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Protein

V-set and immunoglobulin domain-containing protein 8

Gene

VSIG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 8
Gene namesi
Name:VSIG8
Synonyms:C1orf204
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27647. C1orf204.
HGNC:32063. VSIG8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 263242ExtracellularSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Topological domaini285 – 414130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670610.

Polymorphism and mutation databases

BioMutaiVSIG8.
DMDMi74756821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 414393V-set and immunoglobulin domain-containing protein 8PRO_0000313627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 126PROSITE-ProRule annotation
Disulfide bondi167 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ5VU13.
PaxDbiQ5VU13.
PeptideAtlasiQ5VU13.
PRIDEiQ5VU13.

PTM databases

PhosphoSiteiQ5VU13.
SwissPalmiQ5VU13.

Expressioni

Gene expression databases

BgeeiQ5VU13.
CleanExiHS_VSIG8.
GenevisibleiQ5VU13. HS.

Organism-specific databases

HPAiHPA023219.
HPA045602.

Interactioni

Protein-protein interaction databases

BioGridi133813. 44 interactions.
IntActiQ5VU13. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5VU13.
SMRiQ5VU13. Positions 35-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 141120Ig-like V-type 1Add
BLAST
Domaini146 – 257112Ig-like V-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi288 – 2914Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEBR. Eukaryota.
ENOG410YIEY. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG094885.
InParanoidiQ5VU13.
OMAiCFANGGS.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ5VU13.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5VU13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVGGAFHLL LVCLSPALLS AVRINGDGQE VLYLAEGDNV RLGCPYVLDP
60 70 80 90 100
EDYGPNGLDI EWMQVNSDPA HHRENVFLSY QDKRINHGSL PHLQQRVRFA
110 120 130 140 150
ASDPSQYDAS INLMNLQVSD TATYECRVKK TTMATRKVIV TVQARPAVPM
160 170 180 190 200
CWTEGHMTYG NDVVLKCYAS GGSQPLSYKW AKISGHHYPY RAGSYTSQHS
210 220 230 240 250
YHSELSYQES FHSSINQGLN NGDLVLKDIS RADDGLYQCT VANNVGYSVC
260 270 280 290 300
VVEVKVSDSR RIGVIIGIVL GSLLALGCLA VGIWGLVCCC CGGSGAGGAR
310 320 330 340 350
GAFGYGNGGG VGGGACGDLA SEIREDAVAP GCKASGRGSR VTHLLGYPTQ
360 370 380 390 400
NVSRSLRRKY APPPCGGPED VALAPCTAAA ACEAGPSPVY VKVKSAEPAD
410
CAEGPVQCKN GLLV
Length:414
Mass (Da):43,891
Last modified:December 7, 2004 - v1
Checksum:i47BCD06CDF6AAF7B
GO
Isoform 2 (identifier: Q5VU13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-303: Missing.
     304-324: GYGNGGGVGGGACGDLASEIR → MGMLAPGPLQGRRPRKGHKGQ
     414-414: V → VSSPHCEEPC...SHLTTSILEQ

Note: No experimental confirmation available.
Show »
Length:235
Mass (Da):25,086
Checksum:i8969191880CFD7BC
GO

Sequence cautioni

The sequence AK096506 differs from that shown. Reason: Erroneous termination at position 409. Translated as Lys.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 303303Missing in isoform 2. 1 PublicationVSP_030068Add
BLAST
Alternative sequencei304 – 32421GYGNG…ASEIR → MGMLAPGPLQGRRPRKGHKG Q in isoform 2. 1 PublicationVSP_030069Add
BLAST
Alternative sequencei414 – 4141V → VSSPHCEEPCAHSCAHPGLP PHLVHKLPLSYLQTQDTDAA SRRINAPLAAGWSWLRLWLV TLASGVDFPQVSAWMRALPS PDCPGLRTTGEQMQKLLLKE NKVKTRKSKRRSGEGSHLTT SILEQ in isoform 2. 1 PublicationVSP_030070

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096506 mRNA. No translation available.
AL590560 Genomic DNA. Translation: CAH71105.1.
AL590560 Genomic DNA. Translation: CAH71106.1.
BC132893 mRNA. Translation: AAI32894.1.
BC132895 mRNA. Translation: AAI32896.1.
CCDSiCCDS30913.1. [Q5VU13-1]
RefSeqiNP_001013683.1. NM_001013661.1. [Q5VU13-1]
NP_001127705.1. NM_001134233.1. [Q5VU13-2]
UniGeneiHs.647718.

Genome annotation databases

EnsembliENST00000368100; ENSP00000357080; ENSG00000243284. [Q5VU13-1]
ENST00000368102; ENSP00000357082; ENSG00000188004. [Q5VU13-2]
ENST00000621242; ENSP00000480481; ENSG00000188004. [Q5VU13-2]
GeneIDi284677.
391123.
KEGGihsa:284677.
hsa:391123.
UCSCiuc001fug.1. human. [Q5VU13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096506 mRNA. No translation available.
AL590560 Genomic DNA. Translation: CAH71105.1.
AL590560 Genomic DNA. Translation: CAH71106.1.
BC132893 mRNA. Translation: AAI32894.1.
BC132895 mRNA. Translation: AAI32896.1.
CCDSiCCDS30913.1. [Q5VU13-1]
RefSeqiNP_001013683.1. NM_001013661.1. [Q5VU13-1]
NP_001127705.1. NM_001134233.1. [Q5VU13-2]
UniGeneiHs.647718.

3D structure databases

ProteinModelPortaliQ5VU13.
SMRiQ5VU13. Positions 35-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133813. 44 interactions.
IntActiQ5VU13. 2 interactions.

PTM databases

PhosphoSiteiQ5VU13.
SwissPalmiQ5VU13.

Polymorphism and mutation databases

BioMutaiVSIG8.
DMDMi74756821.

Proteomic databases

MaxQBiQ5VU13.
PaxDbiQ5VU13.
PeptideAtlasiQ5VU13.
PRIDEiQ5VU13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368100; ENSP00000357080; ENSG00000243284. [Q5VU13-1]
ENST00000368102; ENSP00000357082; ENSG00000188004. [Q5VU13-2]
ENST00000621242; ENSP00000480481; ENSG00000188004. [Q5VU13-2]
GeneIDi284677.
391123.
KEGGihsa:284677.
hsa:391123.
UCSCiuc001fug.1. human. [Q5VU13-1]

Organism-specific databases

CTDi284677.
391123.
GeneCardsiC1orf204.
VSIG8.
HGNCiHGNC:27647. C1orf204.
HGNC:32063. VSIG8.
HPAiHPA023219.
HPA045602.
neXtProtiNX_Q5VU13.
PharmGKBiPA142670610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEBR. Eukaryota.
ENOG410YIEY. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG094885.
InParanoidiQ5VU13.
OMAiCFANGGS.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ5VU13.
TreeFamiTF330875.

Miscellaneous databases

NextBioi95047.
PROiQ5VU13.

Gene expression databases

BgeeiQ5VU13.
CleanExiHS_VSIG8.
GenevisibleiQ5VU13. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiVSIG8_HUMAN
AccessioniPrimary (citable) accession number: Q5VU13
Secondary accession number(s): Q5VU14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.