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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

NMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.UniRule annotation

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferaseUniRule annotation (EC:2.3.1.97UniRule annotation)
Gene namesi
Name:NMT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000152465.17.
HGNCiHGNC:7858. NMT2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152465.

PTM / Processingi

Proteomic databases

MaxQBiQ5VUC6.

Expressioni

Gene expression databases

BgeeiENSG00000152465.
ExpressionAtlasiQ5VUC6. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 283NMTInterPro annotationAdd BLAST154
Domaini297 – 474NMT_CInterPro annotationAdd BLAST178

Sequence similaritiesi

Belongs to the NMT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOVERGENiHBG003404.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiView protein in Pfam
PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiView protein in PROSITE
PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VUC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRRSTPKE VLEGIWEPKR KRRNRREKRR NQIPEAPSQT RHLIPRRLKF
60 70 80 90 100
SSLRNTTPSG SRFQREQPWN PSVPMQKLQD IQRAMELLSA CQGPARNIDE
110 120 130 140 150
AAKHRYQFWD TQPVPKLDEV ITSHGAIEPD KDNVRQEPYS LPQGFMWDTL
160 170 180 190 200
DLSDAEVLKE LYTLLNENYV EDDDNMFRFD YSPEFLLWAL RPPGWLLQWH
210 220 230 240 250
CGVRVSSNKK LVGFISAIPA NIRIYDSVKK MVEINFLCVH KKLRSKRVAP
260 270 280 290 300
VLIREITRRV NLEGIFQAVY TAGVVLPKPI ATCRYWHRSL NPRKLVEVKF
310 320 330 340 350
SHLSRNMTLQ RTMKLYRLPD VTKTSGLRPM EPKDIKSVRE LINTYLKQFH
360 370 380 390 400
LAPVMDEEEV AHWFLPREHI IDTFVVESPN GKLTDFLSFY TLPSTVMHHP
410 420 430 440 450
AHKSLKAAYS FYNIHTETPL LDLMSDALIL AKSKGFDVFN ALDLMENKTF
460 470 480
LEKLKFGIGD GNLQYYLYNW RCPGTDSEKV GLVLQ
Length:485
Mass (Da):56,717
Last modified:December 7, 2004 - v1
Checksum:i735ED931C774D2B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590365 Genomic DNA. No translation available.
EF445001 Genomic DNA. Translation: ACA06027.1.
RefSeqiNP_001295224.1. NM_001308295.1.
UniGeneiHs.60339.

Genome annotation databases

EnsembliENST00000378150; ENSP00000367392; ENSG00000152465.
GeneIDi9397.
UCSCiuc001ioa.2. human.

Similar proteinsi

Entry informationi

Entry nameiQ5VUC6_HUMAN
AccessioniPrimary (citable) accession number: Q5VUC6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported