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Reviewed, UniProtKB/Swiss-Prot Q5VUY2 (ADCL4_HUMAN)

Last modified December 15, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arylacetamide deacetylase-like 4
    EC=3.1.1.-
Gene names
Name: AADACL4
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncarboxylesterase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Arylacetamide deacetylase-like 4
PRO_0000265937

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2521Signal-anchor for type II membrane protein Potential
Topological domain26 – 407382Lumenal Potential

Sites

Active site1191 Potential
Active site1931 Potential

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q5VUY2-1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: CE95EEE9A2C49970

FASTA40746,082
        10         20         30         40         50         60 
MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF 

        70         80         90        100        110        120 
EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG 

       130        140        150        160        170        180 
GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY 

       190        200        210        220        230        240 
GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN 

       250        260        270        280        290        300 
VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ 

       310        320        330        340        350        360 
PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL 

       370        380        390        400 
EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI

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References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AL513016 Genomic DNA. Translation: CAH74173.1.
IPIIPI00179839.
RefSeqNP_001013652.1.
UniGeneHs.209954

3D structure databases

HSSPHSSP built from PDB template 2C7B based on UniProtKB Q5G935.
ModBaseSearch...

Proteomic databases

PRIDEQ5VUY2.

Genome annotation databases

EnsemblENST00000376221; ENSP00000365395; ENSG00000204518; Homo sapiens. [Genome view]
GeneID343066.
KEGGhsa:343066.
UCSCuc001auf.1. human.

Organism-specific databases

CTD343066.
GeneCardsGC01P012627.
HGNCHGNC:32038. AADACL4.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG757640.
HOVERGENQ5VUY2.
InParanoidQ5VUY2.
OMALVSCEND.
OrthoDBEOG9JHG0W.

Enzyme and pathway databases

BioCycCATTLE:ENSBTAG00000020052-MON.

Gene expression databases

BgeeQ5VUY2.
CleanExHS_AADACL4.
GenevestigatorQ5VUY2.

Family and domain databases

InterProIPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
[Graphical view]
PfamPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
PIRSFPIRSF037251. Arylacetamide_deacetylase. 1 hit.
PROSITEPS01173. LIPASE_GDXG_HIS. False negative.
PS01174. LIPASE_GDXG_SER. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio98444.

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Entry information

Entry nameADCL4_HUMAN
AccessionPrimary (citable) accession number: Q5VUY2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 7, 2004
Last modified: December 15, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents