Q5VUY2 (ADCL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylacetamide deacetylase-like 4
EC=3.1.1.-

Gene names

Name:

AADACL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Arylacetamide deacetylase-like 4		PRO_0000265937
Regions
	Topological domain	1 – 4	4	Cytoplasmic Potential
	Transmembrane	5 – 25	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	26 – 407	382	Lumenal Potential
Sites
	Active site	119	1	Potential
	Active site	193	1	Potential
Amino acid modifications
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5VUY2 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: CE95EEE9A2C49970	FASTA	407	46,082
	10 20 30 40 50 60 MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF 70 80 90 100 110 120 EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG 130 140 150 160 170 180 GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY 190 200 210 220 230 240 GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN 250 260 270 280 290 300 VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ 310 320 330 340 350 360 PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL 370 380 390 400 EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL513016 Genomic DNA. Translation: CAH74173.1.
IPI	IPI00179839.
RefSeq	NP_001013652.1. NM_001013630.1.
UniGene	Hs.209954.
3D structure databases
HSSP	HSSP built from PDB template 2C7B based on UniProtKB Q5G935.
ProteinModelPortal	Q5VUY2.
ModBase	Search...
PTM databases
PhosphoSite	Q5VUY2.
Polymorphism databases
DMDM	74747169.
Proteomic databases
PaxDb	Q5VUY2.
PRIDE	Q5VUY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376221; ENSP00000365395; ENSG00000204518.
GeneID	343066.
KEGG	hsa:343066.
UCSC	uc001auf.3. human.
Organism-specific databases
CTD	343066.
GeneCards	GC01P012627.
HGNC	HGNC:32038. AADACL4.
HPA	HPA043588.
neXtProt	NX_Q5VUY2.
PharmGKB	PA145147537.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0657.
HOGENOM	HOG000231073.
HOVERGEN	HBG058974.
InParanoid	Q5VUY2.
KO	K14351.
OMA	VRVTWYH.
OrthoDB	EOG4KSPK4.
Gene expression databases
Bgee	Q5VUY2.
CleanEx	HS_AADACL4.
Genevestigator	Q5VUY2.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. IPR017157. Arylacetamide_deacetylase. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 2 hits. [Graphical view]
PIRSF	PIRSF037251. Arylacetamide_deacetylase. 1 hit.
PROSITE	PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343066.
NextBio	98444.

Entry information

Entry name

ADCL4_HUMAN

Accession

Primary (citable) accession number: Q5VUY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.