Reviewed, UniProtKB/Swiss-Prot Q5VU57 (CBPC6_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytosolic carboxypeptidase 6
    EC=3.4.17.-
Alternative name(s):
    ATP/GTP-binding protein-like 4

Gene names

Name:	AGBL4
Synonyms:	CCP6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in the processing of tubulin By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M14 family.
Sequence caution	The sequence CAH70510.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI13521.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI14372.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI17069.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI19137.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI22167.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23365.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metallocarboxypeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Cytosolic carboxypeptidase 6		PRO_0000284835
Sites
	Active site	280	1	Nucleophile By similarity
	Metal binding	230	1	Zinc By similarity
	Metal binding	233	1	Zinc By similarity
	Metal binding	328	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5VU57-1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: 139DEC2993F2DCF5	FASTA	540	62,385
	10 20 30 40 50 60 MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF ESGNLGRVDQ 70 80 90 100 110 120 VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI VNFSKTKSLY RDGMAPMVKS 130 140 150 160 170 180 TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF AFCFDREEDI YQFAYCYPYT YTRFQHYLDS 190 200 210 220 230 240 LQKRNMDYFF REQLGQSVQQ RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC 250 260 270 280 290 300 QGIIDFLVSQ HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH 310 320 330 340 350 360 PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ RQAIFPKLLC 370 380 390 400 410 420 QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL EVSFYSYIIS GTTAAVPYTE 430 440 450 460 470 480 EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA 490 500 510 520 530 540 SNYPNSKGDK KSSVNHKDPS TPFLKTRSPG RSYGDRSMHF LLGNEINHSS LASKDLWINA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK094826 mRNA. Translation: BAG52938.1. AL590432 , AC099788, AL355809, AL390023, AL391844, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAH70510.1. Sequence problems. AL391844 , AC099788, AL355809, AL390023, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI13521.1. Sequence problems. AL645507 , AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645730 Genomic DNA. Translation: CAI14372.1. Sequence problems. AL645730 , AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645507 Genomic DNA. Translation: CAI17069.1. Sequence problems. AL591602 , AC099788, AL355809, AL390023, AL391844, AL590432, AL645507, AL645730 Genomic DNA. Translation: CAI19137.1. Sequence problems. AL355809 , AC099788, AL390023, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI22167.1. Sequence problems. AL390023 , AC099788, AL355809, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI23365.1. Sequence problems.
IPI	IPI00477383.
RefSeq	NP_116174.3.
UniGene	Hs.551844 Hs.679809
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q5VU57.
Genome annotation databases
Ensembl	ENST00000371839; ENSP00000360905; ENSG00000186094; Homo sapiens. [Genome view]
GeneID	84871.
KEGG	hsa:84871.
Organism-specific databases
CTD	84871.
GeneCards	GC01M048762.
HGNC	HGNC:25892. AGBL4.
PharmGKB	PA142672636.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5VU57.
OrthoDB	EOG9SBHHC
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000012722-MON.
Gene expression databases
ArrayExpress	Q5VU57.
Bgee	Q5VU57.
CleanEx	HS_AGBL4.
Genevestigator	Q5VU57.
Family and domain databases
InterPro	IPR000834. Peptidase_M14. [Graphical view]
Pfam	PF00246. Peptidase_M14. 1 hit. [Graphical view]
PROSITE	PS00132. CARBOXYPEPT_ZN_1. False negative. PS00133. CARBOXYPEPT_ZN_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CBPC6_HUMAN

Accession

Primary (citable) accession number: Q5VU57
Secondary accession number(s): B3KT26

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	November 24, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.