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Q5VVW2 (GARL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase-activating Rap/Ran-GAP domain-like protein 3
Gene names
Name:GARNL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1013 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the GARNL3 family.

Contains 1 CNH domain.

Contains 1 Rap-GAP domain.

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.

Sequence caution

The sequence AAH34983.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB66508.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAH72927.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI41459.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VVW2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VVW2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     797-820: SDIYFTATAAVNEVSSGGSSKGAS → VKFNQKICTRFHLETSWAEASNDL
     821-1013: Missing.
Isoform 3 (identifier: Q5VVW2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     170-210: Missing.
     453-465: ALKLKSIVRGDAP → VGFLLKPFLRDM
     466-1013: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q5VVW2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-770: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10131013GTPase-activating Rap/Ran-GAP domain-like protein 3
PRO_0000312215

Regions

Domain191 – 407217Rap-GAP
Domain489 – 800312CNH

Natural variations

Alternative sequence1 – 770770Missing in isoform 4.
VSP_029745
Alternative sequence170 – 21041Missing in isoform 3.
VSP_029740
Alternative sequence453 – 46513ALKLK…RGDAP → VGFLLKPFLRDM in isoform 3.
VSP_029741
Alternative sequence466 – 1013548Missing in isoform 3.
VSP_029742
Alternative sequence797 – 82024SDIYF…SKGAS → VKFNQKICTRFHLETSWAEA SNDL in isoform 2.
VSP_029743
Alternative sequence821 – 1013193Missing in isoform 2.
VSP_029744
Natural variant1081H → R. Ref.5
Corresponds to variant rs11550746 [ dbSNP | Ensembl ].
VAR_037456
Natural variant7521A → S.
Corresponds to variant rs34608132 [ dbSNP | Ensembl ].
VAR_037457

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 1DF777ECF38DC561

FASTA1,013112,852
        10         20         30         40         50         60 
MVVDFCRRFV ARSLCIILMK HFCSSSVSED LGCRRGDFSR KHYGSVELLI SSDADGAIQR 

        70         80         90        100        110        120 
AGRFRVENGS SDENATALPG TWRRTDVHLE NPEYHTRWYF KYFLGQVHQN YIGNDAEKSP 

       130        140        150        160        170        180 
FFLSVTLSDQ NNQRVPQYRA ILWRKTGTQK ICLPYSPTKT LSVKSILSAM NLDKFEKGPR 

       190        200        210        220        230        240 
EIFHPEIQKD LLVLEEQEGS VNFKFGVLFA KDGQLTDDEM FSNEIGSEPF QKFLNLLGDT 

       250        260        270        280        290        300 
ITLKGWTGYR GGLDTKNDTT GIHSVYTVYQ GHEIMFHVST MLPYSKENKQ QVERKRHIGN 

       310        320        330        340        350        360 
DIVTIVFQEG EESSPAFKPS MIRSHFTHIF ALVRYNQQND NYRLKIFSEE SVPLFGPPLP 

       370        380        390        400        410        420 
TPPVFTDHQE FRDFLLVKLI NGEKATLETP TFAQKRRRTL DMLIRSLHQD LMPDLHKNML 

       430        440        450        460        470        480 
NRRSFSDVLP ESPKSARKKE EARQAEFVRI GQALKLKSIV RGDAPSSLAA SGICKKEPWE 

       490        500        510        520        530        540 
PQCFCSNFPH EAVCADPWGQ ALLVSTDAGV LLVDDDLPSV PVFDRTLPVK QMHVLETLDL 

       550        560        570        580        590        600 
LVLRADKGKD ARLFVFRLSA LQKGLEGKQA GKSRSDCREN KLEKTKGCHL YAINTHHSRE 

       610        620        630        640        650        660 
LRIVVAIRNK LLLITRKHNK PSGVTSTSLL SPLSESPVEE FQYIREICLS DSPMVMTLVD 

       670        680        690        700        710        720 
GPAEESDNLI CVAYRHQFDV VNESTGEAFR LHHVEANRVN FVAAIDVYED GEAGLLLCYN 

       730        740        750        760        770        780 
YSCIYKKVCP FNGGSFLVQP SASDFQFCWN QAPYAIVCAF PYLLAFTTDS MEIRLVVNGN 

       790        800        810        820        830        840 
LVHTAVVPQL QLVASRSDIY FTATAAVNEV SSGGSSKGAS ARNSPQTPPG RDTPVFPSSL 

       850        860        870        880        890        900 
GEGEIQSKNL YKIPLRNLVG RSIERPLKSP LVSKVITPPT PISVGLAAIP VTHSLSLSRM 

       910        920        930        940        950        960 
EIKEIASRTR RELLGLSDEG GPKSEGAPKA KSKPRKRLEE SQGGPKPGAV RSSSSDRIPS 

       970        980        990       1000       1010 
GSLESASTSE ANPEGHSASS DQDPVADREG SPVSGSSPFQ LTAFSDEDII DLK 

« Hide

Isoform 2 [UniParc].

Checksum: E5065CE61A0127D0
Show »

FASTA82093,047
Isoform 3 [UniParc].

Checksum: 3465A220A94F2564
Show »

FASTA42348,776
Isoform 4 [UniParc].

Checksum: 3A9E00377A606011
Show »

FASTA24325,483

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain and Cerebellum.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Testis.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-108.
Tissue: Brain.
[6]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-1013 (ISOFORM 2).
Tissue: Amygdala.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095679 mRNA. Translation: BAC04605.1.
AK293732 mRNA. Translation: BAG57158.1.
AL834149 mRNA. Translation: CAD38860.1.
AL445222, AL450263 Genomic DNA. Translation: CAH72927.1. Different initiation.
AL450263, AL445222 Genomic DNA. Translation: CAI41459.1. Different initiation.
CH471090 Genomic DNA. Translation: EAW87656.1.
BC034983 mRNA. Translation: AAH34983.1. Different initiation.
AL136573 mRNA. Translation: CAB66508.1. Different initiation.
RefSeqNP_001273708.1. NM_001286779.1.
NP_115669.3. NM_032293.4.
UniGeneHs.29304.

3D structure databases

ProteinModelPortalQ5VVW2.
SMRQ5VVW2. Positions 87-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123980. 1 interaction.
STRING9606.ENSP00000362485.

PTM databases

PhosphoSiteQ5VVW2.

Polymorphism databases

DMDM162416278.

Proteomic databases

PaxDbQ5VVW2.
PRIDEQ5VVW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314904; ENSP00000313970; ENSG00000136895. [Q5VVW2-2]
ENST00000373386; ENSP00000362484; ENSG00000136895.
ENST00000373387; ENSP00000362485; ENSG00000136895. [Q5VVW2-1]
GeneID84253.
KEGGhsa:84253.
UCSCuc010mxi.3. human. [Q5VVW2-4]
uc011mae.2. human. [Q5VVW2-1]

Organism-specific databases

CTD84253.
GeneCardsGC09P129987.
H-InvDBHIX0008395.
HIX0125608.
HIX0169331.
HGNCHGNC:25425. GARNL3.
HPAHPA022433.
HPA028757.
neXtProtNX_Q5VVW2.
PharmGKBPA134861523.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240885.
HOGENOMHOG000234088.
HOVERGENHBG059186.
InParanoidQ5VVW2.
OMAIHSVYTV.
OrthoDBEOG7S4X67.
PhylomeDBQ5VVW2.
TreeFamTF318626.

Gene expression databases

ArrayExpressQ5VVW2.
BgeeQ5VVW2.
CleanExHS_GARNL3.
GenevestigatorQ5VVW2.

Family and domain databases

InterProIPR001180. Citron.
IPR000331. Rap_GAP_dom.
[Graphical view]
PfamPF00780. CNH. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view]
PROSITEPS50219. CNH. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84253.
NextBio73752.
PROQ5VVW2.

Entry information

Entry nameGARL3_HUMAN
AccessionPrimary (citable) accession number: Q5VVW2
Secondary accession number(s): B4DEP7 expand/collapse secondary AC list , Q8IYU1, Q8N951, Q8ND89, Q9BQH6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM