Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Attractin-like protein 1

Gene

ATRNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in melanocortin signaling pathways that regulate energy homeostasis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Attractin-like protein 1
Gene namesi
Name:ATRNL1
Synonyms:KIAA0534
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29063. ATRNL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini53 – 1230ExtracellularSequence analysisAdd BLAST1178
Transmembranei1231 – 1251HelicalSequence analysisAdd BLAST21
Topological domaini1252 – 1379CytoplasmicSequence analysisAdd BLAST128

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26033.
OpenTargetsiENSG00000107518.
PharmGKBiPA134961599.

Polymorphism and mutation databases

BioMutaiATRNL1.
DMDMi189081675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 52Sequence analysisAdd BLAST52
ChainiPRO_000033465053 – 1379Attractin-like protein 1Add BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 79By similarity
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi81 ↔ 90By similarity
Disulfide bondi93 ↔ 119By similarity
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi211 ↔ 221By similarity
Disulfide bondi215 ↔ 233By similarity
Disulfide bondi235 ↔ 244By similarity
Glycosylationi380N-linked (GlcNAc...)Sequence analysis1
Glycosylationi763N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi776 ↔ 872By similarity
Glycosylationi778N-linked (GlcNAc...)Sequence analysis1
Glycosylationi898N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1014 ↔ 1022By similarity
Disulfide bondi1016 ↔ 1028By similarity
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1043 ↔ 1057By similarity
Disulfide bondi1060 ↔ 1069By similarity
Disulfide bondi1062 ↔ 1076By similarity
Disulfide bondi1078 ↔ 1088By similarity
Disulfide bondi1091 ↔ 1106By similarity
Glycosylationi1157N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5VV63.
PeptideAtlasiQ5VV63.
PRIDEiQ5VV63.

PTM databases

iPTMnetiQ5VV63.
PhosphoSitePlusiQ5VV63.

Expressioni

Gene expression databases

BgeeiENSG00000107518.
CleanExiHS_ATRNL1.
ExpressionAtlasiQ5VV63. baseline and differential.
GenevisibleiQ5VV63. HS.

Organism-specific databases

HPAiHPA038070.

Interactioni

Subunit structurei

Interacts with MC4R.By similarity

Protein-protein interaction databases

BioGridi117499. 1 interactor.
IntActiQ5VV63. 1 interactor.
STRINGi9606.ENSP00000347152.

Structurei

3D structure databases

ProteinModelPortaliQ5VV63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini93 – 209CUBPROSITE-ProRule annotationAdd BLAST117
Domaini207 – 245EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Repeati316 – 365Kelch 1Add BLAST50
Repeati367 – 415Kelch 2Add BLAST49
Repeati427 – 475Kelch 3Add BLAST49
Repeati480 – 531Kelch 4Add BLAST52
Repeati533 – 591Kelch 5Add BLAST59
Repeati592 – 638Kelch 6Add BLAST47
Domaini614 – 657PSI 1Add BLAST44
Domaini666 – 709PSI 2Add BLAST44
Domaini715 – 760PSI 3Add BLAST46
Domaini755 – 873C-type lectinPROSITE-ProRule annotationAdd BLAST119
Domaini889 – 939PSI 4Add BLAST51
Domaini942 – 1012PSI 5Add BLAST71
Domaini1014 – 1059Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1060 – 1108Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated
Contains 2 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 5 PSI domains.Curated

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOVERGENiHBG004312.
InParanoidiQ5VV63.
OMAiLRTSCSN.
OrthoDBiEOG091G03A0.
PhylomeDBiQ5VV63.
TreeFamiTF321873.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF07974. EGF_2. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 2 hits.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VV63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METGGRARTG TPQPAAPGVW RARPAGGGGG GASSWLLDGN SWLLCYGFLY
60 70 80 90 100
LALYAQVSQS KPCERTGSCF SGRCVNSTCL CDPGWVGDQC QHCQGRFKLT
110 120 130 140 150
EPSGYLTDGP INYKYKTKCT WLIEGYPNAV LRLRFNHFAT ECSWDHMYVY
160 170 180 190 200
DGDSIYAPLI AVLSGLIVPE IRGNETVPEV VTTSGYALLH FFSDAAYNLT
210 220 230 240 250
GFNIFYSINS CPNNCSGHGK CTTSVSVPSQ VYCECDKYWK GEACDIPYCK
260 270 280 290 300
ANCGSPDHGY CDLTGEKLCV CNDSWQGPDC SLNVPSTESY WILPNVKPFS
310 320 330 340 350
PSVGRASHKA VLHGKFMWVI GGYTFNYSSF QMVLNYNLES SIWNVGTPSR
360 370 380 390 400
GPLQRYGHSL ALYQENIFMY GGRIETNDGN VTDELWVFNI HSQSWSTKTP
410 420 430 440 450
TVLGHGQQYA VEGHSAHIME LDSRDVVMII IFGYSAIYGY TSSIQEYHIS
460 470 480 490 500
SNTWLVPETK GAIVQGGYGH TSVYDEITKS IYVHGGYKAL PGNKYGLVDD
510 520 530 540 550
LYKYEVNTKT WTILKESGFA RYLHSAVLIN GAMLIFGGNT HNDTSLSNGA
560 570 580 590 600
KCFSADFLAY DIACDEWKIL PKPNLHRDVN RFGHSAVVIN GSMYIFGGFS
610 620 630 640 650
SVLLNDILVY KPPNCKAFRD EELCKNAGPG IKCVWNKNHC ESWESGNTNN
660 670 680 690 700
ILRAKCPPKT AASDDRCYRY ADCASCTANT NGCQWCDDKK CISANSNCSM
710 720 730 740 750
SVKNYTKCHV RNEQICNKLT SCKSCSLNLN CQWDQRQQEC QALPAHLCGE
760 770 780 790 800
GWSHIGDACL RVNSSRENYD NAKLYCYNLS GNLASLTTSK EVEFVLDEIQ
810 820 830 840 850
KYTQQKVSPW VGLRKINISY WGWEDMSPFT NTTLQWLPGE PNDSGFCAYL
860 870 880 890 900
ERAAVAGLKA NPCTSMANGL VCEKPVVSPN QNARPCKKPC SLRTSCSNCT
910 920 930 940 950
SNGMECMWCS STKRCVDSNA YIISFPYGQC LEWQTATCSP QNCSGLRTCG
960 970 980 990 1000
QCLEQPGCGW CNDPSNTGRG HCIEGSSRGP MKLIGMHHSE MVLDTNLCPK
1010 1020 1030 1040 1050
EKNYEWSFIQ CPACQCNGHS TCINNNVCEQ CKNLTTGKQC QDCMPGYYGD
1060 1070 1080 1090 1100
PTNGGQCTAC TCSGHANICH LHTGKCFCTT KGIKGDQCQL CDSENRYVGN
1110 1120 1130 1140 1150
PLRGTCYYSL LIDYQFTFSL LQEDDRHHTA INFIANPEQS NKNLDISINA
1160 1170 1180 1190 1200
SNNFNLNITW SVGSTAGTIS GEETSIVSKN NIKEYRDSFS YEKFNFRSNP
1210 1220 1230 1240 1250
NITFYVYVSN FSWPIKIQIA FSQHNTIMDL VQFFVTFFSC FLSLLLVAAV
1260 1270 1280 1290 1300
VWKIKQTCWA SRRREQLLRE RQQMASRPFA SVDVALEVGA EQTEFLRGPL
1310 1320 1330 1340 1350
EGAPKPIAIE PCAGNRAAVL TVFLCLPRGS SGAPPPGQSG LAIASALIDI
1360 1370
SQQKASDSKD KTSGVRNRKH LSTRQGTCV
Length:1,379
Mass (Da):152,639
Last modified:February 20, 2007 - v2
Checksum:i67904F946FAF6028
GO
Isoform 2 (identifier: Q5VV63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-467: SSNTWLVPETKGAIVQGG → CELLKNCNFFIDWECFSL
     468-1379: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):51,867
Checksum:iC66273EDFFEC1E01
GO

Sequence cautioni

The sequence BAC86914 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI13482 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40416 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40793 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043446989S → N.2 PublicationsCorresponds to variant rs1953758dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033718450 – 467SSNTW…IVQGG → CELLKNCNFFIDWECFSL in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_033719468 – 1379Missing in isoform 2. 1 PublicationAdd BLAST912

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY442317 mRNA. Translation: AAR14297.1.
AL357059
, AC022542, AC091667, AL355530, AL356100, AL392087, AL512304 Genomic DNA. Translation: CAH70625.2.
AL512304
, AC022542, AC091667, AL355530, AL356100, AL357059, AL392087 Genomic DNA. Translation: CAH74015.2.
AL355530
, AC022542, AC091667, AL356100, AL357059, AL392087, AL512304 Genomic DNA. Translation: CAI13483.2.
AL356100
, AC022542, AC091667, AL355530, AL357059, AL392087, AL512304 Genomic DNA. Translation: CAI40417.2.
AL392087
, AC022542, AC091667, AL355530, AL356100, AL357059, AL512304 Genomic DNA. Translation: CAI40794.2.
AL355530 Genomic DNA. Translation: CAI13482.1. Sequence problems.
AL356100, AL392087 Genomic DNA. Translation: CAI40416.1. Sequence problems.
AL392087, AL356100 Genomic DNA. Translation: CAI40793.1. Sequence problems.
BC047716 mRNA. Translation: AAH47716.1.
BC139916 mRNA. Translation: AAI39917.1.
BC139923 mRNA. Translation: AAI39924.1.
AK127277 mRNA. Translation: BAC86914.1. Different initiation.
AB011106 mRNA. Translation: BAA25460.2.
CCDSiCCDS73204.1. [Q5VV63-2]
CCDS7592.1. [Q5VV63-1]
PIRiT00266.
RefSeqiNP_001263211.1. NM_001276282.3. [Q5VV63-2]
NP_997186.1. NM_207303.4. [Q5VV63-1]
UniGeneiHs.501127.

Genome annotation databases

EnsembliENST00000355044; ENSP00000347152; ENSG00000107518. [Q5VV63-1]
ENST00000609571; ENSP00000476902; ENSG00000107518. [Q5VV63-2]
GeneIDi26033.
KEGGihsa:26033.
UCSCiuc001lcg.4. human. [Q5VV63-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY442317 mRNA. Translation: AAR14297.1.
AL357059
, AC022542, AC091667, AL355530, AL356100, AL392087, AL512304 Genomic DNA. Translation: CAH70625.2.
AL512304
, AC022542, AC091667, AL355530, AL356100, AL357059, AL392087 Genomic DNA. Translation: CAH74015.2.
AL355530
, AC022542, AC091667, AL356100, AL357059, AL392087, AL512304 Genomic DNA. Translation: CAI13483.2.
AL356100
, AC022542, AC091667, AL355530, AL357059, AL392087, AL512304 Genomic DNA. Translation: CAI40417.2.
AL392087
, AC022542, AC091667, AL355530, AL356100, AL357059, AL512304 Genomic DNA. Translation: CAI40794.2.
AL355530 Genomic DNA. Translation: CAI13482.1. Sequence problems.
AL356100, AL392087 Genomic DNA. Translation: CAI40416.1. Sequence problems.
AL392087, AL356100 Genomic DNA. Translation: CAI40793.1. Sequence problems.
BC047716 mRNA. Translation: AAH47716.1.
BC139916 mRNA. Translation: AAI39917.1.
BC139923 mRNA. Translation: AAI39924.1.
AK127277 mRNA. Translation: BAC86914.1. Different initiation.
AB011106 mRNA. Translation: BAA25460.2.
CCDSiCCDS73204.1. [Q5VV63-2]
CCDS7592.1. [Q5VV63-1]
PIRiT00266.
RefSeqiNP_001263211.1. NM_001276282.3. [Q5VV63-2]
NP_997186.1. NM_207303.4. [Q5VV63-1]
UniGeneiHs.501127.

3D structure databases

ProteinModelPortaliQ5VV63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117499. 1 interactor.
IntActiQ5VV63. 1 interactor.
STRINGi9606.ENSP00000347152.

PTM databases

iPTMnetiQ5VV63.
PhosphoSitePlusiQ5VV63.

Polymorphism and mutation databases

BioMutaiATRNL1.
DMDMi189081675.

Proteomic databases

PaxDbiQ5VV63.
PeptideAtlasiQ5VV63.
PRIDEiQ5VV63.

Protocols and materials databases

DNASUi26033.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355044; ENSP00000347152; ENSG00000107518. [Q5VV63-1]
ENST00000609571; ENSP00000476902; ENSG00000107518. [Q5VV63-2]
GeneIDi26033.
KEGGihsa:26033.
UCSCiuc001lcg.4. human. [Q5VV63-1]

Organism-specific databases

CTDi26033.
DisGeNETi26033.
GeneCardsiATRNL1.
H-InvDBHIX0021959.
HGNCiHGNC:29063. ATRNL1.
HPAiHPA038070.
MIMi612869. gene.
neXtProtiNX_Q5VV63.
OpenTargetsiENSG00000107518.
PharmGKBiPA134961599.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOVERGENiHBG004312.
InParanoidiQ5VV63.
OMAiLRTSCSN.
OrthoDBiEOG091G03A0.
PhylomeDBiQ5VV63.
TreeFamiTF321873.

Miscellaneous databases

ChiTaRSiATRNL1. human.
GenomeRNAii26033.
PROiQ5VV63.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107518.
CleanExiHS_ATRNL1.
ExpressionAtlasiQ5VV63. baseline and differential.
GenevisibleiQ5VV63. HS.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF07974. EGF_2. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 2 hits.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATRN1_HUMAN
AccessioniPrimary (citable) accession number: Q5VV63
Secondary accession number(s): O60283
, Q5JSE8, Q5T5Y9, Q6T256, Q6ZSN4, Q86WX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.