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Protein

Interleukin-1 receptor-associated kinase 1-binding protein 1

Gene

IRAK1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase 1-binding protein 1
Short name:
IRAK1-binding protein 1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146243.13.
HGNCiHGNC:17368. IRAK1BP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi134728.
OpenTargetsiENSG00000146243.
PharmGKBiPA134919096.

Polymorphism and mutation databases

DMDMi74747244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137331 – 260Interleukin-1 receptor-associated kinase 1-binding protein 1Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei237PhosphothreonineBy similarity1
Modified residuei242PhosphoserineBy similarity1
Modified residuei247PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VVH5.
PaxDbiQ5VVH5.
PeptideAtlasiQ5VVH5.
PRIDEiQ5VVH5.

PTM databases

iPTMnetiQ5VVH5.
PhosphoSitePlusiQ5VVH5.

Expressioni

Gene expression databases

BgeeiENSG00000146243.
CleanExiHS_IRAK1BP1.
ExpressionAtlasiQ5VVH5. baseline and differential.
GenevisibleiQ5VVH5. HS.

Organism-specific databases

HPAiHPA035742.
HPA035743.

Interactioni

Subunit structurei

Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TFCP2Q128003EBI-9658404,EBI-717422

Protein-protein interaction databases

BioGridi126412. 4 interactors.
IntActiQ5VVH5. 2 interactors.
STRINGi9606.ENSP00000358956.

Structurei

3D structure databases

ProteinModelPortaliQ5VVH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 91Intrinsically disorderedAdd BLAST91
Regioni240 – 260Required for nuclear localization (NLS)By similarityAdd BLAST21

Domaini

The intrinsically disordered region interacts with HSPA1 and HSPA8.By similarity

Sequence similaritiesi

Belongs to the IRAK1BP1 family.Curated

Phylogenomic databases

eggNOGiENOG410II1K. Eukaryota.
ENOG4111TM2. LUCA.
GeneTreeiENSGT00390000012588.
HOGENOMiHOG000015413.
HOVERGENiHBG100113.
InParanoidiQ5VVH5.
OMAiDRGRENN.
OrthoDBiEOG091G0MNV.
PhylomeDBiQ5VVH5.
TreeFamiTF328455.

Family and domain databases

InterProiView protein in InterPro
IPR007497. DUF541.
IPR030312. IRAK1BP1.
PANTHERiPTHR18842. PTHR18842. 1 hit.
PfamiView protein in Pfam
PF04402. SIMPL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VVH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT
60 70 80 90 100
REVQVSGTSE VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ
110 120 130 140 150
QQGVQAENIT VTKDFRRVEN AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD
160 170 180 190 200
SSVVISPPQF YHTPGSVENL RRQACLVAVE NAWRKAQEVC NLVGQTLGKP
210 220 230 240 250
LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA ASKVFITFEV
260
KGKEKRKKHL
Length:260
Mass (Da):29,106
Last modified:December 7, 2004 - v1
Checksum:iF8576A4ED9C40352
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450327 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48721.1.
BC112253 mRNA. Translation: AAI12254.1.
BC112255 mRNA. Translation: AAI12256.1.
CCDSiCCDS34488.1.
RefSeqiNP_001010844.1. NM_001010844.3.
UniGeneiHs.656212.

Genome annotation databases

EnsembliENST00000369940; ENSP00000358956; ENSG00000146243.
GeneIDi134728.
KEGGihsa:134728.
UCSCiuc003pim.6. human.

Similar proteinsi

Entry informationi

Entry nameiIKBP1_HUMAN
AccessioniPrimary (citable) accession number: Q5VVH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families