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Q5VU57

- CBPC6_HUMAN

UniProt

Q5VU57 - CBPC6_HUMAN

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Protein
Cytosolic carboxypeptidase 6
Gene
AGBL4, CCP6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi230 – 2301Zinc By similarity
Metal bindingi233 – 2331Zinc By similarity
Active sitei280 – 2801Nucleophile By similarity
Metal bindingi328 – 3281Zinc By similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: UniProtKB
  2. tubulin binding Source: UniProtKB
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. C-terminal protein deglutamylation Source: UniProtKB
  2. protein side chain deglutamylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase 6 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 4
Gene namesi
Name:AGBL4
Synonyms:CCP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25892. AGBL4.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytosolic carboxypeptidase 6
PRO_0000284835Add
BLAST

Proteomic databases

PaxDbiQ5VU57.
PRIDEiQ5VU57.

PTM databases

PhosphoSiteiQ5VU57.

Expressioni

Gene expression databases

ArrayExpressiQ5VU57.
BgeeiQ5VU57.
CleanExiHS_AGBL4.
GenevestigatoriQ5VU57.

Organism-specific databases

HPAiHPA037994.

Interactioni

Subunit structurei

Interacts with MYLK By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5VU57.
SMRiQ5VU57. Positions 48-386.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.

Phylogenomic databases

eggNOGiCOG2866.
HOGENOMiHOG000231164.
HOVERGENiHBG107588.
InParanoidiQ5VU57.
OMAiYRYERHL.
OrthoDBiEOG71VSTM.
PhylomeDBiQ5VU57.
TreeFamiTF333009.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VU57-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF    50
ESGNLGRVDQ VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI 100
VNFSKTKSLY RDGMAPMVKS TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF 150
AFCFDREEDI YQFAYCYPYT YTRFQHYLDS LQKRNMDYFF REQLGQSVQQ 200
RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC QGIIDFLVSQ 250
HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH 300
PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ 350
RQAIFPKLLC QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL 400
EVSFYSYIIS GTTAAVPYTE EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP 450
MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA SNYPNSKGDK KSSVNHKDPS 500
TPF 503
Length:503
Mass (Da):58,230
Last modified:January 11, 2011 - v3
Checksum:i4D1AD20229664D90
GO
Isoform 2 (identifier: Q5VU57-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-94: Q → QVREIVDTFRVVL
     455-463: Missing.

Note: No experimental confirmation available.

Show »
Length:506
Mass (Da):58,505
Checksum:i20C9AED5564F23F9
GO

Sequence cautioni

The sequence BAG52938.1 differs from that shown. Reason: Frameshift at position 501.
The sequence BAG57648.1 differs from that shown. Reason: Frameshift at position 501.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti443 – 4431V → M.
Corresponds to variant rs60977321 [ dbSNP | Ensembl ].
VAR_061078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 941Q → QVREIVDTFRVVL in isoform 2.
VSP_040435
Alternative sequencei455 – 4639Missing in isoform 2.
VSP_040436

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371S → L in BAG57648. 1 Publication
Sequence conflicti490 – 4901K → R in BAG57648. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094826 mRNA. Translation: BAG52938.1. Frameshift.
AK294394 mRNA. Translation: BAG57648.1. Frameshift.
AL590432
, AC099788, AL355809, AL390023, AL391844, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAH70510.1.
AL391844
, AC099788, AL355809, AL390023, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI13521.1.
AL645507
, AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645730 Genomic DNA. Translation: CAI14372.1.
AL645730
, AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645507 Genomic DNA. Translation: CAI17069.1.
AL591602
, AC099788, AL355809, AL390023, AL391844, AL590432, AL645507, AL645730 Genomic DNA. Translation: CAI19137.1.
AL355809
, AC099788, AL390023, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI22167.1.
AL390023
, AC099788, AL355809, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI23365.1.
CCDSiCCDS44137.1. [Q5VU57-1]
RefSeqiNP_116174.3. NM_032785.3. [Q5VU57-1]
UniGeneiHs.551844.
Hs.679809.

Genome annotation databases

EnsembliENST00000371839; ENSP00000360905; ENSG00000186094. [Q5VU57-1]
GeneIDi84871.
KEGGihsa:84871.
UCSCiuc001cru.2. human. [Q5VU57-1]
uc010omx.1. human. [Q5VU57-2]

Polymorphism databases

DMDMi317373463.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094826 mRNA. Translation: BAG52938.1 . Frameshift.
AK294394 mRNA. Translation: BAG57648.1 . Frameshift.
AL590432
, AC099788 , AL355809 , AL390023 , AL391844 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAH70510.1 .
AL391844
, AC099788 , AL355809 , AL390023 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI13521.1 .
AL645507
, AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL591602 , AL645730 Genomic DNA. Translation: CAI14372.1 .
AL645730
, AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL591602 , AL645507 Genomic DNA. Translation: CAI17069.1 .
AL591602
, AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL645507 , AL645730 Genomic DNA. Translation: CAI19137.1 .
AL355809
, AC099788 , AL390023 , AL391844 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI22167.1 .
AL390023
, AC099788 , AL355809 , AL391844 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI23365.1 .
CCDSi CCDS44137.1. [Q5VU57-1 ]
RefSeqi NP_116174.3. NM_032785.3. [Q5VU57-1 ]
UniGenei Hs.551844.
Hs.679809.

3D structure databases

ProteinModelPortali Q5VU57.
SMRi Q5VU57. Positions 48-386.
ModBasei Search...

Protein family/group databases

MEROPSi M14.027.

PTM databases

PhosphoSitei Q5VU57.

Polymorphism databases

DMDMi 317373463.

Proteomic databases

PaxDbi Q5VU57.
PRIDEi Q5VU57.

Protocols and materials databases

DNASUi 84871.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371839 ; ENSP00000360905 ; ENSG00000186094 . [Q5VU57-1 ]
GeneIDi 84871.
KEGGi hsa:84871.
UCSCi uc001cru.2. human. [Q5VU57-1 ]
uc010omx.1. human. [Q5VU57-2 ]

Organism-specific databases

CTDi 84871.
GeneCardsi GC01M048998.
HGNCi HGNC:25892. AGBL4.
HPAi HPA037994.
neXtProti NX_Q5VU57.
PharmGKBi PA142672636.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2866.
HOGENOMi HOG000231164.
HOVERGENi HBG107588.
InParanoidi Q5VU57.
OMAi YRYERHL.
OrthoDBi EOG71VSTM.
PhylomeDBi Q5VU57.
TreeFami TF333009.

Miscellaneous databases

ChiTaRSi AGBL4. human.
GenomeRNAii 84871.
NextBioi 75159.
PROi Q5VU57.

Gene expression databases

ArrayExpressi Q5VU57.
Bgeei Q5VU57.
CleanExi HS_AGBL4.
Genevestigatori Q5VU57.

Family and domain databases

InterProi IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCBPC6_HUMAN
AccessioniPrimary (citable) accession number: Q5VU57
Secondary accession number(s): B3KT26, B4DG37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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