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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

NMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.UniRule annotation

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferaseUniRule annotation (EC:2.3.1.97UniRule annotation)
Gene namesi
Name:NMT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7858. NMT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ5VUC6.

Expressioni

Gene expression databases

ExpressionAtlasiQ5VUC6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367407.

Structurei

3D structure databases

SMRiQ5VUC6. Positions 98-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 283154NMTInterPro annotationAdd
BLAST
Domaini297 – 474178NMT_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NMT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOVERGENiHBG003404.
KOiK00671.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5VUC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRRSTPKE VLEGIWEPKR KRRNRREKRR NQIPEAPSQT RHLIPRRLKF
60 70 80 90 100
SSLRNTTPSG SRFQREQPWN PSVPMQKLQD IQRAMELLSA CQGPARNIDE
110 120 130 140 150
AAKHRYQFWD TQPVPKLDEV ITSHGAIEPD KDNVRQEPYS LPQGFMWDTL
160 170 180 190 200
DLSDAEVLKE LYTLLNENYV EDDDNMFRFD YSPEFLLWAL RPPGWLLQWH
210 220 230 240 250
CGVRVSSNKK LVGFISAIPA NIRIYDSVKK MVEINFLCVH KKLRSKRVAP
260 270 280 290 300
VLIREITRRV NLEGIFQAVY TAGVVLPKPI ATCRYWHRSL NPRKLVEVKF
310 320 330 340 350
SHLSRNMTLQ RTMKLYRLPD VTKTSGLRPM EPKDIKSVRE LINTYLKQFH
360 370 380 390 400
LAPVMDEEEV AHWFLPREHI IDTFVVESPN GKLTDFLSFY TLPSTVMHHP
410 420 430 440 450
AHKSLKAAYS FYNIHTETPL LDLMSDALIL AKSKGFDVFN ALDLMENKTF
460 470 480
LEKLKFGIGD GNLQYYLYNW RCPGTDSEKV GLVLQ
Length:485
Mass (Da):56,717
Last modified:December 7, 2004 - v1
Checksum:i735ED931C774D2B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590365 Genomic DNA. No translation available.
EF445001 Genomic DNA. Translation: ACA06027.1.
RefSeqiNP_001295224.1. NM_001308295.1.
UniGeneiHs.60339.

Genome annotation databases

EnsembliENST00000378150; ENSP00000367392; ENSG00000152465.
GeneIDi9397.
KEGGihsa:9397.
UCSCiuc001ioa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590365 Genomic DNA. No translation available.
EF445001 Genomic DNA. Translation: ACA06027.1.
RefSeqiNP_001295224.1. NM_001308295.1.
UniGeneiHs.60339.

3D structure databases

SMRiQ5VUC6. Positions 98-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367407.

Proteomic databases

EPDiQ5VUC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378150; ENSP00000367392; ENSG00000152465.
GeneIDi9397.
KEGGihsa:9397.
UCSCiuc001ioa.2. human.

Organism-specific databases

CTDi9397.
HGNCiHGNC:7858. NMT2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOVERGENiHBG003404.
KOiK00671.

Miscellaneous databases

ChiTaRSiNMT2. human.
GenomeRNAii9397.

Gene expression databases

ExpressionAtlasiQ5VUC6. baseline and differential.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Stockwell T.B., Busam D.A., Ferriera S.M., Brownley A.N., Strausberg R.L., Kirkness E.F., Rogers Y.-H., Levy S.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5VUC6_HUMAN
AccessioniPrimary (citable) accession number: Q5VUC6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.