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Q5VV17

- OTUD1_HUMAN

UniProt

Q5VV17 - OTUD1_HUMAN

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Protein

OTU domain-containing protein 1

Gene
OTUD1, DUBA7, OTDC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei317 – 3171 By similarity
Active sitei320 – 3201Nucleophile By similarity
Active sitei431 – 4311 By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K63-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.004.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 1 (EC:3.4.19.12)
Alternative name(s):
DUBA-7
Gene namesi
Name:OTUD1
Synonyms:DUBA7, OTDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:27346. OTUD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481OTU domain-containing protein 1PRO_0000271018Add
BLAST

Proteomic databases

PaxDbiQ5VV17.
PRIDEiQ5VV17.

PTM databases

PhosphoSiteiQ5VV17.

Expressioni

Gene expression databases

BgeeiQ5VV17.
CleanExiHS_OTUD1.
GenevestigatoriQ5VV17.

Organism-specific databases

HPAiHPA038504.

Interactioni

Protein-protein interaction databases

BioGridi128638. 7 interactions.
IntActiQ5VV17. 10 interactions.
STRINGi9606.ENSP00000365678.

Structurei

Secondary structure

1
481
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi290 – 30617
Beta strandi310 – 3123
Helixi320 – 33011
Helixi333 – 3353
Helixi336 – 34914
Helixi351 – 3544
Helixi355 – 3573
Helixi362 – 3698
Helixi378 – 38811
Beta strandi391 – 3999
Beta strandi402 – 4109
Beta strandi412 – 4143
Beta strandi421 – 4277
Turni428 – 4303
Beta strandi431 – 4366

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BOPX-ray2.10A/B287-437[»]
ProteinModelPortaliQ5VV17.
SMRiQ5VV17. Positions 288-437.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 438130OTUAdd
BLAST
Repeati457 – 47620UIMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni314 – 3207Cys-loop
Regioni369 – 37911His-loopAdd
BLAST
Regioni426 – 4316Variable-loop

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 155143Ala-richAdd
BLAST

Domaini

The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin (1 Publication).
Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops) (1 Publication).

Sequence similaritiesi

Contains 1 OTU domain.

Phylogenomic databases

eggNOGiNOG327202.
HOGENOMiHOG000115304.
HOVERGENiHBG080487.
InParanoidiQ5VV17.
KOiK13716.
OMAiNFRLSEH.
OrthoDBiEOG7TBC35.
PhylomeDBiQ5VV17.
TreeFamiTF338508.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VV17-1 [UniParc]FASTAAdd to Basket

« Hide

MQLYSSVCTH YPAGAPGPTA AAPAPPAAAT PFKVSLQPPG AAGAAPEPET    50
GECQPAAAAE HREAAAVPAA KMPAFSSCFE VVSGAAAPAS AAAGPPGASC 100
KPPLPPHYTS TAQITVRALG ADRLLLHGPD PVPGAAGSAA APRGRCLLLA 150
PAPAAPVPPR RGSSAWLLEE LLRPDCPEPA GLDATREGPD RNFRLSEHRQ 200
ALAAAKHRGP AATPGSPDPG PGPWGEEHLA ERGPRGWERG GDRCDAPGGD 250
AARRPDPEAE APPAGSIEAA PSSAAEPVIV SRSDPRDEKL ALYLAEVEKQ 300
DKYLRQRNKY RFHIIPDGNC LYRAVSKTVY GDQSLHRELR EQTVHYIADH 350
LDHFSPLIEG DVGEFIIAAA QDGAWAGYPE LLAMGQMLNV NIHLTTGGRL 400
ESPTVSTMIH YLGPEDSLRP SIWLSWLSNG HYDAVFDHSY PNPEYDNWCK 450
QTQVQRKRDE ELAKSMAISL SKMYIEQNAC S 481
Length:481
Mass (Da):51,063
Last modified:December 7, 2004 - v1
Checksum:i37B3AEB0B3851982
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL512603 Genomic DNA. Translation: CAH73715.1.
CCDSiCCDS44366.1.
RefSeqiNP_001138845.1. NM_001145373.2.
UniGeneiHs.499042.

Genome annotation databases

EnsembliENST00000376495; ENSP00000365678; ENSG00000165312.
GeneIDi220213.
KEGGihsa:220213.
UCSCiuc001irr.2. human.

Polymorphism databases

DMDMi74747188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL512603 Genomic DNA. Translation: CAH73715.1 .
CCDSi CCDS44366.1.
RefSeqi NP_001138845.1. NM_001145373.2.
UniGenei Hs.499042.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BOP X-ray 2.10 A/B 287-437 [» ]
ProteinModelPortali Q5VV17.
SMRi Q5VV17. Positions 288-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128638. 7 interactions.
IntActi Q5VV17. 10 interactions.
STRINGi 9606.ENSP00000365678.

Protein family/group databases

MEROPSi C85.004.

PTM databases

PhosphoSitei Q5VV17.

Polymorphism databases

DMDMi 74747188.

Proteomic databases

PaxDbi Q5VV17.
PRIDEi Q5VV17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376495 ; ENSP00000365678 ; ENSG00000165312 .
GeneIDi 220213.
KEGGi hsa:220213.
UCSCi uc001irr.2. human.

Organism-specific databases

CTDi 220213.
GeneCardsi GC10P023768.
HGNCi HGNC:27346. OTUD1.
HPAi HPA038504.
MIMi 612022. gene.
neXtProti NX_Q5VV17.
PharmGKBi PA134932304.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327202.
HOGENOMi HOG000115304.
HOVERGENi HBG080487.
InParanoidi Q5VV17.
KOi K13716.
OMAi NFRLSEH.
OrthoDBi EOG7TBC35.
PhylomeDBi Q5VV17.
TreeFami TF338508.

Miscellaneous databases

GenomeRNAii 220213.
NextBioi 91030.
PROi Q5VV17.
SOURCEi Search...

Gene expression databases

Bgeei Q5VV17.
CleanExi HS_OTUD1.
Genevestigatori Q5VV17.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
    Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
    Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 287-437, FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiOTUD1_HUMAN
AccessioniPrimary (citable) accession number: Q5VV17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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