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Protein

Alpha N-terminal protein methyltransferase 1B

Gene

METTL11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein].1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei129S-adenosyl-L-methionineBy similarity1
Binding sitei190S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.299. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha N-terminal protein methyltransferase 1B (EC:2.1.1.299)
Alternative name(s):
Methyltransferase-like protein 11B
X-Pro-Lys N-terminal protein methyltransferase 1B
Short name:
NTM1B
Gene namesi
Name:METTL11B
Synonyms:C1orf184, NRMT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31932. METTL11B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203740.
PharmGKBiPA162395801.

Polymorphism and mutation databases

BioMutaiMETTL11B.
DMDMi269849617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710771 – 283Alpha N-terminal protein methyltransferase 1BAdd BLAST283

Proteomic databases

PaxDbiQ5VVY1.
PRIDEiQ5VVY1.

PTM databases

iPTMnetiQ5VVY1.
PhosphoSitePlusiQ5VVY1.

Expressioni

Gene expression databases

BgeeiENSG00000203740.
CleanExiHS_METTL11B.

Organism-specific databases

HPAiHPA028049.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000408058.

Structurei

Secondary structure

1283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi65 – 76Combined sources12
Helixi83 – 87Combined sources5
Helixi91 – 93Combined sources3
Helixi94 – 106Combined sources13
Beta strandi109 – 111Combined sources3
Beta strandi117 – 123Combined sources7
Turni126 – 128Combined sources3
Helixi129 – 133Combined sources5
Turni134 – 138Combined sources5
Beta strandi140 – 147Combined sources8
Helixi149 – 158Combined sources10
Beta strandi169 – 171Combined sources3
Helixi174 – 176Combined sources3
Beta strandi184 – 191Combined sources8
Helixi193 – 195Combined sources3
Helixi198 – 210Combined sources13
Beta strandi212 – 223Combined sources12
Beta strandi225 – 228Combined sources4
Beta strandi230 – 232Combined sources3
Turni233 – 236Combined sources4
Beta strandi237 – 239Combined sources3
Helixi242 – 251Combined sources10
Beta strandi256 – 261Combined sources6
Beta strandi272 – 277Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UBBX-ray2.00A58-278[»]
ProteinModelPortaliQ5VVY1.
SMRiQ5VVY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 175S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3178. Eukaryota.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00390000008371.
HOVERGENiHBG054992.
InParanoidiQ5VVY1.
KOiK19579.
OMAiKVESYHC.
OrthoDBiEOG091G0NA7.
PhylomeDBiQ5VVY1.
TreeFamiTF314174.

Family and domain databases

InterProiView protein in InterPro
IPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiView protein in Pfam
PF05891. Methyltransf_PK. 1 hit.
PIRSFiPIRSF016958. DUF858_MeTrfase_lik. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRGAHFAF RSRWQKTDDE LCRHSMSFIL HKAIRNDFFQ SYLYLLEKIP
60 70 80 90 100
LVKLYALTSQ VINGEMQFYA RAKLFYQEVP ATEEGMMGNF IELSSPDIQA
110 120 130 140 150
SQKFLRKFVG GPGRAGTDCA LDCGSGIGRV SKHVLLPVFN SVELVDMMES
160 170 180 190 200
FLLEAQNYLQ VKGDKVESYH CYSLQEFTPP FRRYDVIWIQ WVSGHLTDKD
210 220 230 240 250
LLAFLSRCRD GLKENGIIIL KDNVAREGCI LDLSDSSVTR DMDILRSLIR
260 270 280
KSGLVVLGQE KQDGFPEQCI PVWMFALHSD RHS
Length:283
Mass (Da):32,400
Last modified:November 24, 2009 - v2
Checksum:iF1FEAB7391A229C4
GO

Sequence cautioni

The sequence CAH72139 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06062172A → G. Corresponds to variant dbSNP:rs12073565Ensembl.1
Natural variantiVAR_029859150S → P. Corresponds to variant dbSNP:rs6427235Ensembl.1
Natural variantiVAR_060622247S → R. Corresponds to variant dbSNP:rs12735494Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445203 Genomic DNA. Translation: CAH72139.1. Sequence problems.
BC157860 mRNA. Translation: AAI57861.1.
BC171858 mRNA. Translation: AAI71858.1.
CCDSiCCDS44275.1.
RefSeqiNP_001129579.1. NM_001136107.1.
UniGeneiHs.553612.

Genome annotation databases

EnsembliENST00000439373; ENSP00000408058; ENSG00000203740.
GeneIDi149281.
KEGGihsa:149281.
UCSCiuc009wvv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNTM1B_HUMAN
AccessioniPrimary (citable) accession number: Q5VVY1
Secondary accession number(s): B2RXI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 24, 2009
Last modified: July 5, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families