Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5VVB8 (TM244_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 244
Gene names
Name:TMEM244
Synonyms:C6orf191
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128128Transmembrane protein 244
PRO_0000238467

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane93 – 11321Helical; Potential

Natural variations

Natural variant601N → I.
Corresponds to variant rs7760577 [ dbSNP | Ensembl ].
VAR_033681
Natural variant801F → L.
Corresponds to variant rs4629709 [ dbSNP | Ensembl ].
VAR_026549
Natural variant861E → G.
Corresponds to variant rs9492393 [ dbSNP | Ensembl ].
VAR_026550
Natural variant1111F → V.
Corresponds to variant rs7776426 [ dbSNP | Ensembl ].
VAR_026551

Sequences

Sequence LengthMass (Da)Tools
Q5VVB8 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 9AB7F28C72185C38

FASTA12814,657
        10         20         30         40         50         60 
MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF DFKTNPSWLN 

        70         80         90        100        110        120 
INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH VAITSTVMLE FPLTSHWWAA 


LGISKLLV 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL451046 Genomic DNA. Translation: CAH70899.1.
CCDSCCDS34536.1.
RefSeqNP_001010876.1. NM_001010876.1.
UniGeneHs.448372.

3D structure databases

ProteinModelPortalQ5VVB8.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74747217.

Proteomic databases

PRIDEQ5VVB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368143; ENSP00000357125; ENSG00000203756.
ENST00000438392; ENSP00000403755; ENSG00000203756.
GeneID253582.
KEGGhsa:253582.
UCSCuc003qbs.3. human.

Organism-specific databases

CTD253582.
GeneCardsGC06M130152.
HGNCHGNC:21571. TMEM244.
HPAHPA045247.
neXtProtNX_Q5VVB8.
PharmGKBPA134909151.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85849.
HOGENOMHOG000007700.
HOVERGENHBG057717.
InParanoidQ5VVB8.
OMASTVMLEF.
OrthoDBEOG71CFNR.
PhylomeDBQ5VVB8.
TreeFamTF340485.

Gene expression databases

CleanExHS_C6orf191.
GenevestigatorQ5VVB8.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi253582.
NextBio92131.
PROQ5VVB8.

Entry information

Entry nameTM244_HUMAN
AccessionPrimary (citable) accession number: Q5VVB8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM