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Protein

Threonylcarbamoyladenosine tRNA methylthiotransferase

Gene

CDKAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t6A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) at position 37 in tRNAs that read codons beginning with adenine.1 Publication

Catalytic activityi

N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor.1 Publication

Cofactori

[4Fe-4S] clusterPROSITE-ProRule annotationNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
Metal bindingi109 – 1091Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
Metal bindingi138 – 1381Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
Metal bindingi214 – 2141Iron-sulfur (4Fe-4S-S-AdoMet)PROSITE-ProRule annotation
Metal bindingi218 – 2181Iron-sulfur (4Fe-4S-S-AdoMet)PROSITE-ProRule annotation
Metal bindingi221 – 2211Iron-sulfur (4Fe-4S-S-AdoMet)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonylcarbamoyladenosine tRNA methylthiotransferase (EC:2.8.4.51 Publication)
Alternative name(s):
CDK5 regulatory subunit-associated protein 1-like 1
tRNA-t(6)A37 methylthiotransferase
Gene namesi
Name:CDKAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21050. CDKAL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei556 – 57823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

MalaCardsiCDKAL1.
MIMi125853. phenotype.
PharmGKBiPA134871999.

Polymorphism and mutation databases

BioMutaiCDKAL1.
DMDMi74747199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Threonylcarbamoyladenosine tRNA methylthiotransferasePRO_0000298670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei499 – 4991PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5VV42.
MaxQBiQ5VV42.
PaxDbiQ5VV42.
PeptideAtlasiQ5VV42.
PRIDEiQ5VV42.

PTM databases

iPTMnetiQ5VV42.
PhosphoSiteiQ5VV42.
SwissPalmiQ5VV42.

Expressioni

Tissue specificityi

Expressed in pancreatic islets.1 Publication

Gene expression databases

BgeeiQ5VV42.
CleanExiHS_CDKAL1.
GenevisibleiQ5VV42. HS.

Organism-specific databases

HPAiHPA014374.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LCKP062393EBI-10194801,EBI-1348

Protein-protein interaction databases

BioGridi120247. 21 interactions.
IntActiQ5VV42. 9 interactions.
STRINGi9606.ENSP00000274695.

Structurei

3D structure databases

ProteinModelPortaliQ5VV42.
SMRiQ5VV42. Positions 65-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 172109MTTase N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini431 – 49363TRAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MTTase N-terminal domain.PROSITE-ProRule annotation
Contains 1 TRAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4355. Eukaryota.
COG0621. LUCA.
GeneTreeiENSGT00530000063447.
HOGENOMiHOG000224768.
HOVERGENiHBG097712.
InParanoidiQ5VV42.
KOiK15865.
OMAiDLFYSYE.
OrthoDBiEOG7SFHWS.
PhylomeDBiQ5VV42.
TreeFamiTF317476.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006466. MiaB-like_B.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01578. MiaB-like-B. 1 hit.
TIGR00089. TIGR00089. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VV42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSASCDTLL DDIEDIVSQE DSKPQDRHFV RKDVVPKVRR RNTQKYLQEE
60 70 80 90 100
ENSPPSDSTI PGIQKIWIRT WGCSHNNSDG EYMAGQLAAY GYKITENASD
110 120 130 140 150
ADLWLLNSCT VKNPAEDHFR NSIKKAQEEN KKIVLAGCVP QAQPRQDYLK
160 170 180 190 200
GLSIIGVQQI DRVVEVVEET IKGHSVRLLG QKKDNGRRLG GARLDLPKIR
210 220 230 240 250
KNPLIEIISI NTGCLNACTY CKTKHARGNL ASYPIDELVD RAKQSFQEGV
260 270 280 290 300
CEIWLTSEDT GAYGRDIGTN LPTLLWKLVE VIPEGAMLRL GMTNPPYILE
310 320 330 340 350
HLEEMAKILN HPRVYAFLHI PVQSASDSVL MEMKREYCVA DFKRVVDFLK
360 370 380 390 400
EKVPGITIAT DIICGFPGET DQDFQETVKL VEEYKFPSLF INQFYPRPGT
410 420 430 440 450
PAAKMEQVPA QVKKQRTKDL SRVFHSYSPY DHKIGERQQV LVTEESFDSK
460 470 480 490 500
FYVAHNQFYE QVLVPKNPAF MGKMVEVDIY ESGKHFMKGQ PVSDAKVYTP
510 520 530 540 550
SISKPLAKGE VSGLTKDFRN GLGNQLSSGS HTSAASQCDS ASSRMVLPMP
560 570
RLHQDCALRM SVGLALLGLL FAFFVKVYN
Length:579
Mass (Da):65,111
Last modified:December 7, 2004 - v1
Checksum:i90818A8A0A19FD1C
GO
Isoform 2 (identifier: Q5VV42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MPSASCDTLL...GQLAAYGYKI → MLSRRYEGEIPKNICKRKKTVHQV
     413-433: Missing.

Show »
Length:488
Mass (Da):54,667
Checksum:i8671593E9CE5F149
GO
Isoform 3 (identifier: Q5VV42-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-97: EN → GE
     98-579: Missing.

Show »
Length:97
Mass (Da):11,043
Checksum:i1558DE995C15E75F
GO

Sequence cautioni

The sequence BAC87494.1 differs from that shown. Reason: Frameshift at position 575. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111N → S in BAA91102 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti484 – 4841K → R.
Corresponds to variant rs9460608 [ dbSNP | Ensembl ].
VAR_052705

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494MPSAS…YGYKI → MLSRRYEGEIPKNICKRKKT VHQV in isoform 2. 1 PublicationVSP_027450Add
BLAST
Alternative sequencei96 – 972EN → GE in isoform 3. 1 PublicationVSP_027451
Alternative sequencei98 – 579482Missing in isoform 3. 1 PublicationVSP_027452Add
BLAST
Alternative sequencei413 – 43321Missing in isoform 2. 1 PublicationVSP_027453Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000349 mRNA. Translation: BAA91102.1.
AK128546 mRNA. Translation: BAC87494.1. Frameshift.
AK291735 mRNA. Translation: BAF84424.1.
AL513188
, AL022717, AL033521, AL035090, AL451080, AL512405, AL513015, AL513549 Genomic DNA. Translation: CAH72467.1.
AL451080
, AL022717, AL033521, AL035090, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAH72474.1.
AL512405
, AL022717, AL033521, AL035090, AL451080, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAH73074.1.
AL513549
, AL022717, AL033521, AL035090, AL451080, AL512405, AL513015, AL513188 Genomic DNA. Translation: CAH73706.1.
AL022717
, AL033521, AL035090, AL451080, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAI19768.1.
AL035090
, AL022717, AL033521, AL451080, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAI20280.1.
AL033521
, AL022717, AL035090, AL451080, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAI21023.1.
AL513015
, AL022717, AL033521, AL035090, AL451080, AL512405, AL513188, AL513549 Genomic DNA. Translation: CAI21687.1.
CH471087 Genomic DNA. Translation: EAW55426.1.
BC064145 mRNA. Translation: AAH64145.1.
BC121020 mRNA. Translation: AAI21021.1.
BC121021 mRNA. Translation: AAI21022.1.
CCDSiCCDS4546.1. [Q5VV42-1]
RefSeqiNP_060244.2. NM_017774.3. [Q5VV42-1]
UniGeneiHs.657604.
Hs.672504.

Genome annotation databases

EnsembliENST00000274695; ENSP00000274695; ENSG00000145996. [Q5VV42-1]
ENST00000378610; ENSP00000367873; ENSG00000145996. [Q5VV42-1]
ENST00000613575; ENSP00000481755; ENSG00000145996. [Q5VV42-3]
GeneIDi54901.
KEGGihsa:54901.
UCSCiuc003ndb.2. human. [Q5VV42-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000349 mRNA. Translation: BAA91102.1.
AK128546 mRNA. Translation: BAC87494.1. Frameshift.
AK291735 mRNA. Translation: BAF84424.1.
AL513188
, AL022717, AL033521, AL035090, AL451080, AL512405, AL513015, AL513549 Genomic DNA. Translation: CAH72467.1.
AL451080
, AL022717, AL033521, AL035090, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAH72474.1.
AL512405
, AL022717, AL033521, AL035090, AL451080, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAH73074.1.
AL513549
, AL022717, AL033521, AL035090, AL451080, AL512405, AL513015, AL513188 Genomic DNA. Translation: CAH73706.1.
AL022717
, AL033521, AL035090, AL451080, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAI19768.1.
AL035090
, AL022717, AL033521, AL451080, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAI20280.1.
AL033521
, AL022717, AL035090, AL451080, AL512405, AL513015, AL513188, AL513549 Genomic DNA. Translation: CAI21023.1.
AL513015
, AL022717, AL033521, AL035090, AL451080, AL512405, AL513188, AL513549 Genomic DNA. Translation: CAI21687.1.
CH471087 Genomic DNA. Translation: EAW55426.1.
BC064145 mRNA. Translation: AAH64145.1.
BC121020 mRNA. Translation: AAI21021.1.
BC121021 mRNA. Translation: AAI21022.1.
CCDSiCCDS4546.1. [Q5VV42-1]
RefSeqiNP_060244.2. NM_017774.3. [Q5VV42-1]
UniGeneiHs.657604.
Hs.672504.

3D structure databases

ProteinModelPortaliQ5VV42.
SMRiQ5VV42. Positions 65-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120247. 21 interactions.
IntActiQ5VV42. 9 interactions.
STRINGi9606.ENSP00000274695.

PTM databases

iPTMnetiQ5VV42.
PhosphoSiteiQ5VV42.
SwissPalmiQ5VV42.

Polymorphism and mutation databases

BioMutaiCDKAL1.
DMDMi74747199.

Proteomic databases

EPDiQ5VV42.
MaxQBiQ5VV42.
PaxDbiQ5VV42.
PeptideAtlasiQ5VV42.
PRIDEiQ5VV42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274695; ENSP00000274695; ENSG00000145996. [Q5VV42-1]
ENST00000378610; ENSP00000367873; ENSG00000145996. [Q5VV42-1]
ENST00000613575; ENSP00000481755; ENSG00000145996. [Q5VV42-3]
GeneIDi54901.
KEGGihsa:54901.
UCSCiuc003ndb.2. human. [Q5VV42-1]

Organism-specific databases

CTDi54901.
GeneCardsiCDKAL1.
HGNCiHGNC:21050. CDKAL1.
HPAiHPA014374.
MalaCardsiCDKAL1.
MIMi125853. phenotype.
611259. gene.
neXtProtiNX_Q5VV42.
PharmGKBiPA134871999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4355. Eukaryota.
COG0621. LUCA.
GeneTreeiENSGT00530000063447.
HOGENOMiHOG000224768.
HOVERGENiHBG097712.
InParanoidiQ5VV42.
KOiK15865.
OMAiDLFYSYE.
OrthoDBiEOG7SFHWS.
PhylomeDBiQ5VV42.
TreeFamiTF317476.

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Miscellaneous databases

ChiTaRSiCDKAL1. human.
GeneWikiiCDKAL1.
GenomeRNAii54901.
NextBioi57928.
PROiQ5VV42.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VV42.
CleanExiHS_CDKAL1.
GenevisibleiQ5VV42. HS.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006466. MiaB-like_B.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01578. MiaB-like-B. 1 hit.
TIGR00089. TIGR00089. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Trachea.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  5. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM.
  6. "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels."
    Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., Roix J.J., Kathiresan S., Hirschhorn J.N., Daly M.J., Hughes T.E., Groop L., Altshuler D., Almgren P., Florez J.C., Meyer J., Ardlie K., Bengtsson Bostrom K.
    , Isomaa B., Lettre G., Lindblad U., Lyon H.N., Melander O., Newton-Cheh C., Nilsson P., Orho-Melander M., Rastam L., Speliotes E.K., Taskinen M.R., Tuomi T., Guiducci C., Berglund A., Carlson J., Gianniny L., Hackett R., Hall L., Holmkvist J., Laurila E., Sjogren M., Sterner M., Surti A., Svensson M., Svensson M., Tewhey R., Blumenstiel B., Parkin M., Defelice M., Barry R., Brodeur W., Camarata J., Chia N., Fava M., Gibbons J., Handsaker B., Healy C., Nguyen K., Gates C., Sougnez C., Gage D., Nizzari M., Gabriel S.B., Chirn G.W., Ma Q., Parikh H., Richardson D., Ricke D., Purcell S.
    Science 316:1331-1336(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA."
    Arragain S., Handelman S.K., Forouhar F., Wei F.Y., Tomizawa K., Hunt J.F., Douki T., Fontecave M., Mulliez E., Atta M.
    J. Biol. Chem. 285:28425-28433(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells."
    Brambillasca S., Altkrueger A., Colombo S., Friedrich A., Eickelmann P., Mark M., Borgese N., Solimena M.
    J. Biol. Chem. 287:41808-41819(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCDKAL_HUMAN
AccessioniPrimary (citable) accession number: Q5VV42
Secondary accession number(s): A8K6S0
, Q6P385, Q6ZR27, Q9NXB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: April 13, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.