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Q5VVB8

- TM244_HUMAN

UniProt

Q5VVB8 - TM244_HUMAN

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Protein

Transmembrane protein 244

Gene

TMEM244

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 244
Gene namesi
Name:TMEM244
Synonyms:C6orf191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21571. TMEM244.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Transmembrane protein 244PRO_0000238467Add
BLAST

Proteomic databases

PRIDEiQ5VVB8.

Expressioni

Gene expression databases

CleanExiHS_C6orf191.
GenevestigatoriQ5VVB8.

Organism-specific databases

HPAiHPA045247.

Structurei

3D structure databases

ProteinModelPortaliQ5VVB8.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85849.
GeneTreeiENSGT00390000007791.
HOGENOMiHOG000007700.
HOVERGENiHBG057717.
InParanoidiQ5VVB8.
OMAiSTVMLEF.
OrthoDBiEOG71CFNR.
PhylomeDBiQ5VVB8.
TreeFamiTF340485.

Sequencei

Sequence statusi: Complete.

Q5VVB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF
60 70 80 90 100
DFKTNPSWLN INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH
110 120
VAITSTVMLE FPLTSHWWAA LGISKLLV
Length:128
Mass (Da):14,657
Last modified:December 7, 2004 - v1
Checksum:i9AB7F28C72185C38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601N → I.
Corresponds to variant rs7760577 [ dbSNP | Ensembl ].
VAR_033681
Natural varianti80 – 801F → L.
Corresponds to variant rs4629709 [ dbSNP | Ensembl ].
VAR_026549
Natural varianti86 – 861E → G.
Corresponds to variant rs9492393 [ dbSNP | Ensembl ].
VAR_026550
Natural varianti111 – 1111F → V.
Corresponds to variant rs7776426 [ dbSNP | Ensembl ].
VAR_026551

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL451046 Genomic DNA. Translation: CAH70899.1.
CCDSiCCDS34536.1.
RefSeqiNP_001010876.1. NM_001010876.1.
UniGeneiHs.448372.

Genome annotation databases

EnsembliENST00000368143; ENSP00000357125; ENSG00000203756.
ENST00000438392; ENSP00000403755; ENSG00000203756.
GeneIDi253582.
KEGGihsa:253582.
UCSCiuc003qbs.3. human.

Polymorphism databases

DMDMi74747217.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL451046 Genomic DNA. Translation: CAH70899.1 .
CCDSi CCDS34536.1.
RefSeqi NP_001010876.1. NM_001010876.1.
UniGenei Hs.448372.

3D structure databases

ProteinModelPortali Q5VVB8.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74747217.

Proteomic databases

PRIDEi Q5VVB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368143 ; ENSP00000357125 ; ENSG00000203756 .
ENST00000438392 ; ENSP00000403755 ; ENSG00000203756 .
GeneIDi 253582.
KEGGi hsa:253582.
UCSCi uc003qbs.3. human.

Organism-specific databases

CTDi 253582.
GeneCardsi GC06M130152.
HGNCi HGNC:21571. TMEM244.
HPAi HPA045247.
neXtProti NX_Q5VVB8.
PharmGKBi PA134909151.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85849.
GeneTreei ENSGT00390000007791.
HOGENOMi HOG000007700.
HOVERGENi HBG057717.
InParanoidi Q5VVB8.
OMAi STVMLEF.
OrthoDBi EOG71CFNR.
PhylomeDBi Q5VVB8.
TreeFami TF340485.

Miscellaneous databases

GenomeRNAii 253582.
NextBioi 92131.
PROi Q5VVB8.

Gene expression databases

CleanExi HS_C6orf191.
Genevestigatori Q5VVB8.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM244_HUMAN
AccessioniPrimary (citable) accession number: Q5VVB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3