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Protein

Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7

Gene

AGAP7P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative GTPase-activating protein.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32498-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
Short name:
AGAP-7
Alternative name(s):
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 pseudogene
Centaurin-gamma-like family member 4
Gene namesi
Name:AGAP7P
Synonyms:AGAP7, CTGLF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23465. AGAP7P.

Pathology & Biotechi

Organism-specific databases

DisGeNETi653268.
PharmGKBiPA164715167.

Polymorphism and mutation databases

DMDMi74756856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846751 – 663Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7Add BLAST663

Proteomic databases

PaxDbiQ5VUJ5.
PeptideAtlasiQ5VUJ5.
PRIDEiQ5VUJ5.

PTM databases

iPTMnetiQ5VUJ5.
PhosphoSitePlusiQ5VUJ5.

Expressioni

Gene expression databases

BgeeiENSG00000204169.
CleanExiHS_AGAP7.

Organism-specific databases

HPAiHPA042490.

Interactioni

Protein-protein interaction databases

BioGridi575652. 1 interactor.
IntActiQ5VUJ5. 1 interactor.
STRINGi9606.ENSP00000363208.

Structurei

3D structure databases

ProteinModelPortaliQ5VUJ5.
SMRiQ5VUJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 420PHPROSITE-ProRule annotationAdd BLAST162
Domaini441 – 561Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati600 – 629ANK 1Add BLAST30
Repeati633 – 662ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 479C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ5VUJ5.
PhylomeDBiQ5VUJ5.
TreeFamiTF317762.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VUJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE
110 120 130 140 150
IRRSNCTNHV STVHFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH
160 170 180 190 200
HITQRDADRS LSIPDEQLHS FAVSTVHITK NRNGGGSLNN YSSSIPSTPS
210 220 230 240 250
TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA
260 270 280 290 300
DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
310 320 330 340 350
KYIHKKEIDL QTSTIKVPGK WPSLATLACT PISSSKSDGL SKDMDTGLGD
360 370 380 390 400
SICFSPSISS TTIPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF
410 420 430 440 450
EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSE AMALQSIQNM
460 470 480 490 500
RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD
510 520 530 540 550
WPVELRKVMS SIGNDLANSI WEGSSQGRTK PTEKSTREEK ERWIRSKYEE
560 570 580 590 600
KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
610 620 630 640 650
GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI
660
NVLLQYGCPD ECV
Length:663
Mass (Da):73,211
Last modified:December 7, 2004 - v1
Checksum:i036912A99532FAE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589822 Genomic DNA. Translation: CAH70062.1.
UniGeneiHs.447454.
Hs.528346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589822 Genomic DNA. Translation: CAH70062.1.
UniGeneiHs.447454.
Hs.528346.

3D structure databases

ProteinModelPortaliQ5VUJ5.
SMRiQ5VUJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575652. 1 interactor.
IntActiQ5VUJ5. 1 interactor.
STRINGi9606.ENSP00000363208.

PTM databases

iPTMnetiQ5VUJ5.
PhosphoSitePlusiQ5VUJ5.

Polymorphism and mutation databases

DMDMi74756856.

Proteomic databases

PaxDbiQ5VUJ5.
PeptideAtlasiQ5VUJ5.
PRIDEiQ5VUJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi653268.
GeneCardsiAGAP7P.
HGNCiHGNC:23465. AGAP7P.
HPAiHPA042490.
neXtProtiNX_Q5VUJ5.
PharmGKBiPA164715167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ5VUJ5.
PhylomeDBiQ5VUJ5.
TreeFamiTF317762.

Enzyme and pathway databases

BioCyciZFISH:G66-32498-MONOMER.

Miscellaneous databases

PROiQ5VUJ5.

Gene expression databases

BgeeiENSG00000204169.
CleanExiHS_AGAP7.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGAP7_HUMAN
AccessioniPrimary (citable) accession number: Q5VUJ5
Secondary accession number(s): A6NGH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.