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Q5VUY2

- ADCL4_HUMAN

UniProt

Q5VUY2 - ADCL4_HUMAN

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Protein
Arylacetamide deacetylase-like 4
Gene
AADACL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191 Reviewed prediction
Active sitei193 – 1931 Reviewed prediction

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylacetamide deacetylase-like 4 (EC:3.1.1.-)
    Gene namesi
    Name:AADACL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:32038. AADACL4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44Cytoplasmic Reviewed prediction
    Transmembranei5 – 2521Helical; Signal-anchor for type II membrane protein; Reviewed prediction
    Add
    BLAST
    Topological domaini26 – 407382Lumenal Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145147537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Arylacetamide deacetylase-like 4
    PRO_0000265937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5VUY2.
    PRIDEiQ5VUY2.

    PTM databases

    PhosphoSiteiQ5VUY2.

    Expressioni

    Gene expression databases

    BgeeiQ5VUY2.
    CleanExiHS_AADACL4.
    GenevestigatoriQ5VUY2.

    Organism-specific databases

    HPAiHPA043588.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VUY2.
    SMRiQ5VUY2. Positions 79-383.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 1213Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0657.
    HOGENOMiHOG000231073.
    HOVERGENiHBG058974.
    InParanoidiQ5VUY2.
    KOiK14351.
    OMAiAYLEAKH.
    OrthoDBiEOG7P8P80.
    PhylomeDBiQ5VUY2.
    TreeFamiTF314978.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR017157. Arylacetamide_deacetylase.
    [Graphical view]
    PfamiPF07859. Abhydrolase_3. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037251. Arylacetamide_deacetylase. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5VUY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF    50
    LYLVTLGNIF EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR 100
    LFQPKAASSR PRRGIIFYHG GATVFGSLDC YHGLCNYLAR ETESVLLMIG 150
    YRKLPDHHSP ALFQDCMNAS IHFLKALETY GVDPSRVVVC GESVGGAAVA 200
    AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN VPLLSRKFMV 250
    TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ 300
    PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR 350
    DDSLLYKKRL EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV 400
    VSYIKGI 407
    Length:407
    Mass (Da):46,082
    Last modified:December 7, 2004 - v1
    Checksum:iCE95EEE9A2C49970
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513016 Genomic DNA. Translation: CAH74173.1.
    CCDSiCCDS30590.1.
    RefSeqiNP_001013652.1. NM_001013630.1.
    UniGeneiHs.209954.

    Genome annotation databases

    EnsembliENST00000376221; ENSP00000365395; ENSG00000204518.
    GeneIDi343066.
    KEGGihsa:343066.
    UCSCiuc001auf.3. human.

    Polymorphism databases

    DMDMi74747169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513016 Genomic DNA. Translation: CAH74173.1 .
    CCDSi CCDS30590.1.
    RefSeqi NP_001013652.1. NM_001013630.1.
    UniGenei Hs.209954.

    3D structure databases

    ProteinModelPortali Q5VUY2.
    SMRi Q5VUY2. Positions 79-383.
    ModBasei Search...

    PTM databases

    PhosphoSitei Q5VUY2.

    Polymorphism databases

    DMDMi 74747169.

    Proteomic databases

    PaxDbi Q5VUY2.
    PRIDEi Q5VUY2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376221 ; ENSP00000365395 ; ENSG00000204518 .
    GeneIDi 343066.
    KEGGi hsa:343066.
    UCSCi uc001auf.3. human.

    Organism-specific databases

    CTDi 343066.
    GeneCardsi GC01P012627.
    HGNCi HGNC:32038. AADACL4.
    HPAi HPA043588.
    neXtProti NX_Q5VUY2.
    PharmGKBi PA145147537.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0657.
    HOGENOMi HOG000231073.
    HOVERGENi HBG058974.
    InParanoidi Q5VUY2.
    KOi K14351.
    OMAi AYLEAKH.
    OrthoDBi EOG7P8P80.
    PhylomeDBi Q5VUY2.
    TreeFami TF314978.

    Miscellaneous databases

    GeneWikii AADACL4_(gene).
    GenomeRNAii 343066.
    NextBioi 98444.
    PROi Q5VUY2.

    Gene expression databases

    Bgeei Q5VUY2.
    CleanExi HS_AADACL4.
    Genevestigatori Q5VUY2.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR017157. Arylacetamide_deacetylase.
    [Graphical view ]
    Pfami PF07859. Abhydrolase_3. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037251. Arylacetamide_deacetylase. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiADCL4_HUMAN
    AccessioniPrimary (citable) accession number: Q5VUY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 7, 2004
    Last modified: July 9, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi