Q5VU65 (P210L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore membrane glycoprotein 210-like

Alternative name(s):
Nucleoporin 210 kDa-like
Nucleoporin Nup210-like

Gene names

Name:

NUP210L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1888 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the NUP210 family.
Sequence caution	The sequence BAC86345.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC87279.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 1888	1853	Nuclear pore membrane glycoprotein 210-like		PRO_0000236048
Regions
	Transmembrane	1813 – 1833	21	Helical; Potential
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	304	1	N-linked (GlcNAc...) Potential
	Glycosylation	348	1	N-linked (GlcNAc...) Potential
	Glycosylation	495	1	N-linked (GlcNAc...) Potential
	Glycosylation	522	1	N-linked (GlcNAc...) Potential
	Glycosylation	812	1	N-linked (GlcNAc...) Potential
	Glycosylation	931	1	N-linked (GlcNAc...) Potential
	Glycosylation	1445	1	N-linked (GlcNAc...) Potential
	Glycosylation	1859	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	1491	1	V → I. Corresponds to variant rs11264875 [ dbSNP | Ensembl ].		VAR_050574
Experimental info
	Sequence conflict	318	1	T → A in BAC87225. Ref.1
	Sequence conflict	506	1	V → I in BAC87225. Ref.1
	Sequence conflict	843	1	D → G in BAC86345. Ref.1
	Sequence conflict	898	1	D → G in BAC87279. Ref.1
	Sequence conflict	1005	1	R → K in BAC87279. Ref.1
	Sequence conflict	1686	1	Q → R in BAC87279. Ref.1
	Sequence conflict	1833	1	N → S in BAC86345. Ref.1
	Sequence conflict	1858 – 1872	15	FNSTS…MSLQP → LTPQVLPLTS in BAC86345. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5VU65 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: F8B1194A9BB5D986	FASTA	1,888	210,605
	10 20 30 40 50 60 MTGCPASSRR RGFGLFFFLR LHRLLLLFLV LRGTLANKLN VPQVLLPFGR EPGRVPFLLE 70 80 90 100 110 120 AQRGCYTWHS THHDAVTVEP LYENGTLCSQ KAVLIAESTQ PIRLSSIILA REIVTDHELR 130 140 150 160 170 180 CDVKVDVINS IEIVSRAREL YVDDSPLELM VRALDAEGNT FSSLAGMMFE WSIAQDNESA 190 200 210 220 230 240 REELSSKIRI LKYSEAEYAP PIYIAEMEKE EKQGDVILVS GIRTGAAVVK VRIHEPFYKK 250 260 270 280 290 300 VAAALIRLLV LENIFLIPSH DIYLLVGTYI KYQVAKMVQG RVTEVKFPLE HYILELQDHR 310 320 330 340 350 360 VALNGSHSEK VAILDDKTAM VTASQLGQTN LVFVHKNVHM RSVSGLPNCT IYVVEPGFLG 370 380 390 400 410 420 FTVQPGNRWS LEVGQVYVIT VDVFDKSSTK VYISDNLRIT YDFPKEYFEE QLTTVNGSYH 430 440 450 460 470 480 IVKALKDGVV VINASLTSII YQNKDIQPIK FLIKHQQEVK IYFPIMLTPK FLAFPHHPMG 490 500 510 520 530 540 MLYRYKVQVE GGSGNFTWTS SNETVVIVTT KGVVTAGQVR GNSTVLARDV QNPFRYGEIK 550 560 570 580 590 600 IHVLKLNKME LLPFHADVEI GQIIEIPIAM YHINKETKEA MAFTDCSHLS LDLNMDKQGV 610 620 630 640 650 660 FTLLKEGIQR PGPMHCSSTH IAAKSLGHTL VTVSVNECDK YLESSATFAA YEPLKALNPV 670 680 690 700 710 720 EVALVTWQSV KEMVFEGGPR PWILEPSRFF LELNAEKTEK IGIAQVWLPS KRKQNQYIYR 730 740 750 760 770 780 IQCLDLGEQV LTFRIGNHPG VLNPSPAVEV LQVRFICAHP ASMSVTPVYK VPAGAQPCPL 790 800 810 820 830 840 PQHNKWLIPV SRLRDTVLEL AVFDQHRRKF DNFSSLMLEW KSSNETLAHF EDYKSVEMVA 850 860 870 880 890 900 KDDGSGQTRL HGHQILKVHQ IKGTVLIGVN FVGYSEKKSP KEISNLPRSV DVELLLVDDV 910 920 930 940 950 960 TVVPENATIY NHPDVKETFS LVEGSGYFLV NSSEQGVVTI TYMEAESSVE LVPLHPGFFT 970 980 990 1000 1010 1020 LEVYDLCLAF LGPATAHLRV SDIQELELDL IDKVEIDKTV LVTVRVLGSS KRPFQNKYFR 1030 1040 1050 1060 1070 1080 NMELKLQLAS AIVTLTPMEQ QDEYSENYIL RATTIGQTTL VAIAKDKMGR KYTSTPRHIE 1090 1100 1110 1120 1130 1140 VFPPFRLLPE KMTLIPMNMM QVMSEGGPQP QSIVHFSISN QTVAVVNRRG QVTGKIVGTA 1150 1160 1170 1180 1190 1200 VVHGTIQTVN EDTGKVIVFS QDEVQIEVVQ LRAVRILAAA TRLITATKMP VYVMGVTSTQ 1210 1220 1230 1240 1250 1260 TPFSFSNANP GLTFHWSMSK RDVLDLVPRH SEVFLQLPVE HNFAMVVHTK AAGRTSIKVT 1270 1280 1290 1300 1310 1320 VHCMNSSSGQ FEGNLLELSD EVQILVFEKL QLFYPECQPE QILMPINSQL KLHTNREGAA 1330 1340 1350 1360 1370 1380 FVSSRVLKCF PNSSVIEEDG EGLLKAGSIA GTAVLEVTSI EPFGVNQTTI TGVQVAPVTY 1390 1400 1410 1420 1430 1440 LRVSSQPKLY TAQGRTLSAF PLGMSLTFTV QFYNSIGEKF HTHNTQLYLA LNRDDLLHIG 1450 1460 1470 1480 1490 1500 PGNKNYTYMA QAVNRGLTLV GLWDRRHPGM ADYIPVAVEH AIEPDTKLTF VGDIICFSTH 1510 1520 1530 1540 1550 1560 LVSQHGEPGI WMISANNILQ TDIVTGVGVA RSPGTAMIFH DIPGVVKTYR EVVVNASSRL 1570 1580 1590 1600 1610 1620 MLSYDLKTYL TNTLNSTVFK LFITTGRNGV NLKGFCTPNQ ALAITKVLLP ATLMLCHVQF 1630 1640 1650 1660 1670 1680 SNTLLDIPAS KVFQVHSDFS MEKGVYVCII KVRPQSEELL QALSVADTSV YGWATLVSER 1690 1700 1710 1720 1730 1740 SKNGMQRILI PFIPAFYINQ SELVLSHKQD IGEIRVLGVD RVLRKLEVIS SSPVLVVAGH 1750 1760 1770 1780 1790 1800 SHSPLTPGLA IYSVRVVNFT SFQQMASPVF INISCVLTSQ SEAVVVRAMK DKLGADHCED 1810 1820 1830 1840 1850 1860 SAILKRFTGS YQILLLTLFA VLASTASIFL AYNAFLNKIQ TVPVVYVPTL GTPQPGFFNS 1870 1880 TSSPPHFMSL QPPLAQSRLQ HWLWSIRH

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-1888. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK125924 mRNA. Translation: BAC86345.1. Different initiation. AK128000 mRNA. Translation: BAC87225.1. AK128108 mRNA. Translation: BAC87279.1. Different initiation. AL590431, AL358472, AL513546 Genomic DNA. Translation: CAH71259.1. AL358472 Genomic DNA. Translation: CAI14034.1. Sequence problems. AL513546, AL358472, AL590431 Genomic DNA. Translation: CAH70552.1. AL358472, AL590431, AL513546 Genomic DNA. Translation: CAI14015.1. AL833964 mRNA. Translation: CAD38812.1.
IPI	IPI00410401.
PIR	T43452.
RefSeq	NP_001152956.1. NM_001159484.1. NP_997191.2. NM_207308.2.
UniGene	Hs.67639.
3D structure databases
ProteinModelPortal	Q5VU65.
SMR	Q5VU65. Positions 481-549, 1096-1146, 1326-1374, 1509-1541.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000357547.
PTM databases
PhosphoSite	Q5VU65.
Polymorphism databases
DMDM	74747057.
Proteomic databases
PaxDb	Q5VU65.
PRIDE	Q5VU65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368553; ENSP00000357541; ENSG00000143552. ENST00000368559; ENSP00000357547; ENSG00000143552.
GeneID	91181.
KEGG	hsa:91181.
UCSC	uc001fdw.3. human.
Organism-specific databases
CTD	91181.
GeneCards	GC01M153965.
H-InvDB	HIX0001099.
HGNC	HGNC:29915. NUP210L.
neXtProt	NX_Q5VU65.
PharmGKB	PA134984604.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315446.
HOGENOM	HOG000115312.
HOVERGEN	HBG082098.
InParanoid	Q5VU65.
KO	K14314.
OMA	IKYRVAK.
OrthoDB	EOG4W9J31.
Gene expression databases
ArrayExpress	Q5VU65.
Bgee	Q5VU65.
CleanEx	HS_NUP210L.
Genevestigator	Q5VU65.
GermOnline	ENSG00000143552. Homo sapiens.
Family and domain databases
InterPro	IPR003343. Big_2. IPR008964. Invasin/intimin_cell_adhesion. [Graphical view]
Pfam	PF02368. Big_2. 1 hit. [Graphical view]
SMART	SM00635. BID_2. 1 hit. [Graphical view]
SUPFAM	SSF49373. Invasin_intimin. 2 hits.
ProtoNet	Search...
Other
GenomeRNAi	91181.
NextBio	77138.

Entry information

Entry name

P210L_HUMAN

Accession

Primary (citable) accession number: Q5VU65
Secondary accession number(s): Q5T4L7 , Q6ZRN1, Q6ZRT4, Q6ZU81, Q8NDI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.