Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat and calponin homology domain-containing protein 2

Gene

LRCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and calponin homology domain-containing protein 2
Gene namesi
Name:LRCH2
Synonyms:KIAA1495
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29292. LRCH2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134890613.

Polymorphism and mutation databases

BioMutaiLRCH2.
DMDMi116248529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Leucine-rich repeat and calponin homology domain-containing protein 2PRO_0000253482Add
BLAST

Proteomic databases

MaxQBiQ5VUJ6.
PaxDbiQ5VUJ6.
PRIDEiQ5VUJ6.

PTM databases

PhosphoSiteiQ5VUJ6.

Expressioni

Gene expression databases

BgeeiQ5VUJ6.
CleanExiHS_LRCH2.
GenevisibleiQ5VUJ6. HS.

Organism-specific databases

HPAiHPA003233.

Interactioni

Protein-protein interaction databases

BioGridi121674. 19 interactions.
IntActiQ5VUJ6. 8 interactions.
STRINGi9606.ENSP00000325091.

Structurei

3D structure databases

ProteinModelPortaliQ5VUJ6.
SMRiQ5VUJ6. Positions 65-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 11022LRR 1Add
BLAST
Repeati112 – 13322LRR 2Add
BLAST
Repeati135 – 15622LRR 3Add
BLAST
Repeati158 – 17922LRR 4Add
BLAST
Repeati180 – 20122LRR 5Add
BLAST
Repeati203 – 22422LRR 6Add
BLAST
Repeati226 – 24823LRR 7Add
BLAST
Repeati249 – 26921LRR 8Add
BLAST
Repeati271 – 29222LRR 9Add
BLAST
Domaini642 – 755114CHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili438 – 47235Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 4439Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0532. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000049055.
HOVERGENiHBG052350.
InParanoidiQ5VUJ6.
OMAiEQGDAHI.
OrthoDBiEOG7288QT.
PhylomeDBiQ5VUJ6.
TreeFamiTF318428.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VUJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASQGGGGN SGGGGCGGGG SSGGCGTAGG GGGGAGGGGG GGGGTLVVPI
60 70 80 90 100
PVPTLFGQPF PNGPPWNPGS LQPQHTVRSL DRALEEAGSS GILSLSGRKL
110 120 130 140 150
RDFPGSGYDL TDTTQADLSR NRFTEIPSDV WLFAPLETLN LYHNCIKTIP
160 170 180 190 200
EAIKNLQMLT YLNISRNLLS TLPKYLFDLP LKVLVVSNNK LVSIPEEIGK
210 220 230 240 250
LKDLMELDIS CNEIQVLPQQ MGKLHSLREL NIRRNNLHVL PDELGDLPLV
260 270 280 290 300
KLDFSCNKVT EIPVCYRKLH HLQVIILDNN PLQVPPAQIC LKGKVHIFKY
310 320 330 340 350
LNIQACCRMD KKPDSLDLPS LSKRMPSQPL TDSMEDFYPN KNHGPDSGIG
360 370 380 390 400
SDNGEKRLST TEPSDDDTVS LHSQVSESNR EQTSRNDSHI IGSKTDSQKD
410 420 430 440 450
QEVYDFVDPN TEDVAVPEQG NAHIGSFVSF FKGKEKCSEK SRKNEELGDE
460 470 480 490 500
KRLEKEQLLA EEEDDDLKEV TDLRKIAAQL LQQEQKNRIL NHSTSVMRNK
510 520 530 540 550
PKQTVECEKS VSADEVNSPL SPLTWQPLEN QKDQIDEQPW PESHPIIWQS
560 570 580 590 600
EERRRSKQIR KEYFKYKSMR KSSSGNENDE QDSDNANMST QSPVSSEEYD
610 620 630 640 650
RTDGFSHSPF GLKPRSAFSR SSRQEYGAAD PGFTMRRKME HLREEREQIR
660 670 680 690 700
QLRNNLESRL KVILPDDIGA ALMDGVVLCH LANHIRPRSV ASIHVPSPAV
710 720 730 740 750
PKLSMAKCRR NVENFLDACK KLGVSQERLC LPHHILEERG LVKVGVTVQA
760
LLELPTTKAS QLSVA
Length:765
Mass (Da):84,588
Last modified:October 17, 2006 - v2
Checksum:i89A56712621F52F9
GO
Isoform 2 (identifier: Q5VUJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-596: Missing.

Note: No experimental confirmation available.
Show »
Length:748
Mass (Da):82,810
Checksum:iC0E80AA77CD20C0C
GO

Sequence cautioni

The sequence BAA96019.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH70721.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI42077.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI43033.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti710 – 7101R → K in AAI25225 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei580 – 59617Missing in isoform 2. 1 PublicationVSP_044969Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589786, AL121878, AL445164 Genomic DNA. Translation: CAH70721.1. Sequence problems.
AL121878, AL445164, AL589786 Genomic DNA. Translation: CAI42077.1. Sequence problems.
AL445164, AL121878, AL589786 Genomic DNA. Translation: CAI43033.1. Sequence problems.
BC125224 mRNA. Translation: AAI25225.1.
AK022128 mRNA. Translation: BAB13966.1.
AB040928 mRNA. Translation: BAA96019.1. Different initiation.
CCDSiCCDS48155.1. [Q5VUJ6-1]
CCDS59175.1. [Q5VUJ6-2]
RefSeqiNP_001230892.1. NM_001243963.1. [Q5VUJ6-2]
NP_065922.3. NM_020871.3. [Q5VUJ6-1]
UniGeneiHs.65366.

Genome annotation databases

EnsembliENST00000317135; ENSP00000325091; ENSG00000130224. [Q5VUJ6-1]
ENST00000538422; ENSP00000439366; ENSG00000130224. [Q5VUJ6-2]
GeneIDi57631.
KEGGihsa:57631.
UCSCiuc004epz.4. human. [Q5VUJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589786, AL121878, AL445164 Genomic DNA. Translation: CAH70721.1. Sequence problems.
AL121878, AL445164, AL589786 Genomic DNA. Translation: CAI42077.1. Sequence problems.
AL445164, AL121878, AL589786 Genomic DNA. Translation: CAI43033.1. Sequence problems.
BC125224 mRNA. Translation: AAI25225.1.
AK022128 mRNA. Translation: BAB13966.1.
AB040928 mRNA. Translation: BAA96019.1. Different initiation.
CCDSiCCDS48155.1. [Q5VUJ6-1]
CCDS59175.1. [Q5VUJ6-2]
RefSeqiNP_001230892.1. NM_001243963.1. [Q5VUJ6-2]
NP_065922.3. NM_020871.3. [Q5VUJ6-1]
UniGeneiHs.65366.

3D structure databases

ProteinModelPortaliQ5VUJ6.
SMRiQ5VUJ6. Positions 65-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121674. 19 interactions.
IntActiQ5VUJ6. 8 interactions.
STRINGi9606.ENSP00000325091.

PTM databases

PhosphoSiteiQ5VUJ6.

Polymorphism and mutation databases

BioMutaiLRCH2.
DMDMi116248529.

Proteomic databases

MaxQBiQ5VUJ6.
PaxDbiQ5VUJ6.
PRIDEiQ5VUJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317135; ENSP00000325091; ENSG00000130224. [Q5VUJ6-1]
ENST00000538422; ENSP00000439366; ENSG00000130224. [Q5VUJ6-2]
GeneIDi57631.
KEGGihsa:57631.
UCSCiuc004epz.4. human. [Q5VUJ6-1]

Organism-specific databases

CTDi57631.
GeneCardsiLRCH2.
H-InvDBHIX0017001.
HGNCiHGNC:29292. LRCH2.
HPAiHPA003233.
neXtProtiNX_Q5VUJ6.
PharmGKBiPA134890613.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0532. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000049055.
HOVERGENiHBG052350.
InParanoidiQ5VUJ6.
OMAiEQGDAHI.
OrthoDBiEOG7288QT.
PhylomeDBiQ5VUJ6.
TreeFamiTF318428.

Miscellaneous databases

GenomeRNAii57631.
NextBioi64337.
PROiQ5VUJ6.

Gene expression databases

BgeeiQ5VUJ6.
CleanExiHS_LRCH2.
GenevisibleiQ5VUJ6. HS.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-765 (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 406-765 (ISOFORM 1).
    Tissue: Embryo.

Entry informationi

Entry nameiLRCH2_HUMAN
AccessioniPrimary (citable) accession number: Q5VUJ6
Secondary accession number(s): F5H2T1
, Q08AD5, Q9HA88, Q9P233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.