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Q5VUY0

- ADCL3_HUMAN

UniProt

Q5VUY0 - ADCL3_HUMAN

Protein

Arylacetamide deacetylase-like 3

Gene

AADACL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Sequence Analysis
    Active sitei136 – 1361Sequence Analysis

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylacetamide deacetylase-like 3 (EC:3.1.1.-)
    Gene namesi
    Name:AADACL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:32037. AADACL3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145147526.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Arylacetamide deacetylase-like 3PRO_0000265936Add
    BLAST

    Proteomic databases

    PaxDbiQ5VUY0.
    PRIDEiQ5VUY0.

    PTM databases

    PhosphoSiteiQ5VUY0.

    Expressioni

    Gene expression databases

    BgeeiQ5VUY0.
    CleanExiHS_AADACL3.
    GenevestigatoriQ5VUY0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VUY0.
    SMRiQ5VUY0. Positions 10-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi62 – 643Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

    Sequence similaritiesi

    Belongs to the 'GDXG' lipolytic enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG0657.
    HOGENOMiHOG000231073.
    HOVERGENiHBG058974.
    InParanoidiQ5VUY0.
    KOiK14351.
    OMAiMPQFVRF.
    OrthoDBiEOG7P8P80.
    PhylomeDBiQ5VUY0.
    TreeFamiTF314978.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    [Graphical view]
    PfamiPF07859. Abhydrolase_3. 2 hits.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VUY0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIFEKLRICS MPQFFCFMQD LPPLKYDPDV VVTDFRFGTI PVKLYQSKAS    50
    TCTLKPGIVY YHGGGGVMGS LKTHHGICSR LCKESDSVVL AVGYRKLPKH 100
    KFPVPVRDCL VATIHFLKSL DAYGVDPARV VVCGDSFGGA IAAVVCQQLV 150
    DRPDLPRIRA QILIYAILQA LDLQTPSFQQ RKNIPLLTWS FICYCFFQNL 200
    DFSSSWQEVI MKGAHLPAEV WEKYRKWLGP ENIPERFKER GYQLKPHEPM 250
    NEAAYLEVSV VLDVMCSPLI AEDDIVSQLP ETCIVSCEYD ALRDNSLLYK 300
    KRLEDLGVPV TWHHMEDGFH GVLRTIDMSF LHFPCSMRIL SALVQFVKGL 350
    Length:350
    Mass (Da):39,743
    Last modified:January 11, 2011 - v4
    Checksum:i2EDF93328B3CBB9E
    GO
    Isoform 2 (identifier: Q5VUY0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.
         71-72: LK → ME

    Note: No experimental confirmation available.

    Show »
    Length:280
    Mass (Da):31,908
    Checksum:iB099056B11C19988
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471S → P.
    Corresponds to variant rs3010877 [ dbSNP | Ensembl ].
    VAR_060666
    Natural varianti71 – 711L → M.
    Corresponds to variant rs3000859 [ dbSNP | Ensembl ].
    VAR_060667
    Natural varianti129 – 1291R → W.
    Corresponds to variant rs17038445 [ dbSNP | Ensembl ].
    VAR_060668
    Natural varianti195 – 1951C → F.1 Publication
    Corresponds to variant rs7513079 [ dbSNP | Ensembl ].
    VAR_060665
    Natural varianti250 – 2501M → I.
    Corresponds to variant rs3000931 [ dbSNP | Ensembl ].
    VAR_060670
    Natural varianti280 – 2801P → L.
    Corresponds to variant rs11121969 [ dbSNP | Ensembl ].
    VAR_060671

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_038408Add
    BLAST
    Alternative sequencei71 – 722LK → ME in isoform 2. 1 PublicationVSP_038410

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127828 mRNA. Translation: BAG54581.1.
    AL513016 Genomic DNA. Translation: CAH74175.1.
    AL513016 Genomic DNA. Translation: CAH74176.2.
    RefSeqiNP_001096640.2. NM_001103170.2.
    UniGeneiHs.464705.

    Genome annotation databases

    EnsembliENST00000332530; ENSP00000333352; ENSG00000188984. [Q5VUY0-2]
    ENST00000359318; ENSP00000352268; ENSG00000188984. [Q5VUY0-1]
    GeneIDi126767.
    KEGGihsa:126767.
    UCSCiuc001aug.1. human. [Q5VUY0-2]
    uc009vnn.1. human. [Q5VUY0-1]

    Polymorphism databases

    DMDMi317373552.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127828 mRNA. Translation: BAG54581.1 .
    AL513016 Genomic DNA. Translation: CAH74175.1 .
    AL513016 Genomic DNA. Translation: CAH74176.2 .
    RefSeqi NP_001096640.2. NM_001103170.2.
    UniGenei Hs.464705.

    3D structure databases

    ProteinModelPortali Q5VUY0.
    SMRi Q5VUY0. Positions 10-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000352268.

    PTM databases

    PhosphoSitei Q5VUY0.

    Polymorphism databases

    DMDMi 317373552.

    Proteomic databases

    PaxDbi Q5VUY0.
    PRIDEi Q5VUY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332530 ; ENSP00000333352 ; ENSG00000188984 . [Q5VUY0-2 ]
    ENST00000359318 ; ENSP00000352268 ; ENSG00000188984 . [Q5VUY0-1 ]
    GeneIDi 126767.
    KEGGi hsa:126767.
    UCSCi uc001aug.1. human. [Q5VUY0-2 ]
    uc009vnn.1. human. [Q5VUY0-1 ]

    Organism-specific databases

    GeneCardsi GC01P012776.
    HGNCi HGNC:32037. AADACL3.
    neXtProti NX_Q5VUY0.
    PharmGKBi PA145147526.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0657.
    HOGENOMi HOG000231073.
    HOVERGENi HBG058974.
    InParanoidi Q5VUY0.
    KOi K14351.
    OMAi MPQFVRF.
    OrthoDBi EOG7P8P80.
    PhylomeDBi Q5VUY0.
    TreeFami TF314978.

    Miscellaneous databases

    GeneWikii AADACL3_(gene).
    NextBioi 81906.
    PROi Q5VUY0.

    Gene expression databases

    Bgeei Q5VUY0.
    CleanExi HS_AADACL3.
    Genevestigatori Q5VUY0.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    [Graphical view ]
    Pfami PF07859. Abhydrolase_3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-195.
      Tissue: Placenta.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiADCL3_HUMAN
    AccessioniPrimary (citable) accession number: Q5VUY0
    Secondary accession number(s): B3KXR9, Q5VUY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 79 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3