Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5VV67 (PPRC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Alternative name(s):
PGC-1-related coactivator
Short name=PRC
Gene names
Name:PPRC1
Synonyms:KIAA0595
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1664 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. Ref.1 Ref.7

Subunit structure

Interacts with CREB1 and NRF1. Ref.1 Ref.7

Subcellular location

Nucleus. Note: Colocalizes with NRF1 By similarity. Ref.1

Tissue specificity

Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors. Ref.1 Ref.6

Induction

Up-regulated by serum (at protein level). Ref.7

Sequence similarities

Contains 1 RRM (RNA recognition motif) domain.

Sequence caution

The sequence AAH02561.2 differs from that shown. Reason: Frameshift at position 1643.

The sequence BAA25521.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandRNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay. Source: HPA

   Molecular_functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VV67-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VV67-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     121-147: DQNEVSLLTALTEILDNADSENLSPFD → MRHCWGPCRATWMPPLSPSLRILGALE
     1518-1519: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16641664Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
PRO_0000296666

Regions

Domain1543 – 161977RRM
Region433 – 46735Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivation
Region1379 – 145072Necessary for interaction with CREB1 and NRF1
Compositional bias772 – 1137366Pro-rich
Compositional bias1400 – 1543144Arg-rich
Compositional bias1411 – 1523113Ser-rich

Amino acid modifications

Modified residue5361Phosphoserine Ref.8
Modified residue14111Phosphoserine Ref.9
Modified residue14131Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 120120Missing in isoform 2.
VSP_027229
Alternative sequence121 – 14727DQNEV…LSPFD → MRHCWGPCRATWMPPLSPSL RILGALE in isoform 2.
VSP_027230
Alternative sequence1518 – 15192Missing in isoform 2.
VSP_027231
Natural variant5361S → G.
Corresponds to variant rs17114388 [ dbSNP | Ensembl ].
VAR_034633
Natural variant8341P → R. Ref.5
Corresponds to variant rs17855877 [ dbSNP | Ensembl ].
VAR_034634

Experimental info

Sequence conflict331G → R in AAK11573. Ref.1
Sequence conflict691L → Q in AAK11573. Ref.1
Sequence conflict1221Q → H in AAK11573. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 01D4138F80C620E8

FASTA1,664177,544
        10         20         30         40         50         60 
MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE QVLLHEEAGD 

        70         80         90        100        110        120 
SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA SLISLIEDFG SLGESRLSLE 

       130        140        150        160        170        180 
DQNEVSLLTA LTEILDNADS ENLSPFDSIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI 

       190        200        210        220        230        240 
TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP 

       250        260        270        280        290        300 
QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE 

       310        320        330        340        350        360 
SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE 

       370        380        390        400        410        420 
IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE 

       430        440        450        460        470        480 
KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR 

       490        500        510        520        530        540 
SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL 

       550        560        570        580        590        600 
ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV 

       610        620        630        640        650        660 
LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP 

       670        680        690        700        710        720 
SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK 

       730        740        750        760        770        780 
TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP 

       790        800        810        820        830        840 
SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA 

       850        860        870        880        890        900 
SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP 

       910        920        930        940        950        960 
SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS 

       970        980        990       1000       1010       1020 
VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG 

      1030       1040       1050       1060       1070       1080 
TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK 

      1090       1100       1110       1120       1130       1140 
ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL 

      1150       1160       1170       1180       1190       1200 
RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG 

      1210       1220       1230       1240       1250       1260 
NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK AKSPKSTAQE 

      1270       1280       1290       1300       1310       1320 
GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV RSRTPPKKMP ALVIPEVGSR 

      1330       1340       1350       1360       1370       1380 
WNVKRHQDIT IKPVLSLGPA APPPPCIAAS REPLDHRTSS EQADPSAPCL APSSLLSPEA 

      1390       1400       1410       1420       1430       1440 
SPCRNDMNTR TPPEPSAKQR SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA 

      1450       1460       1470       1480       1490       1500 
SSSSSSSSSS SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR 

      1510       1520       1530       1540       1550       1560 
SRSRSPSPRR RSDRRRRYSS YRSHDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK 

      1570       1580       1590       1600       1610       1620 
QRFSVFGEIE ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR 

      1630       1640       1650       1660 
QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR 

« Hide

Isoform 2 [UniParc].

Checksum: 9B120057AA1A0CA4
Show »

FASTA1,542164,965

References

« Hide 'large scale' references
[1]"Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells."
Andersson U., Scarpulla R.C.
Mol. Cell. Biol. 21:3738-3749(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH NRF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 998-1664 (ISOFORM 1), VARIANT ARG-834.
Tissue: Placenta and Uterus.
[6]"PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma."
Savagner F., Mirebeau D., Jacques C., Guyetant S., Morgan C., Franc B., Reynier P., Malthiery Y.
Biochem. Biophys. Res. Commun. 310:779-784(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."
Vercauteren K., Pasko R.A., Gleyzer N., Marino V.M., Scarpulla R.C.
Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CREB1 AND NRF1, INDUCTION.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1411 AND SER-1413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF325193 mRNA. Translation: AAK11573.1.
AB011167 mRNA. Translation: BAA25521.2. Different initiation.
AL500527 Genomic DNA. Translation: CAH72218.1.
AL500527 Genomic DNA. Translation: CAH72219.1.
BC002561 mRNA. Translation: AAH02561.2. Frameshift.
BC063806 mRNA. Translation: AAH63806.1.
BC063829 mRNA. Translation: AAH63829.1.
CCDSCCDS7529.1. [Q5VV67-1]
PIRT00273.
RefSeqNP_001275656.1. NM_001288727.1.
NP_001275657.1. NM_001288728.1. [Q5VV67-2]
NP_055877.3. NM_015062.4. [Q5VV67-1]
UniGeneHs.533551.

3D structure databases

ProteinModelPortalQ5VV67.
SMRQ5VV67. Positions 1543-1599.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116713. 4 interactions.
IntActQ5VV67. 2 interactions.
STRING9606.ENSP00000278070.

PTM databases

PhosphoSiteQ5VV67.

Polymorphism databases

DMDM74756889.

Proteomic databases

MaxQBQ5VV67.
PaxDbQ5VV67.
PRIDEQ5VV67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278070; ENSP00000278070; ENSG00000148840. [Q5VV67-1]
GeneID23082.
KEGGhsa:23082.
UCSCuc001kum.3. human. [Q5VV67-1]
uc001kun.3. human. [Q5VV67-2]

Organism-specific databases

CTD23082.
GeneCardsGC10P103882.
HGNCHGNC:30025. PPRC1.
HPAHPA038511.
neXtProtNX_Q5VV67.
PharmGKBPA134886297.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69689.
HOVERGENHBG103282.
InParanoidQ5VV67.
KOK17963.
OMAFCKRSYS.
OrthoDBEOG7S4X5H.
PhylomeDBQ5VV67.
TreeFamTF343068.

Enzyme and pathway databases

ReactomeREACT_200751. Organelle biogenesis and maintenance.

Gene expression databases

ArrayExpressQ5VV67.
BgeeQ5VV67.
CleanExHS_PPRC1.
GenevestigatorQ5VV67.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPPRC1.
GenomeRNAi23082.
NextBio44209.
PROQ5VV67.

Entry information

Entry namePPRC1_HUMAN
AccessionPrimary (citable) accession number: Q5VV67
Secondary accession number(s): Q5VV66 expand/collapse secondary AC list , Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5, Q9Y4E0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM