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Q5VV41

- ARHGG_HUMAN

UniProt

Q5VV41 - ARHGG_HUMAN

Protein

Rho guanine nucleotide exchange factor 16

Gene

ARHGEF16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.1 Publication

    GO - Molecular functioni

    1. PDZ domain binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. receptor tyrosine kinase binding Source: UniProtKB
    4. Rho GTPase binding Source: UniProtKB
    5. Rho guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. activation of Cdc42 GTPase activity Source: BHF-UCL
    2. activation of Rac GTPase activity Source: UniProtKB
    3. apoptotic signaling pathway Source: Reactome
    4. cell chemotaxis Source: UniProtKB
    5. neurotrophin TRK receptor signaling pathway Source: Reactome
    6. positive regulation of apoptotic process Source: Reactome
    7. positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
    8. regulation of small GTPase mediated signal transduction Source: Reactome
    9. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 16
    Alternative name(s):
    Ephexin-4
    Gene namesi
    Name:ARHGEF16
    Synonyms:EPHEXIN4, NBR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15515. ARHGEF16.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24971.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 709708Rho guanine nucleotide exchange factor 16PRO_0000233690Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei6 – 61Phosphoserine1 Publication
    Modified residuei41 – 411Phosphoserine2 Publications
    Modified residuei107 – 1071Phosphoserine4 Publications
    Modified residuei174 – 1741Phosphoserine1 Publication
    Modified residuei191 – 1911Phosphoserine1 Publication
    Modified residuei208 – 2081Phosphoserine2 Publications
    Modified residuei227 – 2271Phosphoserine1 Publication
    Modified residuei230 – 2301Phosphoserine2 Publications
    Modified residuei240 – 2401Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ5VV41.
    PaxDbiQ5VV41.
    PRIDEiQ5VV41.

    PTM databases

    PhosphoSiteiQ5VV41.

    Expressioni

    Inductioni

    Up-regulated by HPV16 E6 (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ5VV41.
    BgeeiQ5VV41.
    CleanExiHS_ARHGEF16.
    GenevestigatoriQ5VV41.

    Organism-specific databases

    HPAiHPA010609.

    Interactioni

    Subunit structurei

    Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain). May interact with CDC42; stimulated by HPV16 E6.2 Publications

    Protein-protein interaction databases

    BioGridi118085. 3 interactions.
    IntActiQ5VV41. 2 interactions.
    MINTiMINT-3295714.
    STRINGi9606.ENSP00000367629.

    Structurei

    Secondary structure

    1
    709
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi633 – 6386
    Beta strandi644 – 6474
    Beta strandi654 – 6629
    Beta strandi665 – 6706
    Turni671 – 6733
    Beta strandi676 – 6794
    Helixi681 – 6833
    Beta strandi685 – 6873

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X6BNMR-A622-687[»]
    ProteinModelPortaliQ5VV41.
    SMRiQ5VV41. Positions 276-618, 628-688.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5VV41.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini284 – 468185DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini501 – 620120PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini629 – 68961SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni275 – 481207Required for RHOG activation and mediates interaction with EPHA2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi707 – 7093PDZ-binding motif

    Domaini

    The PDZ-binding motif mediates interaction with TAX1BP3.

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5422.
    HOGENOMiHOG000007536.
    HOVERGENiHBG059167.
    InParanoidiQ5VV41.
    OMAiQTEHHHL.
    OrthoDBiEOG73NG2P.
    PhylomeDBiQ5VV41.
    TreeFamiTF316357.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VV41-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQRHSDSSL EEKLLGHRFH SELRLDAGGN PASGLPMVRG SPRVRDDAAF    50
    QPQVPAPPQP RPPGHEEPWP IVLSTESPAA LKLGTQQLIP KSLAVASKAK 100
    TPARHQSFGA AVLSREAARR DPKLLPAPSF SLDDMDVDKD PGGMLRRNLR 150
    NQSYRAAMKG LGKPGGQGDA IQLSPKLQAL AEEPSQPHTR SPAKNKKTLG 200
    RKRGHKGSFK DDPQLYQEIQ ERGLNTSQES DDDILDESSS PEGTQKVDAT 250
    IVVKSYRPAQ VTWSQLPEVV ELGILDQLST EERKRQEAMF EILTSEFSYQ 300
    HSLSILVEEF LQSKELRATV TQMEHHHLFS NILDVLGASQ RFFEDLEQRH 350
    KAQVLVEDIS DILEEHAEKH FHPYIAYCSN EVYQQRTLQK LISSNAAFRE 400
    ALREIERRPA CGGLPMLSFL ILPMQRVTRL PLLMDTLCLK TQGHSERYKA 450
    ASRALKAISK LVRQCNEGAH RMERMEQMYT LHTQLDFSKV KSLPLISASR 500
    WLLKRGELFL VEETGLFRKI ASRPTCYLFL FNDVLVVTKK KSEESYMVQD 550
    YAQMNHIQVE KIEPSELPLP GGGNRSSSVP HPFQVTLLRN SEGRQEQLLL 600
    SSDSASDRAR WIVALTHSER QWQGLSSKGD LPQVEITKAF FAKQADEVTL 650
    QQADVVLVLQ QEDGWLYGER LRDGETGWFP EDFARFITSR VAVEGNVRRM 700
    ERLRVETDV 709
    Length:709
    Mass (Da):80,105
    Last modified:December 7, 2004 - v1
    Checksum:i9672AB3C92311BEB
    GO
    Isoform 2 (identifier: Q5VV41-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-288: Missing.

    Show »
    Length:421
    Mass (Da):48,629
    Checksum:i7A75C46922C40EA4
    GO

    Sequence cautioni

    The sequence AAH02681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti157 – 1582AM → RG in AAH02681. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti137 – 1371V → M.
    Corresponds to variant rs3806164 [ dbSNP | Ensembl ].
    VAR_059796
    Natural varianti370 – 3701H → Y.3 Publications
    Corresponds to variant rs2185639 [ dbSNP | Ensembl ].
    VAR_059797
    Natural varianti681 – 6811E → K.
    Corresponds to variant rs56309807 [ dbSNP | Ensembl ].
    VAR_061796

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 288288Missing in isoform 2. 3 PublicationsVSP_018149Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89016 mRNA. Translation: BAA13745.1.
    BT007270 mRNA. Translation: AAP35934.1.
    AL512413 Genomic DNA. Translation: CAH70832.1.
    AL512413 Genomic DNA. Translation: CAH70833.1.
    BC002681 mRNA. Translation: AAH02681.1. Different initiation.
    BC051838 mRNA. Translation: AAH51838.1.
    CCDSiCCDS46.2. [Q5VV41-1]
    RefSeqiNP_055263.2. NM_014448.3. [Q5VV41-1]
    XP_006710641.1. XM_006710578.1. [Q5VV41-1]
    UniGeneiHs.87435.

    Genome annotation databases

    EnsembliENST00000378371; ENSP00000367622; ENSG00000130762. [Q5VV41-2]
    ENST00000378373; ENSP00000367624; ENSG00000130762. [Q5VV41-2]
    ENST00000378378; ENSP00000367629; ENSG00000130762. [Q5VV41-1]
    GeneIDi27237.
    KEGGihsa:27237.
    UCSCiuc001akg.4. human. [Q5VV41-1]

    Polymorphism databases

    DMDMi74747198.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89016 mRNA. Translation: BAA13745.1 .
    BT007270 mRNA. Translation: AAP35934.1 .
    AL512413 Genomic DNA. Translation: CAH70832.1 .
    AL512413 Genomic DNA. Translation: CAH70833.1 .
    BC002681 mRNA. Translation: AAH02681.1 . Different initiation.
    BC051838 mRNA. Translation: AAH51838.1 .
    CCDSi CCDS46.2. [Q5VV41-1 ]
    RefSeqi NP_055263.2. NM_014448.3. [Q5VV41-1 ]
    XP_006710641.1. XM_006710578.1. [Q5VV41-1 ]
    UniGenei Hs.87435.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X6B NMR - A 622-687 [» ]
    ProteinModelPortali Q5VV41.
    SMRi Q5VV41. Positions 276-618, 628-688.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118085. 3 interactions.
    IntActi Q5VV41. 2 interactions.
    MINTi MINT-3295714.
    STRINGi 9606.ENSP00000367629.

    PTM databases

    PhosphoSitei Q5VV41.

    Polymorphism databases

    DMDMi 74747198.

    Proteomic databases

    MaxQBi Q5VV41.
    PaxDbi Q5VV41.
    PRIDEi Q5VV41.

    Protocols and materials databases

    DNASUi 27237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378371 ; ENSP00000367622 ; ENSG00000130762 . [Q5VV41-2 ]
    ENST00000378373 ; ENSP00000367624 ; ENSG00000130762 . [Q5VV41-2 ]
    ENST00000378378 ; ENSP00000367629 ; ENSG00000130762 . [Q5VV41-1 ]
    GeneIDi 27237.
    KEGGi hsa:27237.
    UCSCi uc001akg.4. human. [Q5VV41-1 ]

    Organism-specific databases

    CTDi 27237.
    GeneCardsi GC01P003394.
    HGNCi HGNC:15515. ARHGEF16.
    HPAi HPA010609.
    neXtProti NX_Q5VV41.
    PharmGKBi PA24971.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5422.
    HOGENOMi HOG000007536.
    HOVERGENi HBG059167.
    InParanoidi Q5VV41.
    OMAi QTEHHHL.
    OrthoDBi EOG73NG2P.
    PhylomeDBi Q5VV41.
    TreeFami TF316357.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Miscellaneous databases

    ChiTaRSi ARHGEF16. human.
    EvolutionaryTracei Q5VV41.
    GenomeRNAii 27237.
    NextBioi 50111.
    PROi Q5VV41.

    Gene expression databases

    ArrayExpressi Q5VV41.
    Bgeei Q5VV41.
    CleanExi HS_ARHGEF16.
    Genevestigatori Q5VV41.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a candidate gene for human neuroblastoma mapped to 1p36.3, NBR: a new member of the Rho/Rac GEF family."
      Sasaki S., Takei Y., Ito M., Nakagawara A., Fujiwara T., Takahashi E., Muto T., Tokino T., Nakamura Y.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT TYR-370.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT TYR-370.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-709, VARIANT TYR-370.
      Tissue: PNS.
    5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-107; SER-208; SER-227; SER-230 AND SER-240, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism."
      Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H.
      J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ELMO2; EPHA2; RAC1 AND RHOG.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-107; SER-174 AND SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42."
      Oliver A.W., He X., Borthwick K., Donne A.J., Hampson L., Hampson I.N.
      Br. J. Cancer 104:324-331(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDC42 AND TAX1BP3, INDUCTION BY HPV16 E6.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; SER-107; SER-208 AND SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. "Solution structures of the SH3 domain of human rho guanine exchange factor (GEF) 16."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: STRUCTURE BY NMR OF 622-687.

    Entry informationi

    Entry nameiARHGG_HUMAN
    AccessioniPrimary (citable) accession number: Q5VV41
    Secondary accession number(s): Q86TF0, Q99434
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3