Q5VU43 (MYOME_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myomegalin

Alternative name(s):
Cardiomyopathy-associated protein 2
Phosphodiesterase 4D-interacting protein

Gene names

Name:	PDE4DIP
Synonyms:	CMYA2, KIAA0454, KIAA0477, MMGL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes By similarity.
Subunit structure	Interacts with PDE4D By similarity.
Subcellular location	Golgi apparatus By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Cytoplasm. Nucleus Ref.1.
Tissue specificity	Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. Ref.1
Developmental stage	Expressed in fetal heart. Ref.1
Involvement in disease	A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.
Sequence similarities	Contains 1 NBPF domain.
Sequence caution	The sequence AAH04860.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA32299.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA32322.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD91152.1 differs from that shown. Reason: Frameshift at position 1507. The sequence CAH18128.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein complex assembly Inferred from sequence or structural similarity PubMed 11134006. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from sequence or structural similarity PubMed 11134006. Source: UniProtKB centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB myofibril Inferred from sequence or structural similarity PubMed 11134006. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	enzyme binding Inferred from sequence or structural similarity PubMed 11134006. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VU43-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VU43-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: MSNGYRTLSQ...HLLEEPTSME → MKEICRICAR...DLCEDYLPLR
     970-2346: Missing.

Isoform 3 (identifier: Q5VU43-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MEQTWTRDYF...QTQALRDFEK
     1082-1191: Missing.
     1695-1756: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5VU43-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2334-2346: VKSLRALPCTPAL → EPCKKRSHQKSLKQQERWACPPFVQLPIC

Isoform 6 (identifier: Q5VU43-6)

The sequence of this isoform differs from the canonical sequence as follows:
     970-2346: Missing.

Isoform 7 (identifier: Q5VU43-7)

The sequence of this isoform differs from the canonical sequence as follows:
     968-988: QLVKVALEKSLATVETQNPSF → QVSQCQGLGLPGWTAHSPSEV
     989-2346: Missing.

Isoform 8 (identifier: Q5VU43-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MKGTDSGSCC...QTQALRDFEK
     174-2346: Missing.

Isoform 9 (identifier: Q5VU43-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MKGTDSGSCC...QTQALRDFEK
     174-174: R → I
     175-2346: Missing.

Isoform 10 (identifier: Q5VU43-10)

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: R → I
     175-2346: Missing.

Isoform 11 (identifier: Q5VU43-11)

The sequence of this isoform differs from the canonical sequence as follows:
     174-2346: Missing.

Isoform 12 (identifier: Q5VU43-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MSNGYRTLSQ → MEQTWTRDYF...QTQALRDFEK
     174-174: R → I
     175-2346: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2346	2346	Myomegalin		PRO_0000307690
Regions
	Domain	1551 – 1642	92	NBPF
	Coiled coil	41 – 132	92	Potential
	Coiled coil	162 – 205	44	Potential
	Coiled coil	238 – 318	81	Potential
	Coiled coil	350 – 684	335	Potential
	Coiled coil	743 – 936	194	Potential
	Coiled coil	1002 – 1043	42	Potential
	Coiled coil	1096 – 1124	29	Potential
	Coiled coil	1212 – 1240	29	Potential
	Coiled coil	1346 – 1385	40	Potential
	Coiled coil	1431 – 1455	25	Potential
	Coiled coil	1736 – 1760	25	Potential
	Coiled coil	1840 – 2077	238	Potential
	Coiled coil	2273 – 2312	40	Potential
Sites
	Site	742 – 743	2	Breakpoint for insertion to form PDE4DIP-PDGFRB fusion protein
Amino acid modifications
	Modified residue	704	1	Phosphothreonine Ref.9
Natural variations
	Alternative sequence	1 – 210	210	MSNGY…PTSME → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VPRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSIERLQ KLLLEKDRLKFCIASMYRKN NDDSGAEIKAGNGTVDMSVL PDARYSALLQEDFAYSGFEC WVENEDQIQEPHSCHGSEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISCGPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEETPGS SVESLDASVQASPPQQKDEE TERSAKELGKCDCCSDDQAP QHGCNHKLELALSMIKGLDY KPIQSPRGSRLPIPVKSSLP GAKPGPSMTDGVSSGFLNRS LKPLYKTPVSYPLELSDLQE LWDDLCEDYLPLR in isoform 2.		VSP_028772
	Alternative sequence	1 – 10	10	MSNGYRTLSQ → MEQTWTRDYFAEDDGEMVPR TSHTAAFLSDTKDRGPPVQS QIWRSGEKVPFVQTYSLRAF EKPPQVQTQALRDFEK in isoform 3 and isoform 12.		VSP_028773
	Alternative sequence	1 – 10	10	MSNGYRTLSQ → MKGTDSGSCCRRRCDFGCCC RASRRAHYTPYRSGDATRTP QSPRQTPSRERRRPEPAGSW AAAAEEEEAAAAATPWMRDY FAEDDGEMVPRTSHTAAFLS DTKDRGPPVQSQIWRSGEKV PFVQTYSLRAFEKPPQVQTQ ALRDFEK in isoform 8 and isoform 9.		VSP_028774
	Alternative sequence	174 – 2346	2173	Missing in isoform 8 and isoform 11.		VSP_028775
	Alternative sequence	174	1	R → I in isoform 9, isoform 10 and isoform 12.		VSP_028776
	Alternative sequence	175 – 2346	2172	Missing in isoform 9, isoform 10 and isoform 12.		VSP_028777
	Alternative sequence	968 – 988	21	QLVKV…QNPSF → QVSQCQGLGLPGWTAHSPSE V in isoform 7.		VSP_028778
	Alternative sequence	970 – 2346	1377	Missing in isoform 2 and isoform 6.		VSP_028779
	Alternative sequence	989 – 2346	1358	Missing in isoform 7.		VSP_028780
	Alternative sequence	1082 – 1191	110	Missing in isoform 3.		VSP_028781
	Alternative sequence	1695 – 1756	62	Missing in isoform 3.		VSP_028782
	Alternative sequence	2334 – 2346	13	VKSLR…CTPAL → EPCKKRSHQKSLKQQERWAC PPFVQLPIC in isoform 4.		VSP_028783
	Natural variant	13	1	N → S. Corresponds to variant rs3010980 [ dbSNP | Ensembl ].		VAR_036627
	Natural variant	25	1	R → L. Corresponds to variant rs1664022 [ dbSNP | Ensembl ].		VAR_036628
	Natural variant	49	1	I → T. Ref.1 Ref.6 Corresponds to variant rs573724 [ dbSNP | Ensembl ].		VAR_036629
	Natural variant	143	1	K → E. Corresponds to variant rs1747958 [ dbSNP | Ensembl ].		VAR_056951
	Natural variant	150	1	N → S. Corresponds to variant rs3010980 [ dbSNP | Ensembl ].		VAR_056952
	Natural variant	167	1	A → T. Corresponds to variant rs2590120 [ dbSNP | Ensembl ].		VAR_036630
	Natural variant	171	1	R → K. Corresponds to variant rs3121544 [ dbSNP | Ensembl ].		VAR_051204
	Natural variant	391	1	E → A. Corresponds to variant rs1324366 [ dbSNP | Ensembl ].		VAR_051205
	Natural variant	410	1	E → V. Corresponds to variant rs17425009 [ dbSNP | Ensembl ].		VAR_051206
	Natural variant	482	1	H → R. Corresponds to variant rs1698681 [ dbSNP | Ensembl ].		VAR_051207
	Natural variant	681	1	R → H. Corresponds to variant rs1629011 [ dbSNP | Ensembl ].		VAR_051208
	Natural variant	708	1	C → R. Ref.2 Ref.4 Ref.6 Ref.9 Corresponds to variant rs1628172 [ dbSNP | Ensembl ].		VAR_051209
	Natural variant	1013	1	F → I. Ref.4 Corresponds to variant rs1698624 [ dbSNP | Ensembl ].		VAR_051210
	Natural variant	1066	1	A → T. Ref.4 Corresponds to variant rs1698647 [ dbSNP | Ensembl ].		VAR_051211
	Natural variant	1359	1	K → E. Ref.4 Corresponds to variant rs1747958 [ dbSNP | Ensembl ].		VAR_051212
	Natural variant	1736	1	V → E. Ref.4 Corresponds to variant rs1778159 [ dbSNP | Ensembl ].		VAR_051213
	Natural variant	1742	1	A → S. Ref.4 Corresponds to variant rs1698605 [ dbSNP | Ensembl ].		VAR_051214
Experimental info
	Sequence conflict	33	1	M → T in CAD89923. Ref.4
	Sequence conflict	98	1	T → M in BAB17761. Ref.1
	Sequence conflict	98	1	T → M in BAB17762. Ref.1
	Sequence conflict	109	1	I → M in BAB17759. Ref.1
	Sequence conflict	109	1	I → M in BAB17760. Ref.1
	Sequence conflict	109	1	I → M in BAB17761. Ref.1
	Sequence conflict	109	1	I → M in BAB17762. Ref.1
	Sequence conflict	109	1	I → M in AAH25406. Ref.6
	Sequence conflict	109	1	I → M in AAI10295. Ref.6
	Sequence conflict	401	1	R → Q in CAD91152. Ref.4
	Sequence conflict	643	1	M → V in CAD91152. Ref.4
	Sequence conflict	776	1	L → P in CAD91152. Ref.4
	Sequence conflict	783	1	M → I in CAD38529. Ref.4
	Sequence conflict	783	1	M → I in AAI32718. Ref.6
	Sequence conflict	830	1	L → P in CAD91152. Ref.4
	Sequence conflict	863	1	L → P in CAD38529. Ref.4
	Sequence conflict	1266	1	K → E in CAH18128. Ref.4
	Sequence conflict	1286	1	E → G in CAD91152. Ref.4
	Sequence conflict	1356	1	K → R in CAD91152. Ref.4
	Sequence conflict	1396	1	W → R in BAA32299. Ref.2
	Sequence conflict	1396	1	W → R in CAD91152. Ref.4
	Sequence conflict	1396	1	W → R in CAH18128. Ref.4
	Sequence conflict	1397	1	K → E in CAD91152. Ref.4
	Sequence conflict	1454	1	K → E in CAH18128. Ref.4
	Sequence conflict	1504	1	R → Q in CAH18128. Ref.4
	Sequence conflict	1598	1	H → R in CAH18128. Ref.4
	Sequence conflict	1610	1	T → P in CAH18128. Ref.4
	Sequence conflict	1727	1	L → P in CAH18128. Ref.4
	Sequence conflict	1757	1	A → T in CAH18128. Ref.4
	Sequence conflict	1867	1	R → C in CAH18128. Ref.4
	Sequence conflict	1910	1	D → E in CAH18128. Ref.4
	Sequence conflict	2001	1	E → G in CAH18128. Ref.4
	Sequence conflict	2088	1	Missing in CAH18128. Ref.4
	Sequence conflict	2291	1	R → Q in CAH18128. Ref.4
	Sequence conflict	2317	1	Q → R in CAH18128. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 6A3F3A12F959F799	FASTA	2,346	265,080
	10 20 30 40 50 60 MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE LKVEVESLKR 70 80 90 100 110 120 ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH VYELLENKIQ LLQEESRLAK 130 140 150 160 170 180 NEAARMAALV EAEKECNLEL SEKLKGVTKN WEDVPGDQVK PDQYTEALAQ RDKRIEELNQ 190 200 210 220 230 240 SLAAQERLVE QLSREKQQLL HLLEEPTSME VQPMTEELLK QQKLNSHETT ITQQSVSDSH 250 260 270 280 290 300 LAELQEKIQQ TEATNKILQE KLNEMSYELK CAQESSQKQD GTIQNLKETL KSRERETEEL 310 320 330 340 350 360 YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GTSPAQQQVA LLDLQSALFC SQLEIQKLQR 370 380 390 400 410 420 VVRQKERQLA DAKQCVQFVE AAAHESEQQK EASWKHNQEL RKALQQLQEE LQNKSQQLRA 430 440 450 460 470 480 WEAEKYNEIR TQEQNIQHLN HSLSHKEQLL QEFRELLQYR DNSDKTLEAN EMLLEKLRQR 490 500 510 520 530 540 IHDKAVALER AIDEKFSALE EKEKELRQLR LAVRERDHDL ERLRDVLSSN EATMQSMESL 550 560 570 580 590 600 LRAKGLEVEQ LSTTCQNLQW LKEEMETKFS RWQKEQESII QQLQTSLHDR NKEVEDLSAT 610 620 630 640 650 660 LLCKLGPGQS EIAEELCQRL QRKERMLQDL LSDRNKQVLE HEMEIQGLLQ SVSTREQESQ 670 680 690 700 710 720 AAAEKLVQAL MERNSELQAL RQYLGGRDSL MSQAPISNQQ AEVTPTGCLG KQTDQGSMQI 730 740 750 760 770 780 PSRDDSTSLT AKEDVSIPRS TLGDLDTVAG LEKELSNAKE ELELMAKKER ESQMELSALQ 790 800 810 820 830 840 SMMAVQEEEL QVQAADMESL TRNIQIKEDL IKDLQMQLVD PEDIPAMERL TQEVLLLREK 850 860 870 880 890 900 VASVESQGQE ISGNRRQQLL LMLEGLVDER SRLNEALQAE RQLYSSLVKF HAHPESSERD 910 920 930 940 950 960 RTLQVELEGA QVLRSRLEEV LGRSLERLNR LETLAAIGGA AAGDDTEDTS TEFTDSIEEE 970 980 990 1000 1010 1020 AAHHSHQQLV KVALEKSLAT VETQNPSFSP PSPMGGDSNR CLQEEMLHLR AEFHQHLEEK 1030 1040 1050 1060 1070 1080 RKAEEELKEL KAQIEEAGFS SVSHIRNTML SLCLENAELK EQMGEAMSDG WEIEEDKEKG 1090 1100 1110 1120 1130 1140 EVMVETVVTK EGLSESSLQA EFRKLQGKLK NAHNIINLLK EQLVLSSKEG NSKLTPELLV 1150 1160 1170 1180 1190 1200 HLTSTIERIN TELVGSPGKH QHQEEGNVTV RPFPRPQSLD LGATFTVDAH QLDNQSQPRD 1210 1220 1230 1240 1250 1260 PGPQSAFSLP GSTQHLRSQL SQCKQRYQDL QEKLLLSEAT VFAQANELEK YRVMLTGESL 1270 1280 1290 1300 1310 1320 VKQDSKQIQV DLQDLGYETC GRSENEAERE ETTSPECEEH NSLKEMVLME GLCSEQGRRG 1330 1340 1350 1360 1370 1380 STLASSSERK PLENQLGKQE EFRVYGKSEN ILVLRKDIKD LKAQLQNANK VIQNLKSRVR 1390 1400 1410 1420 1430 1440 SLSVTSDYSS SLERPWKLRA VGTLEGSSPH SVPDEDEGWL SDGTGAFYSP GLQAKKDLES 1450 1460 1470 1480 1490 1500 LIQRVSQLEA QLPKNGLEEK LAEELRSASW PGKYDSLIQD QARELSYLRQ KIREGRGICY 1510 1520 1530 1540 1550 1560 LITRHAKDTV KSFEDLLRSN DIDYYLGQSF REQLAQGSQL TERLTSKLST KDHKSEKDQA 1570 1580 1590 1600 1610 1620 GLEPLALRLS RELQEKEKVI EVLQAKLDAR SLTPSSSHAL SDSHRSPSST SFLSDELEAC 1630 1640 1650 1660 1670 1680 SDMDIVSEYT HYEEKKASPS HSDSIHHSSH SAVLSSKPSS TSASQGAKAE SNSNPISLPT 1690 1700 1710 1720 1730 1740 PQNTPKEANQ AHSGFHFHSI PKLASLPQAP LPSAPSSFLP FSPTGPLLLG CCETPVVSLA 1750 1760 1770 1780 1790 1800 EAQQELQMLQ KQLGESASTV PPASTATLLS NDLEADSSYY LNSAQPHSPP RGTIELGRIL 1810 1820 1830 1840 1850 1860 EPGYLGSSGK WDVMRPQKGS VSGDLSSGSS VYQLNSKPTG ADLLEEHLGE IRNLRQRLEE 1870 1880 1890 1900 1910 1920 SICINDRLRE QLEHRLTSTA RGRGSTSNFY SQGLESIPQL CNENRVLRED NRRLQAQLSH 1930 1940 1950 1960 1970 1980 VSREHSQETE SLREALLSSR SHLQELEKEL EHQKVERQQL LEDLREKQQE VLHFREERLS 1990 2000 2010 2020 2030 2040 LQENDSRLQH KLVLLQQQCE EKQQLFESLQ SELQIYEALY GNSKKGLKAY SLDACHQIPL 2050 2060 2070 2080 2090 2100 SSDLSHLVAE VRALRGQLEQ SIQGNNCLRL QLQQQLESGA GKASLSPSSI NQNFPASTDP 2110 2120 2130 2140 2150 2160 GNKQLLLQDS AVSPPVRDVG MNSPALVFPS SASSTPGSET PIINRANGLG LDTSPVMKTP 2170 2180 2190 2200 2210 2220 PKLEGDATDG SFANKHGRHV IGHIDDYSAL RQQIAEGKLL VKKIVSLVRS ACSFPGLEAQ 2230 2240 2250 2260 2270 2280 GTEVLGSKGI HELRSSTSAL HHALEESASL LTMFWRAALP STHIPVLPGK VGESTERELL 2290 2300 2310 2320 2330 2340 ELRTKVSKQE RLLQSTTEHL KNANQQKESM EQFIVSQLTR THDVLKKART NLEVKSLRAL PCTPAL
	Isoform 2 [UniParc]. Checksum: 40CEB5FFCA2BABB4	FASTA	1,132	128,464
	10 20 30 40 50 60 MKEICRICAR ELCGNQRRWI FHTASKLNLQ VLLSHVLGKD VPRDGKAEFA CSKCAFMLDR 70 80 90 100 110 120 IYRFDTVIAR IEALSIERLQ KLLLEKDRLK FCIASMYRKN NDDSGAEIKA GNGTVDMSVL 130 140 150 160 170 180 PDARYSALLQ EDFAYSGFEC WVENEDQIQE PHSCHGSEGP GNRPRRCRGC AALRVADSDY 190 200 210 220 230 240 EAICKVPRKV ARSISCGPSS RWSTSICTEE PALSEVGPPD LASTKVPPDG ESMEEETPGS 250 260 270 280 290 300 SVESLDASVQ ASPPQQKDEE TERSAKELGK CDCCSDDQAP QHGCNHKLEL ALSMIKGLDY 310 320 330 340 350 360 KPIQSPRGSR LPIPVKSSLP GAKPGPSMTD GVSSGFLNRS LKPLYKTPVS YPLELSDLQE 370 380 390 400 410 420 LWDDLCEDYL PLRVQPMTEE LLKQQKLNSH ETTITQQSVS DSHLAELQEK IQQTEATNKI 430 440 450 460 470 480 LQEKLNEMSY ELKCAQESSQ KQDGTIQNLK ETLKSRERET EELYQVIEGQ NDTMAKLREM 490 500 510 520 530 540 LHQSQLGQLH SSEGTSPAQQ QVALLDLQSA LFCSQLEIQK LQRVVRQKER QLADAKQCVQ 550 560 570 580 590 600 FVEAAAHESE QQKEASWKHN QELRKALQQL QEELQNKSQQ LRAWEAEKYN EIRTQEQNIQ 610 620 630 640 650 660 HLNHSLSHKE QLLQEFRELL QYRDNSDKTL EANEMLLEKL RQRIHDKAVA LERAIDEKFS 670 680 690 700 710 720 ALEEKEKELR QLRLAVRERD HDLERLRDVL SSNEATMQSM ESLLRAKGLE VEQLSTTCQN 730 740 750 760 770 780 LQWLKEEMET KFSRWQKEQE SIIQQLQTSL HDRNKEVEDL SATLLCKLGP GQSEIAEELC 790 800 810 820 830 840 QRLQRKERML QDLLSDRNKQ VLEHEMEIQG LLQSVSTREQ ESQAAAEKLV QALMERNSEL 850 860 870 880 890 900 QALRQYLGGR DSLMSQAPIS NQQAEVTPTG CLGKQTDQGS MQIPSRDDST SLTAKEDVSI 910 920 930 940 950 960 PRSTLGDLDT VAGLEKELSN AKEELELMAK KERESQMELS ALQSMMAVQE EELQVQAADM 970 980 990 1000 1010 1020 ESLTRNIQIK EDLIKDLQMQ LVDPEDIPAM ERLTQEVLLL REKVASVESQ GQEISGNRRQ 1030 1040 1050 1060 1070 1080 QLLLMLEGLV DERSRLNEAL QAERQLYSSL VKFHAHPESS ERDRTLQVEL EGAQVLRSRL 1090 1100 1110 1120 1130 EEVLGRSLER LNRLETLAAI GGAAAGDDTE DTSTEFTDSI EEEAAHHSHQ QL
	Isoform 3 [UniParc]. Checksum: 2DFC5B468527B49F	FASTA	2,240	254,046
	10 20 30 40 50 60 MEQTWTRDYF AEDDGEMVPR TSHTAAFLSD TKDRGPPVQS QIWRSGEKVP FVQTYSLRAF 70 80 90 100 110 120 EKPPQVQTQA LRDFEKHLND LKKENFSLKL RIYFLEERMQ QKYEASREDI YKRNIELKVE 130 140 150 160 170 180 VESLKRELQD KKQHLDKTWA DVENLNSQNE AELRRQFEER QQETEHVYEL LENKIQLLQE 190 200 210 220 230 240 ESRLAKNEAA RMAALVEAEK ECNLELSEKL KGVTKNWEDV PGDQVKPDQY TEALAQRDKR 250 260 270 280 290 300 IEELNQSLAA QERLVEQLSR EKQQLLHLLE EPTSMEVQPM TEELLKQQKL NSHETTITQQ 310 320 330 340 350 360 SVSDSHLAEL QEKIQQTEAT NKILQEKLNE MSYELKCAQE SSQKQDGTIQ NLKETLKSRE 370 380 390 400 410 420 RETEELYQVI EGQNDTMAKL REMLHQSQLG QLHSSEGTSP AQQQVALLDL QSALFCSQLE 430 440 450 460 470 480 IQKLQRVVRQ KERQLADAKQ CVQFVEAAAH ESEQQKEASW KHNQELRKAL QQLQEELQNK 490 500 510 520 530 540 SQQLRAWEAE KYNEIRTQEQ NIQHLNHSLS HKEQLLQEFR ELLQYRDNSD KTLEANEMLL 550 560 570 580 590 600 EKLRQRIHDK AVALERAIDE KFSALEEKEK ELRQLRLAVR ERDHDLERLR DVLSSNEATM 610 620 630 640 650 660 QSMESLLRAK GLEVEQLSTT CQNLQWLKEE METKFSRWQK EQESIIQQLQ TSLHDRNKEV 670 680 690 700 710 720 EDLSATLLCK LGPGQSEIAE ELCQRLQRKE RMLQDLLSDR NKQVLEHEME IQGLLQSVST 730 740 750 760 770 780 REQESQAAAE KLVQALMERN SELQALRQYL GGRDSLMSQA PISNQQAEVT PTGCLGKQTD 790 800 810 820 830 840 QGSMQIPSRD DSTSLTAKED VSIPRSTLGD LDTVAGLEKE LSNAKEELEL MAKKERESQM 850 860 870 880 890 900 ELSALQSMMA VQEEELQVQA ADMESLTRNI QIKEDLIKDL QMQLVDPEDI PAMERLTQEV 910 920 930 940 950 960 LLLREKVASV ESQGQEISGN RRQQLLLMLE GLVDERSRLN EALQAERQLY SSLVKFHAHP 970 980 990 1000 1010 1020 ESSERDRTLQ VELEGAQVLR SRLEEVLGRS LERLNRLETL AAIGGAAAGD DTEDTSTEFT 1030 1040 1050 1060 1070 1080 DSIEEEAAHH SHQQLVKVAL EKSLATVETQ NPSFSPPSPM GGDSNRCLQE EMLHLRAEFH 1090 1100 1110 1120 1130 1140 QHLEEKRKAE EELKELKAQI EEAGFSSVSH IRNTMLSLCL ENAELKEQMG EAMSDGWEIE 1150 1160 1170 1180 1190 1200 EDKEKGELDN QSQPRDPGPQ SAFSLPGSTQ HLRSQLSQCK QRYQDLQEKL LLSEATVFAQ 1210 1220 1230 1240 1250 1260 ANELEKYRVM LTGESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNSLK 1270 1280 1290 1300 1310 1320 EMVLMEGLCS EQGRRGSTLA SSSERKPLEN QLGKQEEFRV YGKSENILVL RKDIKDLKAQ 1330 1340 1350 1360 1370 1380 LQNANKVIQN LKSRVRSLSV TSDYSSSLER PWKLRAVGTL EGSSPHSVPD EDEGWLSDGT 1390 1400 1410 1420 1430 1440 GAFYSPGLQA KKDLESLIQR VSQLEAQLPK NGLEEKLAEE LRSASWPGKY DSLIQDQARE 1450 1460 1470 1480 1490 1500 LSYLRQKIRE GRGICYLITR HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGSQLTERL 1510 1520 1530 1540 1550 1560 TSKLSTKDHK SEKDQAGLEP LALRLSRELQ EKEKVIEVLQ AKLDARSLTP SSSHALSDSH 1570 1580 1590 1600 1610 1620 RSPSSTSFLS DELEACSDMD IVSEYTHYEE KKASPSHSDS IHHSSHSAVL SSKPSSTSAS 1630 1640 1650 1660 1670 1680 QGAKAESNSN PISLPTPQNT PKEANQAHSG ASTVPPASTA TLLSNDLEAD SSYYLNSAQP 1690 1700 1710 1720 1730 1740 HSPPRGTIEL GRILEPGYLG SSGKWDVMRP QKGSVSGDLS SGSSVYQLNS KPTGADLLEE 1750 1760 1770 1780 1790 1800 HLGEIRNLRQ RLEESICIND RLREQLEHRL TSTARGRGST SNFYSQGLES IPQLCNENRV 1810 1820 1830 1840 1850 1860 LREDNRRLQA QLSHVSREHS QETESLREAL LSSRSHLQEL EKELEHQKVE RQQLLEDLRE 1870 1880 1890 1900 1910 1920 KQQEVLHFRE ERLSLQENDS RLQHKLVLLQ QQCEEKQQLF ESLQSELQIY EALYGNSKKG 1930 1940 1950 1960 1970 1980 LKAYSLDACH QIPLSSDLSH LVAEVRALRG QLEQSIQGNN CLRLQLQQQL ESGAGKASLS 1990 2000 2010 2020 2030 2040 PSSINQNFPA STDPGNKQLL LQDSAVSPPV RDVGMNSPAL VFPSSASSTP GSETPIINRA 2050 2060 2070 2080 2090 2100 NGLGLDTSPV MKTPPKLEGD ATDGSFANKH GRHVIGHIDD YSALRQQIAE GKLLVKKIVS 2110 2120 2130 2140 2150 2160 LVRSACSFPG LEAQGTEVLG SKGIHELRSS TSALHHALEE SASLLTMFWR AALPSTHIPV 2170 2180 2190 2200 2210 2220 LPGKVGESTE RELLELRTKV SKQERLLQST TEHLKNANQQ KESMEQFIVS QLTRTHDVLK 2230 2240 KARTNLEVKS LRALPCTPAL
	Isoform 4 [UniParc]. Checksum: C6BD7842F5469163	FASTA	2,362	267,177
	10 20 30 40 50 60 MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE LKVEVESLKR 70 80 90 100 110 120 ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH VYELLENKIQ LLQEESRLAK 130 140 150 160 170 180 NEAARMAALV EAEKECNLEL SEKLKGVTKN WEDVPGDQVK PDQYTEALAQ RDKRIEELNQ 190 200 210 220 230 240 SLAAQERLVE QLSREKQQLL HLLEEPTSME VQPMTEELLK QQKLNSHETT ITQQSVSDSH 250 260 270 280 290 300 LAELQEKIQQ TEATNKILQE KLNEMSYELK CAQESSQKQD GTIQNLKETL KSRERETEEL 310 320 330 340 350 360 YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GTSPAQQQVA LLDLQSALFC SQLEIQKLQR 370 380 390 400 410 420 VVRQKERQLA DAKQCVQFVE AAAHESEQQK EASWKHNQEL RKALQQLQEE LQNKSQQLRA 430 440 450 460 470 480 WEAEKYNEIR TQEQNIQHLN HSLSHKEQLL QEFRELLQYR DNSDKTLEAN EMLLEKLRQR 490 500 510 520 530 540 IHDKAVALER AIDEKFSALE EKEKELRQLR LAVRERDHDL ERLRDVLSSN EATMQSMESL 550 560 570 580 590 600 LRAKGLEVEQ LSTTCQNLQW LKEEMETKFS RWQKEQESII QQLQTSLHDR NKEVEDLSAT 610 620 630 640 650 660 LLCKLGPGQS EIAEELCQRL QRKERMLQDL LSDRNKQVLE HEMEIQGLLQ SVSTREQESQ 670 680 690 700 710 720 AAAEKLVQAL MERNSELQAL RQYLGGRDSL MSQAPISNQQ AEVTPTGCLG KQTDQGSMQI 730 740 750 760 770 780 PSRDDSTSLT AKEDVSIPRS TLGDLDTVAG LEKELSNAKE ELELMAKKER ESQMELSALQ 790 800 810 820 830 840 SMMAVQEEEL QVQAADMESL TRNIQIKEDL IKDLQMQLVD PEDIPAMERL TQEVLLLREK 850 860 870 880 890 900 VASVESQGQE ISGNRRQQLL LMLEGLVDER SRLNEALQAE RQLYSSLVKF HAHPESSERD 910 920 930 940 950 960 RTLQVELEGA QVLRSRLEEV LGRSLERLNR LETLAAIGGA AAGDDTEDTS TEFTDSIEEE 970 980 990 1000 1010 1020 AAHHSHQQLV KVALEKSLAT VETQNPSFSP PSPMGGDSNR CLQEEMLHLR AEFHQHLEEK 1030 1040 1050 1060 1070 1080 RKAEEELKEL KAQIEEAGFS SVSHIRNTML SLCLENAELK EQMGEAMSDG WEIEEDKEKG 1090 1100 1110 1120 1130 1140 EVMVETVVTK EGLSESSLQA EFRKLQGKLK NAHNIINLLK EQLVLSSKEG NSKLTPELLV 1150 1160 1170 1180 1190 1200 HLTSTIERIN TELVGSPGKH QHQEEGNVTV RPFPRPQSLD LGATFTVDAH QLDNQSQPRD 1210 1220 1230 1240 1250 1260 PGPQSAFSLP GSTQHLRSQL SQCKQRYQDL QEKLLLSEAT VFAQANELEK YRVMLTGESL 1270 1280 1290 1300 1310 1320 VKQDSKQIQV DLQDLGYETC GRSENEAERE ETTSPECEEH NSLKEMVLME GLCSEQGRRG 1330 1340 1350 1360 1370 1380 STLASSSERK PLENQLGKQE EFRVYGKSEN ILVLRKDIKD LKAQLQNANK VIQNLKSRVR 1390 1400 1410 1420 1430 1440 SLSVTSDYSS SLERPWKLRA VGTLEGSSPH SVPDEDEGWL SDGTGAFYSP GLQAKKDLES 1450 1460 1470 1480 1490 1500 LIQRVSQLEA QLPKNGLEEK LAEELRSASW PGKYDSLIQD QARELSYLRQ KIREGRGICY 1510 1520 1530 1540 1550 1560 LITRHAKDTV KSFEDLLRSN DIDYYLGQSF REQLAQGSQL TERLTSKLST KDHKSEKDQA 1570 1580 1590 1600 1610 1620 GLEPLALRLS RELQEKEKVI EVLQAKLDAR SLTPSSSHAL SDSHRSPSST SFLSDELEAC 1630 1640 1650 1660 1670 1680 SDMDIVSEYT HYEEKKASPS HSDSIHHSSH SAVLSSKPSS TSASQGAKAE SNSNPISLPT 1690 1700 1710 1720 1730 1740 PQNTPKEANQ AHSGFHFHSI PKLASLPQAP LPSAPSSFLP FSPTGPLLLG CCETPVVSLA 1750 1760 1770 1780 1790 1800 EAQQELQMLQ KQLGESASTV PPASTATLLS NDLEADSSYY LNSAQPHSPP RGTIELGRIL 1810 1820 1830 1840 1850 1860 EPGYLGSSGK WDVMRPQKGS VSGDLSSGSS VYQLNSKPTG ADLLEEHLGE IRNLRQRLEE 1870 1880 1890 1900 1910 1920 SICINDRLRE QLEHRLTSTA RGRGSTSNFY SQGLESIPQL CNENRVLRED NRRLQAQLSH 1930 1940 1950 1960 1970 1980 VSREHSQETE SLREALLSSR SHLQELEKEL EHQKVERQQL LEDLREKQQE VLHFREERLS 1990 2000 2010 2020 2030 2040 LQENDSRLQH KLVLLQQQCE EKQQLFESLQ SELQIYEALY GNSKKGLKAY SLDACHQIPL 2050 2060 2070 2080 2090 2100 SSDLSHLVAE VRALRGQLEQ SIQGNNCLRL QLQQQLESGA GKASLSPSSI NQNFPASTDP 2110 2120 2130 2140 2150 2160 GNKQLLLQDS AVSPPVRDVG MNSPALVFPS SASSTPGSET PIINRANGLG LDTSPVMKTP 2170 2180 2190 2200 2210 2220 PKLEGDATDG SFANKHGRHV IGHIDDYSAL RQQIAEGKLL VKKIVSLVRS ACSFPGLEAQ 2230 2240 2250 2260 2270 2280 GTEVLGSKGI HELRSSTSAL HHALEESASL LTMFWRAALP STHIPVLPGK VGESTERELL 2290 2300 2310 2320 2330 2340 ELRTKVSKQE RLLQSTTEHL KNANQQKESM EQFIVSQLTR THDVLKKART NLEEPCKKRS 2350 2360 HQKSLKQQER WACPPFVQLP IC
	Isoform 6 [UniParc]. Checksum: FCF313B1FF5F570A	FASTA	969	112,232
	10 20 30 40 50 60 MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE LKVEVESLKR 70 80 90 100 110 120 ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH VYELLENKIQ LLQEESRLAK 130 140 150 160 170 180 NEAARMAALV EAEKECNLEL SEKLKGVTKN WEDVPGDQVK PDQYTEALAQ RDKRIEELNQ 190 200 210 220 230 240 SLAAQERLVE QLSREKQQLL HLLEEPTSME VQPMTEELLK QQKLNSHETT ITQQSVSDSH 250 260 270 280 290 300 LAELQEKIQQ TEATNKILQE KLNEMSYELK CAQESSQKQD GTIQNLKETL KSRERETEEL 310 320 330 340 350 360 YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GTSPAQQQVA LLDLQSALFC SQLEIQKLQR 370 380 390 400 410 420 VVRQKERQLA DAKQCVQFVE AAAHESEQQK EASWKHNQEL RKALQQLQEE LQNKSQQLRA 430 440 450 460 470 480 WEAEKYNEIR TQEQNIQHLN HSLSHKEQLL QEFRELLQYR DNSDKTLEAN EMLLEKLRQR 490 500 510 520 530 540 IHDKAVALER AIDEKFSALE EKEKELRQLR LAVRERDHDL ERLRDVLSSN EATMQSMESL 550 560 570 580 590 600 LRAKGLEVEQ LSTTCQNLQW LKEEMETKFS RWQKEQESII QQLQTSLHDR NKEVEDLSAT 610 620 630 640 650 660 LLCKLGPGQS EIAEELCQRL QRKERMLQDL LSDRNKQVLE HEMEIQGLLQ SVSTREQESQ 670 680 690 700 710 720 AAAEKLVQAL MERNSELQAL RQYLGGRDSL MSQAPISNQQ AEVTPTGCLG KQTDQGSMQI 730 740 750 760 770 780 PSRDDSTSLT AKEDVSIPRS TLGDLDTVAG LEKELSNAKE ELELMAKKER ESQMELSALQ 790 800 810 820 830 840 SMMAVQEEEL QVQAADMESL TRNIQIKEDL IKDLQMQLVD PEDIPAMERL TQEVLLLREK 850 860 870 880 890 900 VASVESQGQE ISGNRRQQLL LMLEGLVDER SRLNEALQAE RQLYSSLVKF HAHPESSERD 910 920 930 940 950 960 RTLQVELEGA QVLRSRLEEV LGRSLERLNR LETLAAIGGA AAGDDTEDTS TEFTDSIEEE AAHHSHQQL
	Isoform 7 [UniParc]. Checksum: 57F22472B4FCC6E8	FASTA	988	114,154
	10 20 30 40 50 60 MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE LKVEVESLKR 70 80 90 100 110 120 ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH VYELLENKIQ LLQEESRLAK 130 140 150 160 170 180 NEAARMAALV EAEKECNLEL SEKLKGVTKN WEDVPGDQVK PDQYTEALAQ RDKRIEELNQ 190 200 210 220 230 240 SLAAQERLVE QLSREKQQLL HLLEEPTSME VQPMTEELLK QQKLNSHETT ITQQSVSDSH 250 260 270 280 290 300 LAELQEKIQQ TEATNKILQE KLNEMSYELK CAQESSQKQD GTIQNLKETL KSRERETEEL 310 320 330 340 350 360 YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GTSPAQQQVA LLDLQSALFC SQLEIQKLQR 370 380 390 400 410 420 VVRQKERQLA DAKQCVQFVE AAAHESEQQK EASWKHNQEL RKALQQLQEE LQNKSQQLRA 430 440 450 460 470 480 WEAEKYNEIR TQEQNIQHLN HSLSHKEQLL QEFRELLQYR DNSDKTLEAN EMLLEKLRQR 490 500 510 520 530 540 IHDKAVALER AIDEKFSALE EKEKELRQLR LAVRERDHDL ERLRDVLSSN EATMQSMESL 550 560 570 580 590 600 LRAKGLEVEQ LSTTCQNLQW LKEEMETKFS RWQKEQESII QQLQTSLHDR NKEVEDLSAT 610 620 630 640 650 660 LLCKLGPGQS EIAEELCQRL QRKERMLQDL LSDRNKQVLE HEMEIQGLLQ SVSTREQESQ 670 680 690 700 710 720 AAAEKLVQAL MERNSELQAL RQYLGGRDSL MSQAPISNQQ AEVTPTGCLG KQTDQGSMQI 730 740 750 760 770 780 PSRDDSTSLT AKEDVSIPRS TLGDLDTVAG LEKELSNAKE ELELMAKKER ESQMELSALQ 790 800 810 820 830 840 SMMAVQEEEL QVQAADMESL TRNIQIKEDL IKDLQMQLVD PEDIPAMERL TQEVLLLREK 850 860 870 880 890 900 VASVESQGQE ISGNRRQQLL LMLEGLVDER SRLNEALQAE RQLYSSLVKF HAHPESSERD 910 920 930 940 950 960 RTLQVELEGA QVLRSRLEEV LGRSLERLNR LETLAAIGGA AAGDDTEDTS TEFTDSIEEE 970 980 AAHHSHQQVS QCQGLGLPGW TAHSPSEV
	Isoform 8 [UniParc]. Checksum: 0E2AF02001FE1AD7	FASTA	310	36,121
	10 20 30 40 50 60 MKGTDSGSCC RRRCDFGCCC RASRRAHYTP YRSGDATRTP QSPRQTPSRE RRRPEPAGSW 70 80 90 100 110 120 AAAAEEEEAA AAATPWMRDY FAEDDGEMVP RTSHTAAFLS DTKDRGPPVQ SQIWRSGEKV 130 140 150 160 170 180 PFVQTYSLRA FEKPPQVQTQ ALRDFEKHLN DLKKENFSLK LRIYFLEERM QQKYEASRED 190 200 210 220 230 240 IYKRNIELKV EVESLKRELQ DKKQHLDKTW ADVENLNSQN EAELRRQFEE RQQETEHVYE 250 260 270 280 290 300 LLENKIQLLQ EESRLAKNEA ARMAALVEAE KECNLELSEK LKGVTKNWED VPGDQVKPDQ 310 YTEALAQRDK
	Isoform 9 [UniParc]. Checksum: CB2E2AF02001FE1A	FASTA	311	36,234
	10 20 30 40 50 60 MKGTDSGSCC RRRCDFGCCC RASRRAHYTP YRSGDATRTP QSPRQTPSRE RRRPEPAGSW 70 80 90 100 110 120 AAAAEEEEAA AAATPWMRDY FAEDDGEMVP RTSHTAAFLS DTKDRGPPVQ SQIWRSGEKV 130 140 150 160 170 180 PFVQTYSLRA FEKPPQVQTQ ALRDFEKHLN DLKKENFSLK LRIYFLEERM QQKYEASRED 190 200 210 220 230 240 IYKRNIELKV EVESLKRELQ DKKQHLDKTW ADVENLNSQN EAELRRQFEE RQQETEHVYE 250 260 270 280 290 300 LLENKIQLLQ EESRLAKNEA ARMAALVEAE KECNLELSEK LKGVTKNWED VPGDQVKPDQ 310 YTEALAQRDK I
	Isoform 10 [UniParc]. Checksum: 1A5F8C9A64D2F3F7	FASTA	174	20,798
	10 20 30 40 50 60 MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE LKVEVESLKR 70 80 90 100 110 120 ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH VYELLENKIQ LLQEESRLAK 130 140 150 160 170 NEAARMAALV EAEKECNLEL SEKLKGVTKN WEDVPGDQVK PDQYTEALAQ RDKI
	Isoform 11 [UniParc]. Checksum: EF8C9A64D2F3F758	FASTA	173	20,685
	10 20 30 40 50 60 MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEAS REDIYKRNIE LKVEVESLKR 70 80 90 100 110 120 ELQDKKQHLD KTWADVENLN SQNEAELRRQ FEERQQETEH VYELLENKIQ LLQEESRLAK 130 140 150 160 170 NEAARMAALV EAEKECNLEL SEKLKGVTKN WEDVPGDQVK PDQYTEALAQ RDK
	Isoform 12 [UniParc]. Checksum: F145659765664C06	FASTA	240	28,507
	10 20 30 40 50 60 MEQTWTRDYF AEDDGEMVPR TSHTAAFLSD TKDRGPPVQS QIWRSGEKVP FVQTYSLRAF 70 80 90 100 110 120 EKPPQVQTQA LRDFEKHLND LKKENFSLKL RIYFLEERMQ QKYEASREDI YKRNIELKVE 130 140 150 160 170 180 VESLKRELQD KKQHLDKTWA DVENLNSQNE AELRRQFEER QQETEHVYEL LENKIQLLQE 190 200 210 220 230 240 ESRLAKNEAA RMAALVEAEK ECNLELSEKL KGVTKNWEDV PGDQVKPDQY TEALAQRDKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of novel heart-specific genes using the BodyMap database." Soejima H., Kawamoto S., Akai J., Miyoshi O., Arai Y., Morohka T., Matsuo S., Niikawa N., Kimura A., Okubo K., Mukai T. Genomics 74:115-120(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10; 11 AND 12), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT THR-49. Tissue: Myocardium.
[2]	"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-708. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 6 AND 7), VARIANTS ARG-708; ILE-1013; THR-1066; GLU-1359; GLU-1736 AND SER-1742. Tissue: Amygdala and Skeletal muscle.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 8 AND 9), VARIANTS THR-49 AND ARG-708. Tissue: Brain and Placenta.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2261-2346 (ISOFORM 4). Tissue: Skeletal muscle.
[8]	"Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib." Wilkinson K., Velloso E.R.P., Lopes L.F., Lee C., Aster J.C., Shipp M.A., Aguiar R.C.T. Blood 102:4187-4190(2003) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PDGFRB.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-704, VARIANT [LARGE SCALE ANALYSIS] ARG-708, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB042555 mRNA. Translation: BAB17759.1. AB042556 mRNA. Translation: BAB17760.1. AB042557 mRNA. Translation: BAB17761.1. AB042558 mRNA. Translation: BAB17762.1. AB007923 mRNA. Translation: BAA32299.2. Different initiation. AB007946 mRNA. Translation: BAA32322.2. Different initiation. AL831815 mRNA. Translation: CAD38529.1. AL832024 mRNA. Translation: CAD89923.1. AL833273 mRNA. Translation: CAD91152.1. Frameshift. CR749273 mRNA. Translation: CAH18128.1. Sequence problems. AL590452, AL138791 Genomic DNA. Translation: CAH72521.1. AL590452, AL138796 Genomic DNA. Translation: CAH72522.1. AL590452, AL138796 Genomic DNA. Translation: CAH72523.1. AL590452, AL138796 Genomic DNA. Translation: CAH72524.1. AL590452 Genomic DNA. Translation: CAH72525.1. AL590452, AL138796 Genomic DNA. Translation: CAH72526.1. AL590452, AL138796 Genomic DNA. Translation: CAH72527.1. AL590452, AL138796 Genomic DNA. Translation: CAH72528.1. AL138791, AL590452 Genomic DNA. Translation: CAI22527.1. AL138796, AL590452 Genomic DNA. Translation: CAI22822.1. AL138796, AL590452 Genomic DNA. Translation: CAI22823.1. AL138796, AL590452 Genomic DNA. Translation: CAI22824.1. AL138796, AL590452 Genomic DNA. Translation: CAI22825.1. AL138796, AL590452 Genomic DNA. Translation: CAI22826.1. AL138796, AL590452 Genomic DNA. Translation: CAI22827.1. BC004860 mRNA. Translation: AAH04860.1. Sequence problems. BC025406 mRNA. Translation: AAH25406.1. BC078660 mRNA. Translation: AAH78660.1. BC110294 mRNA. Translation: AAI10295.1. BC132717 mRNA. Translation: AAI32718.1. BC152439 mRNA. Translation: AAI52440.1. DA900724 mRNA. No translation available.
IPI	IPI00337544. IPI00401276. IPI00456484. IPI00470939. IPI00479644. IPI00642902. IPI00643207. IPI00868730. IPI00869114. IPI00869124. IPI00869196. IPI00977575.
PIR	T00069. T00259.
RefSeq	NP_001002810.1. NM_001002810.3. NP_001002811.1. NM_001002811.1. NP_001002812.1. NM_001002812.1. NP_001182189.1. NM_001195260.1. NP_001182190.1. NM_001195261.1. NP_001185761.1. NM_001198832.1. NP_001185763.2. NM_001198834.2. NP_055459.4. NM_014644.4. NP_071754.3. NM_022359.5. XP_003846569.1. XM_003846521.1. XP_003960115.1. XM_003960066.1. XP_003960293.1. XM_003960244.1. XP_003960303.1. XM_003960254.1. XP_003960307.1. XM_003960258.1.
UniGene	Hs.584841. Hs.613082. Hs.657490. Hs.708687.
3D structure databases
HSSP	HSSP built from PDB template 1Y7Q based on UniProtKB Q15697.
ProteinModelPortal	Q5VU43.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-51263N.
IntAct	Q5VU43. 19 interactions.
MINT	MINT-1183984.
Polymorphism databases
DMDM	74747041.
Proteomic databases
PaxDb	Q5VU43.
PRIDE	Q5VU43.
Protocols and materials databases
DNASU	9659.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313382; ENSP00000327209; ENSG00000178104. ENST00000313431; ENSP00000316434; ENSG00000178104. ENST00000369347; ENSP00000358353; ENSG00000178104. ENST00000369348; ENSP00000358354; ENSG00000178104. ENST00000369349; ENSP00000358355; ENSG00000178104. ENST00000369351; ENSP00000358357; ENSG00000178104. ENST00000369354; ENSP00000358360; ENSG00000178104. ENST00000369356; ENSP00000358363; ENSG00000178104.
GeneID	100996761. 101060291. 101060353. 9659.
KEGG	hsa:100996761. hsa:101060291. hsa:101060353. hsa:9659.
UCSC	uc001elk.2. human. uc001eln.4. human. uc001elo.3. human. uc001elv.4. human. uc001elx.4. human. uc001emb.1. human. uc001emc.2. human. uc001emd.2. human. uc021ouh.1. human.
Organism-specific databases
CTD	9659.
GeneCards	GC01M144836.
H-InvDB	HIX0178151.
HGNC	HGNC:15580. PDE4DIP.
HPA	HPA008162. HPA012678.
MIM	608117. gene.
neXtProt	NX_Q5VU43.
PharmGKB	PA33131.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46262.
HOVERGEN	HBG108166.
KO	K16549.
OMA	MYRRNNE.
Gene expression databases
ArrayExpress	Q5VU43.
Bgee	Q5VU43.
Genevestigator	Q5VU43.
Family and domain databases
InterPro	IPR010630. NBPF_dom. IPR012943. Spindle_assoc. [Graphical view]
Pfam	PF06758. DUF1220. 1 hit. PF07989. Microtub_assoc. 1 hit. [Graphical view]
PROSITE	PS51316. NBPF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	36269.
SOURCE	Search...

Entry information

Entry name

MYOME_HUMAN

Accession

Primary (citable) accession number: Q5VU43
Secondary accession number(s): A2RU15 , O75042, O75065, Q2YDC1, Q5VU42, Q5VU44, Q5VU45, Q5VU46, Q5VU47, Q5VU48, Q5VU49, Q68DU2, Q6AZ93, Q6PK88, Q86T40, Q86TB2, Q8N3W0, Q8TAY9, Q9HCP2, Q9HCP3, Q9HCP4, Q9HCP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.