Q5VVX4 (Q5VVX4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Parkin variant SV5DEL EMBL ADB90270.1
EC=6.3.2.19 EMBL ADB90270.1

Submitted name:
Parkinson disease (Autosomal recessive, juvenile) 2, parkin, isoform CRA_d EMBL EAW47574.1

Gene names

Name:	PARK2 EMBL ADB90270.1
ORF Names:	hCG_2029643 EMBL EAW47574.1

Organism

Homo sapiens (Human) EMBL ADB90270.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Zinc-finger SAAS SAAS002867
Ligand	Metal-binding Zinc
Molecular function	Ligase EMBL ADB90270.1
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: GOC
Cellular_component	cytosol Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from electronic annotation. Source: InterPro
Molecular_function	ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5VVX4 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: A435AF6495DED559	FASTA	437	48,713
	10 20 30 40 50 60 MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD 70 80 90 100 110 120 LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA 130 140 150 160 170 180 VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQEF 190 200 210 220 230 240 FFKCGAHPTS DKETSVALHL IATNSRNITC ITCTDVRSPV LVFQCNSRHV ICLDCFHLYC 250 260 270 280 290 300 VTRLNDRQFV HDPQLGYSLP CVAGCPNSLI KELHHFRILG EEQYNRYQQY GAEECVLQMG 310 320 330 340 350 360 GVLCPRPGCG AGLLPEPDQR KVTCEGGNGL GCGFAFCREC KEAYHEGECS AVFEASGTTT 370 380 390 400 410 420 QAYRVDERAA EQARWEAASK ETIKKTTKPC PRCHVPVEKN GGCMHMKCPQ PQCRLEWCWN 430 CGCEWNRVCM GDHWFDV

References

[1]	"The sequence of the human genome." Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X. Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Homo sapiens PARK2 SV5DEL transcript variant." Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J. Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Retina EMBL ADB90270.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GU345839 mRNA. Translation: ADB90270.1. CH471051 Genomic DNA. Translation: EAW47574.1.
IPI	IPI00332282.
RefSeq	NP_054642.2. NM_013987.2.
UniGene	Hs.132954.
3D structure databases
SMR	Q5VVX4. Positions 1-76, 279-356, 382-436.
ModBase	Search...
Proteomic databases
PRIDE	Q5VVX4.
Protocols and materials databases
DNASU	5071.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5071.
KEGG	hsa:5071.
UCSC	uc003qty.4. human.
Organism-specific databases
CTD	5071.
PharmGKB	PA32942.
Phylogenomic databases
HOGENOM	HOG000013184.
HOVERGEN	HBG053682.
KO	K04556.
Gene expression databases
ArrayExpress	Q5VVX4.
Family and domain databases
InterPro	IPR003977. Parkin. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. IPR002867. Znf_C6HC. [Graphical view]
PANTHER	PTHR11685:SF2. PTHR11685:SF2. 1 hit.
Pfam	PF01485. IBR. 2 hits. PF00240. ubiquitin. 1 hit. [Graphical view]
PIRSF	PIRSF037880. Parkin. 1 hit.
PRINTS	PR01475. PARKIN.
SMART	SM00647. IBR. 2 hits. SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5071.
NextBio	19538.

Entry information

Entry name

Q5VVX4_HUMAN

Accession

Primary (citable) accession number: Q5VVX4

Entry history

Integrated into UniProtKB/TrEMBL:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.