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Protein
Submitted name:

Transcription factor 7-like 2

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15.
HGNCiHGNC:11641. TCF7L2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737.

PTM / Processingi

Proteomic databases

MaxQBiQ5VVR5.
PeptideAtlasiQ5VVR5.
PRIDEiQ5VVR5.

Expressioni

Gene expression databases

BgeeiENSG00000148737.
ExpressionAtlasiQ5VVR5. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5VVR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 222CTNNB1_bindingInterPro annotationAdd BLAST221

Phylogenomic databases

GeneTreeiENSGT00390000009964.
HOGENOMiHOG000116032.
HOVERGENiHBG000419.

Family and domain databases

InterProiView protein in InterPro
IPR013558. CTNNB1-bd_N.
IPR024940. TCF/LEF.
IPR028773. TCF7L.
PANTHERiPTHR10373. PTHR10373. 2 hits.
PTHR10373:SF25. PTHR10373:SF25. 2 hits.
PfamiView protein in Pfam
PF08347. CTNNB1_binding. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5VVR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TNQNSSSDSE AERRPPPRSE SFRDKSRESL EEAAKRQDGG LFKGPPYPGY
60 70 80 90 100
PFIMIPDLTS PYLPNGSLSP TARTLHFQSG STHYSAYKTI EHQIAVQYLQ
110 120 130 140 150
MKWPLLDVQA GSLQSRQALK DARSPSPAHI VSPLPCCTQG HDCQHFYPPS
160 170 180 190 200
DFTVSTQVFR DMKRSHSLQK VGEPWCIESN KVPVVQHPHH VHPLTPLITY
210 220
SNEHFTPGNP PPHLPADVDP KT
Length:222
Mass (Da):24,851
Last modified:December 7, 2004 - v1
Checksum:i771D9F5D12B13C02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei222Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA. No translation available.
AL158212 Genomic DNA. No translation available.
AL445486 Genomic DNA. No translation available.
AL451084 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000346198; ENSP00000345640; ENSG00000148737.
UCSCiuc057wbe.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ5VVR5_HUMAN
AccessioniPrimary (citable) accession number: Q5VVR5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported