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Protein

Protein FAM171A1

Gene

FAM171A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM171A1
Alternative name(s):
Astroprincin
Gene namesi
Name:FAM171A1
Synonyms:C10orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23522. FAM171A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 303282ExtracellularSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 890566CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387176.

Polymorphism and mutation databases

BioMutaiFAM171A1.
DMDMi74747078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 890869Protein FAM171A1PRO_0000274263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...)1 Publication
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Modified residuei371 – 3711PhosphoserineCombined sources
Modified residuei443 – 4431PhosphoserineCombined sources
Modified residuei849 – 8491PhosphoserineCombined sources
Modified residuei855 – 8551PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ5VUB5.
MaxQBiQ5VUB5.
PaxDbiQ5VUB5.
PRIDEiQ5VUB5.

PTM databases

iPTMnetiQ5VUB5.
PhosphoSiteiQ5VUB5.
SwissPalmiQ5VUB5.

Expressioni

Gene expression databases

BgeeiQ5VUB5.
CleanExiHS_FAM171A1.
ExpressionAtlasiQ5VUB5. baseline and differential.
GenevisibleiQ5VUB5. HS.

Organism-specific databases

HPAiHPA051345.

Interactioni

Protein-protein interaction databases

BioGridi128680. 5 interactions.
IntActiQ5VUB5. 3 interactions.
STRINGi9606.ENSP00000367356.

Structurei

3D structure databases

ProteinModelPortaliQ5VUB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM171 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKM3. Eukaryota.
ENOG410ZV9V. LUCA.
GeneTreeiENSGT00530000063318.
HOGENOMiHOG000231925.
HOVERGENiHBG057508.
InParanoidiQ5VUB5.
OMAiDGRSNAH.
OrthoDBiEOG78PV8F.
PhylomeDBiQ5VUB5.
TreeFamiTF331338.

Family and domain databases

InterProiIPR018890. Uncharacterised_FAM171.
[Graphical view]
PfamiPF10577. UPF0560. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5VUB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSATLLLC LLGCHVWKAV TKTLREPGAG AQEVTLKVHI SDASTHQPVA
60 70 80 90 100
DALIEIFTNQ ASIASGTSGT DGVAFIKFQY KLGSQLIVTA SKHAYVPNSA
110 120 130 140 150
PWKPIRLPVF SSLSLGLLPE RSATLMVYED VVQIVSGFQG ARPQPRVHFQ
160 170 180 190 200
RRALRLPENT SYSDLTAFLT AASSPSEVDS FPYLRGLDGN GTGNSTRHDL
210 220 230 240 250
TPVTAVSVHL LSSNGTPVLV DGPIYVTVPL ATQSSLRHNA YVAAWRFDQK
260 270 280 290 300
LGTWLKSGLG LVHQEGSQLT WTYIAPQLGY WVAAMSPPIP GPVVTQDITT
310 320 330 340 350
YHTVFLLAIL GGMAFILLVL LCLLLYYCRR KCLKPRQHHR KLQLPAGLES
360 370 380 390 400
SKRDQSTSMS HINLLFSRRA SEFPGPLSVT SHGRPEAPGT KELMSGVHLE
410 420 430 440 450
MMSPGGEGDL HTPMLKLSYS TSQEFSSREE LLSCKEEDKS QISFDNLTPS
460 470 480 490 500
GTLGKDYHKS VEVFPLKARK SMEREGYESS GNDDYRGSYN TVLSQPLFEK
510 520 530 540 550
QDREGPASTG SKLTIQEHLY PAPSSPEKEQ LLDRRPTECM MSRSVDHLER
560 570 580 590 600
PTSFPRPGQL ICCSSVDQVN DSVYRKVLPA LVIPAHYMKL PGDHSYVSQP
610 620 630 640 650
LVVPADQQLE IERLQAELSN PHAGIFPHPS SQIQPQPLSS QAISQQHLQD
660 670 680 690 700
AGTREWSPQN ASMSESLSIP ASLNDAALAQ MNSEVQLLTE KALMELGGGK
710 720 730 740 750
PLPHPRAWFV SLDGRSNAHV RHSYIDLQRA GRNGSNDASL DSGVDMNEPK
760 770 780 790 800
SARKGRGDAL SLQQNYPPVQ EHQQKEPRAP DSTAYTQLVY LDDVEQSGSE
810 820 830 840 850
CGTTVCTPED SALRCLLEGS SRRSGGQLPS LQEETTRRTA DAPSEPAASP
860 870 880 890
HQRRSAHEEE EDDDDDDQGE DKKSPWQKRE ERPLMAFNIK
Length:890
Mass (Da):97,854
Last modified:December 7, 2004 - v1
Checksum:iA0718E29A639FB72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181L → P in AAI09304 (PubMed:15489334).Curated
Sequence conflicti592 – 5921G → R in AAH34232 (PubMed:15489334).Curated
Sequence conflicti670 – 6701P → Q in AAH34232 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti465 – 4651P → S.1 Publication
Corresponds to variant rs3814165 [ dbSNP | Ensembl ].
VAR_030220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY683003 mRNA. Translation: AAV85904.1.
AL590365, AL139338, AL607028 Genomic DNA. Translation: CAH73963.1.
AL139338, AL590365, AL607028 Genomic DNA. Translation: CAI12244.1.
AL607028, AL139338, AL590365 Genomic DNA. Translation: CAI12941.1.
CH471072 Genomic DNA. Translation: EAW86237.1.
BC034232 mRNA. Translation: AAH34232.1.
BC109302 mRNA. Translation: AAI09303.1.
BC109303 mRNA. Translation: AAI09304.1.
CCDSiCCDS31154.1.
RefSeqiNP_001010924.1. NM_001010924.1.
UniGeneiHs.66762.

Genome annotation databases

EnsembliENST00000378116; ENSP00000367356; ENSG00000148468.
GeneIDi221061.
KEGGihsa:221061.
UCSCiuc001iob.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY683003 mRNA. Translation: AAV85904.1.
AL590365, AL139338, AL607028 Genomic DNA. Translation: CAH73963.1.
AL139338, AL590365, AL607028 Genomic DNA. Translation: CAI12244.1.
AL607028, AL139338, AL590365 Genomic DNA. Translation: CAI12941.1.
CH471072 Genomic DNA. Translation: EAW86237.1.
BC034232 mRNA. Translation: AAH34232.1.
BC109302 mRNA. Translation: AAI09303.1.
BC109303 mRNA. Translation: AAI09304.1.
CCDSiCCDS31154.1.
RefSeqiNP_001010924.1. NM_001010924.1.
UniGeneiHs.66762.

3D structure databases

ProteinModelPortaliQ5VUB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128680. 5 interactions.
IntActiQ5VUB5. 3 interactions.
STRINGi9606.ENSP00000367356.

PTM databases

iPTMnetiQ5VUB5.
PhosphoSiteiQ5VUB5.
SwissPalmiQ5VUB5.

Polymorphism and mutation databases

BioMutaiFAM171A1.
DMDMi74747078.

Proteomic databases

EPDiQ5VUB5.
MaxQBiQ5VUB5.
PaxDbiQ5VUB5.
PRIDEiQ5VUB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378116; ENSP00000367356; ENSG00000148468.
GeneIDi221061.
KEGGihsa:221061.
UCSCiuc001iob.4. human.

Organism-specific databases

CTDi221061.
GeneCardsiFAM171A1.
H-InvDBHIX0008675.
HGNCiHGNC:23522. FAM171A1.
HPAiHPA051345.
neXtProtiNX_Q5VUB5.
PharmGKBiPA162387176.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKM3. Eukaryota.
ENOG410ZV9V. LUCA.
GeneTreeiENSGT00530000063318.
HOGENOMiHOG000231925.
HOVERGENiHBG057508.
InParanoidiQ5VUB5.
OMAiDGRSNAH.
OrthoDBiEOG78PV8F.
PhylomeDBiQ5VUB5.
TreeFamiTF331338.

Miscellaneous databases

ChiTaRSiFAM171A1. human.
GenomeRNAii221061.
PROiQ5VUB5.

Gene expression databases

BgeeiQ5VUB5.
CleanExiHS_FAM171A1.
ExpressionAtlasiQ5VUB5. baseline and differential.
GenevisibleiQ5VUB5. HS.

Family and domain databases

InterProiIPR018890. Uncharacterised_FAM171.
[Graphical view]
PfamiPF10577. UPF0560. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression profile of a novel gene isolated from DiGeorge syndrome critical region on chromosome 10."
    Attalla H., Karlsson L., Paetau A., Andersson L.C.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-465.
    Tissue: Brain.
  5. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-159.
    Tissue: Liver.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371; SER-443 AND SER-849, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiF1711_HUMAN
AccessioniPrimary (citable) accession number: Q5VUB5
Secondary accession number(s): D3DRT9, Q32M49, Q8N4I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.