Q5VUY0 (ADCL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylacetamide deacetylase-like 3
EC=3.1.1.-

Gene names

Name:

AADACL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VUY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VUY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-72: LK → ME

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Arylacetamide deacetylase-like 3		PRO_0000265936
Sites
	Active site	62	1	Potential
	Active site	136	1	Potential
Natural variations
	Alternative sequence	1 – 70	70	Missing in isoform 2.		VSP_038408
	Alternative sequence	71 – 72	2	LK → ME in isoform 2.		VSP_038410
	Natural variant	47	1	S → P. Corresponds to variant rs3010877 [ dbSNP | Ensembl ].		VAR_060666
	Natural variant	71	1	L → M. Corresponds to variant rs3000859 [ dbSNP | Ensembl ].		VAR_060667
	Natural variant	129	1	R → W. Corresponds to variant rs17038445 [ dbSNP | Ensembl ].		VAR_060668
	Natural variant	195	1	C → F. Ref.1 Corresponds to variant rs7513079 [ dbSNP | Ensembl ].		VAR_060665
	Natural variant	250	1	M → I. Corresponds to variant rs3000931 [ dbSNP | Ensembl ].		VAR_060670
	Natural variant	280	1	P → L. Corresponds to variant rs11121969 [ dbSNP | Ensembl ].		VAR_060671

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 4. Checksum: 2EDF93328B3CBB9E	FASTA	350	39,743
	10 20 30 40 50 60 MIFEKLRICS MPQFFCFMQD LPPLKYDPDV VVTDFRFGTI PVKLYQSKAS TCTLKPGIVY 70 80 90 100 110 120 YHGGGGVMGS LKTHHGICSR LCKESDSVVL AVGYRKLPKH KFPVPVRDCL VATIHFLKSL 130 140 150 160 170 180 DAYGVDPARV VVCGDSFGGA IAAVVCQQLV DRPDLPRIRA QILIYAILQA LDLQTPSFQQ 190 200 210 220 230 240 RKNIPLLTWS FICYCFFQNL DFSSSWQEVI MKGAHLPAEV WEKYRKWLGP ENIPERFKER 250 260 270 280 290 300 GYQLKPHEPM NEAAYLEVSV VLDVMCSPLI AEDDIVSQLP ETCIVSCEYD ALRDNSLLYK 310 320 330 340 350 KRLEDLGVPV TWHHMEDGFH GVLRTIDMSF LHFPCSMRIL SALVQFVKGL
	Isoform 2 [UniParc]. Checksum: B099056B11C19988	FASTA	280	31,908
	10 20 30 40 50 60 METHHGICSR LCKESDSVVL AVGYRKLPKH KFPVPVRDCL VATIHFLKSL DAYGVDPARV 70 80 90 100 110 120 VVCGDSFGGA IAAVVCQQLV DRPDLPRIRA QILIYAILQA LDLQTPSFQQ RKNIPLLTWS 130 140 150 160 170 180 FICYCFFQNL DFSSSWQEVI MKGAHLPAEV WEKYRKWLGP ENIPERFKER GYQLKPHEPM 190 200 210 220 230 240 NEAAYLEVSV VLDVMCSPLI AEDDIVSQLP ETCIVSCEYD ALRDNSLLYK KRLEDLGVPV 250 260 270 280 TWHHMEDGFH GVLRTIDMSF LHFPCSMRIL SALVQFVKGL

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-195. Tissue: Placenta.

[2]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK127828 mRNA. Translation: BAG54581.1. AL513016 Genomic DNA. Translation: CAH74175.1. AL513016 Genomic DNA. Translation: CAH74176.2.
IPI	IPI00640762. IPI00855762.
RefSeq	NP_001096639.1. NM_001103169.1. NP_001096640.1. NM_001103170.1.
UniGene	Hs.464705.
3D structure databases
HSSP	HSSP built from PDB template 2C7B based on UniProtKB Q5G935.
ProteinModelPortal	Q5VUY0.
SMR	Q5VUY0. Positions 10-319.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000352268.
PTM databases
PhosphoSite	Q5VUY0.
Polymorphism databases
DMDM	269849710.
Proteomic databases
PaxDb	Q5VUY0.
PRIDE	Q5VUY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332530; ENSP00000333352; ENSG00000188984. ENST00000359318; ENSP00000352268; ENSG00000188984.
GeneID	126767.
KEGG	hsa:126767.
UCSC	uc001aug.1. human. uc009vnn.1. human.
Organism-specific databases
CTD	126767.
GeneCards	GC01P012776.
HGNC	HGNC:32037. AADACL3.
neXtProt	NX_Q5VUY0.
PharmGKB	PA145147526.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0657.
HOGENOM	HOG000231073.
HOVERGEN	HBG058974.
InParanoid	Q5VUY0.
KO	K14351.
OMA	VKLYQPK.
Gene expression databases
Bgee	Q5VUY0.
CleanEx	HS_AADACL3.
Genevestigator	Q5VUY0.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 2 hits. [Graphical view]
PROSITE	PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	81906.

Entry information

Entry name

ADCL3_HUMAN

Accession

Primary (citable) accession number: Q5VUY0
Secondary accession number(s): B3KXR9, Q5VUY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 65 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.