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Q5VU65

- P210L_HUMAN

UniProt

Q5VU65 - P210L_HUMAN

Protein

Nuclear pore membrane glycoprotein 210-like

Gene

NUP210L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. Sertoli cell development Source: Ensembl
    2. spermatid development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore membrane glycoprotein 210-like
    Alternative name(s):
    Nucleoporin 210 kDa-like
    Nucleoporin Nup210-like
    Gene namesi
    Name:NUP210L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29915. NUP210L.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 18881853Nuclear pore membrane glycoprotein 210-likePRO_0000236048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1445 – 14451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1859 – 18591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ5VU65.
    PaxDbiQ5VU65.
    PRIDEiQ5VU65.

    PTM databases

    PhosphoSiteiQ5VU65.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VU65.
    BgeeiQ5VU65.
    CleanExiHS_NUP210L.
    GenevestigatoriQ5VU65.

    Interactioni

    Protein-protein interaction databases

    BioGridi124804. 1 interaction.
    STRINGi9606.ENSP00000357547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VU65.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1813 – 183321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NUP210 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG315446.
    HOGENOMiHOG000115312.
    HOVERGENiHBG082098.
    InParanoidiQ5VU65.
    KOiK14314.
    OMAiKEMVFEG.
    OrthoDBiEOG7PS1DJ.
    PhylomeDBiQ5VU65.
    TreeFamiTF313331.

    Family and domain databases

    InterProiIPR003343. Big_2.
    IPR008964. Invasin/intimin_cell_adhesion.
    [Graphical view]
    PfamiPF02368. Big_2. 1 hit.
    [Graphical view]
    SMARTiSM00635. BID_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49373. SSF49373. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VU65-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGCPASSRR RGFGLFFFLR LHRLLLLFLV LRGTLANKLN VPQVLLPFGR     50
    EPGRVPFLLE AQRGCYTWHS THHDAVTVEP LYENGTLCSQ KAVLIAESTQ 100
    PIRLSSIILA REIVTDHELR CDVKVDVINS IEIVSRAREL YVDDSPLELM 150
    VRALDAEGNT FSSLAGMMFE WSIAQDNESA REELSSKIRI LKYSEAEYAP 200
    PIYIAEMEKE EKQGDVILVS GIRTGAAVVK VRIHEPFYKK VAAALIRLLV 250
    LENIFLIPSH DIYLLVGTYI KYQVAKMVQG RVTEVKFPLE HYILELQDHR 300
    VALNGSHSEK VAILDDKTAM VTASQLGQTN LVFVHKNVHM RSVSGLPNCT 350
    IYVVEPGFLG FTVQPGNRWS LEVGQVYVIT VDVFDKSSTK VYISDNLRIT 400
    YDFPKEYFEE QLTTVNGSYH IVKALKDGVV VINASLTSII YQNKDIQPIK 450
    FLIKHQQEVK IYFPIMLTPK FLAFPHHPMG MLYRYKVQVE GGSGNFTWTS 500
    SNETVVIVTT KGVVTAGQVR GNSTVLARDV QNPFRYGEIK IHVLKLNKME 550
    LLPFHADVEI GQIIEIPIAM YHINKETKEA MAFTDCSHLS LDLNMDKQGV 600
    FTLLKEGIQR PGPMHCSSTH IAAKSLGHTL VTVSVNECDK YLESSATFAA 650
    YEPLKALNPV EVALVTWQSV KEMVFEGGPR PWILEPSRFF LELNAEKTEK 700
    IGIAQVWLPS KRKQNQYIYR IQCLDLGEQV LTFRIGNHPG VLNPSPAVEV 750
    LQVRFICAHP ASMSVTPVYK VPAGAQPCPL PQHNKWLIPV SRLRDTVLEL 800
    AVFDQHRRKF DNFSSLMLEW KSSNETLAHF EDYKSVEMVA KDDGSGQTRL 850
    HGHQILKVHQ IKGTVLIGVN FVGYSEKKSP KEISNLPRSV DVELLLVDDV 900
    TVVPENATIY NHPDVKETFS LVEGSGYFLV NSSEQGVVTI TYMEAESSVE 950
    LVPLHPGFFT LEVYDLCLAF LGPATAHLRV SDIQELELDL IDKVEIDKTV 1000
    LVTVRVLGSS KRPFQNKYFR NMELKLQLAS AIVTLTPMEQ QDEYSENYIL 1050
    RATTIGQTTL VAIAKDKMGR KYTSTPRHIE VFPPFRLLPE KMTLIPMNMM 1100
    QVMSEGGPQP QSIVHFSISN QTVAVVNRRG QVTGKIVGTA VVHGTIQTVN 1150
    EDTGKVIVFS QDEVQIEVVQ LRAVRILAAA TRLITATKMP VYVMGVTSTQ 1200
    TPFSFSNANP GLTFHWSMSK RDVLDLVPRH SEVFLQLPVE HNFAMVVHTK 1250
    AAGRTSIKVT VHCMNSSSGQ FEGNLLELSD EVQILVFEKL QLFYPECQPE 1300
    QILMPINSQL KLHTNREGAA FVSSRVLKCF PNSSVIEEDG EGLLKAGSIA 1350
    GTAVLEVTSI EPFGVNQTTI TGVQVAPVTY LRVSSQPKLY TAQGRTLSAF 1400
    PLGMSLTFTV QFYNSIGEKF HTHNTQLYLA LNRDDLLHIG PGNKNYTYMA 1450
    QAVNRGLTLV GLWDRRHPGM ADYIPVAVEH AIEPDTKLTF VGDIICFSTH 1500
    LVSQHGEPGI WMISANNILQ TDIVTGVGVA RSPGTAMIFH DIPGVVKTYR 1550
    EVVVNASSRL MLSYDLKTYL TNTLNSTVFK LFITTGRNGV NLKGFCTPNQ 1600
    ALAITKVLLP ATLMLCHVQF SNTLLDIPAS KVFQVHSDFS MEKGVYVCII 1650
    KVRPQSEELL QALSVADTSV YGWATLVSER SKNGMQRILI PFIPAFYINQ 1700
    SELVLSHKQD IGEIRVLGVD RVLRKLEVIS SSPVLVVAGH SHSPLTPGLA 1750
    IYSVRVVNFT SFQQMASPVF INISCVLTSQ SEAVVVRAMK DKLGADHCED 1800
    SAILKRFTGS YQILLLTLFA VLASTASIFL AYNAFLNKIQ TVPVVYVPTL 1850
    GTPQPGFFNS TSSPPHFMSL QPPLAQSRLQ HWLWSIRH 1888
    Length:1,888
    Mass (Da):210,605
    Last modified:December 7, 2004 - v1
    Checksum:iF8B1194A9BB5D986
    GO
    Isoform 2 (identifier: Q5VU65-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1644-1795: Missing.

    Show »
    Length:1,736
    Mass (Da):193,998
    Checksum:i5815738498B3D6DD
    GO

    Sequence cautioni

    The sequence BAC86345.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC87279.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAB63757.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti318 – 3181T → A in BAC87225. (PubMed:14702039)Curated
    Sequence conflicti506 – 5061V → I in BAC87225. (PubMed:14702039)Curated
    Sequence conflicti843 – 8431D → G in BAC86345. (PubMed:14702039)Curated
    Sequence conflicti898 – 8981D → G in BAC87279. (PubMed:14702039)Curated
    Sequence conflicti1005 – 10051R → K in BAC87279. (PubMed:14702039)Curated
    Sequence conflicti1686 – 16861Q → R in BAC87279. (PubMed:14702039)Curated
    Sequence conflicti1833 – 18331N → S in BAC86345. (PubMed:14702039)Curated
    Sequence conflicti1858 – 187215FNSTS…MSLQP → LTPQVLPLTS in BAC86345. (PubMed:14702039)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1491 – 14911V → I.
    Corresponds to variant rs11264875 [ dbSNP | Ensembl ].
    VAR_050574

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1644 – 1795152Missing in isoform 2. 1 PublicationVSP_053811Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125924 mRNA. Translation: BAC86345.1. Different initiation.
    AK128000 mRNA. Translation: BAC87225.1.
    AK128108 mRNA. Translation: BAC87279.1. Different initiation.
    AL590431, AL358472, AL513546 Genomic DNA. Translation: CAH71259.1.
    AL358472 Genomic DNA. Translation: CAI14034.1. Sequence problems.
    AL513546, AL358472, AL590431 Genomic DNA. Translation: CAH70552.1.
    AL358472, AL590431, AL513546 Genomic DNA. Translation: CAI14015.1.
    AL833964 mRNA. Translation: CAD38812.1.
    AL133633 mRNA. Translation: CAB63757.1. Different initiation.
    CCDSiCCDS41399.1. [Q5VU65-1]
    CCDS53370.1. [Q5VU65-2]
    PIRiT43452.
    RefSeqiNP_001152956.1. NM_001159484.1. [Q5VU65-2]
    NP_997191.2. NM_207308.2. [Q5VU65-1]
    UniGeneiHs.67639.

    Genome annotation databases

    EnsembliENST00000271854; ENSP00000271854; ENSG00000143552. [Q5VU65-2]
    ENST00000368559; ENSP00000357547; ENSG00000143552. [Q5VU65-1]
    GeneIDi91181.
    KEGGihsa:91181.
    UCSCiuc001fdw.3. human. [Q5VU65-1]

    Polymorphism databases

    DMDMi74747057.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125924 mRNA. Translation: BAC86345.1 . Different initiation.
    AK128000 mRNA. Translation: BAC87225.1 .
    AK128108 mRNA. Translation: BAC87279.1 . Different initiation.
    AL590431 , AL358472 , AL513546 Genomic DNA. Translation: CAH71259.1 .
    AL358472 Genomic DNA. Translation: CAI14034.1 . Sequence problems.
    AL513546 , AL358472 , AL590431 Genomic DNA. Translation: CAH70552.1 .
    AL358472 , AL590431 , AL513546 Genomic DNA. Translation: CAI14015.1 .
    AL833964 mRNA. Translation: CAD38812.1 .
    AL133633 mRNA. Translation: CAB63757.1 . Different initiation.
    CCDSi CCDS41399.1. [Q5VU65-1 ]
    CCDS53370.1. [Q5VU65-2 ]
    PIRi T43452.
    RefSeqi NP_001152956.1. NM_001159484.1. [Q5VU65-2 ]
    NP_997191.2. NM_207308.2. [Q5VU65-1 ]
    UniGenei Hs.67639.

    3D structure databases

    ProteinModelPortali Q5VU65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124804. 1 interaction.
    STRINGi 9606.ENSP00000357547.

    PTM databases

    PhosphoSitei Q5VU65.

    Polymorphism databases

    DMDMi 74747057.

    Proteomic databases

    MaxQBi Q5VU65.
    PaxDbi Q5VU65.
    PRIDEi Q5VU65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271854 ; ENSP00000271854 ; ENSG00000143552 . [Q5VU65-2 ]
    ENST00000368559 ; ENSP00000357547 ; ENSG00000143552 . [Q5VU65-1 ]
    GeneIDi 91181.
    KEGGi hsa:91181.
    UCSCi uc001fdw.3. human. [Q5VU65-1 ]

    Organism-specific databases

    CTDi 91181.
    GeneCardsi GC01M153965.
    H-InvDB HIX0001099.
    HGNCi HGNC:29915. NUP210L.
    neXtProti NX_Q5VU65.
    PharmGKBi PA134984604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315446.
    HOGENOMi HOG000115312.
    HOVERGENi HBG082098.
    InParanoidi Q5VU65.
    KOi K14314.
    OMAi KEMVFEG.
    OrthoDBi EOG7PS1DJ.
    PhylomeDBi Q5VU65.
    TreeFami TF313331.

    Miscellaneous databases

    GenomeRNAii 91181.
    NextBioi 77138.
    PROi Q5VU65.

    Gene expression databases

    ArrayExpressi Q5VU65.
    Bgeei Q5VU65.
    CleanExi HS_NUP210L.
    Genevestigatori Q5VU65.

    Family and domain databases

    InterProi IPR003343. Big_2.
    IPR008964. Invasin/intimin_cell_adhesion.
    [Graphical view ]
    Pfami PF02368. Big_2. 1 hit.
    [Graphical view ]
    SMARTi SM00635. BID_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49373. SSF49373. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-1888 (ISOFORMS 1 AND 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiP210L_HUMAN
    AccessioniPrimary (citable) accession number: Q5VU65
    Secondary accession number(s): E7EP56
    , Q5T4L7, Q6ZRN1, Q6ZRT4, Q6ZU81, Q8NDI6, Q9UF31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3