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Protein

OTU domain-containing protein 1

Gene

OTUD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei317By similarity1
Active sitei320NucleophileBy similarity1
Active sitei431By similarity1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  • protein K63-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.004.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 1 (EC:3.4.19.12)
Alternative name(s):
DUBA-7
Gene namesi
Name:OTUD1
Synonyms:DUBA7, OTDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:27346. OTUD1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi220213.
OpenTargetsiENSG00000165312.
PharmGKBiPA134932304.

Polymorphism and mutation databases

BioMutaiOTUD1.
DMDMi74747188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710181 – 481OTU domain-containing protein 1Add BLAST481

Proteomic databases

EPDiQ5VV17.
MaxQBiQ5VV17.
PaxDbiQ5VV17.
PeptideAtlasiQ5VV17.
PRIDEiQ5VV17.

PTM databases

iPTMnetiQ5VV17.
PhosphoSitePlusiQ5VV17.

Expressioni

Gene expression databases

BgeeiENSG00000165312.
CleanExiHS_OTUD1.
GenevisibleiQ5VV17. HS.

Organism-specific databases

HPAiHPA038504.

Interactioni

Protein-protein interaction databases

BioGridi128638. 9 interactors.
IntActiQ5VV17. 11 interactors.
STRINGi9606.ENSP00000365678.

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi290 – 306Combined sources17
Beta strandi310 – 312Combined sources3
Helixi320 – 330Combined sources11
Helixi333 – 335Combined sources3
Helixi336 – 349Combined sources14
Helixi351 – 354Combined sources4
Helixi355 – 357Combined sources3
Helixi362 – 369Combined sources8
Helixi378 – 388Combined sources11
Beta strandi391 – 399Combined sources9
Beta strandi402 – 410Combined sources9
Beta strandi412 – 414Combined sources3
Beta strandi421 – 427Combined sources7
Turni428 – 430Combined sources3
Beta strandi431 – 436Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BOPX-ray2.10A/B287-437[»]
ProteinModelPortaliQ5VV17.
SMRiQ5VV17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 438OTUPROSITE-ProRule annotationAdd BLAST130
Domaini457 – 476UIMCuratedAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni314 – 320Cys-loop7
Regioni369 – 379His-loopAdd BLAST11
Regioni426 – 431Variable-loop6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 155Ala-richAdd BLAST143

Domaini

The UIM repeat increases the specificity and efficiency of the enzyme toward 'Lys-63'-linked polyubiquitin.1 Publication
Specificity is not given by the S1' ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).1 Publication

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410INQC. Eukaryota.
ENOG4111V2X. LUCA.
GeneTreeiENSGT00510000049635.
HOGENOMiHOG000115304.
HOVERGENiHBG080487.
InParanoidiQ5VV17.
KOiK13716.
OMAiPHYTSTA.
OrthoDBiEOG091G05T1.
PhylomeDBiQ5VV17.
TreeFamiTF338508.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VV17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYSSVCTH YPAGAPGPTA AAPAPPAAAT PFKVSLQPPG AAGAAPEPET
60 70 80 90 100
GECQPAAAAE HREAAAVPAA KMPAFSSCFE VVSGAAAPAS AAAGPPGASC
110 120 130 140 150
KPPLPPHYTS TAQITVRALG ADRLLLHGPD PVPGAAGSAA APRGRCLLLA
160 170 180 190 200
PAPAAPVPPR RGSSAWLLEE LLRPDCPEPA GLDATREGPD RNFRLSEHRQ
210 220 230 240 250
ALAAAKHRGP AATPGSPDPG PGPWGEEHLA ERGPRGWERG GDRCDAPGGD
260 270 280 290 300
AARRPDPEAE APPAGSIEAA PSSAAEPVIV SRSDPRDEKL ALYLAEVEKQ
310 320 330 340 350
DKYLRQRNKY RFHIIPDGNC LYRAVSKTVY GDQSLHRELR EQTVHYIADH
360 370 380 390 400
LDHFSPLIEG DVGEFIIAAA QDGAWAGYPE LLAMGQMLNV NIHLTTGGRL
410 420 430 440 450
ESPTVSTMIH YLGPEDSLRP SIWLSWLSNG HYDAVFDHSY PNPEYDNWCK
460 470 480
QTQVQRKRDE ELAKSMAISL SKMYIEQNAC S
Length:481
Mass (Da):51,063
Last modified:December 7, 2004 - v1
Checksum:i37B3AEB0B3851982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512603 Genomic DNA. Translation: CAH73715.1.
CCDSiCCDS44366.1.
RefSeqiNP_001138845.1. NM_001145373.2.
UniGeneiHs.499042.

Genome annotation databases

EnsembliENST00000376495; ENSP00000365678; ENSG00000165312.
GeneIDi220213.
KEGGihsa:220213.
UCSCiuc001irr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512603 Genomic DNA. Translation: CAH73715.1.
CCDSiCCDS44366.1.
RefSeqiNP_001138845.1. NM_001145373.2.
UniGeneiHs.499042.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BOPX-ray2.10A/B287-437[»]
ProteinModelPortaliQ5VV17.
SMRiQ5VV17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128638. 9 interactors.
IntActiQ5VV17. 11 interactors.
STRINGi9606.ENSP00000365678.

Protein family/group databases

MEROPSiC85.004.

PTM databases

iPTMnetiQ5VV17.
PhosphoSitePlusiQ5VV17.

Polymorphism and mutation databases

BioMutaiOTUD1.
DMDMi74747188.

Proteomic databases

EPDiQ5VV17.
MaxQBiQ5VV17.
PaxDbiQ5VV17.
PeptideAtlasiQ5VV17.
PRIDEiQ5VV17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376495; ENSP00000365678; ENSG00000165312.
GeneIDi220213.
KEGGihsa:220213.
UCSCiuc001irr.3. human.

Organism-specific databases

CTDi220213.
DisGeNETi220213.
GeneCardsiOTUD1.
HGNCiHGNC:27346. OTUD1.
HPAiHPA038504.
MIMi612022. gene.
neXtProtiNX_Q5VV17.
OpenTargetsiENSG00000165312.
PharmGKBiPA134932304.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INQC. Eukaryota.
ENOG4111V2X. LUCA.
GeneTreeiENSGT00510000049635.
HOGENOMiHOG000115304.
HOVERGENiHBG080487.
InParanoidiQ5VV17.
KOiK13716.
OMAiPHYTSTA.
OrthoDBiEOG091G05T1.
PhylomeDBiQ5VV17.
TreeFamiTF338508.

Miscellaneous databases

GenomeRNAii220213.
PROiQ5VV17.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165312.
CleanExiHS_OTUD1.
GenevisibleiQ5VV17. HS.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTUD1_HUMAN
AccessioniPrimary (citable) accession number: Q5VV17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.