Q5VU92 (DC121_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DDB1- and CUL4-associated factor 12-like protein 1

Alternative name(s):
WD repeat-containing protein 40B

Gene names

Name:	DCAF12L1
Synonyms:	WDR40B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the WD repeat DCAF12 family. Contains 4 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	DDB1- and CUL4-associated factor 12-like protein 1		PRO_0000306848
Regions
	Repeat	147 – 187	41	WD 1
	Repeat	192 – 230	39	WD 2
	Repeat	260 – 299	40	WD 3
	Repeat	348 – 385	38	WD 4
Natural variations
	Natural variant	19	1	D → G. Ref.3 Corresponds to variant rs11095722 [ dbSNP | Ensembl ].		VAR_035323

Sequences

	Sequence		Length	Mass (Da)
	Q5VU92 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: D499893FBE4D4E49	FASTA	463	51,201
	10 20 30 40 50 60 MAQQQTGSRK RKAPAVEADA ESSPSQGLAA ADGEGPLLLK RQRRPATYRS MAHYLKVREV 70 80 90 100 110 120 GGWGPARLQG FDGELRGYAV QRLPELLTER QLELGTVNKV FASQWLNSRQ VVCGTKCNTL 130 140 150 160 170 180 FVVDVESGHI ARIPLLRDSE ARLAQDQQGC GIHAIELNPS KTLLATGGEN PNSLAIYQLP 190 200 210 220 230 240 SLDPLCLGDR HGHKDWIFAV AWLSDTVAVS GSRDGTVALW RMDPDKFDDT VAWHSEVGLP 250 260 270 280 290 300 VYAHIRPRDV EAIPRAIINP SNRKVRALAC GGKNQELGAV SLDGYFHLWK AGSALSRLLS 310 320 330 340 350 360 IRLPYFRDNV CLTYCDDMSV YAVGSHSHVS FLDLRQDQQN IRPLCSREGG TGVRSLSFYR 370 380 390 400 410 420 HIITVGTGQG SLLFYDVRAQ KFLEERASAT LESSSGPARR KLRLACGRGW LNHNDFWVNY 430 440 450 460 FGGMEVFPNA LYTHCYNWPE MKLFVAGGPL PAGLHGNYAG LWS

References

[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-19. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590425 Genomic DNA. Translation: CAH69964.1. CH471107 Genomic DNA. Translation: EAX11841.1. BC035674 mRNA. Translation: AAH35674.1.
IPI	IPI00217792.
RefSeq	NP_848565.2. NM_178470.4.
UniGene	Hs.120403.
3D structure databases
ProteinModelPortal	Q5VU92.
SMR	Q5VU92. Positions 107-225, 363-409.
ModBase	Search...
Polymorphism databases
DMDM	74762259.
Proteomic databases
PRIDE	Q5VU92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371126; ENSP00000360167; ENSG00000198889.
GeneID	139170.
KEGG	hsa:139170.
UCSC	uc004eul.1. human.
Organism-specific databases
CTD	139170.
GeneCards	GC0XM125683.
HGNC	HGNC:29395. DCAF12L1.
neXtProt	NX_Q5VU92.
PharmGKB	PA134927654. PA165756488.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG17437.
GeneTree	ENSGT00390000001132.
HOGENOM	HBG713195.
HOVERGEN	HBG055605.
InParanoid	Q5VU92.
OMA	VAWHSEV.
OrthoDB	EOG4PK27V.
PhylomeDB	Q5VU92.
Gene expression databases
ArrayExpress	Q5VU92.
Bgee	Q5VU92.
CleanEx	HS_WDR40B.
Genevestigator	Q5VU92.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	83906.

Entry information

Entry name

DC121_HUMAN

Accession

Primary (citable) accession number: Q5VU92
Secondary accession number(s): Q8IYK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 7, 2004
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.