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Q5VW22

- AGAP6_HUMAN

UniProt

Q5VW22 - AGAP6_HUMAN

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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Gene

AGAP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri456 – 47924C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ARF GTPase activator activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of ARF GTPase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
Short name:
AGAP-6
Alternative name(s):
Centaurin-gamma-like family member 3
Gene namesi
Name:AGAP6
Synonyms:CTGLF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23466. AGAP6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6PRO_0000284674Add
BLAST

Proteomic databases

PRIDEiQ5VW22.

PTM databases

PhosphoSiteiQ5VW22.

Expressioni

Gene expression databases

BgeeiQ5VW22.
GenevestigatoriQ5VW22.

Organism-specific databases

HPAiHPA042490.

Structurei

3D structure databases

ProteinModelPortaliQ5VW22.
SMRiQ5VW22. Positions 257-424, 447-641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 420162PHPROSITE-ProRule annotationAdd
BLAST
Domaini441 – 561121Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Repeati600 – 62930ANK 1Add
BLAST
Repeati633 – 66230ANK 2Add
BLAST

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri456 – 47924C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118874.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ5VW22.
OMAiCPSESET.
OrthoDBiEOG72VH5V.
PhylomeDBiQ5VW22.
TreeFamiTF317762.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VW22-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV SAVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRT LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM
310 320 330 340 350
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGPHL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD ECV

Note: Prediction based on family homologs sequence.

Length:663
Mass (Da):73,127
Last modified:December 7, 2004 - v1
Checksum:iD37B8B139F967113
GO
Isoform 2 (identifier: Q5VW22-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: P → PEALEFNLSANPESSTIFQRNSQT

Show »
Length:686
Mass (Da):75,692
Checksum:i8EC96B32C51A8552
GO

Sequence cautioni

The sequence BC131545 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371R → G in BC131545. (PubMed:15489334)Curated
Sequence conflicti70 – 701R → Q in BC131545. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 731P → PEALEFNLSANPESSTIFQR NSQT in isoform 2. 1 PublicationVSP_040815

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL442003 Genomic DNA. Translation: CAH72489.1.
BC131545 mRNA. No translation available.
CCDSiCCDS44397.1. [Q5VW22-2]
RefSeqiNP_001071133.2. NM_001077665.2. [Q5VW22-2]
XP_006717917.1. XM_006717854.1. [Q5VW22-2]
XP_006717918.1. XM_006717855.1. [Q5VW22-2]
UniGeneiHs.536158.

Genome annotation databases

EnsembliENST00000374056; ENSP00000363168; ENSG00000204149. [Q5VW22-1]
ENST00000412531; ENSP00000400972; ENSG00000204149. [Q5VW22-2]
GeneIDi414189.
KEGGihsa:414189.
UCSCiuc001jix.4. human. [Q5VW22-2]

Polymorphism databases

DMDMi74756919.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL442003 Genomic DNA. Translation: CAH72489.1 .
BC131545 mRNA. No translation available.
CCDSi CCDS44397.1. [Q5VW22-2 ]
RefSeqi NP_001071133.2. NM_001077665.2. [Q5VW22-2 ]
XP_006717917.1. XM_006717854.1. [Q5VW22-2 ]
XP_006717918.1. XM_006717855.1. [Q5VW22-2 ]
UniGenei Hs.536158.

3D structure databases

ProteinModelPortali Q5VW22.
SMRi Q5VW22. Positions 257-424, 447-641.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5VW22.

Polymorphism databases

DMDMi 74756919.

Proteomic databases

PRIDEi Q5VW22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374056 ; ENSP00000363168 ; ENSG00000204149 . [Q5VW22-1 ]
ENST00000412531 ; ENSP00000400972 ; ENSG00000204149 . [Q5VW22-2 ]
GeneIDi 414189.
KEGGi hsa:414189.
UCSCi uc001jix.4. human. [Q5VW22-2 ]

Organism-specific databases

CTDi 414189.
GeneCardsi GC10P051748.
HGNCi HGNC:23466. AGAP6.
HPAi HPA042490.
neXtProti NX_Q5VW22.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118874.
HOGENOMi HOG000007233.
HOVERGENi HBG054045.
InParanoidi Q5VW22.
OMAi CPSESET.
OrthoDBi EOG72VH5V.
PhylomeDBi Q5VW22.
TreeFami TF317762.

Miscellaneous databases

GenomeRNAii 414189.
NextBioi 108430.
PROi Q5VW22.

Gene expression databases

Bgeei Q5VW22.
Genevestigatori Q5VW22.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00405. REVINTRACTNG.
SMARTi SM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiAGAP6_HUMAN
AccessioniPrimary (citable) accession number: Q5VW22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3