##gff-version 3
Q5VVQ6	UniProtKB	Chain	1	348	.	.	.	ID=PRO_0000282356;Note=Ubiquitin thioesterase OTU1	
Q5VVQ6	UniProtKB	Domain	149	274	.	.	.	Note=OTU;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00139	
Q5VVQ6	UniProtKB	Zinc finger	318	342	.	.	.	Note=C2H2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042	
Q5VVQ6	UniProtKB	Region	1	39	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q5VVQ6	UniProtKB	Region	50	128	.	.	.	Note=UBX-like;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Region	154	160	.	.	.	Note=Cys-loop;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Region	213	223	.	.	.	Note=Variable-loop;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Region	263	267	.	.	.	Note=His-loop;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Region	291	296	.	.	.	Note=S2 site;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Active site	157	157	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96FW1	
Q5VVQ6	UniProtKB	Active site	160	160	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Active site	267	267	.	.	.	Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Active site	342	342	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96FW1	
Q5VVQ6	UniProtKB	Binding site	266	266	.	.	.	Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23827681,ECO:0007744|PDB:4BOS;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Alternative sequence	1	61	.	.	.	ID=VSP_024122;Note=In isoform 2. MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVLQ->METLHIIYSEAKSFTVE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
Q5VVQ6	UniProtKB	Mutagenesis	160	160	.	.	.	Note=Abolishes deubiquitinase activity without affecting interaction with VCP. Specifically blocks a step in the course of dislocation and/or degradation of endoplasmic reticulum-resident proteins destined for proteasomal degradation. Prevents the macroautophagy of damaged lysosome membranes decorated with K48-linked ubiquitin chains. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19818707,ECO:0000269|PubMed:27753622;Dbxref=PMID:19818707,PMID:27753622	
Q5VVQ6	UniProtKB	Mutagenesis	292	292	.	.	.	Note=Does not affect activity or specificity. Impairs ability to cleave longer 'Lys-11'-linked ubiquitin chains%3B when associated with Q-295. I->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Mutagenesis	295	295	.	.	.	Note=Does not affect activity or specificity. Impairs ability to cleave longer 'Lys-11'-linked ubiquitin chains%3B when associated with Q-292. V->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Mutagenesis	336	336	.	.	.	Note=Reduced activity toward 'Lys-27'-%2C 'Lys-29'- and 'Lys-33'-linked ubiquitin without affecting activity toward 'Lys-11'-linked ubiquitin%3B when associated with A-342. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Mutagenesis	342	342	.	.	.	Note=Reduced activity toward 'Lys-27'-%2C 'Lys-29'- and 'Lys-33'-linked ubiquitin without affecting activity toward 'Lys-11'-linked ubiquitin%3B when associated with A-336. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23827681;Dbxref=PMID:23827681	
Q5VVQ6	UniProtKB	Sequence conflict	8	8	.	.	.	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q5VVQ6	UniProtKB	Sequence conflict	90	90	.	.	.	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q5VVQ6	UniProtKB	Helix	138	140	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	148	151	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Helix	160	169	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Helix	176	178	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOS	
Q5VVQ6	UniProtKB	Helix	179	192	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Turn	194	196	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Helix	199	202	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Helix	206	213	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	215	217	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Helix	222	232	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	234	240	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Turn	241	244	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	245	249	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Turn	250	252	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	256	263	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	268	274	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	276	280	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ	
Q5VVQ6	UniProtKB	Beta strand	285	287	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOZ	
Q5VVQ6	UniProtKB	Helix	292	308	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BOQ