENGFI YFQKIPTEAP QLELKANYGL
360 370 380 390 400
VEPIPFEFPP TSVQWTPETL AAFDLTKRPK DDSTKPKPEE EVKPVKEPDI
410
KPQKDTGCYI S
Length:411
Mass (Da):46,476
Last modified:December 7, 2004 - v1
Checksum:i6ED03F79BE1514C6
GO
Isoform 2 (identifier: Q5VW32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-134: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):42,872
Checksum:iD089C76DDBFE7DFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335I → T in BAF56045 (PubMed:18190528).Curated1
Sequence conflicti335I → T in BAB71331 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055551103 – 134Missing in isoform 2. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB276123 mRNA. Translation: BAF56045.1.
AK056983 mRNA. Translation: BAB71331.1.
AK315930 mRNA. Translation: BAH14301.1.
AL392172 Genomic DNA. Translation: CAH73932.1.
CH471100 Genomic DNA. Translation: EAW93265.1.
BC113635 mRNA. Translation: AAI13636.1.
BC113637 mRNA. Translation: AAI13638.1.
BC143811 mRNA. Translation: AAI43812.1.
CCDSiCCDS1534.1. [Q5VW32-1]
CCDS73037.1. [Q5VW32-2]
RefSeqiNP_001275508.1. NM_001288579.1. [Q5VW32-2]
NP_001275509.1. NM_001288580.1. [Q5VW32-2]
NP_001275510.1. NM_001288581.1.
NP_653296.2. NM_144695.3. [Q5VW32-1]
XP_005273122.2. XM_005273065.2. [Q5VW32-1]
XP_011507516.1. XM_011509214.2. [Q5VW32-1]
XP_016855863.1. XM_017000374.1. [Q5VW32-1]
UniGeneiHs.534965.
Hs.552608.
Hs.600844.

Genome annotation databases

EnsembliENST00000340934; ENSP00000343742; ENSG00000162819. [Q5VW32-1]
ENST00000539697; ENSP00000441080; ENSG00000162819. [Q5VW32-2]
ENST00000612948; ENSP00000478496; ENSG00000162819. [Q5VW32-2]
GeneIDi148362.
KEGGihsa:148362.
UCSCiuc001hns.2. human. [Q5VW32-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB276123 mRNA. Translation: BAF56045.1.
AK056983 mRNA. Translation: BAB71331.1.
AK315930 mRNA. Translation: BAH14301.1.
AL392172 Genomic DNA. Translation: CAH73932.1.
CH471100 Genomic DNA. Translation: EAW93265.1.
BC113635 mRNA. Translation: AAI13636.1.
BC113637 mRNA. Translation: AAI13638.1.
BC143811 mRNA. Translation: AAI43812.1.
CCDSiCCDS1534.1. [Q5VW32-1]
CCDS73037.1. [Q5VW32-2]
RefSeqiNP_001275508.1. NM_001288579.1. [Q5VW32-2]
NP_001275509.1. NM_001288580.1. [Q5VW32-2]
NP_001275510.1. NM_001288581.1.
NP_653296.2. NM_144695.3. [Q5VW32-1]
XP_005273122.2. XM_005273065.2. [Q5VW32-1]
XP_011507516.1. XM_011509214.2. [Q5VW32-1]
XP_016855863.1. XM_017000374.1. [Q5VW32-1]
UniGeneiHs.534965.
Hs.552608.
Hs.600844.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R9MX-ray1.95A2-374[»]
3ULYX-ray2.60A2-408[»]
3UM0X-ray3.10A2-408[»]
3UM1X-ray2.71A/D2-377[»]
3UM2X-ray2.59A/D2-377[»]
3UM3X-ray3.80A2-411[»]
3ZXPX-ray2.50A/B/C1-401[»]
ProteinModelPortaliQ5VW32.
SMRiQ5VW32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127145. 10 interactors.
DIPiDIP-59406N.
IntActiQ5VW32. 1 interactor.
STRINGi9606.ENSP00000343742.

PTM databases

iPTMnetiQ5VW32.
PhosphoSitePlusiQ5VW32.
SwissPalmiQ5VW32.

Polymorphism and mutation databases

DMDMi74747339.

Proteomic databases

EPDiQ5VW32.
MaxQBiQ5VW32.
PaxDbiQ5VW32.
PeptideAtlasiQ5VW32.
PRIDEiQ5VW32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340934; ENSP00000343742; ENSG00000162819. [Q5VW32-1]
ENST00000539697; ENSP00000441080; ENSG00000162819. [Q5VW32-2]
ENST00000612948; ENSP00000478496; ENSG00000162819. [Q5VW32-2]
GeneIDi148362.
KEGGihsa:148362.
UCSCiuc001hns.2. human. [Q5VW32-1]

Organism-specific databases

CTDi148362.
GeneCardsiBROX.
H-InvDBHIX0001617.
HIX0001618.
HGNCiHGNC:26512. BROX.
HPAiHPA031445.
neXtProtiNX_Q5VW32.
OpenTargetsiENSG00000162819.
PharmGKBiPA142672509.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEDQ. Eukaryota.
ENOG410ZHPX. LUCA.
GeneTreeiENSGT00390000006681.
HOGENOMiHOG000007224.
HOVERGENiHBG107541.
InParanoidiQ5VW32.
OMAiEAKDVHR.
OrthoDBiEOG091G0E9F.
PhylomeDBiQ5VW32.
TreeFamiTF314743.

Miscellaneous databases

ChiTaRSiBROX. human.
GenomeRNAii148362.
PROiQ5VW32.

Gene expression databases

BgeeiENSG00000162819.
CleanExiHS_C1orf58.
ExpressionAtlasiQ5VW32. baseline and differential.
GenevisibleiQ5VW32. HS.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
InterProiIPR004328. BRO1_dom.
[Graphical view]
PfamiPF03097. BRO1. 1 hit.
[Graphical view]
SMARTiSM01041. BRO1. 1 hit.
[Graphical view]
PROSITEiPS51180. BRO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBROX_HUMAN
AccessioniPrimary (citable) accession number: Q5VW32
Secondary accession number(s): B7Z9G5, Q96MG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.