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Q5VW00 (DC122_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DDB1- and CUL4-associated factor 12-like protein 2
Alternative name(s):
WD repeat-containing protein 40C
Gene names
Name:DCAF12L2
Synonyms:WDR40C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the WD repeat DCAF12 family.

Contains 4 WD repeats.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463DDB1- and CUL4-associated factor 12-like protein 2
PRO_0000306850

Regions

Repeat146 – 18742WD 1
Repeat192 – 23039WD 2
Repeat260 – 29940WD 3
Repeat348 – 38538WD 4

Natural variations

Natural variant1471H → Q.
Corresponds to variant rs10126452 [ dbSNP | Ensembl ].
VAR_062104

Sequences

Sequence LengthMass (Da)Tools
Q5VW00 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 94B41809F2243CD7

FASTA46350,803
        10         20         30         40         50         60 
MAQQQTGSRK RKAPAVEAGA GSSSSQGLAA ADGEGPLLPK KQKRPATRRR LVHYLKGREV 

        70         80         90        100        110        120 
GARGPAGLQG FEGELRGYAV QRLPELLTER QLDLGTLNKV FASQWLNARQ VVCGTKCNTL 

       130        140        150        160        170        180 
FVVDVQSGHI TRIPLMRDKE AGLAQAHQGC GIHAIELNPS KTLLATGGEN PNSLAIYQLP 

       190        200        210        220        230        240 
TLDPLCLGDR HGHKDWIFAV AWLSDTVAVS GSRDGTVALW RMDPDMFNGS IAWHSEVGLP 

       250        260        270        280        290        300 
VYAHIRPRDV EAIPRASTNP SNRKVRALAF SGKNQELGAV SLDGYFHLWK ARSTLSRLLS 

       310        320        330        340        350        360 
IRLPYCRENV CLTYCDELSL YAVGSQSHVS FLDPRQRQQN IRPLCSREGG TGVRSLSFYQ 

       370        380        390        400        410        420 
HIITVGTGHG SLLFYDIRAQ KFLEERASSS LDSMPGPAGR KLKLACGRGW LNQDDVWVNY 

       430        440        450        460 
FGGMGEFPNA LYTHCYNWPE MKLFVAGGPL PSGLHGNYAG LWS 

« Hide

References

[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445072 Genomic DNA. Translation: CAH70502.1.
CH471107 Genomic DNA. Translation: EAX11842.1.
BC136673 mRNA. Translation: AAI36674.1.
BC136674 mRNA. Translation: AAI36675.1.
CCDSCCDS43991.1.
RefSeqNP_001013650.1. NM_001013628.2.
UniGeneHs.181867.

3D structure databases

ProteinModelPortalQ5VW00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131079. 2 interactions.
IntActQ5VW00. 1 interaction.
STRING9606.ENSP00000353128.

PTM databases

PhosphoSiteQ5VW00.

Polymorphism databases

DMDM74756914.

Proteomic databases

PaxDbQ5VW00.
PRIDEQ5VW00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360028; ENSP00000353128; ENSG00000198354.
ENST00000538699; ENSP00000441489; ENSG00000198354.
GeneID340578.
KEGGhsa:340578.
UCSCuc004euk.2. human.

Organism-specific databases

CTD340578.
GeneCardsGC0XM125298.
HGNCHGNC:32950. DCAF12L2.
neXtProtNX_Q5VW00.
PharmGKBPA165756531.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG67718.
HOGENOMHOG000047356.
HOVERGENHBG055605.
InParanoidQ5VW00.
OMAIGEFPNA.
OrthoDBEOG73NG34.
PhylomeDBQ5VW00.
TreeFamTF323731.

Enzyme and pathway databases

SignaLinkQ5VW00.

Gene expression databases

BgeeQ5VW00.
CleanExHS_WDR40C.
GenevestigatorQ5VW00.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi340578.
NextBio97942.
PROQ5VW00.

Entry information

Entry nameDC122_HUMAN
AccessionPrimary (citable) accession number: Q5VW00
Secondary accession number(s): B2RN42
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM