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Q5VV67

- PPRC1_HUMAN

UniProt

Q5VV67 - PPRC1_HUMAN

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Protein
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Gene
PPRC1, KIAA0595
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.2 Publications

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_200608. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Alternative name(s):
PGC-1-related coactivator
Short name:
PRC
Gene namesi
Name:PPRC1
Synonyms:KIAA0595
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30025. PPRC1.

Subcellular locationi

Nucleus
Note: Colocalizes with NRF1 By similarity.1 Publication

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16641664Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
PRO_0000296666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei536 – 5361Phosphoserine1 Publication
Modified residuei1411 – 14111Phosphoserine1 Publication
Modified residuei1413 – 14131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5VV67.
PaxDbiQ5VV67.
PRIDEiQ5VV67.

PTM databases

PhosphoSiteiQ5VV67.

Expressioni

Tissue specificityi

Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.2 Publications

Inductioni

Up-regulated by serum (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ5VV67.
BgeeiQ5VV67.
CleanExiHS_PPRC1.
GenevestigatoriQ5VV67.

Organism-specific databases

HPAiHPA038511.

Interactioni

Subunit structurei

Interacts with CREB1 and NRF1.2 Publications

Protein-protein interaction databases

BioGridi116713. 4 interactions.
IntActiQ5VV67. 2 interactions.
STRINGi9606.ENSP00000278070.

Structurei

3D structure databases

ProteinModelPortaliQ5VV67.
SMRiQ5VV67. Positions 1543-1599.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1543 – 161977RRM
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni433 – 46735Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivation
Add
BLAST
Regioni1379 – 145072Necessary for interaction with CREB1 and NRF1
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi772 – 1137366Pro-rich
Add
BLAST
Compositional biasi1400 – 1543144Arg-rich
Add
BLAST
Compositional biasi1411 – 1523113Ser-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69689.
HOVERGENiHBG103282.
InParanoidiQ5VV67.
KOiK17963.
OMAiFCKRSYS.
OrthoDBiEOG7S4X5H.
PhylomeDBiQ5VV67.
TreeFamiTF343068.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VV67-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE     50
QVLLHEEAGD SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA 100
SLISLIEDFG SLGESRLSLE DQNEVSLLTA LTEILDNADS ENLSPFDSIP 150
DSELLVSPRE GSSLHKLLTL SRTPPERDLI TPVDPLGPST GSSRGSGVEM 200
SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP QQRSDGEEEE 250
EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE 300
SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG 350
QAATAGDDLE IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA 400
AVPKVTLCSE KEGLSLNSEE KLDSACLLKP REVVEPVVPK EPQNPPANAA 450
PGSQRARKGR KKKSKEQPAA CVEGYARRLR SSSRGQSTVG TEVTSQVDNL 500
QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL ERSAGQSSPA 550
KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV 600
LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS 650
DNLPPVDAVP SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS 700
ALGGSAPQLL VESESLDPPK TIIPEVKEVV DSLKIESGTS ATTHEARPRP 750
LSLSEYRRRR QQRQAETEER SPQPPTGKWP SLPETPTGLA DIPCLVIPPA 800
PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA SSPTEQVPSQ 850
EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP 900
SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP 950
GAYAVPPTCS VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP 1000
PLPPASIGRA VPQPKMESRG TPAGPPENVL PLSMAPPLSL GLPGHGAPQT 1050
EPTKVEVKPV PASPHPKHKV SALVQSPQMK ALACVSAEGV TVEEPASERL 1100
KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL RKLSFLPTPR 1150
TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG 1200
NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK 1250
AKSPKSTAQE GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV 1300
RSRTPPKKMP ALVIPEVGSR WNVKRHQDIT IKPVLSLGPA APPPPCIAAS 1350
REPLDHRTSS EQADPSAPCL APSSLLSPEA SPCRNDMNTR TPPEPSAKQR 1400
SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA SSSSSSSSSS 1450
SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR 1500
SRSRSPSPRR RSDRRRRYSS YRSHDHYQRQ RVLQKERAIE ERRVVFIGKI 1550
PGRMTRSELK QRFSVFGEIE ECTIHFRVQG DNYGFVTYRY AEEAFAAIES 1600
GHKLRQADEQ PFDLCFGGRR QFCKRSYSDL DSNREDFDPA PVKSKFDSLD 1650
FDTLLKQAQK NLRR 1664
Length:1,664
Mass (Da):177,544
Last modified:December 7, 2004 - v1
Checksum:i01D4138F80C620E8
GO
Isoform 2 (identifier: Q5VV67-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     121-147: DQNEVSLLTALTEILDNADSENLSPFD → MRHCWGPCRATWMPPLSPSLRILGALE
     1518-1519: Missing.

Show »
Length:1,542
Mass (Da):164,965
Checksum:i9B120057AA1A0CA4
GO

Sequence cautioni

The sequence AAH02561.2 differs from that shown. Reason: Frameshift at position 1643.
The sequence BAA25521.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti536 – 5361S → G.
Corresponds to variant rs17114388 [ dbSNP | Ensembl ].
VAR_034633
Natural varianti834 – 8341P → R.1 Publication
Corresponds to variant rs17855877 [ dbSNP | Ensembl ].
VAR_034634

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 2.
VSP_027229Add
BLAST
Alternative sequencei121 – 14727DQNEV…LSPFD → MRHCWGPCRATWMPPLSPSL RILGALE in isoform 2.
VSP_027230Add
BLAST
Alternative sequencei1518 – 15192Missing in isoform 2.
VSP_027231

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331G → R in AAK11573. 1 Publication
Sequence conflicti69 – 691L → Q in AAK11573. 1 Publication
Sequence conflicti122 – 1221Q → H in AAK11573. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325193 mRNA. Translation: AAK11573.1.
AB011167 mRNA. Translation: BAA25521.2. Different initiation.
AL500527 Genomic DNA. Translation: CAH72218.1.
AL500527 Genomic DNA. Translation: CAH72219.1.
BC002561 mRNA. Translation: AAH02561.2. Frameshift.
BC063806 mRNA. Translation: AAH63806.1.
BC063829 mRNA. Translation: AAH63829.1.
CCDSiCCDS7529.1. [Q5VV67-1]
PIRiT00273.
RefSeqiNP_001275656.1. NM_001288727.1.
NP_001275657.1. NM_001288728.1. [Q5VV67-2]
NP_055877.3. NM_015062.4. [Q5VV67-1]
UniGeneiHs.533551.

Genome annotation databases

EnsembliENST00000278070; ENSP00000278070; ENSG00000148840. [Q5VV67-1]
GeneIDi23082.
KEGGihsa:23082.
UCSCiuc001kum.3. human. [Q5VV67-1]
uc001kun.3. human. [Q5VV67-2]

Polymorphism databases

DMDMi74756889.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325193 mRNA. Translation: AAK11573.1 .
AB011167 mRNA. Translation: BAA25521.2 . Different initiation.
AL500527 Genomic DNA. Translation: CAH72218.1 .
AL500527 Genomic DNA. Translation: CAH72219.1 .
BC002561 mRNA. Translation: AAH02561.2 . Frameshift.
BC063806 mRNA. Translation: AAH63806.1 .
BC063829 mRNA. Translation: AAH63829.1 .
CCDSi CCDS7529.1. [Q5VV67-1 ]
PIRi T00273.
RefSeqi NP_001275656.1. NM_001288727.1.
NP_001275657.1. NM_001288728.1. [Q5VV67-2 ]
NP_055877.3. NM_015062.4. [Q5VV67-1 ]
UniGenei Hs.533551.

3D structure databases

ProteinModelPortali Q5VV67.
SMRi Q5VV67. Positions 1543-1599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116713. 4 interactions.
IntActi Q5VV67. 2 interactions.
STRINGi 9606.ENSP00000278070.

PTM databases

PhosphoSitei Q5VV67.

Polymorphism databases

DMDMi 74756889.

Proteomic databases

MaxQBi Q5VV67.
PaxDbi Q5VV67.
PRIDEi Q5VV67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278070 ; ENSP00000278070 ; ENSG00000148840 . [Q5VV67-1 ]
GeneIDi 23082.
KEGGi hsa:23082.
UCSCi uc001kum.3. human. [Q5VV67-1 ]
uc001kun.3. human. [Q5VV67-2 ]

Organism-specific databases

CTDi 23082.
GeneCardsi GC10P103882.
HGNCi HGNC:30025. PPRC1.
HPAi HPA038511.
neXtProti NX_Q5VV67.
PharmGKBi PA134886297.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69689.
HOVERGENi HBG103282.
InParanoidi Q5VV67.
KOi K17963.
OMAi FCKRSYS.
OrthoDBi EOG7S4X5H.
PhylomeDBi Q5VV67.
TreeFami TF343068.

Enzyme and pathway databases

Reactomei REACT_200608. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

GeneWikii PPRC1.
GenomeRNAii 23082.
NextBioi 44209.
PROi Q5VV67.

Gene expression databases

ArrayExpressi Q5VV67.
Bgeei Q5VV67.
CleanExi HS_PPRC1.
Genevestigatori Q5VV67.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells."
    Andersson U., Scarpulla R.C.
    Mol. Cell. Biol. 21:3738-3749(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH NRF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 998-1664 (ISOFORM 1), VARIANT ARG-834.
    Tissue: Placenta and Uterus.
  6. Cited for: TISSUE SPECIFICITY.
  7. "PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."
    Vercauteren K., Pasko R.A., Gleyzer N., Marino V.M., Scarpulla R.C.
    Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CREB1 AND NRF1, INDUCTION.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1411 AND SER-1413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPRC1_HUMAN
AccessioniPrimary (citable) accession number: Q5VV67
Secondary accession number(s): Q5VV66
, Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5, Q9Y4E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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