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Q5VUY0 (ADCL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arylacetamide deacetylase-like 3

EC=3.1.1.-
Gene names
Name:AADACL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VUY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VUY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-72: LK → ME
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Arylacetamide deacetylase-like 3
PRO_0000265936

Regions

Motif62 – 643Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole By similarity

Sites

Active site621 Potential
Active site1361 Potential

Natural variations

Alternative sequence1 – 7070Missing in isoform 2.
VSP_038408
Alternative sequence71 – 722LK → ME in isoform 2.
VSP_038410
Natural variant471S → P.
Corresponds to variant rs3010877 [ dbSNP | Ensembl ].
VAR_060666
Natural variant711L → M.
Corresponds to variant rs3000859 [ dbSNP | Ensembl ].
VAR_060667
Natural variant1291R → W.
Corresponds to variant rs17038445 [ dbSNP | Ensembl ].
VAR_060668
Natural variant1951C → F. Ref.1
Corresponds to variant rs7513079 [ dbSNP | Ensembl ].
VAR_060665
Natural variant2501M → I.
Corresponds to variant rs3000931 [ dbSNP | Ensembl ].
VAR_060670
Natural variant2801P → L.
Corresponds to variant rs11121969 [ dbSNP | Ensembl ].
VAR_060671

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 4.
Checksum: 2EDF93328B3CBB9E

FASTA35039,743
        10         20         30         40         50         60 
MIFEKLRICS MPQFFCFMQD LPPLKYDPDV VVTDFRFGTI PVKLYQSKAS TCTLKPGIVY 

        70         80         90        100        110        120 
YHGGGGVMGS LKTHHGICSR LCKESDSVVL AVGYRKLPKH KFPVPVRDCL VATIHFLKSL 

       130        140        150        160        170        180 
DAYGVDPARV VVCGDSFGGA IAAVVCQQLV DRPDLPRIRA QILIYAILQA LDLQTPSFQQ 

       190        200        210        220        230        240 
RKNIPLLTWS FICYCFFQNL DFSSSWQEVI MKGAHLPAEV WEKYRKWLGP ENIPERFKER 

       250        260        270        280        290        300 
GYQLKPHEPM NEAAYLEVSV VLDVMCSPLI AEDDIVSQLP ETCIVSCEYD ALRDNSLLYK 

       310        320        330        340        350 
KRLEDLGVPV TWHHMEDGFH GVLRTIDMSF LHFPCSMRIL SALVQFVKGL 

« Hide

Isoform 2 [UniParc].

Checksum: B099056B11C19988
Show »

FASTA28031,908

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-195.
Tissue: Placenta.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK127828 mRNA. Translation: BAG54581.1.
AL513016 Genomic DNA. Translation: CAH74175.1.
AL513016 Genomic DNA. Translation: CAH74176.2.
RefSeqNP_001096639.1. NM_001103169.1.
NP_001096640.1. NM_001103170.1.
UniGeneHs.464705.

3D structure databases

ProteinModelPortalQ5VUY0.
SMRQ5VUY0. Positions 10-349.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000352268.

PTM databases

PhosphoSiteQ5VUY0.

Polymorphism databases

DMDM317373552.

Proteomic databases

PaxDbQ5VUY0.
PRIDEQ5VUY0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332530; ENSP00000333352; ENSG00000188984. [Q5VUY0-2]
ENST00000359318; ENSP00000352268; ENSG00000188984. [Q5VUY0-1]
GeneID126767.
KEGGhsa:126767.
UCSCuc001aug.1. human. [Q5VUY0-2]
uc009vnn.1. human. [Q5VUY0-1]

Organism-specific databases

CTD126767.
GeneCardsGC01P012776.
HGNCHGNC:32037. AADACL3.
neXtProtNX_Q5VUY0.
PharmGKBPA145147526.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0657.
HOGENOMHOG000231073.
HOVERGENHBG058974.
InParanoidQ5VUY0.
KOK14351.
OMARLPEACI.
OrthoDBEOG7P8P80.
PhylomeDBQ5VUY0.
TreeFamTF314978.

Gene expression databases

BgeeQ5VUY0.
CleanExHS_AADACL3.
GenevestigatorQ5VUY0.

Family and domain databases

InterProIPR013094. AB_hydrolase_3.
[Graphical view]
PfamPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAADACL3_(gene).
NextBio81906.
PROQ5VUY0.

Entry information

Entry nameADCL3_HUMAN
AccessionPrimary (citable) accession number: Q5VUY0
Secondary accession number(s): B3KXR9, Q5VUY1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 74 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM