ID P210L_HUMAN Reviewed; 1888 AA. AC Q5VU65; E7EP56; Q5T4L7; Q6ZRN1; Q6ZRT4; Q6ZU81; Q8NDI6; Q9UF31; DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 27-MAR-2024, entry version 142. DE RecName: Full=Nuclear pore membrane glycoprotein 210-like; DE AltName: Full=Nucleoporin 210 kDa-like; DE AltName: Full=Nucleoporin Nup210-like; DE Flags: Precursor; GN Name=NUP210L; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-1888 (ISOFORMS 1 AND 2). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q5VU65-1; Sequence=Displayed; CC Name=2; CC IsoId=Q5VU65-2; Sequence=VSP_053811; CC -!- SIMILARITY: Belongs to the NUP210 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC86345.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAC87279.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAB63757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK125924; BAC86345.1; ALT_INIT; mRNA. DR EMBL; AK128000; BAC87225.1; -; mRNA. DR EMBL; AK128108; BAC87279.1; ALT_INIT; mRNA. DR EMBL; AL590431; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL358472; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL513546; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL833964; CAD38812.1; -; mRNA. DR EMBL; AL133633; CAB63757.1; ALT_INIT; mRNA. DR CCDS; CCDS41399.1; -. [Q5VU65-1] DR CCDS; CCDS53370.1; -. [Q5VU65-2] DR PIR; T43452; T43452. DR RefSeq; NP_001152956.1; NM_001159484.1. [Q5VU65-2] DR RefSeq; NP_997191.2; NM_207308.2. [Q5VU65-1] DR AlphaFoldDB; Q5VU65; -. DR SMR; Q5VU65; -. DR BioGRID; 124804; 3. DR STRING; 9606.ENSP00000357547; -. DR GlyCosmos; Q5VU65; 9 sites, No reported glycans. DR GlyGen; Q5VU65; 13 sites, 2 O-linked glycans (4 sites). DR iPTMnet; Q5VU65; -. DR PhosphoSitePlus; Q5VU65; -. DR BioMuta; NUP210L; -. DR DMDM; 74747057; -. DR EPD; Q5VU65; -. DR MassIVE; Q5VU65; -. DR PaxDb; 9606-ENSP00000357547; -. DR PeptideAtlas; Q5VU65; -. DR ProteomicsDB; 17287; -. DR ProteomicsDB; 65391; -. [Q5VU65-1] DR Antibodypedia; 77096; 36 antibodies from 14 providers. DR DNASU; 91181; -. DR Ensembl; ENST00000271854.3; ENSP00000271854.3; ENSG00000143552.10. [Q5VU65-2] DR Ensembl; ENST00000368559.8; ENSP00000357547.3; ENSG00000143552.10. [Q5VU65-1] DR GeneID; 91181; -. DR KEGG; hsa:91181; -. DR MANE-Select; ENST00000368559.8; ENSP00000357547.3; NM_207308.3; NP_997191.2. DR UCSC; uc001fdw.4; human. [Q5VU65-1] DR AGR; HGNC:29915; -. DR CTD; 91181; -. DR DisGeNET; 91181; -. DR GeneCards; NUP210L; -. DR HGNC; HGNC:29915; NUP210L. DR HPA; ENSG00000143552; Tissue enriched (testis). DR neXtProt; NX_Q5VU65; -. DR OpenTargets; ENSG00000143552; -. DR PharmGKB; PA134984604; -. DR VEuPathDB; HostDB:ENSG00000143552; -. DR eggNOG; KOG1833; Eukaryota. DR GeneTree; ENSGT00390000009491; -. DR HOGENOM; CLU_001205_1_1_1; -. DR InParanoid; Q5VU65; -. DR OMA; GFYYCDI; -. DR OrthoDB; 6312at2759; -. DR PhylomeDB; Q5VU65; -. DR TreeFam; TF313331; -. DR PathwayCommons; Q5VU65; -. DR BioGRID-ORCS; 91181; 8 hits in 1145 CRISPR screens. DR ChiTaRS; NUP210L; human. DR GenomeRNAi; 91181; -. DR Pharos; Q5VU65; Tdark. DR PRO; PR:Q5VU65; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q5VU65; Protein. DR Bgee; ENSG00000143552; Expressed in sperm and 96 other cell types or tissues. DR ExpressionAtlas; Q5VU65; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central. DR Gene3D; 2.60.40.1080; -; 1. DR InterPro; IPR003343; Big_2. DR InterPro; IPR008964; Invasin/intimin_cell_adhesion. DR InterPro; IPR045197; NUP210-like. DR PANTHER; PTHR23019:SF1; NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210-LIKE; 1. DR PANTHER; PTHR23019; NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED; 1. DR Pfam; PF02368; Big_2; 1. DR SMART; SM00635; BID_2; 1. DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 2. DR Genevisible; Q5VU65; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1..35 FT /evidence="ECO:0000255" FT CHAIN 36..1888 FT /note="Nuclear pore membrane glycoprotein 210-like" FT /id="PRO_0000236048" FT TRANSMEM 1813..1833 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 1082..1154 FT /note="BIG2" FT /evidence="ECO:0000255" FT CARBOHYD 84 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 304 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 348 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 495 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 522 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 812 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 931 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1445 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1859 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 1644..1795 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_053811" FT VARIANT 1491 FT /note="V -> I (in dbSNP:rs11264875)" FT /id="VAR_050574" FT CONFLICT 318 FT /note="T -> A (in Ref. 1; BAC87225)" FT /evidence="ECO:0000305" FT CONFLICT 506 FT /note="V -> I (in Ref. 1; BAC87225)" FT /evidence="ECO:0000305" FT CONFLICT 843 FT /note="D -> G (in Ref. 1; BAC86345)" FT /evidence="ECO:0000305" FT CONFLICT 898 FT /note="D -> G (in Ref. 1; BAC87279)" FT /evidence="ECO:0000305" FT CONFLICT 1005 FT /note="R -> K (in Ref. 1; BAC87279)" FT /evidence="ECO:0000305" FT CONFLICT 1686 FT /note="Q -> R (in Ref. 1; BAC87279)" FT /evidence="ECO:0000305" FT CONFLICT 1833 FT /note="N -> S (in Ref. 1; BAC86345)" FT /evidence="ECO:0000305" FT CONFLICT 1858..1872 FT /note="FNSTSSPPHFMSLQP -> LTPQVLPLTS (in Ref. 1; BAC86345)" FT /evidence="ECO:0000305" SQ SEQUENCE 1888 AA; 210605 MW; F8B1194A9BB5D986 CRC64; MTGCPASSRR RGFGLFFFLR LHRLLLLFLV LRGTLANKLN VPQVLLPFGR EPGRVPFLLE AQRGCYTWHS THHDAVTVEP LYENGTLCSQ KAVLIAESTQ PIRLSSIILA REIVTDHELR CDVKVDVINS IEIVSRAREL YVDDSPLELM VRALDAEGNT FSSLAGMMFE WSIAQDNESA REELSSKIRI LKYSEAEYAP PIYIAEMEKE EKQGDVILVS GIRTGAAVVK VRIHEPFYKK VAAALIRLLV LENIFLIPSH DIYLLVGTYI KYQVAKMVQG RVTEVKFPLE HYILELQDHR VALNGSHSEK VAILDDKTAM VTASQLGQTN LVFVHKNVHM RSVSGLPNCT IYVVEPGFLG FTVQPGNRWS LEVGQVYVIT VDVFDKSSTK VYISDNLRIT YDFPKEYFEE QLTTVNGSYH IVKALKDGVV VINASLTSII YQNKDIQPIK FLIKHQQEVK IYFPIMLTPK FLAFPHHPMG MLYRYKVQVE GGSGNFTWTS SNETVVIVTT KGVVTAGQVR GNSTVLARDV QNPFRYGEIK IHVLKLNKME LLPFHADVEI GQIIEIPIAM YHINKETKEA MAFTDCSHLS LDLNMDKQGV FTLLKEGIQR PGPMHCSSTH IAAKSLGHTL VTVSVNECDK YLESSATFAA YEPLKALNPV EVALVTWQSV KEMVFEGGPR PWILEPSRFF LELNAEKTEK IGIAQVWLPS KRKQNQYIYR IQCLDLGEQV LTFRIGNHPG VLNPSPAVEV LQVRFICAHP ASMSVTPVYK VPAGAQPCPL PQHNKWLIPV SRLRDTVLEL AVFDQHRRKF DNFSSLMLEW KSSNETLAHF EDYKSVEMVA KDDGSGQTRL HGHQILKVHQ IKGTVLIGVN FVGYSEKKSP KEISNLPRSV DVELLLVDDV TVVPENATIY NHPDVKETFS LVEGSGYFLV NSSEQGVVTI TYMEAESSVE LVPLHPGFFT LEVYDLCLAF LGPATAHLRV SDIQELELDL IDKVEIDKTV LVTVRVLGSS KRPFQNKYFR NMELKLQLAS AIVTLTPMEQ QDEYSENYIL RATTIGQTTL VAIAKDKMGR KYTSTPRHIE VFPPFRLLPE KMTLIPMNMM QVMSEGGPQP QSIVHFSISN QTVAVVNRRG QVTGKIVGTA VVHGTIQTVN EDTGKVIVFS QDEVQIEVVQ LRAVRILAAA TRLITATKMP VYVMGVTSTQ TPFSFSNANP GLTFHWSMSK RDVLDLVPRH SEVFLQLPVE HNFAMVVHTK AAGRTSIKVT VHCMNSSSGQ FEGNLLELSD EVQILVFEKL QLFYPECQPE QILMPINSQL KLHTNREGAA FVSSRVLKCF PNSSVIEEDG EGLLKAGSIA GTAVLEVTSI EPFGVNQTTI TGVQVAPVTY LRVSSQPKLY TAQGRTLSAF PLGMSLTFTV QFYNSIGEKF HTHNTQLYLA LNRDDLLHIG PGNKNYTYMA QAVNRGLTLV GLWDRRHPGM ADYIPVAVEH AIEPDTKLTF VGDIICFSTH LVSQHGEPGI WMISANNILQ TDIVTGVGVA RSPGTAMIFH DIPGVVKTYR EVVVNASSRL MLSYDLKTYL TNTLNSTVFK LFITTGRNGV NLKGFCTPNQ ALAITKVLLP ATLMLCHVQF SNTLLDIPAS KVFQVHSDFS MEKGVYVCII KVRPQSEELL QALSVADTSV YGWATLVSER SKNGMQRILI PFIPAFYINQ SELVLSHKQD IGEIRVLGVD RVLRKLEVIS SSPVLVVAGH SHSPLTPGLA IYSVRVVNFT SFQQMASPVF INISCVLTSQ SEAVVVRAMK DKLGADHCED SAILKRFTGS YQILLLTLFA VLASTASIFL AYNAFLNKIQ TVPVVYVPTL GTPQPGFFNS TSSPPHFMSL QPPLAQSRLQ HWLWSIRH //