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Protein
Submitted name:

Very low density lipoprotein receptor

Gene

VLDLR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Very low density lipoprotein receptorImported
Submitted name:
Very low density lipoprotein receptor, isoform CRA_aImported
Gene namesi
Name:VLDLRImported
ORF Names:hCG_27927Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000147852.15

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei770 – 791HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501431017225 – 845Sequence analysisAdd BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 58PROSITE-ProRule annotation
Disulfide bondi52 ↔ 67PROSITE-ProRule annotation
Disulfide bondi72 ↔ 84PROSITE-ProRule annotation
Disulfide bondi79 ↔ 97PROSITE-ProRule annotation
Disulfide bondi134 ↔ 149PROSITE-ProRule annotation
Disulfide bondi154 ↔ 166PROSITE-ProRule annotation
Disulfide bondi161 ↔ 179PROSITE-ProRule annotation
Disulfide bondi173 ↔ 188PROSITE-ProRule annotation
Disulfide bondi193 ↔ 205PROSITE-ProRule annotation
Disulfide bondi200 ↔ 218PROSITE-ProRule annotation
Disulfide bondi239 ↔ 251PROSITE-ProRule annotation
Disulfide bondi246 ↔ 264PROSITE-ProRule annotation
Disulfide bondi258 ↔ 273PROSITE-ProRule annotation
Disulfide bondi278 ↔ 290PROSITE-ProRule annotation
Disulfide bondi285 ↔ 303PROSITE-ProRule annotation
Disulfide bondi297 ↔ 312PROSITE-ProRule annotation
Disulfide bondi326 ↔ 344PROSITE-ProRule annotation
Disulfide bondi400 ↔ 410PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation, LipoproteinImported

Proteomic databases

MaxQBiQ5VVF5
PRIDEiQ5VVF5

Expressioni

Gene expression databases

BgeeiENSG00000147852
ExpressionAtlasiQ5VVF5 baseline and differential

Structurei

3D structure databases

SMRiQ5VVF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 395EGF-likeInterPro annotationAdd BLAST40
Domaini396 – 431EGF-likeInterPro annotationAdd BLAST36
Repeati481 – 524LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati525 – 567LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati568 – 611LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati612 – 656LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati657 – 697LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPT5 Eukaryota
ENOG410YQ6J LUCA
HOGENOMiHOG000115656
HOVERGENiHBG006250

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR032931 VLDLR
PANTHERiPTHR43966:SF6 PTHR43966:SF6, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 8 hits
SM00135 LY, 5 hits
SUPFAMiSSF57424 SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 4 hits
PS50068 LDLRA_2, 8 hits
PS51120 LDLRB, 5 hits

Sequencei

Sequence statusi: Complete.

Q5VVF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSALWALW LLLALCWAPR ESGATGTGRK AKCEPSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCVD GSDEKNCVKK TCAESDFVCN NGQCVPSRWK CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRIHEISC GAHSTQCIPV SWRCDGENDC DSGEDEENCG
160 170 180 190 200
NITCSPDEFT CSSGRCISRN FVCNGQDDCS DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP ASEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDISKVCNQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHVKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTADIQ
610 620 630 640 650
WPNGITLDLI KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP
710 720 730 740 750
SGKNWCEEDM ENGGCEYLCL PAPQINDHSP KYTCSCPSGY NVEENGRDCQ
760 770 780 790 800
RINVTTAVSE VSVPPKGTSA AWAILPLLLL VMAAVGGYLM WRNWQHKNMK
810 820 830 840
SMNFDNPVYL KTTEEDLSID IGRHSASVGH TYPAISVVST DDDLA
Length:845
Mass (Da):93,383
Last modified:May 10, 2005 - v1
Checksum:i588311D7C6B2C1FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142653 mRNA Translation: AAI42654.1
BC144245 mRNA Translation: AAI44246.1
CH471071 Genomic DNA Translation: EAW58804.1
CH471071 Genomic DNA Translation: EAW58807.1
RefSeqiNP_001018066.1, NM_001018056.2
UniGeneiHs.370422

Genome annotation databases

GeneIDi7436
UCSCiuc003zhl.2 human

Similar proteinsi

Entry informationi

Entry nameiQ5VVF5_HUMAN
AccessioniPrimary (citable) accession number: Q5VVF5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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