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Q5VVX9

- UBE2U_HUMAN

UniProt

Q5VVX9 - UBE2U_HUMAN

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Protein

Ubiquitin-conjugating enzyme E2 U

Gene

UBE2U

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ5VVX9.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 U (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein U
Ubiquitin-protein ligase U
Gene namesi
Name:UBE2U
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28559. UBE2U.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Ubiquitin-conjugating enzyme E2 UPRO_0000082512Add
BLAST

Proteomic databases

PaxDbiQ5VVX9.
PRIDEiQ5VVX9.

Expressioni

Gene expression databases

BgeeiQ5VVX9.
CleanExiHS_UBE2U.
ExpressionAtlasiQ5VVX9. baseline and differential.
GenevestigatoriQ5VVX9.

Organism-specific databases

HPAiHPA020472.
HPA021660.

Interactioni

Protein-protein interaction databases

BioGridi127156. 66 interactions.
IntActiQ5VVX9. 66 interactions.
STRINGi9606.ENSP00000360116.

Structurei

Secondary structure

1
321
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1916
Beta strandi24 – 285
Beta strandi35 – 417
Turni47 – 504
Beta strandi52 – 587
Beta strandi69 – 746
Turni83 – 853
Helixi91 – 944
Helixi96 – 983
Helixi105 – 11612
Helixi127 – 1348
Helixi137 – 14711

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YRVX-ray2.18A1-150[»]
ProteinModelPortaliQ5VVX9.
SMRiQ5VVX9. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5VVX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119350.
HOGENOMiHOG000049184.
HOVERGENiHBG080217.
InParanoidiQ5VVX9.
KOiK10584.
OMAiHPNVDPH.
OrthoDBiEOG7G4QGZ.
PhylomeDBiQ5VVX9.
TreeFamiTF329302.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VVX9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHGRAYLLLH RDFCDLKENN YKGITAKPVS EDMMEWEVEI EGLQNSVWQG
60 70 80 90 100
LVFQLTIHFT SEYNYAPPVV KFITIPFHPN VDPHTGQPCI DFLDNPEKWN
110 120 130 140 150
TNYTLSSILL ALQVMLSNPV LENPVNLEAA RILVKDESLY RTILRLFNRP
160 170 180 190 200
LQMKDDSQEL PKDPRKCIRP IKTTSFSDYY QTWSRIATSK ATEYYRTPLL
210 220 230 240 250
KVPNFIGQYY KWKKMDLQHQ KEWNLKYSVI KCWLARKRMP HEVTHSMEEI
260 270 280 290 300
KLCPTLIPTT DEIFLESPTA INSITDIYET EEEGWKSDTS LYENDTDEPR
310 320
EEEVEDLISW TNTLNTNTSE D
Length:321
Mass (Da):37,741
Last modified:December 7, 2004 - v1
Checksum:i8104FE91620417BB
GO
Isoform 2 (identifier: Q5VVX9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-321: Missing.

Show »
Length:226
Mass (Da):26,689
Checksum:i2DFF8434DD9452FB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901I → T.
Corresponds to variant rs7532933 [ dbSNP | Ensembl ].
VAR_057323

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei227 – 32195Missing in isoform 2. 1 PublicationVSP_016003Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445205, AL161916 Genomic DNA. Translation: CAH71707.1.
AL445205, AL161916 Genomic DNA. Translation: CAH71708.1.
AL161916, AL445205 Genomic DNA. Translation: CAI22119.1.
AL161916, AL445205 Genomic DNA. Translation: CAI22120.1.
BC029895 mRNA. Translation: AAH29895.1.
CCDSiCCDS627.1. [Q5VVX9-2]
RefSeqiNP_689702.1. NM_152489.1. [Q5VVX9-2]
UniGeneiHs.388746.

Genome annotation databases

EnsembliENST00000371076; ENSP00000360116; ENSG00000177414. [Q5VVX9-2]
ENST00000611228; ENSP00000481174; ENSG00000177414. [Q5VVX9-1]
GeneIDi148581.
KEGGihsa:148581.
UCSCiuc001dbn.1. human. [Q5VVX9-1]

Polymorphism databases

DMDMi74747311.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445205 , AL161916 Genomic DNA. Translation: CAH71707.1 .
AL445205 , AL161916 Genomic DNA. Translation: CAH71708.1 .
AL161916 , AL445205 Genomic DNA. Translation: CAI22119.1 .
AL161916 , AL445205 Genomic DNA. Translation: CAI22120.1 .
BC029895 mRNA. Translation: AAH29895.1 .
CCDSi CCDS627.1. [Q5VVX9-2 ]
RefSeqi NP_689702.1. NM_152489.1. [Q5VVX9-2 ]
UniGenei Hs.388746.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YRV X-ray 2.18 A 1-150 [» ]
ProteinModelPortali Q5VVX9.
SMRi Q5VVX9. Positions 1-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127156. 66 interactions.
IntActi Q5VVX9. 66 interactions.
STRINGi 9606.ENSP00000360116.

Polymorphism databases

DMDMi 74747311.

Proteomic databases

PaxDbi Q5VVX9.
PRIDEi Q5VVX9.

Protocols and materials databases

DNASUi 148581.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371076 ; ENSP00000360116 ; ENSG00000177414 . [Q5VVX9-2 ]
ENST00000611228 ; ENSP00000481174 ; ENSG00000177414 . [Q5VVX9-1 ]
GeneIDi 148581.
KEGGi hsa:148581.
UCSCi uc001dbn.1. human. [Q5VVX9-1 ]

Organism-specific databases

CTDi 148581.
GeneCardsi GC01P064669.
HGNCi HGNC:28559. UBE2U.
HPAi HPA020472.
HPA021660.
neXtProti NX_Q5VVX9.
PharmGKBi PA142670656.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00760000119350.
HOGENOMi HOG000049184.
HOVERGENi HBG080217.
InParanoidi Q5VVX9.
KOi K10584.
OMAi HPNVDPH.
OrthoDBi EOG7G4QGZ.
PhylomeDBi Q5VVX9.
TreeFami TF329302.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki Q5VVX9.

Miscellaneous databases

EvolutionaryTracei Q5VVX9.
GenomeRNAii 148581.
NextBioi 85955.
PROi Q5VVX9.

Gene expression databases

Bgeei Q5VVX9.
CleanExi HS_UBE2U.
ExpressionAtlasi Q5VVX9. baseline and differential.
Genevestigatori Q5VVX9.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Novel ubiquitin-conjugating enzyme."
    Avvakumov G.V., Walker J.R., Choe J., Newman E.M., MacKenzie F., Bochkarev A., Dhe-Paganon S.
    Submitted (FEB-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 1-150.

Entry informationi

Entry nameiUBE2U_HUMAN
AccessioniPrimary (citable) accession number: Q5VVX9
Secondary accession number(s): Q8N1D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3