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Q5VU57 (CBPC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytosolic carboxypeptidase 6

EC=3.4.17.-
Alternative name(s):
ATP/GTP-binding protein-like 4
Gene names
Name:AGBL4
Synonyms:CCP6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Interacts with MYLK By similarity.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the peptidase M14 family.

Sequence caution

The sequence BAG52938.1 differs from that shown. Reason: Frameshift at position 501.

The sequence BAG57648.1 differs from that shown. Reason: Frameshift at position 501.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5VU57-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5VU57-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-94: Q → QVREIVDTFRVVL
     455-463: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytosolic carboxypeptidase 6
PRO_0000284835

Sites

Active site2801Nucleophile By similarity
Metal binding2301Zinc By similarity
Metal binding2331Zinc By similarity
Metal binding3281Zinc By similarity

Natural variations

Alternative sequence941Q → QVREIVDTFRVVL in isoform 2.
VSP_040435
Alternative sequence455 – 4639Missing in isoform 2.
VSP_040436
Natural variant4431V → M.
Corresponds to variant rs60977321 [ dbSNP | Ensembl ].
VAR_061078

Experimental info

Sequence conflict2371S → L in BAG57648. Ref.1
Sequence conflict4901K → R in BAG57648. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 4D1AD20229664D90

FASTA50358,230
        10         20         30         40         50         60 
MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF ESGNLGRVDQ 

        70         80         90        100        110        120 
VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI VNFSKTKSLY RDGMAPMVKS 

       130        140        150        160        170        180 
TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF AFCFDREEDI YQFAYCYPYT YTRFQHYLDS 

       190        200        210        220        230        240 
LQKRNMDYFF REQLGQSVQQ RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC 

       250        260        270        280        290        300 
QGIIDFLVSQ HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH 

       310        320        330        340        350        360 
PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ RQAIFPKLLC 

       370        380        390        400        410        420 
QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL EVSFYSYIIS GTTAAVPYTE 

       430        440        450        460        470        480 
EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA 

       490        500 
SNYPNSKGDK KSSVNHKDPS TPF 

« Hide

Isoform 2 [UniParc].

Checksum: 20C9AED5564F23F9
Show »

FASTA50658,505

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Amygdala and Brain.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK094826 mRNA. Translation: BAG52938.1. Frameshift.
AK294394 mRNA. Translation: BAG57648.1. Frameshift.
AL590432 expand/collapse EMBL AC list , AC099788, AL355809, AL390023, AL391844, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAH70510.1.
AL391844 expand/collapse EMBL AC list , AC099788, AL355809, AL390023, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI13521.1.
AL645507 expand/collapse EMBL AC list , AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645730 Genomic DNA. Translation: CAI14372.1.
AL645730 expand/collapse EMBL AC list , AC099788, AL355809, AL390023, AL391844, AL590432, AL591602, AL645507 Genomic DNA. Translation: CAI17069.1.
AL591602 expand/collapse EMBL AC list , AC099788, AL355809, AL390023, AL391844, AL590432, AL645507, AL645730 Genomic DNA. Translation: CAI19137.1.
AL355809 expand/collapse EMBL AC list , AC099788, AL390023, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI22167.1.
AL390023 expand/collapse EMBL AC list , AC099788, AL355809, AL391844, AL590432, AL591602, AL645507, AL645730 Genomic DNA. Translation: CAI23365.1.
RefSeqNP_116174.3. NM_032785.3.
UniGeneHs.551844.
Hs.679809.

3D structure databases

ProteinModelPortalQ5VU57.
SMRQ5VU57. Positions 44-439.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM14.027.

PTM databases

PhosphoSiteQ5VU57.

Polymorphism databases

DMDM317373463.

Proteomic databases

PaxDbQ5VU57.
PRIDEQ5VU57.

Protocols and materials databases

DNASU84871.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371839; ENSP00000360905; ENSG00000186094. [Q5VU57-1]
GeneID84871.
KEGGhsa:84871.
UCSCuc001cru.2. human. [Q5VU57-1]
uc010omx.1. human. [Q5VU57-2]

Organism-specific databases

CTD84871.
GeneCardsGC01M048998.
HGNCHGNC:25892. AGBL4.
HPAHPA037994.
neXtProtNX_Q5VU57.
PharmGKBPA142672636.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2866.
HOGENOMHOG000231164.
HOVERGENHBG107588.
InParanoidQ5VU57.
OMAYRYERHL.
OrthoDBEOG71VSTM.
PhylomeDBQ5VU57.
TreeFamTF333009.

Gene expression databases

ArrayExpressQ5VU57.
BgeeQ5VU57.
CleanExHS_AGBL4.
GenevestigatorQ5VU57.

Family and domain databases

InterProIPR000834. Peptidase_M14.
[Graphical view]
PfamPF00246. Peptidase_M14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAGBL4. human.
GenomeRNAi84871.
NextBio75159.
PROQ5VU57.

Entry information

Entry nameCBPC6_HUMAN
AccessionPrimary (citable) accession number: Q5VU57
Secondary accession number(s): B3KT26, B4DG37
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM