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Q5VU65

- P210L_HUMAN

UniProt

Q5VU65 - P210L_HUMAN

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Protein
Nuclear pore membrane glycoprotein 210-like
Gene
NUP210L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. Sertoli cell development Source: Ensembl
  2. spermatid development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore membrane glycoprotein 210-like
Alternative name(s):
Nucleoporin 210 kDa-like
Nucleoporin Nup210-like
Gene namesi
Name:NUP210L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29915. NUP210L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1813 – 183321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 18881853Nuclear pore membrane glycoprotein 210-like
PRO_0000236048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi495 – 4951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi812 – 8121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi931 – 9311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1445 – 14451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1859 – 18591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5VU65.
PaxDbiQ5VU65.
PRIDEiQ5VU65.

PTM databases

PhosphoSiteiQ5VU65.

Expressioni

Gene expression databases

ArrayExpressiQ5VU65.
BgeeiQ5VU65.
CleanExiHS_NUP210L.
GenevestigatoriQ5VU65.

Interactioni

Protein-protein interaction databases

BioGridi124804. 1 interaction.
STRINGi9606.ENSP00000357547.

Structurei

3D structure databases

ProteinModelPortaliQ5VU65.

Family & Domainsi

Sequence similaritiesi

Belongs to the NUP210 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315446.
HOGENOMiHOG000115312.
HOVERGENiHBG082098.
InParanoidiQ5VU65.
KOiK14314.
OMAiKEMVFEG.
OrthoDBiEOG7PS1DJ.
PhylomeDBiQ5VU65.
TreeFamiTF313331.

Family and domain databases

InterProiIPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF02368. Big_2. 1 hit.
[Graphical view]
SMARTiSM00635. BID_2. 1 hit.
[Graphical view]
SUPFAMiSSF49373. SSF49373. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VU65-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTGCPASSRR RGFGLFFFLR LHRLLLLFLV LRGTLANKLN VPQVLLPFGR     50
EPGRVPFLLE AQRGCYTWHS THHDAVTVEP LYENGTLCSQ KAVLIAESTQ 100
PIRLSSIILA REIVTDHELR CDVKVDVINS IEIVSRAREL YVDDSPLELM 150
VRALDAEGNT FSSLAGMMFE WSIAQDNESA REELSSKIRI LKYSEAEYAP 200
PIYIAEMEKE EKQGDVILVS GIRTGAAVVK VRIHEPFYKK VAAALIRLLV 250
LENIFLIPSH DIYLLVGTYI KYQVAKMVQG RVTEVKFPLE HYILELQDHR 300
VALNGSHSEK VAILDDKTAM VTASQLGQTN LVFVHKNVHM RSVSGLPNCT 350
IYVVEPGFLG FTVQPGNRWS LEVGQVYVIT VDVFDKSSTK VYISDNLRIT 400
YDFPKEYFEE QLTTVNGSYH IVKALKDGVV VINASLTSII YQNKDIQPIK 450
FLIKHQQEVK IYFPIMLTPK FLAFPHHPMG MLYRYKVQVE GGSGNFTWTS 500
SNETVVIVTT KGVVTAGQVR GNSTVLARDV QNPFRYGEIK IHVLKLNKME 550
LLPFHADVEI GQIIEIPIAM YHINKETKEA MAFTDCSHLS LDLNMDKQGV 600
FTLLKEGIQR PGPMHCSSTH IAAKSLGHTL VTVSVNECDK YLESSATFAA 650
YEPLKALNPV EVALVTWQSV KEMVFEGGPR PWILEPSRFF LELNAEKTEK 700
IGIAQVWLPS KRKQNQYIYR IQCLDLGEQV LTFRIGNHPG VLNPSPAVEV 750
LQVRFICAHP ASMSVTPVYK VPAGAQPCPL PQHNKWLIPV SRLRDTVLEL 800
AVFDQHRRKF DNFSSLMLEW KSSNETLAHF EDYKSVEMVA KDDGSGQTRL 850
HGHQILKVHQ IKGTVLIGVN FVGYSEKKSP KEISNLPRSV DVELLLVDDV 900
TVVPENATIY NHPDVKETFS LVEGSGYFLV NSSEQGVVTI TYMEAESSVE 950
LVPLHPGFFT LEVYDLCLAF LGPATAHLRV SDIQELELDL IDKVEIDKTV 1000
LVTVRVLGSS KRPFQNKYFR NMELKLQLAS AIVTLTPMEQ QDEYSENYIL 1050
RATTIGQTTL VAIAKDKMGR KYTSTPRHIE VFPPFRLLPE KMTLIPMNMM 1100
QVMSEGGPQP QSIVHFSISN QTVAVVNRRG QVTGKIVGTA VVHGTIQTVN 1150
EDTGKVIVFS QDEVQIEVVQ LRAVRILAAA TRLITATKMP VYVMGVTSTQ 1200
TPFSFSNANP GLTFHWSMSK RDVLDLVPRH SEVFLQLPVE HNFAMVVHTK 1250
AAGRTSIKVT VHCMNSSSGQ FEGNLLELSD EVQILVFEKL QLFYPECQPE 1300
QILMPINSQL KLHTNREGAA FVSSRVLKCF PNSSVIEEDG EGLLKAGSIA 1350
GTAVLEVTSI EPFGVNQTTI TGVQVAPVTY LRVSSQPKLY TAQGRTLSAF 1400
PLGMSLTFTV QFYNSIGEKF HTHNTQLYLA LNRDDLLHIG PGNKNYTYMA 1450
QAVNRGLTLV GLWDRRHPGM ADYIPVAVEH AIEPDTKLTF VGDIICFSTH 1500
LVSQHGEPGI WMISANNILQ TDIVTGVGVA RSPGTAMIFH DIPGVVKTYR 1550
EVVVNASSRL MLSYDLKTYL TNTLNSTVFK LFITTGRNGV NLKGFCTPNQ 1600
ALAITKVLLP ATLMLCHVQF SNTLLDIPAS KVFQVHSDFS MEKGVYVCII 1650
KVRPQSEELL QALSVADTSV YGWATLVSER SKNGMQRILI PFIPAFYINQ 1700
SELVLSHKQD IGEIRVLGVD RVLRKLEVIS SSPVLVVAGH SHSPLTPGLA 1750
IYSVRVVNFT SFQQMASPVF INISCVLTSQ SEAVVVRAMK DKLGADHCED 1800
SAILKRFTGS YQILLLTLFA VLASTASIFL AYNAFLNKIQ TVPVVYVPTL 1850
GTPQPGFFNS TSSPPHFMSL QPPLAQSRLQ HWLWSIRH 1888
Length:1,888
Mass (Da):210,605
Last modified:December 7, 2004 - v1
Checksum:iF8B1194A9BB5D986
GO
Isoform 2 (identifier: Q5VU65-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1644-1795: Missing.

Show »
Length:1,736
Mass (Da):193,998
Checksum:i5815738498B3D6DD
GO

Sequence cautioni

The sequence BAC86345.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC87279.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAB63757.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1491 – 14911V → I.
Corresponds to variant rs11264875 [ dbSNP | Ensembl ].
VAR_050574

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1644 – 1795152Missing in isoform 2.
VSP_053811Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti318 – 3181T → A in BAC87225. 1 Publication
Sequence conflicti506 – 5061V → I in BAC87225. 1 Publication
Sequence conflicti843 – 8431D → G in BAC86345. 1 Publication
Sequence conflicti898 – 8981D → G in BAC87279. 1 Publication
Sequence conflicti1005 – 10051R → K in BAC87279. 1 Publication
Sequence conflicti1686 – 16861Q → R in BAC87279. 1 Publication
Sequence conflicti1833 – 18331N → S in BAC86345. 1 Publication
Sequence conflicti1858 – 187215FNSTS…MSLQP → LTPQVLPLTS in BAC86345. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK125924 mRNA. Translation: BAC86345.1. Different initiation.
AK128000 mRNA. Translation: BAC87225.1.
AK128108 mRNA. Translation: BAC87279.1. Different initiation.
AL590431, AL358472, AL513546 Genomic DNA. Translation: CAH71259.1.
AL358472 Genomic DNA. Translation: CAI14034.1. Sequence problems.
AL513546, AL358472, AL590431 Genomic DNA. Translation: CAH70552.1.
AL358472, AL590431, AL513546 Genomic DNA. Translation: CAI14015.1.
AL833964 mRNA. Translation: CAD38812.1.
AL133633 mRNA. Translation: CAB63757.1. Different initiation.
CCDSiCCDS41399.1. [Q5VU65-1]
CCDS53370.1. [Q5VU65-2]
PIRiT43452.
RefSeqiNP_001152956.1. NM_001159484.1. [Q5VU65-2]
NP_997191.2. NM_207308.2. [Q5VU65-1]
UniGeneiHs.67639.

Genome annotation databases

EnsembliENST00000271854; ENSP00000271854; ENSG00000143552.
ENST00000368559; ENSP00000357547; ENSG00000143552.
GeneIDi91181.
KEGGihsa:91181.
UCSCiuc001fdw.3. human. [Q5VU65-1]

Polymorphism databases

DMDMi74747057.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK125924 mRNA. Translation: BAC86345.1 . Different initiation.
AK128000 mRNA. Translation: BAC87225.1 .
AK128108 mRNA. Translation: BAC87279.1 . Different initiation.
AL590431 , AL358472 , AL513546 Genomic DNA. Translation: CAH71259.1 .
AL358472 Genomic DNA. Translation: CAI14034.1 . Sequence problems.
AL513546 , AL358472 , AL590431 Genomic DNA. Translation: CAH70552.1 .
AL358472 , AL590431 , AL513546 Genomic DNA. Translation: CAI14015.1 .
AL833964 mRNA. Translation: CAD38812.1 .
AL133633 mRNA. Translation: CAB63757.1 . Different initiation.
CCDSi CCDS41399.1. [Q5VU65-1 ]
CCDS53370.1. [Q5VU65-2 ]
PIRi T43452.
RefSeqi NP_001152956.1. NM_001159484.1. [Q5VU65-2 ]
NP_997191.2. NM_207308.2. [Q5VU65-1 ]
UniGenei Hs.67639.

3D structure databases

ProteinModelPortali Q5VU65.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124804. 1 interaction.
STRINGi 9606.ENSP00000357547.

PTM databases

PhosphoSitei Q5VU65.

Polymorphism databases

DMDMi 74747057.

Proteomic databases

MaxQBi Q5VU65.
PaxDbi Q5VU65.
PRIDEi Q5VU65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271854 ; ENSP00000271854 ; ENSG00000143552 .
ENST00000368559 ; ENSP00000357547 ; ENSG00000143552 .
GeneIDi 91181.
KEGGi hsa:91181.
UCSCi uc001fdw.3. human. [Q5VU65-1 ]

Organism-specific databases

CTDi 91181.
GeneCardsi GC01M153965.
H-InvDB HIX0001099.
HGNCi HGNC:29915. NUP210L.
neXtProti NX_Q5VU65.
PharmGKBi PA134984604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315446.
HOGENOMi HOG000115312.
HOVERGENi HBG082098.
InParanoidi Q5VU65.
KOi K14314.
OMAi KEMVFEG.
OrthoDBi EOG7PS1DJ.
PhylomeDBi Q5VU65.
TreeFami TF313331.

Miscellaneous databases

GenomeRNAii 91181.
NextBioi 77138.
PROi Q5VU65.

Gene expression databases

ArrayExpressi Q5VU65.
Bgeei Q5VU65.
CleanExi HS_NUP210L.
Genevestigatori Q5VU65.

Family and domain databases

InterProi IPR003343. Big_2.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view ]
Pfami PF02368. Big_2. 1 hit.
[Graphical view ]
SMARTi SM00635. BID_2. 1 hit.
[Graphical view ]
SUPFAMi SSF49373. SSF49373. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-1888 (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiP210L_HUMAN
AccessioniPrimary (citable) accession number: Q5VU65
Secondary accession number(s): E7EP56
, Q5T4L7, Q6ZRN1, Q6ZRT4, Q6ZU81, Q8NDI6, Q9UF31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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