##gff-version 3 Q5VV43 UniProtKB Signal peptide 1 20 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Chain 21 1072 . . . ID=PRO_0000042946;Note=Dyslexia-associated protein KIAA0319 Q5VV43 UniProtKB Topological domain 21 955 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Transmembrane 956 976 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Topological domain 977 1072 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Domain 21 99 . . . Note=MANSC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00341 Q5VV43 UniProtKB Domain 341 427 . . . Note=PKD 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00151 Q5VV43 UniProtKB Domain 435 524 . . . Note=PKD 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00151 Q5VV43 UniProtKB Domain 530 620 . . . Note=PKD 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00151 Q5VV43 UniProtKB Domain 621 714 . . . Note=PKD 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00151 Q5VV43 UniProtKB Domain 720 811 . . . Note=PKD 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00151 Q5VV43 UniProtKB Region 168 277 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5VV43 UniProtKB Region 295 327 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5VV43 UniProtKB Region 1045 1072 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5VV43 UniProtKB Motif 995 998 . . . Note=Endocytosis signal Q5VV43 UniProtKB Compositional bias 247 269 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5VV43 UniProtKB Glycosylation 196 196 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 219 219 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 262 262 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 394 394 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 421 421 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 498 498 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 513 513 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 536 536 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 551 551 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Glycosylation 733 733 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5VV43 UniProtKB Alternative sequence 1 45 . . . ID=VSP_036234;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q5VV43 UniProtKB Alternative sequence 1 19 . . . ID=VSP_036235;Note=In isoform 2. MAPPTGVLSSLLLLVTIAG->MTRLGWPSPC;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q5VV43 UniProtKB Alternative sequence 953 1013 . . . ID=VSP_044971;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5VV43 UniProtKB Natural variant 142 142 . . . ID=VAR_023837;Note=T->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9205841;Dbxref=dbSNP:rs4576240,PMID:14702039,PMID:15489334,PMID:9205841 Q5VV43 UniProtKB Natural variant 311 311 . . . ID=VAR_023838;Note=Risk factor for DYX2. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:15717286;Dbxref=dbSNP:rs4504469,PMID:14702039,PMID:15489334,PMID:15717286 Q5VV43 UniProtKB Natural variant 567 567 . . . ID=VAR_049505;Note=G->S;Dbxref=dbSNP:rs2744559 Q5VV43 UniProtKB Natural variant 773 773 . . . ID=VAR_049506;Note=S->G;Dbxref=dbSNP:rs2744550 Q5VV43 UniProtKB Natural variant 774 774 . . . ID=VAR_049507;Note=V->A;Dbxref=dbSNP:rs2817191 Q5VV43 UniProtKB Natural variant 919 919 . . . ID=VAR_034032;Note=G->A;Dbxref=dbSNP:rs10946705 Q5VV43 UniProtKB Natural variant 1013 1013 . . . ID=VAR_049508;Note=Y->C;Dbxref=dbSNP:rs807534 Q5VV43 UniProtKB Mutagenesis 995 995 . . . Note=Loss of interaction with AP2M1 and impaired endocytosis. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19419997;Dbxref=PMID:19419997 Q5VV43 UniProtKB Sequence conflict 97 97 . . . Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5VV43 UniProtKB Sequence conflict 157 157 . . . Note=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5VV43 UniProtKB Sequence conflict 256 256 . . . Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5VV43 UniProtKB Sequence conflict 926 926 . . . Note=L->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5VV43 UniProtKB Beta strand 336 338 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 343 346 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 352 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 357 360 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 374 376 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 389 395 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 400 405 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 408 411 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 414 417 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M Q5VV43 UniProtKB Beta strand 420 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2E7M