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Q5VW22 (AGAP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Short name=AGAP-6
Alternative name(s):
Centaurin-gamma-like family member 3
Gene names
Name:AGAP6
Synonyms:CTGLF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative GTPase-activating protein Potential.

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Sequence similarities

Belongs to the centaurin gamma-like family.

Contains 2 ANK repeats.

Contains 1 Arf-GAP domain.

Contains 1 PH domain.

Sequence caution

The sequence BC131545 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of ARF GTPase activity

Inferred from electronic annotation. Source: InterPro

   Molecular_functionARF GTPase activator activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VW22-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Prediction based on family homologs sequence.
Isoform 2 (identifier: Q5VW22-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: P → PEALEFNLSANPESSTIFQRNSQT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 663663Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
PRO_0000284674

Regions

Domain259 – 420162PH
Domain441 – 561121Arf-GAP
Repeat600 – 62930ANK 1
Repeat633 – 66230ANK 2
Zinc finger456 – 47924C4-type

Natural variations

Alternative sequence731P → PEALEFNLSANPESSTIFQR NSQT in isoform 2.
VSP_040815

Experimental info

Sequence conflict371R → G in BC131545. Ref.2
Sequence conflict701R → Q in BC131545. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: D37B8B139F967113

FASTA66373,127
        10         20         30         40         50         60 
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ PAEVTVEVGE 

        70         80         90        100        110        120 
DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV SAVRFSQQYS 

       130        140        150        160        170        180 
LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRT LSIPDEQLHS FAVSTVHIMK 

       190        200        210        220        230        240 
KRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD 

       250        260        270        280        290        300 
KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM 

       310        320        330        340        350        360 
KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD SICFSPSISS 

       370        380        390        400        410        420 
TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL 

       430        440        450        460        470        480 
ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS 

       490        500        510        520        530        540 
GIHRSLGPHL SRVRSLELDD WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK 

       550        560        570        580        590        600 
ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD 

       610        620        630        640        650        660 
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD 


ECV 

« Hide

Isoform 2 [UniParc].

Checksum: 8EC96B32C51A8552
Show »

FASTA68675,692

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL442003 Genomic DNA. Translation: CAH72489.1.
BC131545 mRNA. No translation available.
CCDSCCDS44397.1. [Q5VW22-2]
RefSeqNP_001071133.2. NM_001077665.2. [Q5VW22-2]
XP_006717917.1. XM_006717854.1. [Q5VW22-2]
XP_006717918.1. XM_006717855.1. [Q5VW22-2]
UniGeneHs.536158.

3D structure databases

ProteinModelPortalQ5VW22.
SMRQ5VW22. Positions 257-424, 447-641.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5VW22.

Polymorphism databases

DMDM74756919.

Proteomic databases

PRIDEQ5VW22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374056; ENSP00000363168; ENSG00000204149. [Q5VW22-1]
ENST00000412531; ENSP00000400972; ENSG00000204149. [Q5VW22-2]
ENST00000606446; ENSP00000475858; ENSG00000271962. [Q5VW22-1]
ENST00000606487; ENSP00000475217; ENSG00000271962. [Q5VW22-2]
GeneID414189.
KEGGhsa:414189.
UCSCuc001jix.4. human. [Q5VW22-2]

Organism-specific databases

CTD414189.
GeneCardsGC10P051748.
HGNCHGNC:23466. AGAP6.
HPAHPA042490.
neXtProtNX_Q5VW22.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000007233.
HOVERGENHBG054045.
InParanoidQ5VW22.
OMACPSESET.
OrthoDBEOG72VH5V.
PhylomeDBQ5VW22.
TreeFamTF317762.

Gene expression databases

BgeeQ5VW22.
GenevestigatorQ5VW22.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00405. REVINTRACTNG.
SMARTSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi414189.
NextBio108430.
PROQ5VW22.

Entry information

Entry nameAGAP6_HUMAN
AccessionPrimary (citable) accession number: Q5VW22
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM