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Protein

Zinc finger protein 691

Gene

ZNF691

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri115 – 13723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30018C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 691
Gene namesi
Name:ZNF691
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28028. ZNF691.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670490.

Polymorphism and mutation databases

BioMutaiZNF691.
DMDMi74756884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Zinc finger protein 691PRO_0000234012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineCombined sources
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources
Cross-linki113 – 113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VV52.
MaxQBiQ5VV52.
PaxDbiQ5VV52.
PeptideAtlasiQ5VV52.
PRIDEiQ5VV52.

PTM databases

iPTMnetiQ5VV52.
PhosphoSiteiQ5VV52.

Expressioni

Gene expression databases

BgeeiQ5VV52.
CleanExiHS_ZNF691.
ExpressionAtlasiQ5VV52. baseline and differential.
GenevisibleiQ5VV52. HS.

Organism-specific databases

HPAiHPA062527.

Interactioni

Protein-protein interaction databases

BioGridi119250. 2 interactions.
IntActiQ5VV52. 2 interactions.
MINTiMINT-1410794.
STRINGi9606.ENSP00000380237.

Structurei

3D structure databases

ProteinModelPortaliQ5VV52.
SMRiQ5VV52. Positions 79-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri115 – 13723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 27723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri283 – 30018C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129916.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5VV52.
OMAiTHLGEQA.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5VV52.
TreeFamiTF337637.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VV52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLCSPTHSA EMSLFLQGPE EMLPLSSEGS EMGSEKEQSP EPHLPEEGEG
60 70 80 90 100
GKPWRVDDSE GSWIPPGEKE HGQESLSDEL QETHPKKPWQ KVTVRARELG
110 120 130 140 150
DPIAHPRHEA DEKPFICAQC GKTFNNTSNL RTHQRIHTGE KPYKCSECGK
160 170 180 190 200
SFSRSSNRIR HERIHLEEKH YKCPKCQESF RRRSDLTTHQ QDHLGKRPYR
210 220 230 240 250
CDICGKSFSQ SATLAVHHRT HLEPAPYICC ECGKSFSNSS SFGVHHRTHT
260 270 280 290 300
GERPYECTEC GRTFSDISNF GAHQRTHRGE KPYRCTVCGK HFSRSSNLKP
310
FIPLWRMVLY SL
Length:312
Mass (Da):35,681
Last modified:December 7, 2004 - v1
Checksum:iA6B25C97DE62B59A
GO
Isoform 2 (identifier: Q5VV52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     299-312: KPFIPLWRMVLYSL → IRHQKTHLGEQAGKDSS

Show »
Length:284
Mass (Da):32,502
Checksum:iB688F8502AECD1D5
GO
Isoform 3 (identifier: Q5VV52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-312: KPFIPLWRMVLYSL → IRHQKTHLGEQAGKDSS

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):35,810
Checksum:i5EDA193FDA237383
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941V → A in BAA91434 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. 3 PublicationsVSP_018183Add
BLAST
Alternative sequencei299 – 31214KPFIP…VLYSL → IRHQKTHLGEQAGKDSS in isoform 2 and isoform 3. 4 PublicationsVSP_018184Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131739 mRNA. Translation: AAD20028.1.
AK000938 mRNA. Translation: BAA91434.1.
AK296201 mRNA. Translation: BAG58929.1.
CR457146 mRNA. Translation: CAG33427.1.
AL512353 Genomic DNA. Translation: CAH72717.1.
AL512353 Genomic DNA. Translation: CAH72720.1.
CH471059 Genomic DNA. Translation: EAX07127.1.
CH471059 Genomic DNA. Translation: EAX07128.1.
BC000157 mRNA. Translation: AAH00157.1.
CCDSiCCDS476.1. [Q5VV52-2]
CCDS55595.1. [Q5VV52-3]
RefSeqiNP_001229668.1. NM_001242739.1. [Q5VV52-3]
NP_056995.1. NM_015911.3. [Q5VV52-2]
XP_011539838.1. XM_011541536.1. [Q5VV52-3]
UniGeneiHs.20879.
Hs.745530.

Genome annotation databases

EnsembliENST00000372502; ENSP00000361580; ENSG00000164011. [Q5VV52-3]
ENST00000372506; ENSP00000361584; ENSG00000164011. [Q5VV52-2]
ENST00000372507; ENSP00000361585; ENSG00000164011. [Q5VV52-2]
ENST00000372508; ENSP00000361586; ENSG00000164011. [Q5VV52-2]
GeneIDi51058.
KEGGihsa:51058.
UCSCiuc001cig.4. human. [Q5VV52-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131739 mRNA. Translation: AAD20028.1.
AK000938 mRNA. Translation: BAA91434.1.
AK296201 mRNA. Translation: BAG58929.1.
CR457146 mRNA. Translation: CAG33427.1.
AL512353 Genomic DNA. Translation: CAH72717.1.
AL512353 Genomic DNA. Translation: CAH72720.1.
CH471059 Genomic DNA. Translation: EAX07127.1.
CH471059 Genomic DNA. Translation: EAX07128.1.
BC000157 mRNA. Translation: AAH00157.1.
CCDSiCCDS476.1. [Q5VV52-2]
CCDS55595.1. [Q5VV52-3]
RefSeqiNP_001229668.1. NM_001242739.1. [Q5VV52-3]
NP_056995.1. NM_015911.3. [Q5VV52-2]
XP_011539838.1. XM_011541536.1. [Q5VV52-3]
UniGeneiHs.20879.
Hs.745530.

3D structure databases

ProteinModelPortaliQ5VV52.
SMRiQ5VV52. Positions 79-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119250. 2 interactions.
IntActiQ5VV52. 2 interactions.
MINTiMINT-1410794.
STRINGi9606.ENSP00000380237.

PTM databases

iPTMnetiQ5VV52.
PhosphoSiteiQ5VV52.

Polymorphism and mutation databases

BioMutaiZNF691.
DMDMi74756884.

Proteomic databases

EPDiQ5VV52.
MaxQBiQ5VV52.
PaxDbiQ5VV52.
PeptideAtlasiQ5VV52.
PRIDEiQ5VV52.

Protocols and materials databases

DNASUi51058.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372502; ENSP00000361580; ENSG00000164011. [Q5VV52-3]
ENST00000372506; ENSP00000361584; ENSG00000164011. [Q5VV52-2]
ENST00000372507; ENSP00000361585; ENSG00000164011. [Q5VV52-2]
ENST00000372508; ENSP00000361586; ENSG00000164011. [Q5VV52-2]
GeneIDi51058.
KEGGihsa:51058.
UCSCiuc001cig.4. human. [Q5VV52-1]

Organism-specific databases

CTDi51058.
GeneCardsiZNF691.
HGNCiHGNC:28028. ZNF691.
HPAiHPA062527.
neXtProtiNX_Q5VV52.
PharmGKBiPA142670490.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129916.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5VV52.
OMAiTHLGEQA.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5VV52.
TreeFamiTF337637.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF691. human.
GenomeRNAii51058.
PROiQ5VV52.

Gene expression databases

BgeeiQ5VV52.
CleanExiHS_ZNF691.
ExpressionAtlasiQ5VV52. baseline and differential.
GenevisibleiQ5VV52. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Embryo and Thalamus.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cervix.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-75 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  10. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN691_HUMAN
AccessioniPrimary (citable) accession number: Q5VV52
Secondary accession number(s): A8MXP6
, B4DJR7, O95878, Q9NWE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.