ID TM244_HUMAN Reviewed; 128 AA. AC Q5VVB8; DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 27-MAR-2024, entry version 114. DE RecName: Full=Putative transmembrane protein 244; GN Name=TMEM244; Synonyms=C6orf191; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL451046; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS34536.1; -. DR RefSeq; NP_001010876.1; NM_001010876.1. DR AlphaFoldDB; Q5VVB8; -. DR STRING; 9606.ENSP00000357125; -. DR BioMuta; TMEM244; -. DR DMDM; 74747217; -. DR MassIVE; Q5VVB8; -. DR PaxDb; 9606-ENSP00000357125; -. DR PeptideAtlas; Q5VVB8; -. DR TopDownProteomics; Q5VVB8; -. DR Antibodypedia; 50386; 43 antibodies from 7 providers. DR DNASU; 253582; -. DR Ensembl; ENST00000368143.6; ENSP00000357125.1; ENSG00000203756.8. DR Ensembl; ENST00000438392.3; ENSP00000403755.1; ENSG00000203756.8. DR GeneID; 253582; -. DR KEGG; hsa:253582; -. DR MANE-Select; ENST00000368143.6; ENSP00000357125.1; NM_001010876.2; NP_001010876.1. DR UCSC; uc003qbs.3; human. DR AGR; HGNC:21571; -. DR CTD; 253582; -. DR GeneCards; TMEM244; -. DR HGNC; HGNC:21571; TMEM244. DR HPA; ENSG00000203756; Tissue enriched (retina). DR neXtProt; NX_Q5VVB8; -. DR OpenTargets; ENSG00000203756; -. DR PharmGKB; PA134909151; -. DR VEuPathDB; HostDB:ENSG00000203756; -. DR eggNOG; ENOG502RA7Q; Eukaryota. DR GeneTree; ENSGT00940000154347; -. DR HOGENOM; CLU_122907_0_0_1; -. DR InParanoid; Q5VVB8; -. DR OMA; FPSTEHW; -. DR OrthoDB; 5396498at2759; -. DR PhylomeDB; Q5VVB8; -. DR TreeFam; TF340485; -. DR PathwayCommons; Q5VVB8; -. DR SignaLink; Q5VVB8; -. DR BioGRID-ORCS; 253582; 11 hits in 1105 CRISPR screens. DR GenomeRNAi; 253582; -. DR Pharos; Q5VVB8; Tdark. DR PRO; PR:Q5VVB8; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q5VVB8; Protein. DR Bgee; ENSG00000203756; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 56 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. PE 4: Predicted; KW Membrane; Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..128 FT /note="Putative transmembrane protein 244" FT /id="PRO_0000238467" FT TRANSMEM 17..37 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 65..85 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 93..113 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 60 FT /note="N -> I (in dbSNP:rs7760577)" FT /id="VAR_033681" FT VARIANT 80 FT /note="F -> L (in dbSNP:rs4629709)" FT /id="VAR_026549" FT VARIANT 86 FT /note="E -> G (in dbSNP:rs9492393)" FT /id="VAR_026550" FT VARIANT 111 FT /note="F -> V (in dbSNP:rs7776426)" FT /id="VAR_026551" SQ SEQUENCE 128 AA; 14657 MW; 9AB7F28C72185C38 CRC64; MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF DFKTNPSWLN INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH VAITSTVMLE FPLTSHWWAA LGISKLLV //