Q5VW22 (AGAP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
Short name=AGAP-6

Alternative name(s):
Centaurin-gamma-like family member 3

Gene names

Name:	AGAP6
Synonyms:	CTGLF3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	663 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Miscellaneous	Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.
Sequence caution	The sequence BC131545 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular_function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VW22-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Prediction based on family homologs sequence.

Isoform 2 (identifier: Q5VW22-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: P → PEALEFNLSANPESSTIFQRNSQT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 663	663	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6		PRO_0000284674
Regions
	Domain	259 – 420	162	PH
	Domain	441 – 561	121	Arf-GAP
	Repeat	600 – 629	30	ANK 1
	Repeat	633 – 662	30	ANK 2
	Zinc finger	456 – 479	24	C4-type
Natural variations
	Alternative sequence	73	1	P → PEALEFNLSANPESSTIFQR NSQT in isoform 2.		VSP_040815
Experimental info
	Sequence conflict	37	1	R → G in BC131545. Ref.2
	Sequence conflict	70	1	R → Q in BC131545. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: D37B8B139F967113	FASTA	663	73,127
	10 20 30 40 50 60 MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ PAEVTVEVGE 70 80 90 100 110 120 DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV SAVRFSQQYS 130 140 150 160 170 180 LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRT LSIPDEQLHS FAVSTVHIMK 190 200 210 220 230 240 KRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD 250 260 270 280 290 300 KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM 310 320 330 340 350 360 KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD SICFSPSISS 370 380 390 400 410 420 TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL 430 440 450 460 470 480 ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS 490 500 510 520 530 540 GIHRSLGPHL SRVRSLELDD WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK 550 560 570 580 590 600 ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD 610 620 630 640 650 660 GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD ECV
	Isoform 2 [UniParc]. Checksum: 8EC96B32C51A8552	FASTA	686	75,692
	10 20 30 40 50 60 MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ PAEVTVEVGE 70 80 90 100 110 120 DLHMHHVRDR EMPEALEFNL SANPESSTIF QRNSQTEALE FNPSANPEAS TIFQRNSQTD 130 140 150 160 170 180 VVEIRRSNCT NHVSAVRFSQ QYSLCSTIFL DDSTAIQHYL TMTIISVTLE IPHHITQRDA 190 200 210 220 230 240 DRTLSIPDEQ LHSFAVSTVH IMKKRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP 250 260 270 280 290 300 TPVCKRSMRW SNLFTSEKGS DPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 310 320 330 340 350 360 KKKYVTLCSN GMLTYYSSLG DYMKNIHKKE IDLQTSTIKV PGKWPSLATS ACTPISSSKS 370 380 390 400 410 420 NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT 430 440 450 460 470 480 WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV 490 500 510 520 530 540 DCETQNPKWA SLNLGVLMCI ECSGIHRSLG PHLSRVRSLE LDDWPVELRK VMSSIVNDLA 550 560 570 580 590 600 NSIWEGSSQG QTKPSEKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQQ LLRATADEDL 610 620 630 640 650 660 QTAILLLAHG SCEEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA 670 680 LTYARQASSQ ECINVLLQYG CPDECV

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL442003 Genomic DNA. Translation: CAH72489.1. BC131545 mRNA. No translation available.
IPI	IPI00645616. IPI00884922.
RefSeq	NP_001071133.2. NM_001077665.2.
UniGene	Hs.536158.
3D structure databases
HSSP	HSSP built from PDB template 2CRR based on UniProtKB Q8IYB5.
ProteinModelPortal	Q5VW22.
ModBase	Search...
PTM databases
PhosphoSite	Q5VW22.
Polymorphism databases
DMDM	74756919.
Proteomic databases
PRIDE	Q5VW22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374056; ENSP00000363168; ENSG00000204149. ENST00000412531; ENSP00000400972; ENSG00000204149.
GeneID	414189.
KEGG	hsa:414189.
Organism-specific databases
CTD	414189.
GeneCards	GC10P051748.
HGNC	HGNC:23466. AGAP6.
HPA	HPA042490.
neXtProt	NX_Q5VW22.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000007233.
HOVERGEN	HBG054045.
InParanoid	Q5VW22.
OrthoDB	EOG4K0QN3.
Gene expression databases
Bgee	Q5VW22.
Genevestigator	Q5VW22.
Family and domain databases
Gene3D	1.25.40.20. 1 hit. 2.30.29.30. 2 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00248. ANK. 2 hits. SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	414189.
NextBio	108430.

Entry information

Entry name

AGAP6_HUMAN

Accession

Primary (citable) accession number: Q5VW22

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.