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Protein

Arylacetamide deacetylase-like 3

Gene

AADACL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Sequence Analysis
Active sitei136 – 1361Sequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKQ5VUY0.

Protein family/group databases

ESTHERihuman-AADACL3. Hormone-sensitive_lipase_like.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase-like 3 (EC:3.1.1.-)
Gene namesi
Name:AADACL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 1, Unplaced

Organism-specific databases

HGNCiHGNC:32037. AADACL3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147526.

Polymorphism and mutation databases

BioMutaiAADACL3.
DMDMi317373552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Arylacetamide deacetylase-like 3PRO_0000265936Add
BLAST

Proteomic databases

PaxDbiQ5VUY0.
PRIDEiQ5VUY0.

PTM databases

PhosphoSiteiQ5VUY0.

Expressioni

Gene expression databases

BgeeiQ5VUY0.
CleanExiHS_AADACL3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352268.

Structurei

3D structure databases

ProteinModelPortaliQ5VUY0.
SMRiQ5VUY0. Positions 10-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi62 – 643Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiCOG0657.
HOGENOMiHOG000231073.
HOVERGENiHBG058974.
InParanoidiQ5VUY0.
KOiK14351.
OrthoDBiEOG7P8P80.
PhylomeDBiQ5VUY0.
TreeFamiTF314978.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VUY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIFEKLRICS MPQFFCFMQD LPPLKYDPDV VVTDFRFGTI PVKLYQSKAS
60 70 80 90 100
TCTLKPGIVY YHGGGGVMGS LKTHHGICSR LCKESDSVVL AVGYRKLPKH
110 120 130 140 150
KFPVPVRDCL VATIHFLKSL DAYGVDPARV VVCGDSFGGA IAAVVCQQLV
160 170 180 190 200
DRPDLPRIRA QILIYAILQA LDLQTPSFQQ RKNIPLLTWS FICYCFFQNL
210 220 230 240 250
DFSSSWQEVI MKGAHLPAEV WEKYRKWLGP ENIPERFKER GYQLKPHEPM
260 270 280 290 300
NEAAYLEVSV VLDVMCSPLI AEDDIVSQLP ETCIVSCEYD ALRDNSLLYK
310 320 330 340 350
KRLEDLGVPV TWHHMEDGFH GVLRTIDMSF LHFPCSMRIL SALVQFVKGL
Length:350
Mass (Da):39,743
Last modified:January 11, 2011 - v4
Checksum:i2EDF93328B3CBB9E
GO
Isoform 2 (identifier: Q5VUY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-72: LK → ME

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):31,908
Checksum:iB099056B11C19988
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471S → P.
Corresponds to variant rs3010877 [ dbSNP | Ensembl ].
VAR_060666
Natural varianti71 – 711L → M.
Corresponds to variant rs3000859 [ dbSNP | Ensembl ].
VAR_060667
Natural varianti129 – 1291R → W.
Corresponds to variant rs17038445 [ dbSNP | Ensembl ].
VAR_060668
Natural varianti195 – 1951C → F.1 Publication
Corresponds to variant rs7513079 [ dbSNP | Ensembl ].
VAR_060665
Natural varianti250 – 2501M → I.
Corresponds to variant rs3000931 [ dbSNP | Ensembl ].
VAR_060670
Natural varianti280 – 2801P → L.
Corresponds to variant rs11121969 [ dbSNP | Ensembl ].
VAR_060671

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_038408Add
BLAST
Alternative sequencei71 – 722LK → ME in isoform 2. 1 PublicationVSP_038410

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127828 mRNA. Translation: BAG54581.1.
AL513016 Genomic DNA. Translation: CAH74175.1.
AL513016 Genomic DNA. Translation: CAH74176.2.
RefSeqiNP_001096640.2. NM_001103170.2.
UniGeneiHs.464705.

Genome annotation databases

EnsembliENST00000332530; ENSP00000333352; ENSG00000188984.
ENST00000359318; ENSP00000352268; ENSG00000188984.
GeneIDi126767.
KEGGihsa:126767.
UCSCiuc001aug.1. human. [Q5VUY0-2]
uc009vnn.1. human. [Q5VUY0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127828 mRNA. Translation: BAG54581.1.
AL513016 Genomic DNA. Translation: CAH74175.1.
AL513016 Genomic DNA. Translation: CAH74176.2.
RefSeqiNP_001096640.2. NM_001103170.2.
UniGeneiHs.464705.

3D structure databases

ProteinModelPortaliQ5VUY0.
SMRiQ5VUY0. Positions 10-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352268.

Protein family/group databases

ESTHERihuman-AADACL3. Hormone-sensitive_lipase_like.

PTM databases

PhosphoSiteiQ5VUY0.

Polymorphism and mutation databases

BioMutaiAADACL3.
DMDMi317373552.

Proteomic databases

PaxDbiQ5VUY0.
PRIDEiQ5VUY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332530; ENSP00000333352; ENSG00000188984.
ENST00000359318; ENSP00000352268; ENSG00000188984.
GeneIDi126767.
KEGGihsa:126767.
UCSCiuc001aug.1. human. [Q5VUY0-2]
uc009vnn.1. human. [Q5VUY0-1]

Organism-specific databases

CTDi126767.
GeneCardsiGC01P012776.
HGNCiHGNC:32037. AADACL3.
neXtProtiNX_Q5VUY0.
PharmGKBiPA145147526.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0657.
HOGENOMiHOG000231073.
HOVERGENiHBG058974.
InParanoidiQ5VUY0.
KOiK14351.
OrthoDBiEOG7P8P80.
PhylomeDBiQ5VUY0.
TreeFamiTF314978.

Enzyme and pathway databases

SABIO-RKQ5VUY0.

Miscellaneous databases

GeneWikiiAADACL3_(gene).
GenomeRNAii126767.
NextBioi81906.
PROiQ5VUY0.

Gene expression databases

BgeeiQ5VUY0.
CleanExiHS_AADACL3.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-195.
    Tissue: Placenta.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiADCL3_HUMAN
AccessioniPrimary (citable) accession number: Q5VUY0
Secondary accession number(s): B3KXR9, Q5VUY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: July 22, 2015
This is version 86 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.