Q5VUJ5 (AGAP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
Short name=AGAP-7

Alternative name(s):
Centaurin-gamma-like family member 4

Gene names

Name:	AGAP7
Synonyms:	CTGLF4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	663 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Miscellaneous	Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.

Ontologies

Keywords
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 663	663	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7		PRO_0000284675
Regions
	Domain	259 – 420	162	PH
	Domain	441 – 561	121	Arf-GAP
	Repeat	600 – 629	30	ANK 1
	Repeat	633 – 662	30	ANK 2
	Zinc finger	456 – 479	24	C4-type

Sequences

	Sequence		Length	Mass (Da)
	Q5VUJ5 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 036912A99532FAE0	FASTA	663	73,211
	10 20 30 40 50 60 MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ PAEVTVEVGE 70 80 90 100 110 120 DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV STVHFSQQYS 130 140 150 160 170 180 LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRS LSIPDEQLHS FAVSTVHITK 190 200 210 220 230 240 NRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD 250 260 270 280 290 300 KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM 310 320 330 340 350 360 KYIHKKEIDL QTSTIKVPGK WPSLATLACT PISSSKSDGL SKDMDTGLGD SICFSPSISS 370 380 390 400 410 420 TTIPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL 430 440 450 460 470 480 ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS 490 500 510 520 530 540 GIHRSLGTRL SRVRSLELDD WPVELRKVMS SIGNDLANSI WEGSSQGRTK PTEKSTREEK 550 560 570 580 590 600 ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD 610 620 630 640 650 660 GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD ECV

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL589822 Genomic DNA. Translation: CAH70062.1.
IPI	IPI00456856.
RefSeq	NP_001071153.1. NM_001077685.1.
UniGene	Hs.528346.
3D structure databases
HSSP	HSSP built from PDB template 2B0O based on UniProtKB Q8TDY4.
ProteinModelPortal	Q5VUJ5.
SMR	Q5VUJ5. Positions 257-424, 442-661.
ModBase	Search...
Polymorphism databases
DMDM	74756856.
Proteomic databases
PRIDE	Q5VUJ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374095; ENSP00000363208; ENSG00000204169.
GeneID	653268.
KEGG	hsa:653268.
UCSC	uc001jio.1. human.
Organism-specific databases
CTD	653268.
GeneCards	GC10M051464.
HGNC	HGNC:23465. AGAP7.
neXtProt	NX_Q5VUJ5.
PharmGKB	PA164715167.
GenAtlas	Search...
Phylogenomic databases
eggNOG	KOG0705.
GeneTree	ENSGT00600000084361.
HOVERGEN	HBG054045.
InParanoid	Q5VUJ5.
OrthoDB	EOG4K0QN3.
PhylomeDB	Q5VUJ5.
Gene expression databases
Bgee	Q5VUJ5.
CleanEx	HS_AGAP7.
Genevestigator	Q5VUJ5.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:2.30.29.30. PH_type. 2 hits.
Pfam	PF12796. Ank_2. 1 hit. PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00248. ANK. 2 hits. SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF57863. ArfGAP. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	123013.

Entry information

Entry name

AGAP7_HUMAN

Accession

Primary (citable) accession number: Q5VUJ5
Secondary accession number(s): A6NGH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	December 7, 2004
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.