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Protein

Interleukin-1 receptor-associated kinase 1-binding protein 1

Gene

IRAK1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase 1-binding protein 1
Short name:
IRAK1-binding protein 1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17368. IRAK1BP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919096.

Polymorphism and mutation databases

DMDMi74747244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Interleukin-1 receptor-associated kinase 1-binding protein 1PRO_0000313733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei237 – 2371PhosphothreonineBy similarity
Modified residuei242 – 2421PhosphoserineBy similarity
Modified residuei247 – 2471PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5VVH5.
PRIDEiQ5VVH5.

PTM databases

iPTMnetiQ5VVH5.
PhosphoSiteiQ5VVH5.

Expressioni

Gene expression databases

BgeeiQ5VVH5.
CleanExiHS_IRAK1BP1.
ExpressionAtlasiQ5VVH5. baseline and differential.
GenevisibleiQ5VVH5. HS.

Organism-specific databases

HPAiHPA035742.
HPA035743.

Interactioni

Subunit structurei

Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-9658404,EBI-717422

Protein-protein interaction databases

BioGridi126412. 2 interactions.
IntActiQ5VVH5. 2 interactions.
STRINGi9606.ENSP00000358956.

Structurei

3D structure databases

ProteinModelPortaliQ5VVH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9191Intrinsically disorderedAdd
BLAST
Regioni240 – 26021Required for nuclear localization (NLS)By similarityAdd
BLAST

Domaini

The intrinsically disordered region interacts with HSPA1 and HSPA8.By similarity

Sequence similaritiesi

Belongs to the IRAK1BP1 family.Curated

Phylogenomic databases

eggNOGiENOG410II1K. Eukaryota.
ENOG4111TM2. LUCA.
GeneTreeiENSGT00390000012588.
HOGENOMiHOG000015413.
HOVERGENiHBG100113.
InParanoidiQ5VVH5.
OMAiDRGRENN.
OrthoDBiEOG7X3QSB.
PhylomeDBiQ5VVH5.
TreeFamiTF328455.

Family and domain databases

InterProiIPR007497. DUF541.
IPR030312. IRAK1BP1.
[Graphical view]
PANTHERiPTHR18842. PTHR18842. 1 hit.
PfamiPF04402. SIMPL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VVH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT
60 70 80 90 100
REVQVSGTSE VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ
110 120 130 140 150
QQGVQAENIT VTKDFRRVEN AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD
160 170 180 190 200
SSVVISPPQF YHTPGSVENL RRQACLVAVE NAWRKAQEVC NLVGQTLGKP
210 220 230 240 250
LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA ASKVFITFEV
260
KGKEKRKKHL
Length:260
Mass (Da):29,106
Last modified:December 7, 2004 - v1
Checksum:iF8576A4ED9C40352
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450327 Genomic DNA. Translation: CAH70883.1.
CH471051 Genomic DNA. Translation: EAW48721.1.
BC112253 mRNA. Translation: AAI12254.1.
BC112255 mRNA. Translation: AAI12256.1.
CCDSiCCDS34488.1.
RefSeqiNP_001010844.1. NM_001010844.3.
UniGeneiHs.656212.

Genome annotation databases

EnsembliENST00000369940; ENSP00000358956; ENSG00000146243.
GeneIDi134728.
KEGGihsa:134728.
UCSCiuc003pim.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450327 Genomic DNA. Translation: CAH70883.1.
CH471051 Genomic DNA. Translation: EAW48721.1.
BC112253 mRNA. Translation: AAI12254.1.
BC112255 mRNA. Translation: AAI12256.1.
CCDSiCCDS34488.1.
RefSeqiNP_001010844.1. NM_001010844.3.
UniGeneiHs.656212.

3D structure databases

ProteinModelPortaliQ5VVH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126412. 2 interactions.
IntActiQ5VVH5. 2 interactions.
STRINGi9606.ENSP00000358956.

PTM databases

iPTMnetiQ5VVH5.
PhosphoSiteiQ5VVH5.

Polymorphism and mutation databases

DMDMi74747244.

Proteomic databases

PaxDbiQ5VVH5.
PRIDEiQ5VVH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369940; ENSP00000358956; ENSG00000146243.
GeneIDi134728.
KEGGihsa:134728.
UCSCiuc003pim.6. human.

Organism-specific databases

CTDi134728.
GeneCardsiIRAK1BP1.
H-InvDBHIX0006019.
HGNCiHGNC:17368. IRAK1BP1.
HPAiHPA035742.
HPA035743.
MIMi615375. gene.
neXtProtiNX_Q5VVH5.
PharmGKBiPA134919096.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1K. Eukaryota.
ENOG4111TM2. LUCA.
GeneTreeiENSGT00390000012588.
HOGENOMiHOG000015413.
HOVERGENiHBG100113.
InParanoidiQ5VVH5.
OMAiDRGRENN.
OrthoDBiEOG7X3QSB.
PhylomeDBiQ5VVH5.
TreeFamiTF328455.

Miscellaneous databases

ChiTaRSiIRAK1BP1. human.
GenomeRNAii134728.
PROiQ5VVH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VVH5.
CleanExiHS_IRAK1BP1.
ExpressionAtlasiQ5VVH5. baseline and differential.
GenevisibleiQ5VVH5. HS.

Family and domain databases

InterProiIPR007497. DUF541.
IPR030312. IRAK1BP1.
[Graphical view]
PANTHERiPTHR18842. PTHR18842. 1 hit.
PfamiPF04402. SIMPL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity."
    Vig E., Green M., Liu Y., Yu K.-Y., Kwon H.-J., Tian J., Goebl M.G., Harrington M.A.
    J. Biol. Chem. 276:7859-7866(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiIKBP1_HUMAN
AccessioniPrimary (citable) accession number: Q5VVH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.