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Q5VVB8

- TM244_HUMAN

UniProt

Q5VVB8 - TM244_HUMAN

Protein

Transmembrane protein 244

Gene

TMEM244

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 244
    Gene namesi
    Name:TMEM244
    Synonyms:C6orf191
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21571. TMEM244.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909151.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128128Transmembrane protein 244PRO_0000238467Add
    BLAST

    Proteomic databases

    PRIDEiQ5VVB8.

    Expressioni

    Gene expression databases

    CleanExiHS_C6orf191.
    GenevestigatoriQ5VVB8.

    Organism-specific databases

    HPAiHPA045247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VVB8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85849.
    HOGENOMiHOG000007700.
    HOVERGENiHBG057717.
    InParanoidiQ5VVB8.
    OMAiSTVMLEF.
    OrthoDBiEOG71CFNR.
    PhylomeDBiQ5VVB8.
    TreeFamiTF340485.

    Sequencei

    Sequence statusi: Complete.

    Q5VVB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF    50
    DFKTNPSWLN INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH 100
    VAITSTVMLE FPLTSHWWAA LGISKLLV 128
    Length:128
    Mass (Da):14,657
    Last modified:December 7, 2004 - v1
    Checksum:i9AB7F28C72185C38
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601N → I.
    Corresponds to variant rs7760577 [ dbSNP | Ensembl ].
    VAR_033681
    Natural varianti80 – 801F → L.
    Corresponds to variant rs4629709 [ dbSNP | Ensembl ].
    VAR_026549
    Natural varianti86 – 861E → G.
    Corresponds to variant rs9492393 [ dbSNP | Ensembl ].
    VAR_026550
    Natural varianti111 – 1111F → V.
    Corresponds to variant rs7776426 [ dbSNP | Ensembl ].
    VAR_026551

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL451046 Genomic DNA. Translation: CAH70899.1.
    CCDSiCCDS34536.1.
    RefSeqiNP_001010876.1. NM_001010876.1.
    UniGeneiHs.448372.

    Genome annotation databases

    EnsembliENST00000368143; ENSP00000357125; ENSG00000203756.
    ENST00000438392; ENSP00000403755; ENSG00000203756.
    GeneIDi253582.
    KEGGihsa:253582.
    UCSCiuc003qbs.3. human.

    Polymorphism databases

    DMDMi74747217.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL451046 Genomic DNA. Translation: CAH70899.1 .
    CCDSi CCDS34536.1.
    RefSeqi NP_001010876.1. NM_001010876.1.
    UniGenei Hs.448372.

    3D structure databases

    ProteinModelPortali Q5VVB8.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74747217.

    Proteomic databases

    PRIDEi Q5VVB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368143 ; ENSP00000357125 ; ENSG00000203756 .
    ENST00000438392 ; ENSP00000403755 ; ENSG00000203756 .
    GeneIDi 253582.
    KEGGi hsa:253582.
    UCSCi uc003qbs.3. human.

    Organism-specific databases

    CTDi 253582.
    GeneCardsi GC06M130152.
    HGNCi HGNC:21571. TMEM244.
    HPAi HPA045247.
    neXtProti NX_Q5VVB8.
    PharmGKBi PA134909151.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85849.
    HOGENOMi HOG000007700.
    HOVERGENi HBG057717.
    InParanoidi Q5VVB8.
    OMAi STVMLEF.
    OrthoDBi EOG71CFNR.
    PhylomeDBi Q5VVB8.
    TreeFami TF340485.

    Miscellaneous databases

    GenomeRNAii 253582.
    NextBioi 92131.
    PROi Q5VVB8.

    Gene expression databases

    CleanExi HS_C6orf191.
    Genevestigatori Q5VVB8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTM244_HUMAN
    AccessioniPrimary (citable) accession number: Q5VVB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3