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Q5VW00

- DC122_HUMAN

UniProt

Q5VW00 - DC122_HUMAN

Protein

DDB1- and CUL4-associated factor 12-like protein 2

Gene

DCAF12L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ5VW00.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DDB1- and CUL4-associated factor 12-like protein 2
    Alternative name(s):
    WD repeat-containing protein 40C
    Gene namesi
    Name:DCAF12L2
    Synonyms:WDR40C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:32950. DCAF12L2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165756531.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463DDB1- and CUL4-associated factor 12-like protein 2PRO_0000306850Add
    BLAST

    Proteomic databases

    PaxDbiQ5VW00.
    PRIDEiQ5VW00.

    PTM databases

    PhosphoSiteiQ5VW00.

    Expressioni

    Gene expression databases

    BgeeiQ5VW00.
    CleanExiHS_WDR40C.
    GenevestigatoriQ5VW00.

    Interactioni

    Protein-protein interaction databases

    BioGridi131079. 2 interactions.
    IntActiQ5VW00. 1 interaction.
    STRINGi9606.ENSP00000353128.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VW00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati146 – 18742WD 1Add
    BLAST
    Repeati192 – 23039WD 2Add
    BLAST
    Repeati260 – 29940WD 3Add
    BLAST
    Repeati348 – 38538WD 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat DCAF12 family.Curated
    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG67718.
    HOGENOMiHOG000047356.
    HOVERGENiHBG055605.
    InParanoidiQ5VW00.
    OMAiIGEFPNA.
    OrthoDBiEOG73NG34.
    PhylomeDBiQ5VW00.
    TreeFamiTF323731.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VW00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQQQTGSRK RKAPAVEAGA GSSSSQGLAA ADGEGPLLPK KQKRPATRRR    50
    LVHYLKGREV GARGPAGLQG FEGELRGYAV QRLPELLTER QLDLGTLNKV 100
    FASQWLNARQ VVCGTKCNTL FVVDVQSGHI TRIPLMRDKE AGLAQAHQGC 150
    GIHAIELNPS KTLLATGGEN PNSLAIYQLP TLDPLCLGDR HGHKDWIFAV 200
    AWLSDTVAVS GSRDGTVALW RMDPDMFNGS IAWHSEVGLP VYAHIRPRDV 250
    EAIPRASTNP SNRKVRALAF SGKNQELGAV SLDGYFHLWK ARSTLSRLLS 300
    IRLPYCRENV CLTYCDELSL YAVGSQSHVS FLDPRQRQQN IRPLCSREGG 350
    TGVRSLSFYQ HIITVGTGHG SLLFYDIRAQ KFLEERASSS LDSMPGPAGR 400
    KLKLACGRGW LNQDDVWVNY FGGMGEFPNA LYTHCYNWPE MKLFVAGGPL 450
    PSGLHGNYAG LWS 463
    Length:463
    Mass (Da):50,803
    Last modified:December 7, 2004 - v1
    Checksum:i94B41809F2243CD7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471H → Q.
    Corresponds to variant rs10126452 [ dbSNP | Ensembl ].
    VAR_062104

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445072 Genomic DNA. Translation: CAH70502.1.
    CH471107 Genomic DNA. Translation: EAX11842.1.
    BC136673 mRNA. Translation: AAI36674.1.
    BC136674 mRNA. Translation: AAI36675.1.
    CCDSiCCDS43991.1.
    RefSeqiNP_001013650.1. NM_001013628.2.
    UniGeneiHs.181867.

    Genome annotation databases

    EnsembliENST00000360028; ENSP00000353128; ENSG00000198354.
    GeneIDi340578.
    KEGGihsa:340578.
    UCSCiuc004euk.2. human.

    Polymorphism databases

    DMDMi74756914.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445072 Genomic DNA. Translation: CAH70502.1 .
    CH471107 Genomic DNA. Translation: EAX11842.1 .
    BC136673 mRNA. Translation: AAI36674.1 .
    BC136674 mRNA. Translation: AAI36675.1 .
    CCDSi CCDS43991.1.
    RefSeqi NP_001013650.1. NM_001013628.2.
    UniGenei Hs.181867.

    3D structure databases

    ProteinModelPortali Q5VW00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131079. 2 interactions.
    IntActi Q5VW00. 1 interaction.
    STRINGi 9606.ENSP00000353128.

    PTM databases

    PhosphoSitei Q5VW00.

    Polymorphism databases

    DMDMi 74756914.

    Proteomic databases

    PaxDbi Q5VW00.
    PRIDEi Q5VW00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360028 ; ENSP00000353128 ; ENSG00000198354 .
    GeneIDi 340578.
    KEGGi hsa:340578.
    UCSCi uc004euk.2. human.

    Organism-specific databases

    CTDi 340578.
    GeneCardsi GC0XM125298.
    HGNCi HGNC:32950. DCAF12L2.
    neXtProti NX_Q5VW00.
    PharmGKBi PA165756531.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG67718.
    HOGENOMi HOG000047356.
    HOVERGENi HBG055605.
    InParanoidi Q5VW00.
    OMAi IGEFPNA.
    OrthoDBi EOG73NG34.
    PhylomeDBi Q5VW00.
    TreeFami TF323731.

    Enzyme and pathway databases

    SignaLinki Q5VW00.

    Miscellaneous databases

    GenomeRNAii 340578.
    NextBioi 97942.
    PROi Q5VW00.

    Gene expression databases

    Bgeei Q5VW00.
    CleanExi HS_WDR40C.
    Genevestigatori Q5VW00.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiDC122_HUMAN
    AccessioniPrimary (citable) accession number: Q5VW00
    Secondary accession number(s): B2RN42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3