Reviewed,
UniProtKB/Swiss-Prot Q5VUY2 (ADCL4_HUMAN)
Last modified
December 15, 2009.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Arylacetamide deacetylase-like 4 EC=3.1.1.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 407 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the 'GDXG' lipolytic enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | carboxylesterase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 407 | 407 | Arylacetamide deacetylase-like 4 | PRO_0000265937 | |||||
Regions | |||||||||
| Topological domain | 1 – 4 | 4 | Cytoplasmic Potential | ||||||
| Transmembrane | 5 – 25 | 21 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 26 – 407 | 382 | Lumenal Potential | ||||||
Sites | |||||||||
| Active site | 119 | 1 | Potential | ||||||
| Active site | 193 | 1 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 168 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 269 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AL513016 Genomic DNA. Translation: CAH74173.1. | |
| IPI | IPI00179839. |
| RefSeq | NP_001013652.1. |
| UniGene | Hs.209954 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2C7B based on UniProtKB Q5G935. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q5VUY2. |
Genome annotation databases | |
| Ensembl | ENST00000376221; ENSP00000365395; ENSG00000204518; Homo sapiens. [Genome view] |
| GeneID | 343066. |
| KEGG | hsa:343066. |
| UCSC | uc001auf.1. human. |
Organism-specific databases | |
| CTD | 343066. |
| GeneCards | GC01P012627. |
| HGNC | HGNC:32038. AADACL4. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG757640. |
| HOVERGEN | Q5VUY2. |
| InParanoid | Q5VUY2. |
| OMA | LVSCEND. |
| OrthoDB | EOG9JHG0W. |
Enzyme and pathway databases | |
| BioCyc | CATTLE:ENSBTAG00000020052-MON. |
Gene expression databases | |
| Bgee | Q5VUY2. |
| CleanEx | HS_AADACL4. |
| Genevestigator | Q5VUY2. |
Family and domain databases | |
| InterPro | IPR013094. AB_hydrolase_3. IPR017157. Arylacetamide_deacetylase. [Graphical view] |
| Pfam | PF07859. Abhydrolase_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF037251. Arylacetamide_deacetylase. 1 hit. |
| PROSITE | PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 98444. |
Entry information
| Entry name | ADCL4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q5VUY2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


