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Q5VV16

- FX4L5_HUMAN

UniProt

Q5VV16 - FX4L5_HUMAN

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Protein
Forkhead box protein D4-like 5
Gene
FOXD4L5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 20295Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. axon extension involved in axon guidance Source: RefGenome
  2. branching involved in ureteric bud morphogenesis Source: RefGenome
  3. cartilage development Source: RefGenome
  4. enteric nervous system development Source: RefGenome
  5. iridophore differentiation Source: RefGenome
  6. kidney development Source: RefGenome
  7. lateral line nerve glial cell development Source: RefGenome
  8. melanocyte differentiation Source: RefGenome
  9. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  10. neural crest cell migration Source: RefGenome
  11. pattern specification process Source: RefGenome
  12. peripheral nervous system development Source: RefGenome
  13. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  14. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  15. sympathetic nervous system development Source: RefGenome
  16. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 5
Short name:
FOXD4-like 5
Gene namesi
Name:FOXD4L5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18522. FOXD4L5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Forkhead box protein D4-like 5
PRO_0000301978Add
BLAST

Proteomic databases

PRIDEiQ5VV16.

Expressioni

Gene expression databases

CleanExiHS_FOXD4L5.
GenevestigatoriQ5VV16.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366637.

Structurei

3D structure databases

ProteinModelPortaliQ5VV16.
SMRiQ5VV16. Positions 108-203.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 26757Pro-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ5VV16.
OMAiNTAPGRC.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ5VV16.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VV16-1 [UniParc]FASTAAdd to Basket

« Hide

MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF    50
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS 100
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP 150
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR 200
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY 250
PNTAPGRCPY ALLHPHPLRY LLLSAPVYAG APKKAEGADL ATPAPFPCCS 300
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG 350
ATATCSSDHQ ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP 400
PRARCWAGTC RPRRRC 416
Length:416
Mass (Da):45,780
Last modified:December 7, 2004 - v1
Checksum:i24607F2BF39393F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL512605 Genomic DNA. Translation: CAH70699.1.
CCDSiCCDS47977.1.
RefSeqiNP_001119806.1. NM_001126334.1.
UniGeneiHs.714683.

Genome annotation databases

EnsembliENST00000377420; ENSP00000366637; ENSG00000204779.
GeneIDi653427.
KEGGihsa:653427.
UCSCiuc010moc.3. human.

Polymorphism databases

DMDMi74747187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL512605 Genomic DNA. Translation: CAH70699.1 .
CCDSi CCDS47977.1.
RefSeqi NP_001119806.1. NM_001126334.1.
UniGenei Hs.714683.

3D structure databases

ProteinModelPortali Q5VV16.
SMRi Q5VV16. Positions 108-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366637.

Polymorphism databases

DMDMi 74747187.

Proteomic databases

PRIDEi Q5VV16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377420 ; ENSP00000366637 ; ENSG00000204779 .
GeneIDi 653427.
KEGGi hsa:653427.
UCSCi uc010moc.3. human.

Organism-specific databases

CTDi 653427.
GeneCardsi GC09M070175.
HGNCi HGNC:18522. FOXD4L5.
HPAi HPA012836.
neXtProti NX_Q5VV16.
PharmGKBi PA162388804.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000231285.
HOVERGENi HBG051641.
InParanoidi Q5VV16.
OMAi NTAPGRC.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q5VV16.
TreeFami TF316127.

Miscellaneous databases

GenomeRNAii 653427.
NextBioi 123231.
PROi Q5VV16.

Gene expression databases

CleanExi HS_FOXD4L5.
Genevestigatori Q5VV16.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFX4L5_HUMAN
AccessioniPrimary (citable) accession number: Q5VV16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi