Q5VV67 (PPRC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Alternative name(s):
PGC-1-related coactivator
Short name=PRC

Gene names

Name:	PPRC1
Synonyms:	KIAA0595

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1664 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. Ref.1 Ref.7
Subunit structure	Interacts with CREB1 and NRF1. Ref.1 Ref.7
Subcellular location	Nucleus. Note: Colocalizes with NRF1 By similarity. Ref.1
Tissue specificity	Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors. Ref.1 Ref.6
Induction	Up-regulated by serum (at protein level). Ref.7
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.
Sequence caution	The sequence AAH02561.2 differs from that shown. Reason: Frameshift at position 1643. The sequence BAA25521.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VV67-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VV67-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     121-147: DQNEVSLLTALTEILDNADSENLSPFD → MRHCWGPCRATWMPPLSPSLRILGALE
     1518-1519: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1664	1664	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1		PRO_0000296666
Regions
	Domain	1543 – 1619	77	RRM
	Region	433 – 467	35	Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivation
	Region	1379 – 1450	72	Necessary for interaction with CREB1 and NRF1
	Compositional bias	772 – 1137	366	Pro-rich
	Compositional bias	1400 – 1543	144	Arg-rich
	Compositional bias	1411 – 1523	113	Ser-rich
Amino acid modifications
	Modified residue	536	1	Phosphoserine Ref.8
	Modified residue	1411	1	Phosphoserine Ref.9
	Modified residue	1413	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 120	120	Missing in isoform 2.		VSP_027229
	Alternative sequence	121 – 147	27	DQNEV…LSPFD → MRHCWGPCRATWMPPLSPSL RILGALE in isoform 2.		VSP_027230
	Alternative sequence	1518 – 1519	2	Missing in isoform 2.		VSP_027231
	Natural variant	536	1	S → G. Corresponds to variant rs17114388 [ dbSNP | Ensembl ].		VAR_034633
	Natural variant	834	1	P → R. Ref.5 Corresponds to variant rs17855877 [ dbSNP | Ensembl ].		VAR_034634
Experimental info
	Sequence conflict	33	1	G → R in AAK11573. Ref.1
	Sequence conflict	69	1	L → Q in AAK11573. Ref.1
	Sequence conflict	122	1	Q → H in AAK11573. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 01D4138F80C620E8	FASTA	1,664	177,544
	10 20 30 40 50 60 MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE QVLLHEEAGD 70 80 90 100 110 120 SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA SLISLIEDFG SLGESRLSLE 130 140 150 160 170 180 DQNEVSLLTA LTEILDNADS ENLSPFDSIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI 190 200 210 220 230 240 TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP 250 260 270 280 290 300 QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE 310 320 330 340 350 360 SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE 370 380 390 400 410 420 IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE 430 440 450 460 470 480 KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR 490 500 510 520 530 540 SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL 550 560 570 580 590 600 ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV 610 620 630 640 650 660 LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP 670 680 690 700 710 720 SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK 730 740 750 760 770 780 TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP 790 800 810 820 830 840 SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA 850 860 870 880 890 900 SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP 910 920 930 940 950 960 SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS 970 980 990 1000 1010 1020 VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG 1030 1040 1050 1060 1070 1080 TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK 1090 1100 1110 1120 1130 1140 ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL 1150 1160 1170 1180 1190 1200 RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG 1210 1220 1230 1240 1250 1260 NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK AKSPKSTAQE 1270 1280 1290 1300 1310 1320 GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV RSRTPPKKMP ALVIPEVGSR 1330 1340 1350 1360 1370 1380 WNVKRHQDIT IKPVLSLGPA APPPPCIAAS REPLDHRTSS EQADPSAPCL APSSLLSPEA 1390 1400 1410 1420 1430 1440 SPCRNDMNTR TPPEPSAKQR SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA 1450 1460 1470 1480 1490 1500 SSSSSSSSSS SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR 1510 1520 1530 1540 1550 1560 SRSRSPSPRR RSDRRRRYSS YRSHDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK 1570 1580 1590 1600 1610 1620 QRFSVFGEIE ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR 1630 1640 1650 1660 QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR
	Isoform 2 [UniParc]. Checksum: 9B120057AA1A0CA4	FASTA	1,542	164,965
	10 20 30 40 50 60 MRHCWGPCRA TWMPPLSPSL RILGALESIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI 70 80 90 100 110 120 TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP 130 140 150 160 170 180 QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE 190 200 210 220 230 240 SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE 250 260 270 280 290 300 IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE 310 320 330 340 350 360 KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR 370 380 390 400 410 420 SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL 430 440 450 460 470 480 ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV 490 500 510 520 530 540 LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP 550 560 570 580 590 600 SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK 610 620 630 640 650 660 TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP 670 680 690 700 710 720 SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA 730 740 750 760 770 780 SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP 790 800 810 820 830 840 SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS 850 860 870 880 890 900 VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG 910 920 930 940 950 960 TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK 970 980 990 1000 1010 1020 ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL 1030 1040 1050 1060 1070 1080 RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG 1090 1100 1110 1120 1130 1140 NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK AKSPKSTAQE 1150 1160 1170 1180 1190 1200 GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV RSRTPPKKMP ALVIPEVGSR 1210 1220 1230 1240 1250 1260 WNVKRHQDIT IKPVLSLGPA APPPPCIAAS REPLDHRTSS EQADPSAPCL APSSLLSPEA 1270 1280 1290 1300 1310 1320 SPCRNDMNTR TPPEPSAKQR SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA 1330 1340 1350 1360 1370 1380 SSSSSSSSSS SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR 1390 1400 1410 1420 1430 1440 SRSRSPSPRR RSDRRRRSYR SHDHYQRQRV LQKERAIEER RVVFIGKIPG RMTRSELKQR 1450 1460 1470 1480 1490 1500 FSVFGEIEEC TIHFRVQGDN YGFVTYRYAE EAFAAIESGH KLRQADEQPF DLCFGGRRQF 1510 1520 1530 1540 CKRSYSDLDS NREDFDPAPV KSKFDSLDFD TLLKQAQKNL RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells." Andersson U., Scarpulla R.C. Mol. Cell. Biol. 21:3738-3749(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH NRF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 998-1664 (ISOFORM 1), VARIANT ARG-834. Tissue: Placenta and Uterus.
[6]	"PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma." Savagner F., Mirebeau D., Jacques C., Guyetant S., Morgan C., Franc B., Reynier P., Malthiery Y. Biochem. Biophys. Res. Commun. 310:779-784(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth." Vercauteren K., Pasko R.A., Gleyzer N., Marino V.M., Scarpulla R.C. Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CREB1 AND NRF1, INDUCTION.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1411 AND SER-1413, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF325193 mRNA. Translation: AAK11573.1. AB011167 mRNA. Translation: BAA25521.2. Different initiation. AL500527 Genomic DNA. Translation: CAH72218.1. AL500527 Genomic DNA. Translation: CAH72219.1. BC002561 mRNA. Translation: AAH02561.2. Frameshift. BC063806 mRNA. Translation: AAH63806.1. BC063829 mRNA. Translation: AAH63829.1.
IPI	IPI00419509. IPI00854820.
PIR	T00273.
RefSeq	NP_055877.3. NM_015062.3.
UniGene	Hs.533551.
3D structure databases
ProteinModelPortal	Q5VV67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5VV67. 2 interactions.
STRING	9606.ENSP00000278070.
PTM databases
PhosphoSite	Q5VV67.
Polymorphism databases
DMDM	74756889.
Proteomic databases
PaxDb	Q5VV67.
PRIDE	Q5VV67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278070; ENSP00000278070; ENSG00000148840. ENST00000370012; ENSP00000359029; ENSG00000148840.
GeneID	23082.
KEGG	hsa:23082.
UCSC	uc001kum.3. human. uc001kun.3. human.
Organism-specific databases
CTD	23082.
GeneCards	GC10P103882.
HGNC	HGNC:30025. PPRC1.
HPA	HPA038511.
neXtProt	NX_Q5VV67.
PharmGKB	PA134886297.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG69689.
HOVERGEN	HBG103282.
InParanoid	Q5VV67.
OMA	GKWPSLP.
OrthoDB	EOG4FN4GZ.
PhylomeDB	Q5VV67.
Gene expression databases
ArrayExpress	Q5VV67.
Bgee	Q5VV67.
CleanEx	HS_PPRC1.
Genevestigator	Q5VV67.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Pfam	PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23082.
NextBio	44209.

Entry information

Entry name

PPRC1_HUMAN

Accession

Primary (citable) accession number: Q5VV67
Secondary accession number(s): Q5VV66 , Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5, Q9Y4E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.