ID   ADCL4_HUMAN             Reviewed;         407 AA.
AC   Q5VUY2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 132.
DE   RecName: Full=Arylacetamide deacetylase-like 4;
DE            EC=3.1.1.-;
GN   Name=AADACL4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AL513016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS30590.1; -.
DR   RefSeq; NP_001013652.1; NM_001013630.1.
DR   AlphaFoldDB; Q5VUY2; -.
DR   SMR; Q5VUY2; -.
DR   IntAct; Q5VUY2; 1.
DR   STRING; 9606.ENSP00000365395; -.
DR   ESTHER; human-AADACL4; Arylacetamide_deacetylase.
DR   GlyCosmos; Q5VUY2; 2 sites, No reported glycans.
DR   GlyGen; Q5VUY2; 2 sites.
DR   iPTMnet; Q5VUY2; -.
DR   PhosphoSitePlus; Q5VUY2; -.
DR   BioMuta; AADACL4; -.
DR   DMDM; 74747169; -.
DR   PaxDb; 9606-ENSP00000365395; -.
DR   PeptideAtlas; Q5VUY2; -.
DR   Antibodypedia; 46608; 103 antibodies from 19 providers.
DR   DNASU; 343066; -.
DR   Ensembl; ENST00000376221.2; ENSP00000365395.1; ENSG00000204518.3.
DR   GeneID; 343066; -.
DR   KEGG; hsa:343066; -.
DR   MANE-Select; ENST00000376221.2; ENSP00000365395.1; NM_001013630.2; NP_001013652.1.
DR   UCSC; uc001auf.3; human.
DR   AGR; HGNC:32038; -.
DR   CTD; 343066; -.
DR   GeneCards; AADACL4; -.
DR   HGNC; HGNC:32038; AADACL4.
DR   HPA; ENSG00000204518; Tissue enhanced (choroid).
DR   neXtProt; NX_Q5VUY2; -.
DR   OpenTargets; ENSG00000204518; -.
DR   PharmGKB; PA145147537; -.
DR   VEuPathDB; HostDB:ENSG00000204518; -.
DR   eggNOG; KOG1515; Eukaryota.
DR   GeneTree; ENSGT00940000157630; -.
DR   HOGENOM; CLU_012494_12_2_1; -.
DR   InParanoid; Q5VUY2; -.
DR   OMA; CHLQEGF; -.
DR   OrthoDB; 1144477at2759; -.
DR   PhylomeDB; Q5VUY2; -.
DR   TreeFam; TF314978; -.
DR   PathwayCommons; Q5VUY2; -.
DR   SignaLink; Q5VUY2; -.
DR   BioGRID-ORCS; 343066; 7 hits in 1138 CRISPR screens.
DR   GeneWiki; AADACL4_(gene); -.
DR   GenomeRNAi; 343066; -.
DR   Pharos; Q5VUY2; Tdark.
DR   PRO; PR:Q5VUY2; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5VUY2; Protein.
DR   Bgee; ENSG00000204518; Expressed in omental fat pad and 34 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR017157; Arylacetamide_deacetylase.
DR   PANTHER; PTHR48081; AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C; 1.
DR   PANTHER; PTHR48081:SF32; ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..407
FT                   /note="Arylacetamide deacetylase-like 4"
FT                   /id="PRO_0000265937"
FT   TOPO_DOM        1..4
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..25
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..407
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           119..121
FT                   /note="Involved in the stabilization of the negatively
FT                   charged intermediate by the formation of the oxyanion hole"
FT                   /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT   ACT_SITE        193
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT   ACT_SITE        347
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT   ACT_SITE        377
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLF1"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   407 AA;  46082 MW;  CE95EEE9A2C49970 CRC64;
     MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF
     EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG
     GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY
     GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN
     VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ
     PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL
     EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI
//