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Protein

DDB1- and CUL4-associated factor 12-like protein 1

Gene

DCAF12L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ5VU92.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 12-like protein 1
Alternative name(s):
WD repeat-containing protein 40B
Gene namesi
Name:DCAF12L1
Synonyms:WDR40B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29395. DCAF12L1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198889.
PharmGKBiPA165756488.

Polymorphism and mutation databases

BioMutaiDCAF12L1.
DMDMi74762259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068481 – 463DDB1- and CUL4-associated factor 12-like protein 1Add BLAST463

Proteomic databases

EPDiQ5VU92.
MaxQBiQ5VU92.
PaxDbiQ5VU92.
PeptideAtlasiQ5VU92.
PRIDEiQ5VU92.

PTM databases

iPTMnetiQ5VU92.
PhosphoSitePlusiQ5VU92.

Expressioni

Gene expression databases

BgeeiENSG00000198889.
CleanExiHS_WDR40B.
GenevisibleiQ5VU92. HS.

Organism-specific databases

HPAiHPA044737.
HPA048981.
HPA053138.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SH2D2AQ9NP313EBI-10694873,EBI-490630

Protein-protein interaction databases

BioGridi126547. 2 interactors.
IntActiQ5VU92. 1 interactor.
STRINGi9606.ENSP00000360167.

Structurei

3D structure databases

ProteinModelPortaliQ5VU92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 137WD 1Add BLAST51
Repeati138 – 184WD 2Add BLAST47
Repeati185 – 252WD 3Add BLAST68
Repeati253 – 297WD 4Add BLAST45
Repeati298 – 341WD 5Add BLAST44
Repeati342 – 376WD 6Add BLAST35

Sequence similaritiesi

Belongs to the WD repeat DCAF12 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410KCCW. Eukaryota.
ENOG410XTH6. LUCA.
GeneTreeiENSGT00390000001132.
HOGENOMiHOG000047356.
HOVERGENiHBG055605.
InParanoidiQ5VU92.
OMAiGCRSYTL.
OrthoDBiEOG091G05P2.
PhylomeDBiQ5VU92.
TreeFamiTF323731.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
SMARTiView protein in SMART
SM00320. WD40. 3 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQQTGSRK RKAPAVEADA ESSPSQGLAA ADGEGPLLLK RQRRPATYRS
60 70 80 90 100
MAHYLKVREV GGWGPARLQG FDGELRGYAV QRLPELLTER QLELGTVNKV
110 120 130 140 150
FASQWLNSRQ VVCGTKCNTL FVVDVESGHI ARIPLLRDSE ARLAQDQQGC
160 170 180 190 200
GIHAIELNPS KTLLATGGEN PNSLAIYQLP SLDPLCLGDR HGHKDWIFAV
210 220 230 240 250
AWLSDTVAVS GSRDGTVALW RMDPDKFDDT VAWHSEVGLP VYAHIRPRDV
260 270 280 290 300
EAIPRAIINP SNRKVRALAC GGKNQELGAV SLDGYFHLWK AGSALSRLLS
310 320 330 340 350
IRLPYFRDNV CLTYCDDMSV YAVGSHSHVS FLDLRQDQQN IRPLCSREGG
360 370 380 390 400
TGVRSLSFYR HIITVGTGQG SLLFYDVRAQ KFLEERASAT LESSSGPARR
410 420 430 440 450
KLRLACGRGW LNHNDFWVNY FGGMEVFPNA LYTHCYNWPE MKLFVAGGPL
460
PAGLHGNYAG LWS
Length:463
Mass (Da):51,201
Last modified:December 7, 2004 - v1
Checksum:iD499893FBE4D4E49
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03532319D → G1 PublicationCorresponds to variant dbSNP:rs11095722Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590425 Genomic DNA. No translation available.
CH471107 Genomic DNA. Translation: EAX11841.1.
BC035674 mRNA. Translation: AAH35674.1.
CCDSiCCDS14610.1.
RefSeqiNP_848565.2. NM_178470.4.
UniGeneiHs.120403.

Genome annotation databases

EnsembliENST00000371126; ENSP00000360167; ENSG00000198889.
GeneIDi139170.
KEGGihsa:139170.
UCSCiuc004eul.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDC121_HUMAN
AccessioniPrimary (citable) accession number: Q5VU92
Secondary accession number(s): Q8IYK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 7, 2004
Last modified: July 5, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families