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Q5VV16

- FX4L5_HUMAN

UniProt

Q5VV16 - FX4L5_HUMAN

Protein

Forkhead box protein D4-like 5

Gene

FOXD4L5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi108 – 20295Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein D4-like 5
    Short name:
    FOXD4-like 5
    Gene namesi
    Name:FOXD4L5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18522. FOXD4L5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Forkhead box protein D4-like 5PRO_0000301978Add
    BLAST

    Proteomic databases

    PRIDEiQ5VV16.

    Expressioni

    Gene expression databases

    CleanExiHS_FOXD4L5.
    GenevestigatoriQ5VV16.

    Organism-specific databases

    HPAiHPA012836.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366637.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VV16.
    SMRiQ5VV16. Positions 108-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi211 – 26757Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000231285.
    HOVERGENiHBG051641.
    InParanoidiQ5VV16.
    OMAiNTAPGRC.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ5VV16.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5VV16-1 [UniParc]FASTAAdd to Basket

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    MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF    50
    LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS 100
    EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP 150
    AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR 200
    RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY 250
    PNTAPGRCPY ALLHPHPLRY LLLSAPVYAG APKKAEGADL ATPAPFPCCS 300
    PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG 350
    ATATCSSDHQ ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP 400
    PRARCWAGTC RPRRRC 416
    Length:416
    Mass (Da):45,780
    Last modified:December 7, 2004 - v1
    Checksum:i24607F2BF39393F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL512605 Genomic DNA. Translation: CAH70699.1.
    CCDSiCCDS47977.1.
    RefSeqiNP_001119806.1. NM_001126334.1.
    UniGeneiHs.714683.

    Genome annotation databases

    EnsembliENST00000377420; ENSP00000366637; ENSG00000204779.
    GeneIDi653427.
    KEGGihsa:653427.
    UCSCiuc010moc.3. human.

    Polymorphism databases

    DMDMi74747187.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL512605 Genomic DNA. Translation: CAH70699.1 .
    CCDSi CCDS47977.1.
    RefSeqi NP_001119806.1. NM_001126334.1.
    UniGenei Hs.714683.

    3D structure databases

    ProteinModelPortali Q5VV16.
    SMRi Q5VV16. Positions 108-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366637.

    Polymorphism databases

    DMDMi 74747187.

    Proteomic databases

    PRIDEi Q5VV16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377420 ; ENSP00000366637 ; ENSG00000204779 .
    GeneIDi 653427.
    KEGGi hsa:653427.
    UCSCi uc010moc.3. human.

    Organism-specific databases

    CTDi 653427.
    GeneCardsi GC09M070175.
    HGNCi HGNC:18522. FOXD4L5.
    HPAi HPA012836.
    neXtProti NX_Q5VV16.
    PharmGKBi PA162388804.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000231285.
    HOVERGENi HBG051641.
    InParanoidi Q5VV16.
    OMAi NTAPGRC.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q5VV16.
    TreeFami TF316127.

    Miscellaneous databases

    GenomeRNAii 653427.
    NextBioi 123231.
    PROi Q5VV16.

    Gene expression databases

    CleanExi HS_FOXD4L5.
    Genevestigatori Q5VV16.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFX4L5_HUMAN
    AccessioniPrimary (citable) accession number: Q5VV16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3