Q5VUB5 (F1711_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM171A1

Alternative name(s):
Astroprincin

Gene names

Name:	FAM171A1
Synonyms:	C10orf38

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	890 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the FAM171 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 890	869	Protein FAM171A1		PRO_0000274263
Regions
	Topological domain	22 – 303	282	Extracellular Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Topological domain	325 – 890	566	Cytoplasmic Potential
Amino acid modifications
	Modified residue	855	1	Phosphoserine Ref.5
	Glycosylation	159	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	465	1	P → S. Ref.4 Corresponds to variant rs3814165 [ dbSNP | Ensembl ].		VAR_030220
Experimental info
	Sequence conflict	118	1	L → P in AAI09304. Ref.4
	Sequence conflict	592	1	G → R in AAH34232. Ref.4
	Sequence conflict	670	1	P → Q in AAH34232. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q5VUB5 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: A0718E29A639FB72	FASTA	890	97,854
	10 20 30 40 50 60 MSRSATLLLC LLGCHVWKAV TKTLREPGAG AQEVTLKVHI SDASTHQPVA DALIEIFTNQ 70 80 90 100 110 120 ASIASGTSGT DGVAFIKFQY KLGSQLIVTA SKHAYVPNSA PWKPIRLPVF SSLSLGLLPE 130 140 150 160 170 180 RSATLMVYED VVQIVSGFQG ARPQPRVHFQ RRALRLPENT SYSDLTAFLT AASSPSEVDS 190 200 210 220 230 240 FPYLRGLDGN GTGNSTRHDL TPVTAVSVHL LSSNGTPVLV DGPIYVTVPL ATQSSLRHNA 250 260 270 280 290 300 YVAAWRFDQK LGTWLKSGLG LVHQEGSQLT WTYIAPQLGY WVAAMSPPIP GPVVTQDITT 310 320 330 340 350 360 YHTVFLLAIL GGMAFILLVL LCLLLYYCRR KCLKPRQHHR KLQLPAGLES SKRDQSTSMS 370 380 390 400 410 420 HINLLFSRRA SEFPGPLSVT SHGRPEAPGT KELMSGVHLE MMSPGGEGDL HTPMLKLSYS 430 440 450 460 470 480 TSQEFSSREE LLSCKEEDKS QISFDNLTPS GTLGKDYHKS VEVFPLKARK SMEREGYESS 490 500 510 520 530 540 GNDDYRGSYN TVLSQPLFEK QDREGPASTG SKLTIQEHLY PAPSSPEKEQ LLDRRPTECM 550 560 570 580 590 600 MSRSVDHLER PTSFPRPGQL ICCSSVDQVN DSVYRKVLPA LVIPAHYMKL PGDHSYVSQP 610 620 630 640 650 660 LVVPADQQLE IERLQAELSN PHAGIFPHPS SQIQPQPLSS QAISQQHLQD AGTREWSPQN 670 680 690 700 710 720 ASMSESLSIP ASLNDAALAQ MNSEVQLLTE KALMELGGGK PLPHPRAWFV SLDGRSNAHV 730 740 750 760 770 780 RHSYIDLQRA GRNGSNDASL DSGVDMNEPK SARKGRGDAL SLQQNYPPVQ EHQQKEPRAP 790 800 810 820 830 840 DSTAYTQLVY LDDVEQSGSE CGTTVCTPED SALRCLLEGS SRRSGGQLPS LQEETTRRTA 850 860 870 880 890 DAPSEPAASP HQRRSAHEEE EDDDDDDQGE DKKSPWQKRE ERPLMAFNIK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression profile of a novel gene isolated from DiGeorge syndrome critical region on chromosome 10." Attalla H., Karlsson L., Paetau A., Andersson L.C. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-465. Tissue: Brain.
[5]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-159, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY683003 mRNA. Translation: AAV85904.1. AL590365, AL139338, AL607028 Genomic DNA. Translation: CAH73963.1. AL139338, AL590365, AL607028 Genomic DNA. Translation: CAI12244.1. AL607028, AL139338, AL590365 Genomic DNA. Translation: CAI12941.1. CH471072 Genomic DNA. Translation: EAW86237.1. BC034232 mRNA. Translation: AAH34232.1. BC109302 mRNA. Translation: AAI09303.1. BC109303 mRNA. Translation: AAI09304.1.
IPI	IPI00000265.
RefSeq	NP_001010924.1. NM_001010924.1.
UniGene	Hs.66762.
3D structure databases
ProteinModelPortal	Q5VUB5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5VUB5. 2 interactions.
STRING	Q5VUB5.
PTM databases
PhosphoSite	Q5VUB5.
Polymorphism databases
DMDM	74747078.
Proteomic databases
PRIDE	Q5VUB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378116; ENSP00000367356; ENSG00000148468.
GeneID	221061.
KEGG	hsa:221061.
UCSC	uc001iob.1. human.
Organism-specific databases
CTD	221061.
GeneCards	GC10M015254.
HGNC	HGNC:23522. FAM171A1.
neXtProt	NX_Q5VUB5.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063318.
HOGENOM	HBG715100.
HOVERGEN	HBG057508.
InParanoid	Q5VUB5.
OMA	VDHLERP.
OrthoDB	EOG4VDPZ3.
Gene expression databases
ArrayExpress	Q5VUB5.
Bgee	Q5VUB5.
CleanEx	HS_FAM171A1.
Genevestigator	Q5VUB5.
Family and domain databases
InterPro	IPR018890. Uncharacterised_FAM171. [Graphical view]
Pfam	PF10577. UPF0560. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91175.

Entry information

Entry name

F1711_HUMAN

Accession

Primary (citable) accession number: Q5VUB5
Secondary accession number(s): D3DRT9, Q32M49, Q8N4I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	December 7, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.