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Q5VU57

- CBPC6_HUMAN

UniProt

Q5VU57 - CBPC6_HUMAN

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Protein

Cytosolic carboxypeptidase 6

Gene

AGBL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity).By similarity

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi230 – 2301ZincBy similarity
Metal bindingi233 – 2331ZincBy similarity
Active sitei280 – 2801NucleophileBy similarity
Metal bindingi328 – 3281ZincBy similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: UniProtKB
  2. tubulin binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. C-terminal protein deglutamylation Source: UniProtKB
  2. protein side chain deglutamylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase 6 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 4
Gene namesi
Name:AGBL4
Synonyms:CCP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25892. AGBL4.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytosolic carboxypeptidase 6PRO_0000284835Add
BLAST

Proteomic databases

PaxDbiQ5VU57.
PRIDEiQ5VU57.

PTM databases

PhosphoSiteiQ5VU57.

Expressioni

Gene expression databases

BgeeiQ5VU57.
CleanExiHS_AGBL4.
ExpressionAtlasiQ5VU57. baseline and differential.
GenevestigatoriQ5VU57.

Organism-specific databases

HPAiHPA037994.

Interactioni

Subunit structurei

Interacts with MYLK.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5VU57.
SMRiQ5VU57. Positions 48-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiCOG2866.
GeneTreeiENSGT00550000074405.
HOGENOMiHOG000231164.
HOVERGENiHBG107588.
InParanoidiQ5VU57.
OMAiYRYERHL.
OrthoDBiEOG71VSTM.
PhylomeDBiQ5VU57.
TreeFamiTF333009.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5VU57-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF
60 70 80 90 100
ESGNLGRVDQ VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI
110 120 130 140 150
VNFSKTKSLY RDGMAPMVKS TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF
160 170 180 190 200
AFCFDREEDI YQFAYCYPYT YTRFQHYLDS LQKRNMDYFF REQLGQSVQQ
210 220 230 240 250
RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC QGIIDFLVSQ
260 270 280 290 300
HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH
310 320 330 340 350
PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ
360 370 380 390 400
RQAIFPKLLC QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL
410 420 430 440 450
EVSFYSYIIS GTTAAVPYTE EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP
460 470 480 490 500
MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA SNYPNSKGDK KSSVNHKDPS

TPF
Length:503
Mass (Da):58,230
Last modified:January 11, 2011 - v3
Checksum:i4D1AD20229664D90
GO
Isoform 2 (identifier: Q5VU57-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-94: Q → QVREIVDTFRVVL
     455-463: Missing.

Note: No experimental confirmation available.

Show »
Length:506
Mass (Da):58,505
Checksum:i20C9AED5564F23F9
GO

Sequence cautioni

The sequence BAG52938.1 differs from that shown. Reason: Frameshift at position 501.
The sequence BAG57648.1 differs from that shown. Reason: Frameshift at position 501.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371S → L in BAG57648. (PubMed:14702039)Curated
Sequence conflicti490 – 4901K → R in BAG57648. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti443 – 4431V → M.
Corresponds to variant rs60977321 [ dbSNP | Ensembl ].
VAR_061078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 941Q → QVREIVDTFRVVL in isoform 2. 1 PublicationVSP_040435
Alternative sequencei455 – 4639Missing in isoform 2. 1 PublicationVSP_040436

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094826 mRNA. Translation: BAG52938.1. Frameshift.
AK294394 mRNA. Translation: BAG57648.1. Frameshift.
AL590432
, AC099788, AL355809, AL390023, AL391844, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAH70510.1.
AL391844
, AC099788, AL355809, AL390023, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI13521.1.
AL645507
, AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645730 Genomic DNA. Translation: CAI14372.1.
AL645730
, AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645507 Genomic DNA. Translation: CAI17069.1.
AL591602
, AC099788, AL355809, AL390023, AL391844, AL590432, AL645507, AL645730 Genomic DNA. Translation: CAI19137.1.
AL355809
, AC099788, AL390023, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI22167.1.
AL390023
, AC099788, AL355809, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI23365.1.
CCDSiCCDS44137.1. [Q5VU57-1]
RefSeqiNP_116174.3. NM_032785.3. [Q5VU57-1]
UniGeneiHs.551844.
Hs.679809.

Genome annotation databases

EnsembliENST00000371839; ENSP00000360905; ENSG00000186094. [Q5VU57-1]
GeneIDi84871.
KEGGihsa:84871.
UCSCiuc001cru.2. human. [Q5VU57-1]
uc010omx.1. human. [Q5VU57-2]

Polymorphism databases

DMDMi317373463.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094826 mRNA. Translation: BAG52938.1 . Frameshift.
AK294394 mRNA. Translation: BAG57648.1 . Frameshift.
AL590432
, AC099788 , AL355809 , AL390023 , AL391844 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAH70510.1 .
AL391844
, AC099788 , AL355809 , AL390023 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI13521.1 .
AL645507
, AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL591602 , AL645730 Genomic DNA. Translation: CAI14372.1 .
AL645730
, AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL591602 , AL645507 Genomic DNA. Translation: CAI17069.1 .
AL591602
, AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL645507 , AL645730 Genomic DNA. Translation: CAI19137.1 .
AL355809
, AC099788 , AL390023 , AL391844 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI22167.1 .
AL390023
, AC099788 , AL355809 , AL391844 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI23365.1 .
CCDSi CCDS44137.1. [Q5VU57-1 ]
RefSeqi NP_116174.3. NM_032785.3. [Q5VU57-1 ]
UniGenei Hs.551844.
Hs.679809.

3D structure databases

ProteinModelPortali Q5VU57.
SMRi Q5VU57. Positions 48-386.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M14.027.

PTM databases

PhosphoSitei Q5VU57.

Polymorphism databases

DMDMi 317373463.

Proteomic databases

PaxDbi Q5VU57.
PRIDEi Q5VU57.

Protocols and materials databases

DNASUi 84871.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371839 ; ENSP00000360905 ; ENSG00000186094 . [Q5VU57-1 ]
GeneIDi 84871.
KEGGi hsa:84871.
UCSCi uc001cru.2. human. [Q5VU57-1 ]
uc010omx.1. human. [Q5VU57-2 ]

Organism-specific databases

CTDi 84871.
GeneCardsi GC01M048998.
HGNCi HGNC:25892. AGBL4.
HPAi HPA037994.
neXtProti NX_Q5VU57.
PharmGKBi PA142672636.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2866.
GeneTreei ENSGT00550000074405.
HOGENOMi HOG000231164.
HOVERGENi HBG107588.
InParanoidi Q5VU57.
OMAi YRYERHL.
OrthoDBi EOG71VSTM.
PhylomeDBi Q5VU57.
TreeFami TF333009.

Miscellaneous databases

ChiTaRSi AGBL4. human.
GenomeRNAii 84871.
NextBioi 75159.
PROi Q5VU57.

Gene expression databases

Bgeei Q5VU57.
CleanExi HS_AGBL4.
ExpressionAtlasi Q5VU57. baseline and differential.
Genevestigatori Q5VU57.

Family and domain databases

InterProi IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCBPC6_HUMAN
AccessioniPrimary (citable) accession number: Q5VU57
Secondary accession number(s): B3KT26, B4DG37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3