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Q5VU57

- CBPC6_HUMAN

UniProt

Q5VU57 - CBPC6_HUMAN

Protein

Cytosolic carboxypeptidase 6

Gene

AGBL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi230 – 2301ZincBy similarity
    Metal bindingi233 – 2331ZincBy similarity
    Active sitei280 – 2801NucleophileBy similarity
    Metal bindingi328 – 3281ZincBy similarity

    GO - Molecular functioni

    1. metallocarboxypeptidase activity Source: UniProtKB
    2. tubulin binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. C-terminal protein deglutamylation Source: UniProtKB
    2. protein side chain deglutamylation Source: UniProtKB

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM14.027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic carboxypeptidase 6 (EC:3.4.17.-)
    Alternative name(s):
    ATP/GTP-binding protein-like 4
    Gene namesi
    Name:AGBL4
    Synonyms:CCP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25892. AGBL4.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672636.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytosolic carboxypeptidase 6PRO_0000284835Add
    BLAST

    Proteomic databases

    PaxDbiQ5VU57.
    PRIDEiQ5VU57.

    PTM databases

    PhosphoSiteiQ5VU57.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5VU57.
    BgeeiQ5VU57.
    CleanExiHS_AGBL4.
    GenevestigatoriQ5VU57.

    Organism-specific databases

    HPAiHPA037994.

    Interactioni

    Subunit structurei

    Interacts with MYLK.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VU57.
    SMRiQ5VU57. Positions 48-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated

    Phylogenomic databases

    eggNOGiCOG2866.
    HOGENOMiHOG000231164.
    HOVERGENiHBG107588.
    InParanoidiQ5VU57.
    OMAiYRYERHL.
    OrthoDBiEOG71VSTM.
    PhylomeDBiQ5VU57.
    TreeFamiTF333009.

    Family and domain databases

    InterProiIPR000834. Peptidase_M14.
    [Graphical view]
    PfamiPF00246. Peptidase_M14. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5VU57-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF    50
    ESGNLGRVDQ VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI 100
    VNFSKTKSLY RDGMAPMVKS TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF 150
    AFCFDREEDI YQFAYCYPYT YTRFQHYLDS LQKRNMDYFF REQLGQSVQQ 200
    RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC QGIIDFLVSQ 250
    HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH 300
    PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ 350
    RQAIFPKLLC QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL 400
    EVSFYSYIIS GTTAAVPYTE EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP 450
    MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA SNYPNSKGDK KSSVNHKDPS 500
    TPF 503
    Length:503
    Mass (Da):58,230
    Last modified:January 11, 2011 - v3
    Checksum:i4D1AD20229664D90
    GO
    Isoform 2 (identifier: Q5VU57-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-94: Q → QVREIVDTFRVVL
         455-463: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:506
    Mass (Da):58,505
    Checksum:i20C9AED5564F23F9
    GO

    Sequence cautioni

    The sequence BAG52938.1 differs from that shown. Reason: Frameshift at position 501.
    The sequence BAG57648.1 differs from that shown. Reason: Frameshift at position 501.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371S → L in BAG57648. (PubMed:14702039)Curated
    Sequence conflicti490 – 4901K → R in BAG57648. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti443 – 4431V → M.
    Corresponds to variant rs60977321 [ dbSNP | Ensembl ].
    VAR_061078

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei94 – 941Q → QVREIVDTFRVVL in isoform 2. 1 PublicationVSP_040435
    Alternative sequencei455 – 4639Missing in isoform 2. 1 PublicationVSP_040436

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094826 mRNA. Translation: BAG52938.1. Frameshift.
    AK294394 mRNA. Translation: BAG57648.1. Frameshift.
    AL590432
    , AC099788, AL355809, AL390023, AL391844, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAH70510.1.
    AL391844
    , AC099788, AL355809, AL390023, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI13521.1.
    AL645507
    , AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645730 Genomic DNA. Translation: CAI14372.1.
    AL645730
    , AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645507 Genomic DNA. Translation: CAI17069.1.
    AL591602
    , AC099788, AL355809, AL390023, AL391844, AL590432, AL645507, AL645730 Genomic DNA. Translation: CAI19137.1.
    AL355809
    , AC099788, AL390023, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI22167.1.
    AL390023
    , AC099788, AL355809, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI23365.1.
    CCDSiCCDS44137.1. [Q5VU57-1]
    RefSeqiNP_116174.3. NM_032785.3. [Q5VU57-1]
    UniGeneiHs.551844.
    Hs.679809.

    Genome annotation databases

    EnsembliENST00000371839; ENSP00000360905; ENSG00000186094. [Q5VU57-1]
    GeneIDi84871.
    KEGGihsa:84871.
    UCSCiuc001cru.2. human. [Q5VU57-1]
    uc010omx.1. human. [Q5VU57-2]

    Polymorphism databases

    DMDMi317373463.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094826 mRNA. Translation: BAG52938.1 . Frameshift.
    AK294394 mRNA. Translation: BAG57648.1 . Frameshift.
    AL590432
    , AC099788 , AL355809 , AL390023 , AL391844 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAH70510.1 .
    AL391844
    , AC099788 , AL355809 , AL390023 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI13521.1 .
    AL645507
    , AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL591602 , AL645730 Genomic DNA. Translation: CAI14372.1 .
    AL645730
    , AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL591602 , AL645507 Genomic DNA. Translation: CAI17069.1 .
    AL591602
    , AC099788 , AL355809 , AL390023 , AL391844 , AL590432 , AL645507 , AL645730 Genomic DNA. Translation: CAI19137.1 .
    AL355809
    , AC099788 , AL390023 , AL391844 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI22167.1 .
    AL390023
    , AC099788 , AL355809 , AL391844 , AL590432 , AL591602 , AL645507 , AL645730 Genomic DNA. Translation: CAI23365.1 .
    CCDSi CCDS44137.1. [Q5VU57-1 ]
    RefSeqi NP_116174.3. NM_032785.3. [Q5VU57-1 ]
    UniGenei Hs.551844.
    Hs.679809.

    3D structure databases

    ProteinModelPortali Q5VU57.
    SMRi Q5VU57. Positions 48-386.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M14.027.

    PTM databases

    PhosphoSitei Q5VU57.

    Polymorphism databases

    DMDMi 317373463.

    Proteomic databases

    PaxDbi Q5VU57.
    PRIDEi Q5VU57.

    Protocols and materials databases

    DNASUi 84871.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371839 ; ENSP00000360905 ; ENSG00000186094 . [Q5VU57-1 ]
    GeneIDi 84871.
    KEGGi hsa:84871.
    UCSCi uc001cru.2. human. [Q5VU57-1 ]
    uc010omx.1. human. [Q5VU57-2 ]

    Organism-specific databases

    CTDi 84871.
    GeneCardsi GC01M048998.
    HGNCi HGNC:25892. AGBL4.
    HPAi HPA037994.
    neXtProti NX_Q5VU57.
    PharmGKBi PA142672636.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2866.
    HOGENOMi HOG000231164.
    HOVERGENi HBG107588.
    InParanoidi Q5VU57.
    OMAi YRYERHL.
    OrthoDBi EOG71VSTM.
    PhylomeDBi Q5VU57.
    TreeFami TF333009.

    Miscellaneous databases

    ChiTaRSi AGBL4. human.
    GenomeRNAii 84871.
    NextBioi 75159.
    PROi Q5VU57.

    Gene expression databases

    ArrayExpressi Q5VU57.
    Bgeei Q5VU57.
    CleanExi HS_AGBL4.
    Genevestigatori Q5VU57.

    Family and domain databases

    InterProi IPR000834. Peptidase_M14.
    [Graphical view ]
    Pfami PF00246. Peptidase_M14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala and Brain.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCBPC6_HUMAN
    AccessioniPrimary (citable) accession number: Q5VU57
    Secondary accession number(s): B3KT26, B4DG37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3