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Q5VUY2 (ADCL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arylacetamide deacetylase-like 4

EC=3.1.1.-
Gene names
Name:AADACL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarboxylic ester hydrolase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Arylacetamide deacetylase-like 4
PRO_0000265937

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain26 – 407382Lumenal Potential
Motif119 – 1213Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole By similarity

Sites

Active site1191 Potential
Active site1931 Potential

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5VUY2 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: CE95EEE9A2C49970

FASTA40746,082
        10         20         30         40         50         60 
MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF 

        70         80         90        100        110        120 
EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG 

       130        140        150        160        170        180 
GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY 

       190        200        210        220        230        240 
GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN 

       250        260        270        280        290        300 
VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ 

       310        320        330        340        350        360 
PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL 

       370        380        390        400 
EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI 

« Hide

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513016 Genomic DNA. Translation: CAH74173.1.
RefSeqNP_001013652.1. NM_001013630.1.
UniGeneHs.209954.

3D structure databases

ProteinModelPortalQ5VUY2.
SMRQ5VUY2. Positions 79-406.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5VUY2.

Polymorphism databases

DMDM74747169.

Proteomic databases

PaxDbQ5VUY2.
PRIDEQ5VUY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376221; ENSP00000365395; ENSG00000204518.
GeneID343066.
KEGGhsa:343066.
UCSCuc001auf.3. human.

Organism-specific databases

CTD343066.
GeneCardsGC01P012627.
HGNCHGNC:32038. AADACL4.
HPAHPA043588.
neXtProtNX_Q5VUY2.
PharmGKBPA145147537.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0657.
HOGENOMHOG000231073.
HOVERGENHBG058974.
InParanoidQ5VUY2.
KOK14351.
OMAAYLEAKH.
OrthoDBEOG7P8P80.
PhylomeDBQ5VUY2.
TreeFamTF314978.

Gene expression databases

BgeeQ5VUY2.
CleanExHS_AADACL4.
GenevestigatorQ5VUY2.

Family and domain databases

InterProIPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
[Graphical view]
PfamPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
PIRSFPIRSF037251. Arylacetamide_deacetylase. 1 hit.
ProtoNetSearch...

Other

GeneWikiAADACL4_(gene).
GenomeRNAi343066.
NextBio98444.
PROQ5VUY2.

Entry information

Entry nameADCL4_HUMAN
AccessionPrimary (citable) accession number: Q5VUY2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM