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Protein

Transmembrane protein 244

Gene

TMEM244

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 244
Gene namesi
Name:TMEM244
Synonyms:C6orf191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21571. TMEM244.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Transmembrane protein 244PRO_0000238467Add
BLAST

Proteomic databases

PRIDEiQ5VVB8.

Expressioni

Gene expression databases

CleanExiHS_C6orf191.
GenevestigatoriQ5VVB8.

Organism-specific databases

HPAiHPA045247.

Structurei

3D structure databases

ProteinModelPortaliQ5VVB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85849.
GeneTreeiENSGT00390000007791.
HOGENOMiHOG000007700.
HOVERGENiHBG057717.
InParanoidiQ5VVB8.
OMAiSTVMLEF.
OrthoDBiEOG71CFNR.
PhylomeDBiQ5VVB8.
TreeFamiTF340485.

Sequencei

Sequence statusi: Complete.

Q5VVB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF
60 70 80 90 100
DFKTNPSWLN INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH
110 120
VAITSTVMLE FPLTSHWWAA LGISKLLV
Length:128
Mass (Da):14,657
Last modified:December 6, 2004 - v1
Checksum:i9AB7F28C72185C38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601N → I.
Corresponds to variant rs7760577 [ dbSNP | Ensembl ].
VAR_033681
Natural varianti80 – 801F → L.
Corresponds to variant rs4629709 [ dbSNP | Ensembl ].
VAR_026549
Natural varianti86 – 861E → G.
Corresponds to variant rs9492393 [ dbSNP | Ensembl ].
VAR_026550
Natural varianti111 – 1111F → V.
Corresponds to variant rs7776426 [ dbSNP | Ensembl ].
VAR_026551

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451046 Genomic DNA. Translation: CAH70899.1.
CCDSiCCDS34536.1.
RefSeqiNP_001010876.1. NM_001010876.1.
UniGeneiHs.448372.

Genome annotation databases

EnsembliENST00000368143; ENSP00000357125; ENSG00000203756.
ENST00000438392; ENSP00000403755; ENSG00000203756.
GeneIDi253582.
KEGGihsa:253582.
UCSCiuc003qbs.3. human.

Polymorphism databases

DMDMi74747217.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451046 Genomic DNA. Translation: CAH70899.1.
CCDSiCCDS34536.1.
RefSeqiNP_001010876.1. NM_001010876.1.
UniGeneiHs.448372.

3D structure databases

ProteinModelPortaliQ5VVB8.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi74747217.

Proteomic databases

PRIDEiQ5VVB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368143; ENSP00000357125; ENSG00000203756.
ENST00000438392; ENSP00000403755; ENSG00000203756.
GeneIDi253582.
KEGGihsa:253582.
UCSCiuc003qbs.3. human.

Organism-specific databases

CTDi253582.
GeneCardsiGC06M130152.
HGNCiHGNC:21571. TMEM244.
HPAiHPA045247.
neXtProtiNX_Q5VVB8.
PharmGKBiPA134909151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85849.
GeneTreeiENSGT00390000007791.
HOGENOMiHOG000007700.
HOVERGENiHBG057717.
InParanoidiQ5VVB8.
OMAiSTVMLEF.
OrthoDBiEOG71CFNR.
PhylomeDBiQ5VVB8.
TreeFamiTF340485.

Miscellaneous databases

GenomeRNAii253582.
NextBioi92131.
PROiQ5VVB8.

Gene expression databases

CleanExiHS_C6orf191.
GenevestigatoriQ5VVB8.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM244_HUMAN
AccessioniPrimary (citable) accession number: Q5VVB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2006
Last sequence update: December 6, 2004
Last modified: January 6, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.