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Q5VW22

- AGAP6_HUMAN

UniProt

Q5VW22 - AGAP6_HUMAN

Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Gene

AGAP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Putative GTPase-activating protein.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri456 – 47924C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of ARF GTPase activity Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
    Short name:
    AGAP-6
    Alternative name(s):
    Centaurin-gamma-like family member 3
    Gene namesi
    Name:AGAP6
    Synonyms:CTGLF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23466. AGAP6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 663663Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6PRO_0000284674Add
    BLAST

    Proteomic databases

    PRIDEiQ5VW22.

    PTM databases

    PhosphoSiteiQ5VW22.

    Expressioni

    Gene expression databases

    BgeeiQ5VW22.
    GenevestigatoriQ5VW22.

    Organism-specific databases

    HPAiHPA042490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VW22.
    SMRiQ5VW22. Positions 257-424, 447-641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini259 – 420162PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini441 – 561121Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Repeati600 – 62930ANK 1Add
    BLAST
    Repeati633 – 66230ANK 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the centaurin gamma-like family.Curated
    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri456 – 47924C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000007233.
    HOVERGENiHBG054045.
    InParanoidiQ5VW22.
    OMAiCPSESET.
    OrthoDBiEOG72VH5V.
    PhylomeDBiQ5VW22.
    TreeFamiTF317762.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.30.29.30. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VW22-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ    50
    PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE 100
    IRRSNCTNHV SAVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH 150
    HITQRDADRT LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS 200
    TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA 250
    DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM 300
    KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD 350
    SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF 400
    EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM 450
    RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGPHL SRVRSLELDD 500
    WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE 550
    KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD 600
    GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI 650
    NVLLQYGCPD ECV 663

    Note: Prediction based on family homologs sequence.

    Length:663
    Mass (Da):73,127
    Last modified:December 7, 2004 - v1
    Checksum:iD37B8B139F967113
    GO
    Isoform 2 (identifier: Q5VW22-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-73: P → PEALEFNLSANPESSTIFQRNSQT

    Show »
    Length:686
    Mass (Da):75,692
    Checksum:i8EC96B32C51A8552
    GO

    Sequence cautioni

    The sequence BC131545 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371R → G in BC131545. (PubMed:15489334)Curated
    Sequence conflicti70 – 701R → Q in BC131545. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei73 – 731P → PEALEFNLSANPESSTIFQR NSQT in isoform 2. 1 PublicationVSP_040815

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL442003 Genomic DNA. Translation: CAH72489.1.
    BC131545 mRNA. No translation available.
    CCDSiCCDS44397.1. [Q5VW22-2]
    RefSeqiNP_001071133.2. NM_001077665.2. [Q5VW22-2]
    XP_006717917.1. XM_006717854.1. [Q5VW22-2]
    XP_006717918.1. XM_006717855.1. [Q5VW22-2]
    UniGeneiHs.536158.

    Genome annotation databases

    EnsembliENST00000374056; ENSP00000363168; ENSG00000204149. [Q5VW22-1]
    ENST00000412531; ENSP00000400972; ENSG00000204149. [Q5VW22-2]
    GeneIDi414189.
    KEGGihsa:414189.
    UCSCiuc001jix.4. human. [Q5VW22-2]

    Polymorphism databases

    DMDMi74756919.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL442003 Genomic DNA. Translation: CAH72489.1 .
    BC131545 mRNA. No translation available.
    CCDSi CCDS44397.1. [Q5VW22-2 ]
    RefSeqi NP_001071133.2. NM_001077665.2. [Q5VW22-2 ]
    XP_006717917.1. XM_006717854.1. [Q5VW22-2 ]
    XP_006717918.1. XM_006717855.1. [Q5VW22-2 ]
    UniGenei Hs.536158.

    3D structure databases

    ProteinModelPortali Q5VW22.
    SMRi Q5VW22. Positions 257-424, 447-641.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5VW22.

    Polymorphism databases

    DMDMi 74756919.

    Proteomic databases

    PRIDEi Q5VW22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374056 ; ENSP00000363168 ; ENSG00000204149 . [Q5VW22-1 ]
    ENST00000412531 ; ENSP00000400972 ; ENSG00000204149 . [Q5VW22-2 ]
    GeneIDi 414189.
    KEGGi hsa:414189.
    UCSCi uc001jix.4. human. [Q5VW22-2 ]

    Organism-specific databases

    CTDi 414189.
    GeneCardsi GC10P051748.
    HGNCi HGNC:23466. AGAP6.
    HPAi HPA042490.
    neXtProti NX_Q5VW22.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000007233.
    HOVERGENi HBG054045.
    InParanoidi Q5VW22.
    OMAi CPSESET.
    OrthoDBi EOG72VH5V.
    PhylomeDBi Q5VW22.
    TreeFami TF317762.

    Miscellaneous databases

    GenomeRNAii 414189.
    NextBioi 108430.
    PROi Q5VW22.

    Gene expression databases

    Bgeei Q5VW22.
    Genevestigatori Q5VW22.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.30.29.30. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiAGAP6_HUMAN
    AccessioniPrimary (citable) accession number: Q5VW22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3