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Protein

Scm-like with four MBT domains protein 2

Gene

SFMBT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor of HOXB13 gene.1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • transcription corepressor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRepressor

Names & Taxonomyi

Protein namesi
Recommended name:
Scm-like with four MBT domains protein 2
Short name:
Scm-like with 4 MBT domains protein 2
Gene namesi
Name:SFMBT2
Synonyms:KIAA1617
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000198879.11
HGNCiHGNC:20256 SFMBT2
MIMi615392 gene
neXtProtiNX_Q5VUG0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198879
PharmGKBiPA134866013

Polymorphism and mutation databases

BioMutaiSFMBT2
DMDMi67461560

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719691 – 894Scm-like with four MBT domains protein 2Add BLAST894

Proteomic databases

EPDiQ5VUG0
MaxQBiQ5VUG0
PaxDbiQ5VUG0
PeptideAtlasiQ5VUG0
PRIDEiQ5VUG0

PTM databases

iPTMnetiQ5VUG0
PhosphoSitePlusiQ5VUG0

Expressioni

Gene expression databases

BgeeiENSG00000198879
CleanExiHS_SFMBT2
ExpressionAtlasiQ5VUG0 baseline and differential
GenevisibleiQ5VUG0 HS

Organism-specific databases

HPAiHPA035447
HPA035448

Interactioni

Subunit structurei

Interacts with YY1. Interacts with methylated histones H3K9me2 and H4K20me2, but not with H3K4me2, nor H3K9Ac.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121736, 4 interactors
IntActiQ5VUG0, 9 interactors
STRINGi9606.ENSP00000355109

Structurei

Secondary structure

1894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi182 – 185Combined sources4
Beta strandi191 – 195Combined sources5
Beta strandi203 – 207Combined sources5
Beta strandi215 – 218Combined sources4
Beta strandi231 – 234Combined sources4
Turni243 – 245Combined sources3
Helixi246 – 249Combined sources4
Turni257 – 262Combined sources6
Helixi265 – 281Combined sources17
Helixi286 – 289Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJRNMR-A182-295[»]
ProteinModelPortaliQ5VUG0
SMRiQ5VUG0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5VUG0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 144MBT 1Add BLAST101
Repeati152 – 256MBT 2Add BLAST105
Repeati266 – 372MBT 3Add BLAST107
Repeati380 – 477MBT 4Add BLAST98
Domaini824 – 887SAMAdd BLAST64

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMEX Eukaryota
ENOG410XSJM LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000004859
HOVERGENiHBG085238
InParanoidiQ5VUG0
OMAiDPPSEIY
OrthoDBiEOG091G02E7
PhylomeDBiQ5VUG0
TreeFamiTF316498

Family and domain databases

CDDicd09581 SAM_Scm-like-4MBT1_2, 1 hit
Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037604 Scm-like-4MBT1/2_SAM
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF02820 MBT, 4 hits
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 4 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits

Sequencei

Sequence statusi: Complete.

Q5VUG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTLSASNM QDPSSSPLEK CLGSANGNGD LDSEEGSSLE ETGFNWGEYL
60 70 80 90 100
EETGASAAPH TSFKHVEISI QSNFQPGMKL EVANKNNPDT YWVATIITTC
110 120 130 140 150
GQLLLLRYCG YGEDRRADFW CDVVIADLHP VGWCTQNNKV LMPPDAIKEK
160 170 180 190 200
YTDWTEFLIR DLTGSRTAPA NLLEGPLRGK GPIDLITVGS LIELQDSQNP
210 220 230 240 250
FQYWIVSVIE NVGGRLRLRY VGLEDTESYD QWLFYLDYRL RPVGWCQENK
260 270 280 290 300
YRMDPPSEIY PLKMASEWKC TLEKSLIDAA KFPLPMEVFK DHADLRSHFF
310 320 330 340 350
TVGMKLETVN MCEPFYISPA SVTKVFNNHF FQVTIDDLRP EPSKLSMLCH
360 370 380 390 400
ADSLGILPVQ WCLKNGVSLT PPKGYSGQDF DWADYHKQHG AQEAPPFCFR
410 420 430 440 450
NTSFSRGFTK NMKLEAVNPR NPGELCVASV VSVKGRLMWL HLEGLQTPVP
460 470 480 490 500
EVIVDVESMD IFPVGWCEAN SYPLTAPHKT VSQKKRKIAV VQPEKQLPPT
510 520 530 540 550
VPVKKIPHDL CLFPHLDTTG TVNGKYCCPQ LFINHRCFSG PYLNKGRIAE
560 570 580 590 600
LPQSVGPGKC VLVLKEVLSM IINAAYKPGR VLRELQLVED PHWNFQEETL
610 620 630 640 650
KAKYRGKTYR AVVKIVRTSD QVANFCRRVC AKLECCPNLF SPVLISENCP
660 670 680 690 700
ENCSIHTKTK YTYYYGKRKK ISKPPIGESN PDSGHPKPAR RRKRRKSIFV
710 720 730 740 750
QKKRRSSAVD FTAGSGEESE EEDADAMDDD TASEETGSEL RDDQTDTSSA
760 770 780 790 800
EVPSARPRRA VTLRSGSEPV RRPPPERTRR GRGAPAASSA EEGEKCPPTK
810 820 830 840 850
PEGTEDTKQE EEERLVLESN PLEWTVTDVV RFIKLTDCAP LAKIFQEQDI
860 870 880 890
DGQALLLLTL PTVQECMELK LGPAIKLCHQ IERVKVAFYA QYAN
Length:894
Mass (Da):100,563
Last modified:December 7, 2004 - v1
Checksum:i20EFF7F789F41787
GO

Sequence cautioni

The sequence BAB13443 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051362675P → R. Corresponds to variant dbSNP:rs3740212Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046837 mRNA Translation: BAB13443.1 Different initiation.
AL590095 Genomic DNA No translation available.
AL158046 Genomic DNA No translation available.
AL139125 Genomic DNA No translation available.
AL138771 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86385.1
BC152430 mRNA Translation: AAI52431.1
CCDSiCCDS31138.1
RefSeqiNP_001018049.1, NM_001018039.1
NP_001025051.1, NM_001029880.2
XP_011517913.1, XM_011519611.1
XP_016871955.1, XM_017016466.1
UniGeneiHs.407983

Genome annotation databases

EnsembliENST00000361972; ENSP00000355109; ENSG00000198879
ENST00000397167; ENSP00000380353; ENSG00000198879
GeneIDi57713
KEGGihsa:57713
UCSCiuc001ijn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSMBT2_HUMAN
AccessioniPrimary (citable) accession number: Q5VUG0
Secondary accession number(s): A7MD09, Q9HCF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health