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Protein

GTPase-activating Rap/Ran-GAP domain-like protein 3

Gene

GARNL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating Rap/Ran-GAP domain-like protein 3
Gene namesi
Name:GARNL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136895.18
HGNCiHGNC:25425 GARNL3
neXtProtiNX_Q5VVW2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi84253
OpenTargetsiENSG00000136895
PharmGKBiPA134861523

Polymorphism and mutation databases

BioMutaiGARNL3
DMDMi162416278

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122151 – 1013GTPase-activating Rap/Ran-GAP domain-like protein 3Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1
Modified residuei426PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei827PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5VVW2
PaxDbiQ5VVW2
PeptideAtlasiQ5VVW2
PRIDEiQ5VVW2

PTM databases

iPTMnetiQ5VVW2
PhosphoSitePlusiQ5VVW2

Expressioni

Gene expression databases

BgeeiENSG00000136895
CleanExiHS_GARNL3
ExpressionAtlasiQ5VVW2 baseline and differential
GenevisibleiQ5VVW2 HS

Organism-specific databases

HPAiHPA022433
HPA028757

Interactioni

Protein-protein interaction databases

BioGridi123980, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5VVW2
SMRiQ5VVW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 407Rap-GAPPROSITE-ProRule annotationAdd BLAST217
Domaini489 – 800CNHPROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Belongs to the GARNL3 family.Curated

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000234088
HOVERGENiHBG059186
InParanoidiQ5VVW2
OMAiIHSVYTV
OrthoDBiEOG091G02D3
PhylomeDBiQ5VVW2
TreeFamiTF318626

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001180 CNH_dom
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF02145 Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS50085 RAPGAP, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VVW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVDFCRRFV ARSLCIILMK HFCSSSVSED LGCRRGDFSR KHYGSVELLI
60 70 80 90 100
SSDADGAIQR AGRFRVENGS SDENATALPG TWRRTDVHLE NPEYHTRWYF
110 120 130 140 150
KYFLGQVHQN YIGNDAEKSP FFLSVTLSDQ NNQRVPQYRA ILWRKTGTQK
160 170 180 190 200
ICLPYSPTKT LSVKSILSAM NLDKFEKGPR EIFHPEIQKD LLVLEEQEGS
210 220 230 240 250
VNFKFGVLFA KDGQLTDDEM FSNEIGSEPF QKFLNLLGDT ITLKGWTGYR
260 270 280 290 300
GGLDTKNDTT GIHSVYTVYQ GHEIMFHVST MLPYSKENKQ QVERKRHIGN
310 320 330 340 350
DIVTIVFQEG EESSPAFKPS MIRSHFTHIF ALVRYNQQND NYRLKIFSEE
360 370 380 390 400
SVPLFGPPLP TPPVFTDHQE FRDFLLVKLI NGEKATLETP TFAQKRRRTL
410 420 430 440 450
DMLIRSLHQD LMPDLHKNML NRRSFSDVLP ESPKSARKKE EARQAEFVRI
460 470 480 490 500
GQALKLKSIV RGDAPSSLAA SGICKKEPWE PQCFCSNFPH EAVCADPWGQ
510 520 530 540 550
ALLVSTDAGV LLVDDDLPSV PVFDRTLPVK QMHVLETLDL LVLRADKGKD
560 570 580 590 600
ARLFVFRLSA LQKGLEGKQA GKSRSDCREN KLEKTKGCHL YAINTHHSRE
610 620 630 640 650
LRIVVAIRNK LLLITRKHNK PSGVTSTSLL SPLSESPVEE FQYIREICLS
660 670 680 690 700
DSPMVMTLVD GPAEESDNLI CVAYRHQFDV VNESTGEAFR LHHVEANRVN
710 720 730 740 750
FVAAIDVYED GEAGLLLCYN YSCIYKKVCP FNGGSFLVQP SASDFQFCWN
760 770 780 790 800
QAPYAIVCAF PYLLAFTTDS MEIRLVVNGN LVHTAVVPQL QLVASRSDIY
810 820 830 840 850
FTATAAVNEV SSGGSSKGAS ARNSPQTPPG RDTPVFPSSL GEGEIQSKNL
860 870 880 890 900
YKIPLRNLVG RSIERPLKSP LVSKVITPPT PISVGLAAIP VTHSLSLSRM
910 920 930 940 950
EIKEIASRTR RELLGLSDEG GPKSEGAPKA KSKPRKRLEE SQGGPKPGAV
960 970 980 990 1000
RSSSSDRIPS GSLESASTSE ANPEGHSASS DQDPVADREG SPVSGSSPFQ
1010
LTAFSDEDII DLK
Length:1,013
Mass (Da):112,852
Last modified:December 4, 2007 - v2
Checksum:i1DF777ECF38DC561
GO
Isoform 2 (identifier: Q5VVW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-820: SDIYFTATAAVNEVSSGGSSKGAS → VKFNQKICTRFHLETSWAEASNDL
     821-1013: Missing.

Show »
Length:820
Mass (Da):93,047
Checksum:iE5065CE61A0127D0
GO
Isoform 3 (identifier: Q5VVW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-210: Missing.
     453-465: ALKLKSIVRGDAP → VGFLLKPFLRDM
     466-1013: Missing.

Note: No experimental confirmation available.
Show »
Length:423
Mass (Da):48,776
Checksum:i3465A220A94F2564
GO
Isoform 4 (identifier: Q5VVW2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-770: Missing.

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):25,483
Checksum:i3A9E00377A606011
GO
Isoform 5 (identifier: Q5VVW2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MVVDFCRRFVARSLCIILMKHFCS → MK

Note: No experimental confirmation available.
Show »
Length:991
Mass (Da):110,254
Checksum:i63C30C9ED9DF3C87
GO

Sequence cautioni

The sequence AAH34983 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66508 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH72927 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI41459 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037456108H → R1 PublicationCorresponds to variant dbSNP:rs11550746Ensembl.1
Natural variantiVAR_037457752A → S. Corresponds to variant dbSNP:rs34608132Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297451 – 770Missing in isoform 4. 1 PublicationAdd BLAST770
Alternative sequenceiVSP_0548751 – 24MVVDF…KHFCS → MK in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_029740170 – 210Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_029741453 – 465ALKLK…RGDAP → VGFLLKPFLRDM in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_029742466 – 1013Missing in isoform 3. 1 PublicationAdd BLAST548
Alternative sequenceiVSP_029743797 – 820SDIYF…SKGAS → VKFNQKICTRFHLETSWAEA SNDL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_029744821 – 1013Missing in isoform 2. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095679 mRNA Translation: BAC04605.1
AK293732 mRNA Translation: BAG57158.1
AK296246 mRNA Translation: BAH12292.1
AL834149 mRNA Translation: CAD38860.1
AL445222, AL450263 Genomic DNA Translation: CAH72927.1 Different initiation.
AL450263, AL445222 Genomic DNA Translation: CAI41459.1 Different initiation.
CH471090 Genomic DNA Translation: EAW87656.1
BC034983 mRNA Translation: AAH34983.1 Different initiation.
AL136573 mRNA Translation: CAB66508.1 Different initiation.
CCDSiCCDS6869.2 [Q5VVW2-1]
CCDS69663.1 [Q5VVW2-5]
RefSeqiNP_001273708.1, NM_001286779.1 [Q5VVW2-5]
NP_115669.3, NM_032293.4 [Q5VVW2-1]
UniGeneiHs.29304
Hs.736053

Genome annotation databases

EnsembliENST00000373387; ENSP00000362485; ENSG00000136895 [Q5VVW2-1]
ENST00000435213; ENSP00000396205; ENSG00000136895 [Q5VVW2-5]
GeneIDi84253
KEGGihsa:84253
UCSCiuc011mad.3 human [Q5VVW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGARL3_HUMAN
AccessioniPrimary (citable) accession number: Q5VVW2
Secondary accession number(s): B4DEP7
, B7Z3Q6, Q8IYU1, Q8N951, Q8ND89, Q9BQH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health