Q5VVB8 (TM244_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 244

Gene names

Name:	TMEM244
Synonyms:	C6orf191

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	Transmembrane protein 244		PRO_0000238467
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
Natural variations
	Natural variant	60	1	N → I. Corresponds to variant rs7760577 [ dbSNP | Ensembl ].		VAR_033681
	Natural variant	80	1	F → L. Corresponds to variant rs4629709 [ dbSNP | Ensembl ].		VAR_026549
	Natural variant	86	1	E → G. Corresponds to variant rs9492393 [ dbSNP | Ensembl ].		VAR_026550
	Natural variant	111	1	F → V. Corresponds to variant rs7776426 [ dbSNP | Ensembl ].		VAR_026551

Sequences

	Sequence		Length	Mass (Da)
	Q5VVB8 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 9AB7F28C72185C38	FASTA	128	14,657
	10 20 30 40 50 60 MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF DFKTNPSWLN 70 80 90 100 110 120 INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH VAITSTVMLE FPLTSHWWAA LGISKLLV

References

[1]

"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL451046 Genomic DNA. Translation: CAH70899.1.
IPI	IPI00161485.
RefSeq	NP_001010876.1. NM_001010876.1.
UniGene	Hs.448372.
3D structure databases
ProteinModelPortal	Q5VVB8.
ModBase	Search...
Polymorphism databases
DMDM	74747217.
Proteomic databases
PRIDE	Q5VVB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368143; ENSP00000357125; ENSG00000203756. ENST00000438392; ENSP00000403755; ENSG00000203756.
GeneID	253582.
KEGG	hsa:253582.
UCSC	uc003qbs.3. human.
Organism-specific databases
CTD	253582.
GeneCards	GC06M130152.
HGNC	HGNC:21571. TMEM244.
HPA	HPA045247.
neXtProt	NX_Q5VVB8.
PharmGKB	PA134909151.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85849.
HOGENOM	HOG000007700.
HOVERGEN	HBG057717.
InParanoid	Q5VVB8.
OMA	STVMLEF.
OrthoDB	EOG4P5KB8.
Gene expression databases
CleanEx	HS_C6orf191.
Genevestigator	Q5VVB8.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	253582.
NextBio	92131.

Entry information

Entry name

TM244_HUMAN

Accession

Primary (citable) accession number: Q5VVB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.