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Protein

Scm-like with four MBT domains protein 2

Gene

SFMBT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor of HOXB13 gene.1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Names & Taxonomyi

Protein namesi
Recommended name:
Scm-like with four MBT domains protein 2
Short name:
Scm-like with 4 MBT domains protein 2
Gene namesi
Name:SFMBT2
Synonyms:KIAA1617
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:20256. SFMBT2.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • aggresome Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866013.

Polymorphism and mutation databases

BioMutaiSFMBT2.
DMDMi67461560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 894894Scm-like with four MBT domains protein 2PRO_0000071969Add
BLAST

Proteomic databases

MaxQBiQ5VUG0.
PaxDbiQ5VUG0.
PRIDEiQ5VUG0.

PTM databases

iPTMnetiQ5VUG0.
PhosphoSiteiQ5VUG0.

Expressioni

Gene expression databases

BgeeiQ5VUG0.
CleanExiHS_SFMBT2.
ExpressionAtlasiQ5VUG0. baseline and differential.
GenevisibleiQ5VUG0. HS.

Organism-specific databases

HPAiHPA035447.
HPA035448.

Interactioni

Subunit structurei

Interacts with YY1. Interacts with methylated histones H3K9me2 and H4K20me2, but not with H3K4me2, nor H3K9Ac.1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121736. 4 interactions.
STRINGi9606.ENSP00000355109.

Structurei

Secondary structure

1
894
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi182 – 1854Combined sources
Beta strandi191 – 1955Combined sources
Beta strandi203 – 2075Combined sources
Beta strandi215 – 2184Combined sources
Beta strandi231 – 2344Combined sources
Turni243 – 2453Combined sources
Helixi246 – 2494Combined sources
Turni257 – 2626Combined sources
Helixi265 – 28117Combined sources
Helixi286 – 2894Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WJRNMR-A182-295[»]
ProteinModelPortaliQ5VUG0.
SMRiQ5VUG0. Positions 43-477, 821-885.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5VUG0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 144101MBT 1Add
BLAST
Repeati152 – 256105MBT 2Add
BLAST
Repeati266 – 372107MBT 3Add
BLAST
Repeati380 – 47798MBT 4Add
BLAST
Domaini824 – 88764SAMAdd
BLAST

Sequence similaritiesi

Contains 4 MBT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMEX. Eukaryota.
ENOG410XSJM. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000004859.
HOVERGENiHBG085238.
InParanoidiQ5VUG0.
OMAiDPPSEIY.
OrthoDBiEOG780RKN.
PhylomeDBiQ5VUG0.
TreeFamiTF316498.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021987. DUF3588.
IPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12140. DUF3588. 1 hit.
PF02820. MBT. 4 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VUG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTLSASNM QDPSSSPLEK CLGSANGNGD LDSEEGSSLE ETGFNWGEYL
60 70 80 90 100
EETGASAAPH TSFKHVEISI QSNFQPGMKL EVANKNNPDT YWVATIITTC
110 120 130 140 150
GQLLLLRYCG YGEDRRADFW CDVVIADLHP VGWCTQNNKV LMPPDAIKEK
160 170 180 190 200
YTDWTEFLIR DLTGSRTAPA NLLEGPLRGK GPIDLITVGS LIELQDSQNP
210 220 230 240 250
FQYWIVSVIE NVGGRLRLRY VGLEDTESYD QWLFYLDYRL RPVGWCQENK
260 270 280 290 300
YRMDPPSEIY PLKMASEWKC TLEKSLIDAA KFPLPMEVFK DHADLRSHFF
310 320 330 340 350
TVGMKLETVN MCEPFYISPA SVTKVFNNHF FQVTIDDLRP EPSKLSMLCH
360 370 380 390 400
ADSLGILPVQ WCLKNGVSLT PPKGYSGQDF DWADYHKQHG AQEAPPFCFR
410 420 430 440 450
NTSFSRGFTK NMKLEAVNPR NPGELCVASV VSVKGRLMWL HLEGLQTPVP
460 470 480 490 500
EVIVDVESMD IFPVGWCEAN SYPLTAPHKT VSQKKRKIAV VQPEKQLPPT
510 520 530 540 550
VPVKKIPHDL CLFPHLDTTG TVNGKYCCPQ LFINHRCFSG PYLNKGRIAE
560 570 580 590 600
LPQSVGPGKC VLVLKEVLSM IINAAYKPGR VLRELQLVED PHWNFQEETL
610 620 630 640 650
KAKYRGKTYR AVVKIVRTSD QVANFCRRVC AKLECCPNLF SPVLISENCP
660 670 680 690 700
ENCSIHTKTK YTYYYGKRKK ISKPPIGESN PDSGHPKPAR RRKRRKSIFV
710 720 730 740 750
QKKRRSSAVD FTAGSGEESE EEDADAMDDD TASEETGSEL RDDQTDTSSA
760 770 780 790 800
EVPSARPRRA VTLRSGSEPV RRPPPERTRR GRGAPAASSA EEGEKCPPTK
810 820 830 840 850
PEGTEDTKQE EEERLVLESN PLEWTVTDVV RFIKLTDCAP LAKIFQEQDI
860 870 880 890
DGQALLLLTL PTVQECMELK LGPAIKLCHQ IERVKVAFYA QYAN
Length:894
Mass (Da):100,563
Last modified:December 7, 2004 - v1
Checksum:i20EFF7F789F41787
GO

Sequence cautioni

The sequence BAB13443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti675 – 6751P → R.
Corresponds to variant rs3740212 [ dbSNP | Ensembl ].
VAR_051362

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046837 mRNA. Translation: BAB13443.1. Different initiation.
AL590095
, AL139125, AL158046, AL138771 Genomic DNA. Translation: CAH73318.1.
AL158046
, AL138771, AL590095, AL139125 Genomic DNA. Translation: CAI19142.1.
AL139125
, AL138771, AL158046, AL590095 Genomic DNA. Translation: CAI18944.1.
AL138771
, AL139125, AL158046, AL590095 Genomic DNA. Translation: CAI21746.1.
CH471072 Genomic DNA. Translation: EAW86385.1.
BC152430 mRNA. Translation: AAI52431.1.
CCDSiCCDS31138.1.
RefSeqiNP_001018049.1. NM_001018039.1.
NP_001025051.1. NM_001029880.2.
XP_011517913.1. XM_011519611.1.
UniGeneiHs.407983.

Genome annotation databases

EnsembliENST00000361972; ENSP00000355109; ENSG00000198879.
ENST00000397167; ENSP00000380353; ENSG00000198879.
GeneIDi57713.
KEGGihsa:57713.
UCSCiuc001ijn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046837 mRNA. Translation: BAB13443.1. Different initiation.
AL590095
, AL139125, AL158046, AL138771 Genomic DNA. Translation: CAH73318.1.
AL158046
, AL138771, AL590095, AL139125 Genomic DNA. Translation: CAI19142.1.
AL139125
, AL138771, AL158046, AL590095 Genomic DNA. Translation: CAI18944.1.
AL138771
, AL139125, AL158046, AL590095 Genomic DNA. Translation: CAI21746.1.
CH471072 Genomic DNA. Translation: EAW86385.1.
BC152430 mRNA. Translation: AAI52431.1.
CCDSiCCDS31138.1.
RefSeqiNP_001018049.1. NM_001018039.1.
NP_001025051.1. NM_001029880.2.
XP_011517913.1. XM_011519611.1.
UniGeneiHs.407983.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WJRNMR-A182-295[»]
ProteinModelPortaliQ5VUG0.
SMRiQ5VUG0. Positions 43-477, 821-885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121736. 4 interactions.
STRINGi9606.ENSP00000355109.

PTM databases

iPTMnetiQ5VUG0.
PhosphoSiteiQ5VUG0.

Polymorphism and mutation databases

BioMutaiSFMBT2.
DMDMi67461560.

Proteomic databases

MaxQBiQ5VUG0.
PaxDbiQ5VUG0.
PRIDEiQ5VUG0.

Protocols and materials databases

DNASUi57713.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361972; ENSP00000355109; ENSG00000198879.
ENST00000397167; ENSP00000380353; ENSG00000198879.
GeneIDi57713.
KEGGihsa:57713.
UCSCiuc001ijn.2. human.

Organism-specific databases

CTDi57713.
GeneCardsiSFMBT2.
H-InvDBHIX0008624.
HGNCiHGNC:20256. SFMBT2.
HPAiHPA035447.
HPA035448.
MIMi615392. gene.
neXtProtiNX_Q5VUG0.
PharmGKBiPA134866013.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMEX. Eukaryota.
ENOG410XSJM. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000004859.
HOVERGENiHBG085238.
InParanoidiQ5VUG0.
OMAiDPPSEIY.
OrthoDBiEOG780RKN.
PhylomeDBiQ5VUG0.
TreeFamiTF316498.

Miscellaneous databases

ChiTaRSiSFMBT2. human.
EvolutionaryTraceiQ5VUG0.
GenomeRNAii57713.
NextBioi64624.
PROiQ5VUG0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5VUG0.
CleanExiHS_SFMBT2.
ExpressionAtlasiQ5VUG0. baseline and differential.
GenevisibleiQ5VUG0. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021987. DUF3588.
IPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12140. DUF3588. 1 hit.
PF02820. MBT. 4 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2."
    Lee K., Na W., Maeng J.H., Wu H., Ju B.G.
    J. Biosci. 38:105-112(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH YY1; HISTONE H3K9ME2 AND HISTONE H4K20ME2, SUBCELLULAR LOCATION.
  6. "Solution structure of the 2nd MBT domain from human KIAA1617 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 191-305.

Entry informationi

Entry nameiSMBT2_HUMAN
AccessioniPrimary (citable) accession number: Q5VUG0
Secondary accession number(s): A7MD09, Q9HCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 7, 2004
Last modified: April 13, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.