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Protein

Alpha N-terminal protein methyltransferase 1B

Gene

METTL11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
Binding sitei129 – 1291S-adenosyl-L-methionineBy similarity
Binding sitei190 – 1901S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.299. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha N-terminal protein methyltransferase 1B (EC:2.1.1.299)
Alternative name(s):
Methyltransferase-like protein 11B
X-Pro-Lys N-terminal protein methyltransferase 1B
Short name:
NTM1B
Gene namesi
Name:METTL11B
Synonyms:C1orf184, NRMT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31932. METTL11B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395801.

Polymorphism and mutation databases

BioMutaiMETTL11B.
DMDMi269849617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Alpha N-terminal protein methyltransferase 1BPRO_0000271077Add
BLAST

Proteomic databases

PaxDbiQ5VVY1.
PRIDEiQ5VVY1.

PTM databases

iPTMnetiQ5VVY1.

Expressioni

Gene expression databases

BgeeiQ5VVY1.
CleanExiHS_METTL11B.

Organism-specific databases

HPAiHPA028049.

Structurei

3D structure databases

ProteinModelPortaliQ5VVY1.
SMRiQ5VVY1. Positions 58-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 1752S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3178. Eukaryota.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00390000008371.
HOVERGENiHBG054992.
InParanoidiQ5VVY1.
KOiK19579.
OMAiFALHSDR.
OrthoDBiEOG7ZPNM6.
PhylomeDBiQ5VVY1.
TreeFamiTF314174.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiPF05891. Methyltransf_PK. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRGAHFAF RSRWQKTDDE LCRHSMSFIL HKAIRNDFFQ SYLYLLEKIP
60 70 80 90 100
LVKLYALTSQ VINGEMQFYA RAKLFYQEVP ATEEGMMGNF IELSSPDIQA
110 120 130 140 150
SQKFLRKFVG GPGRAGTDCA LDCGSGIGRV SKHVLLPVFN SVELVDMMES
160 170 180 190 200
FLLEAQNYLQ VKGDKVESYH CYSLQEFTPP FRRYDVIWIQ WVSGHLTDKD
210 220 230 240 250
LLAFLSRCRD GLKENGIIIL KDNVAREGCI LDLSDSSVTR DMDILRSLIR
260 270 280
KSGLVVLGQE KQDGFPEQCI PVWMFALHSD RHS
Length:283
Mass (Da):32,400
Last modified:November 24, 2009 - v2
Checksum:iF1FEAB7391A229C4
GO

Sequence cautioni

The sequence CAH72139.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721A → G.
Corresponds to variant rs12073565 [ dbSNP | Ensembl ].
VAR_060621
Natural varianti150 – 1501S → P.
Corresponds to variant rs6427235 [ dbSNP | Ensembl ].
VAR_029859
Natural varianti247 – 2471S → R.
Corresponds to variant rs12735494 [ dbSNP | Ensembl ].
VAR_060622

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445203 Genomic DNA. Translation: CAH72139.1. Sequence problems.
BC157860 mRNA. Translation: AAI57861.1.
BC171858 mRNA. Translation: AAI71858.1.
CCDSiCCDS44275.1.
RefSeqiNP_001129579.1. NM_001136107.1.
UniGeneiHs.553612.

Genome annotation databases

EnsembliENST00000439373; ENSP00000408058; ENSG00000203740.
GeneIDi149281.
KEGGihsa:149281.
UCSCiuc009wvv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445203 Genomic DNA. Translation: CAH72139.1. Sequence problems.
BC157860 mRNA. Translation: AAI57861.1.
BC171858 mRNA. Translation: AAI71858.1.
CCDSiCCDS44275.1.
RefSeqiNP_001129579.1. NM_001136107.1.
UniGeneiHs.553612.

3D structure databases

ProteinModelPortaliQ5VVY1.
SMRiQ5VVY1. Positions 58-277.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5VVY1.

Polymorphism and mutation databases

BioMutaiMETTL11B.
DMDMi269849617.

Proteomic databases

PaxDbiQ5VVY1.
PRIDEiQ5VVY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439373; ENSP00000408058; ENSG00000203740.
GeneIDi149281.
KEGGihsa:149281.
UCSCiuc009wvv.2. human.

Organism-specific databases

CTDi149281.
GeneCardsiMETTL11B.
HGNCiHGNC:31932. METTL11B.
HPAiHPA028049.
neXtProtiNX_Q5VVY1.
PharmGKBiPA162395801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3178. Eukaryota.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00390000008371.
HOVERGENiHBG054992.
InParanoidiQ5VVY1.
KOiK19579.
OMAiFALHSDR.
OrthoDBiEOG7ZPNM6.
PhylomeDBiQ5VVY1.
TreeFamiTF314174.

Enzyme and pathway databases

BRENDAi2.1.1.299. 2681.

Miscellaneous databases

GenomeRNAii149281.
PROiQ5VVY1.

Gene expression databases

BgeeiQ5VVY1.
CleanExiHS_METTL11B.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiPF05891. Methyltransf_PK. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNTM1B_HUMAN
AccessioniPrimary (citable) accession number: Q5VVY1
Secondary accession number(s): B2RXI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 24, 2009
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.