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Protein

Zinc finger protein 318

Gene

ZNF318

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Meiosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 318
Alternative name(s):
Endocrine regulatory protein
Gene namesi
Name:ZNF318
ORF Names:HRIHFB2436
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13578. ZNF318.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi24149.
OpenTargetsiENSG00000171467.
PharmGKBiPA134923137.

Polymorphism and mutation databases

BioMutaiZNF318.
DMDMi166215018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918071 – 2279Zinc finger protein 318Add BLAST2279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei205PhosphotyrosineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Cross-linki578Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei842PhosphothreonineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1243PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1420PhosphoserineCombined sources1
Modified residuei1713PhosphoserineCombined sources1
Modified residuei1856PhosphoserineCombined sources1
Modified residuei1896PhosphoserineCombined sources1
Modified residuei1971PhosphoserineCombined sources1
Modified residuei2030PhosphoserineCombined sources1
Modified residuei2035PhosphoserineCombined sources1
Modified residuei2091PhosphoserineCombined sources1
Modified residuei2101PhosphoserineCombined sources1
Modified residuei2189PhosphoserineCombined sources1
Modified residuei2192PhosphoserineCombined sources1
Modified residuei2243PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5VUA4.
MaxQBiQ5VUA4.
PaxDbiQ5VUA4.
PeptideAtlasiQ5VUA4.
PRIDEiQ5VUA4.

PTM databases

iPTMnetiQ5VUA4.
PhosphoSitePlusiQ5VUA4.

Expressioni

Tissue specificityi

Expressed in endocrine tissue.1 Publication

Gene expression databases

BgeeiENSG00000171467.
CleanExiHS_ZNF318.
ExpressionAtlasiQ5VUA4. baseline and differential.
GenevisibleiQ5VUA4. HS.

Organism-specific databases

HPAiHPA027022.
HPA027031.

Interactioni

Subunit structurei

Interacts with the N-terminal domain of AR.By similarity

Protein-protein interaction databases

BioGridi117299. 37 interactors.
IntActiQ5VUA4. 9 interactors.
STRINGi9606.ENSP00000354964.

Structurei

3D structure databases

ProteinModelPortaliQ5VUA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili315 – 343Sequence analysisAdd BLAST29
Coiled coili876 – 980Sequence analysisAdd BLAST105
Coiled coili1768 – 1792Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 103Pro-richAdd BLAST63
Compositional biasi1201 – 1327Lys-richAdd BLAST127
Compositional biasi1433 – 1541Pro-richAdd BLAST109

Sequence similaritiesi

Contains 2 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1063 – 1097Matrin-type 1Add BLAST35
Zinc fingeri1136 – 1166Matrin-type 2Add BLAST31

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHGT. Eukaryota.
ENOG4111IJJ. LUCA.
GeneTreeiENSGT00390000000614.
HOGENOMiHOG000043103.
HOVERGENiHBG107139.
InParanoidiQ5VUA4.
OMAiKTVVAHT.
OrthoDBiEOG091G00B9.
PhylomeDBiQ5VUA4.
TreeFamiTF350583.

Family and domain databases

InterProiIPR003604. Znf_U1.
[Graphical view]
SMARTiSM00451. ZnF_U1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VUA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRSSARSSV SSHRPKDDGG GGPRSGRSSG SSSGPARRSS PPPPPSGSSS
60 70 80 90 100
RTPARRPRSP SGHRGRRASP SPPRGRRVSP SPPRARRGSP SPPRGRRLFP
110 120 130 140 150
PGPAGFRGSS RGESRADYAR DGRGDHPGDS GSRRRSPGLC SDSLEKSLRI
160 170 180 190 200
TVGNDHFCVS TPERRRLSDR LGSPVDNLED MDRDDLTDDS VFTRSSQCSR
210 220 230 240 250
GLERYISQEE GPLSPFLGQL DEDYRTKETF LHRSDYSPHI SCHDELLRGT
260 270 280 290 300
ERNREKLKGY SIRSEERSRE AKRPRYDDTV KINSMGGDHP SFTSGTRNYR
310 320 330 340 350
QRRRSPSPRF LDPEFRELDL ARRKREEEEE RSRSLSQELV GVDGGGTGCS
360 370 380 390 400
IPGLSGVLTA SEPGYSLHRP EEVSVMPKKS ILKKRIEVDI MEPSMQLESF
410 420 430 440 450
SSSTSSSQDH PLYSGHPSLP LSGAIAAFAS EIENKGTMVE TALKEPQGNL
460 470 480 490 500
YQWGPLPGIP KDNSPLREKF GSFLCHKDNL DLKAEGPERH TDFLLPHERA
510 520 530 540 550
SQDGSGFSRI LSMLADSTST QEKRRRSFPD IEDEEKFLYG DEEEDLKAES
560 570 580 590 600
VPKPLGSSES EVMRQKASSL PSSAPAVKLE SLEETNPEYA KIHDLLKTIG
610 620 630 640 650
LDIGVAEISQ LAARTQERLH GKKPSLRSSA DRRSSVDRYF SADHCSSVDH
660 670 680 690 700
RFSADRCSSV DHCFSADRRS SDPHRLESRE AHHSNTHSPE VSHPHPPSPV
710 720 730 740 750
DPYLLTKNSP PFLKSDHPVG HISGPEVVGS GFQSSVAVRC MLPSAPSAPI
760 770 780 790 800
RLPHTAALSQ FHMPRASQFA AARIPPNYQG PAIPPASFDA YRHYMAYAAS
810 820 830 840 850
RWPMYPTSQP SNHPVPEPHR IMPITKQATR SRPNLRVIPT VTPDKPKQKE
860 870 880 890 900
SLRGSIPAAQ VPVQVSIPSL IRYNPEKISD EKNRASQKQK VIEEREKLKN
910 920 930 940 950
DREARQKKMY YLRTELERLH KQQGEMLRKK RREKDGHKDP LLVEVSRLQD
960 970 980 990 1000
NIMKDIAELR QEAEEAEKKQ SELDKVAQIL GINIFDKSQK SLSDSREPTE
1010 1020 1030 1040 1050
KPGKAEKSKS PEKVSSFSNS SSNKESKVNN EKFRTKSPKP AESPQSATKQ
1060 1070 1080 1090 1100
LDQPTAAYEY YDAGNHWCKD CNTICGTMFD FFTHMHNKKH TQTLDPYNRP
1110 1120 1130 1140 1150
WASKTQSEAK QDAIKRTDKI TVPAKGSEFL VPISGFYCQL CEEFLGDPIS
1160 1170 1180 1190 1200
GEQHVKGHQH NEKYKKYVDE NPLYEERRNL DRQAGLAVVL ETERRRQSEL
1210 1220 1230 1240 1250
KRKLSEKPKE EKKEKKAKAV KEVKEDDKVS EKLEDQLSEG RNSPEKAENK
1260 1270 1280 1290 1300
RNTGIKLQLK EEVKKESPTS SSFGKFSWKK PEKEEEKSSL VTPSISKEEI
1310 1320 1330 1340 1350
LESSKDKEDG KTEAGKAKPI KIKLSGKTVV AHTSPWMPVV TTSTQTKIRP
1360 1370 1380 1390 1400
NLPIPSTVLR KSCSATMSKP APLNTFLSIK SSGTTAKPLP VVKESSADLL
1410 1420 1430 1440 1450
LPPDIISKAF GGEEVILKGS PEEKVVLAEK SEPSHLPEQI LPPPPPPPPP
1460 1470 1480 1490 1500
PPPPPPVIPH PAAPSAAQAN AILAPVKSNP VVSQTLSPGF VGPNILNPVL
1510 1520 1530 1540 1550
PVAIMASAQP AAIPSDETAP GVSESDRDQT LFSVLVRPPP PLSSVFSEQA
1560 1570 1580 1590 1600
KKLEKRNSCL ATANAKDLYD IFYSSGGKGA PETKGAPETK LSGGPLANGE
1610 1620 1630 1640 1650
NSNLSRTKSS DTSSTSPLNS SASQEELHQD EGLVAAPIVS NSEKPIAKTL
1660 1670 1680 1690 1700
VALGKWSVVE HVGPKSTGST YGFLQPLTRL CQSRPYETIT PKTDTLAIWT
1710 1720 1730 1740 1750
SSSFQSDTSR DISPEKSELD LGEPGPPGVE PPPQLLDIQC KESQKLVEIH
1760 1770 1780 1790 1800
LRESVNQDKE SQELRKSEDC RESEIETNTE LKERVKELSE GIVDEGVSTS
1810 1820 1830 1840 1850
IGPHSIDDSN LNHGNRYMWE GEVKQPNLLM IDKEAEQSNK LMTGSETPSK
1860 1870 1880 1890 1900
VVIKLSPQAC SFTKAKLDSF LSEARSLLNP QDTPVKISAP ELLLHSPARS
1910 1920 1930 1940 1950
AMCLTGSPQE QGVSVVSEEG LENSAPESAS RTSRYRSLKL KRERSKDFQV
1960 1970 1980 1990 2000
KKIYELAVWD ENKKRPETWE SPEKPKTEAL ELQDVHPELT VTIESKALED
2010 2020 2030 2040 2050
FEATDLKVEE LTALGNLGDM PVDFCTTRVS PAHRSPTVLC QKVCEENSVS
2060 2070 2080 2090 2100
PIGCNSSDPA DFEPIPSFSG FPLDSPKTLV LDFETEGERN SPNPRSVRIP
2110 2120 2130 2140 2150
SPNILKTGLT ENVDRGLGGL EGTHQALDLL AGGMMPEEVK ESSQLDKQES
2160 2170 2180 2190 2200
LGLELKTINS AGLGPSPCLP DLVDFVTRTS GVQKDKLCSP LSEPGDPSKC
2210 2220 2230 2240 2250
SSLELGPLQL EISNASTTEV AILQVDDDSG DPLNLVKAPV SRSPPREQVI
2260 2270
EDNMVPQGMP EQETTVGAIQ DHTESSVHN
Length:2,279
Mass (Da):251,112
Last modified:January 15, 2008 - v2
Checksum:iCC8F7D54710E2450
GO
Isoform 2 (identifier: Q5VUA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1093-1117: TLDPYNRPWASKTQSEAKQDAIKRT → GQFQKSSDFQKEGLQQTFLPPERQG
     1118-2279: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,117
Mass (Da):124,880
Checksum:i65866465A953CF07
GO

Sequence cautioni

The sequence AAD17298 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAD47387 differs from that shown. Reason: Frameshift at positions 4 and 44.Curated
The sequence AAH98434 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 1214.Curated
The sequence AAH98434 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62G → R in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD47387 (Ref. 1) Curated1
Sequence conflicti75G → V in AAD17298 (Ref. 1) Curated1
Sequence conflicti1034 – 1035RT → CI in AAD47387 (Ref. 1) Curated2
Sequence conflicti1034 – 1035RT → CI in AAD17298 (Ref. 1) Curated2
Sequence conflicti1259L → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti1259L → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD47387 (Ref. 1) Curated1
Sequence conflicti1349R → G in AAD17298 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD47387 (Ref. 1) Curated1
Sequence conflicti2160S → F in AAD17298 (Ref. 1) Curated1
Sequence conflicti2173V → D in BAA34799 (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053759407S → I.Corresponds to variant rs34541323dbSNPEnsembl.1
Natural variantiVAR_036056812N → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs141660717dbSNPEnsembl.1
Natural variantiVAR_053760870L → V.Corresponds to variant rs9357410dbSNPEnsembl.1
Natural variantiVAR_0360571274G → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0537611292T → I.Corresponds to variant rs10948072dbSNPEnsembl.1
Natural variantiVAR_0537621580A → T.Corresponds to variant rs3734684dbSNPEnsembl.1
Natural variantiVAR_0537631583T → I.Corresponds to variant rs36107018dbSNPEnsembl.1
Natural variantiVAR_0537641797V → A.1 PublicationCorresponds to variant rs1459675dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0165921093 – 1117TLDPY…AIKRT → GQFQKSSDFQKEGLQQTFLP PERQG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0165931118 – 2279Missing in isoform 2. 1 PublicationAdd BLAST1162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090114 mRNA. Translation: AAD47387.1. Frameshift.
AF121141 mRNA. Translation: AAD17298.1. Different initiation.
AL590383, AL583834 Genomic DNA. Translation: CAH71374.2.
AL583834, AL590383 Genomic DNA. Translation: CAI14459.2.
BC030687 mRNA. No translation available.
BC098434 mRNA. Translation: AAH98434.1. Sequence problems.
AB015342 mRNA. Translation: BAA34799.1.
CCDSiCCDS4895.2. [Q5VUA4-1]
RefSeqiNP_055160.2. NM_014345.2. [Q5VUA4-1]
XP_011512754.1. XM_011514452.2. [Q5VUA4-2]
UniGeneiHs.509718.

Genome annotation databases

EnsembliENST00000361428; ENSP00000354964; ENSG00000171467. [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467. [Q5VUA4-2]
GeneIDi24149.
KEGGihsa:24149.
UCSCiuc003ouw.4. human. [Q5VUA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090114 mRNA. Translation: AAD47387.1. Frameshift.
AF121141 mRNA. Translation: AAD17298.1. Different initiation.
AL590383, AL583834 Genomic DNA. Translation: CAH71374.2.
AL583834, AL590383 Genomic DNA. Translation: CAI14459.2.
BC030687 mRNA. No translation available.
BC098434 mRNA. Translation: AAH98434.1. Sequence problems.
AB015342 mRNA. Translation: BAA34799.1.
CCDSiCCDS4895.2. [Q5VUA4-1]
RefSeqiNP_055160.2. NM_014345.2. [Q5VUA4-1]
XP_011512754.1. XM_011514452.2. [Q5VUA4-2]
UniGeneiHs.509718.

3D structure databases

ProteinModelPortaliQ5VUA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117299. 37 interactors.
IntActiQ5VUA4. 9 interactors.
STRINGi9606.ENSP00000354964.

PTM databases

iPTMnetiQ5VUA4.
PhosphoSitePlusiQ5VUA4.

Polymorphism and mutation databases

BioMutaiZNF318.
DMDMi166215018.

Proteomic databases

EPDiQ5VUA4.
MaxQBiQ5VUA4.
PaxDbiQ5VUA4.
PeptideAtlasiQ5VUA4.
PRIDEiQ5VUA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361428; ENSP00000354964; ENSG00000171467. [Q5VUA4-1]
ENST00000605935; ENSP00000475748; ENSG00000171467. [Q5VUA4-2]
GeneIDi24149.
KEGGihsa:24149.
UCSCiuc003ouw.4. human. [Q5VUA4-1]

Organism-specific databases

CTDi24149.
DisGeNETi24149.
GeneCardsiZNF318.
HGNCiHGNC:13578. ZNF318.
HPAiHPA027022.
HPA027031.
neXtProtiNX_Q5VUA4.
OpenTargetsiENSG00000171467.
PharmGKBiPA134923137.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHGT. Eukaryota.
ENOG4111IJJ. LUCA.
GeneTreeiENSGT00390000000614.
HOGENOMiHOG000043103.
HOVERGENiHBG107139.
InParanoidiQ5VUA4.
OMAiKTVVAHT.
OrthoDBiEOG091G00B9.
PhylomeDBiQ5VUA4.
TreeFamiTF350583.

Miscellaneous databases

ChiTaRSiZNF318. human.
GeneWikiiZNF318.
GenomeRNAii24149.
PROiQ5VUA4.

Gene expression databases

BgeeiENSG00000171467.
CleanExiHS_ZNF318.
ExpressionAtlasiQ5VUA4. baseline and differential.
GenevisibleiQ5VUA4. HS.

Family and domain databases

InterProiIPR003604. Znf_U1.
[Graphical view]
SMARTiSM00451. ZnF_U1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN318_HUMAN
AccessioniPrimary (citable) accession number: Q5VUA4
Secondary accession number(s): O94796
, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.