Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arylacetamide deacetylase-like 3

Gene

AADACL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei136By similarity1
Active sitei290By similarity1
Active sitei320By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKQ5VUY0.

Protein family/group databases

ESTHERihuman-AADACL3. Hormone-sensitive_lipase_like.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase-like 3 (EC:3.1.1.-)
Gene namesi
Name:AADACL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32037. AADACL3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147526.

Polymorphism and mutation databases

BioMutaiAADACL3.
DMDMi317373552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002659361 – 350Arylacetamide deacetylase-like 3Add BLAST350

Proteomic databases

PaxDbiQ5VUY0.
PRIDEiQ5VUY0.

PTM databases

iPTMnetiQ5VUY0.
PhosphoSitePlusiQ5VUY0.

Expressioni

Gene expression databases

BgeeiENSG00000188984.
CleanExiHS_AADACL3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352268.

Structurei

3D structure databases

ProteinModelPortaliQ5VUY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 64Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000231073.
HOVERGENiHBG058974.
InParanoidiQ5VUY0.
KOiK14351.
OrthoDBiEOG091G082E.
PhylomeDBiQ5VUY0.
TreeFamiTF314978.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VUY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIFEKLRICS MPQFFCFMQD LPPLKYDPDV VVTDFRFGTI PVKLYQSKAS
60 70 80 90 100
TCTLKPGIVY YHGGGGVMGS LKTHHGICSR LCKESDSVVL AVGYRKLPKH
110 120 130 140 150
KFPVPVRDCL VATIHFLKSL DAYGVDPARV VVCGDSFGGA IAAVVCQQLV
160 170 180 190 200
DRPDLPRIRA QILIYAILQA LDLQTPSFQQ RKNIPLLTWS FICYCFFQNL
210 220 230 240 250
DFSSSWQEVI MKGAHLPAEV WEKYRKWLGP ENIPERFKER GYQLKPHEPM
260 270 280 290 300
NEAAYLEVSV VLDVMCSPLI AEDDIVSQLP ETCIVSCEYD ALRDNSLLYK
310 320 330 340 350
KRLEDLGVPV TWHHMEDGFH GVLRTIDMSF LHFPCSMRIL SALVQFVKGL
Length:350
Mass (Da):39,743
Last modified:January 11, 2011 - v4
Checksum:i2EDF93328B3CBB9E
GO
Isoform 2 (identifier: Q5VUY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-72: LK → ME

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):31,908
Checksum:iB099056B11C19988
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06066647S → P.Corresponds to variant rs3010877dbSNPEnsembl.1
Natural variantiVAR_06066771L → M.Corresponds to variant rs3000859dbSNPEnsembl.1
Natural variantiVAR_060668129R → W.Corresponds to variant rs17038445dbSNPEnsembl.1
Natural variantiVAR_060665195C → F.1 PublicationCorresponds to variant rs7513079dbSNPEnsembl.1
Natural variantiVAR_060670250M → I.Corresponds to variant rs3000931dbSNPEnsembl.1
Natural variantiVAR_060671280P → L.Corresponds to variant rs11121969dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0384081 – 70Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_03841071 – 72LK → ME in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127828 mRNA. Translation: BAG54581.1.
AL513016 Genomic DNA. Translation: CAH74175.1.
AL513016 Genomic DNA. Translation: CAH74176.2.
RefSeqiNP_001096640.2. NM_001103170.2.
UniGeneiHs.464705.

Genome annotation databases

EnsembliENST00000332530; ENSP00000333352; ENSG00000188984.
ENST00000359318; ENSP00000352268; ENSG00000188984.
GeneIDi126767.
KEGGihsa:126767.
UCSCiuc057ckc.1. human. [Q5VUY0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127828 mRNA. Translation: BAG54581.1.
AL513016 Genomic DNA. Translation: CAH74175.1.
AL513016 Genomic DNA. Translation: CAH74176.2.
RefSeqiNP_001096640.2. NM_001103170.2.
UniGeneiHs.464705.

3D structure databases

ProteinModelPortaliQ5VUY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352268.

Protein family/group databases

ESTHERihuman-AADACL3. Hormone-sensitive_lipase_like.

PTM databases

iPTMnetiQ5VUY0.
PhosphoSitePlusiQ5VUY0.

Polymorphism and mutation databases

BioMutaiAADACL3.
DMDMi317373552.

Proteomic databases

PaxDbiQ5VUY0.
PRIDEiQ5VUY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332530; ENSP00000333352; ENSG00000188984.
ENST00000359318; ENSP00000352268; ENSG00000188984.
GeneIDi126767.
KEGGihsa:126767.
UCSCiuc057ckc.1. human. [Q5VUY0-1]

Organism-specific databases

CTDi126767.
GeneCardsiAADACL3.
HGNCiHGNC:32037. AADACL3.
neXtProtiNX_Q5VUY0.
PharmGKBiPA145147526.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000231073.
HOVERGENiHBG058974.
InParanoidiQ5VUY0.
KOiK14351.
OrthoDBiEOG091G082E.
PhylomeDBiQ5VUY0.
TreeFamiTF314978.

Enzyme and pathway databases

SABIO-RKQ5VUY0.

Miscellaneous databases

GeneWikiiAADACL3_(gene).
GenomeRNAii126767.
PROiQ5VUY0.

Gene expression databases

BgeeiENSG00000188984.
CleanExiHS_AADACL3.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiADCL3_HUMAN
AccessioniPrimary (citable) accession number: Q5VUY0
Secondary accession number(s): B3KXR9, Q5VUY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.