Q5VTY9 (HHAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-cysteine N-palmitoyltransferase HHAT
EC=2.3.1.-

Alternative name(s):
Hedgehog acyltransferase
Melanoma antigen recognized by T-cells 2
Short name=MART-2
Skinny hedgehog protein 1

Gene names

Name:	HHAT
Synonyms:	MART2, SKI1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling By similarity. May bind GTP.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Ubiquitously expressed in normal tissues and cancer cell lines. Ref.1
Sequence similarities	Belongs to the membrane-bound acyltransferase family. HHAT subfamily.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Acyltransferase Developmental protein Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5VTY9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5VTY9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     91-155: Missing.
     465-493: WPWVTLSVLGFLYCYSHVGIAWAQTYATD → GLFLFFLLNP...IENTSELSSY

Isoform 3 (identifier: Q5VTY9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     465-493: WPWVTLSVLGFLYCYSHVGIAWAQTYATD → GLFLFFLLNP...IENTSELSSY

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5VTY9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.
     416-451: ARYFSPQARRRFHAALASCSTSMLILSNLVFLGGNE → VSRILAPVLGDSGTRQIRFIRDGAIRFPAPTMGPFY
     452-493: Missing.

Isoform 5 (identifier: Q5VTY9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     91-155: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q5VTY9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     92-228: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q5VTY9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MLPRWELALYLLASLGFHFYSFYEVYKVSR → MSLGLGSAERGVLGTRGARERCRRRRPGQPG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Protein-cysteine N-palmitoyltransferase HHAT		PRO_0000213134
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Transmembrane	95 – 115	21	Helical; Potential
	Transmembrane	133 – 152	20	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential
	Transmembrane	290 – 310	21	Helical; Potential
	Transmembrane	360 – 380	21	Helical; Potential
	Transmembrane	429 – 449	21	Helical; Potential
	Transmembrane	467 – 487	21	Helical; Potential
	Region	448 – 455	8	GTP-binding Probable
Sites
	Active site	379	1	Potential
Natural variations
	Alternative sequence	1 – 369	369	Missing in isoform 4.		VSP_016685
	Alternative sequence	1 – 30	30	MLPRW…YKVSR → MSLGLGSAERGVLGTRGARE RCRRRRPGQPG in isoform 7.		VSP_044968
	Alternative sequence	91 – 155	65	Missing in isoform 2 and isoform 5.		VSP_016686
	Alternative sequence	92 – 228	137	Missing in isoform 6.		VSP_043481
	Alternative sequence	416 – 451	36	ARYFS…LGGNE → VSRILAPVLGDSGTRQIRFI RDGAIRFPAPTMGPFY in isoform 4.		VSP_016687
	Alternative sequence	452 – 493	42	Missing in isoform 4.		VSP_016688
	Alternative sequence	465 – 493	29	WPWVT…TYATD → GLFLFFLLNPCWETAFQGFP VFLHFLQTEVLATFVPNYFS WNICIENTSELSSY in isoform 2 and isoform 3.		VSP_016689
	Natural variant	165	1	E → G. Corresponds to variant rs2228898 [ dbSNP | Ensembl ].		VAR_050024
	Natural variant	182	1	S → N. Ref.6 Corresponds to variant rs2294851 [ dbSNP | Ensembl ].		VAR_024743
	Natural variant	188	1	C → R. Ref.2 Corresponds to variant rs34228541 [ dbSNP | Ensembl ].		VAR_061336
	Natural variant	448	1	G → E in a melanoma cell line; abolishes GTP-binding. Ref.1		VAR_024744
	Natural variant	450	1	N → S in a lung cancer cell line. Ref.1		VAR_024745
Experimental info
	Sequence conflict	2	1	L → P in BAA91772. Ref.2
	Sequence conflict	204	1	M → V in BAH14561. Ref.2
	Sequence conflict	450	1	N → D in BAA91772. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 5E962E2A61F2DE15	FASTA	493	57,313
	10 20 30 40 50 60 MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 70 80 90 100 110 120 SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KHRPWILMLY GMWACWCVLG TPGVAMVLLH 130 140 150 160 170 180 TTISFCVAQF RSQLLTWLCS LLLLSTLRLQ GVEEVKRRWY KTENEYYLLQ FTLTVRCLYY 190 200 210 220 230 240 TSFSLELCWQ QLPAASTSYS FPWMLAYVFY YPVLHNGPIL SFSEFIKQMQ QQEHDSLKAS 250 260 270 280 290 300 LCVLALGLGR LLCWWWLAEL MAHLMYMHAI YSSIPLLETV SCWTLGGLAL AQVLFFYVKY 310 320 330 340 350 360 LVLFGVPALL MRLDGLTPPA LPRCVSTMFS FTGMWRYFDV GLHNFLIRYV YIPVGGSQHG 370 380 390 400 410 420 LLGTLFSTAM TFAFVSYWHG GYDYLWCWAA LNWLGVTVEN GVRRLVETPC IQDSLARYFS 430 440 450 460 470 480 PQARRRFHAA LASCSTSMLI LSNLVFLGGN EVGKTYWNRI FIQGWPWVTL SVLGFLYCYS 490 HVGIAWAQTY ATD
	Isoform 2 [UniParc]. Checksum: 83441A7D3EAE5A84	FASTA	453	52,891
	10 20 30 40 50 60 MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 70 80 90 100 110 120 SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KRRWYKTENE YYLLQFTLTV RCLYYTSFSL 130 140 150 160 170 180 ELCWQQLPAA STSYSFPWML AYVFYYPVLH NGPILSFSEF IKQMQQQEHD SLKASLCVLA 190 200 210 220 230 240 LGLGRLLCWW WLAELMAHLM YMHAIYSSIP LLETVSCWTL GGLALAQVLF FYVKYLVLFG 250 260 270 280 290 300 VPALLMRLDG LTPPALPRCV STMFSFTGMW RYFDVGLHNF LIRYVYIPVG GSQHGLLGTL 310 320 330 340 350 360 FSTAMTFAFV SYWHGGYDYL WCWAALNWLG VTVENGVRRL VETPCIQDSL ARYFSPQARR 370 380 390 400 410 420 RFHAALASCS TSMLILSNLV FLGGNEVGKT YWNRIFIQGG LFLFFLLNPC WETAFQGFPV 430 440 450 FLHFLQTEVL ATFVPNYFSW NICIENTSEL SSY
	Isoform 3 [UniParc]. Checksum: 9FDB3E0136FB3AFE	FASTA	518	60,308
	10 20 30 40 50 60 MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 70 80 90 100 110 120 SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KHRPWILMLY GMWACWCVLG TPGVAMVLLH 130 140 150 160 170 180 TTISFCVAQF RSQLLTWLCS LLLLSTLRLQ GVEEVKRRWY KTENEYYLLQ FTLTVRCLYY 190 200 210 220 230 240 TSFSLELCWQ QLPAASTSYS FPWMLAYVFY YPVLHNGPIL SFSEFIKQMQ QQEHDSLKAS 250 260 270 280 290 300 LCVLALGLGR LLCWWWLAEL MAHLMYMHAI YSSIPLLETV SCWTLGGLAL AQVLFFYVKY 310 320 330 340 350 360 LVLFGVPALL MRLDGLTPPA LPRCVSTMFS FTGMWRYFDV GLHNFLIRYV YIPVGGSQHG 370 380 390 400 410 420 LLGTLFSTAM TFAFVSYWHG GYDYLWCWAA LNWLGVTVEN GVRRLVETPC IQDSLARYFS 430 440 450 460 470 480 PQARRRFHAA LASCSTSMLI LSNLVFLGGN EVGKTYWNRI FIQGGLFLFF LLNPCWETAF 490 500 510 QGFPVFLHFL QTEVLATFVP NYFSWNICIE NTSELSSY
	Isoform 4 [UniParc]. Checksum: E6DA1D13019D20A2	FASTA	82	9,328
	10 20 30 40 50 60 MTFAFVSYWH GGYDYLWCWA ALNWLGVTVE NGVRRLVETP CIQDSLVSRI LAPVLGDSGT 70 80 RQIRFIRDGA IRFPAPTMGP FY
	Isoform 5 [UniParc]. Checksum: 0EDD316948355C70	FASTA	428	49,896
	10 20 30 40 50 60 MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 70 80 90 100 110 120 SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KRRWYKTENE YYLLQFTLTV RCLYYTSFSL 130 140 150 160 170 180 ELCWQQLPAA STSYSFPWML AYVFYYPVLH NGPILSFSEF IKQMQQQEHD SLKASLCVLA 190 200 210 220 230 240 LGLGRLLCWW WLAELMAHLM YMHAIYSSIP LLETVSCWTL GGLALAQVLF FYVKYLVLFG 250 260 270 280 290 300 VPALLMRLDG LTPPALPRCV STMFSFTGMW RYFDVGLHNF LIRYVYIPVG GSQHGLLGTL 310 320 330 340 350 360 FSTAMTFAFV SYWHGGYDYL WCWAALNWLG VTVENGVRRL VETPCIQDSL ARYFSPQARR 370 380 390 400 410 420 RFHAALASCS TSMLILSNLV FLGGNEVGKT YWNRIFIQGW PWVTLSVLGF LYCYSHVGIA WAQTYATD
	Isoform 6 [UniParc]. Checksum: 7F78984C97B46E08	FASTA	356	41,100
	10 20 30 40 50 60 MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 70 80 90 100 110 120 SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KMQQQEHDSL KASLCVLALG LGRLLCWWWL 130 140 150 160 170 180 AELMAHLMYM HAIYSSIPLL ETVSCWTLGG LALAQVLFFY VKYLVLFGVP ALLMRLDGLT 190 200 210 220 230 240 PPALPRCVST MFSFTGMWRY FDVGLHNFLI RYVYIPVGGS QHGLLGTLFS TAMTFAFVSY 250 260 270 280 290 300 WHGGYDYLWC WAALNWLGVT VENGVRRLVE TPCIQDSLAR YFSPQARRRF HAALASCSTS 310 320 330 340 350 MLILSNLVFL GGNEVGKTYW NRIFIQGWPW VTLSVLGFLY CYSHVGIAWA QTYATD
	Isoform 7 [UniParc]. Checksum: 52FA7301CED685EF	FASTA	494	56,951
	10 20 30 40 50 60 MSLGLGSAER GVLGTRGARE RCRRRRPGQP GEHEEELDQE FELETDTLFG GLKKDATDFE 70 80 90 100 110 120 WSFWMEWGKQ WLVWLLLGHM VVSQMATLLA RKHRPWILML YGMWACWCVL GTPGVAMVLL 130 140 150 160 170 180 HTTISFCVAQ FRSQLLTWLC SLLLLSTLRL QGVEEVKRRW YKTENEYYLL QFTLTVRCLY 190 200 210 220 230 240 YTSFSLELCW QQLPAASTSY SFPWMLAYVF YYPVLHNGPI LSFSEFIKQM QQQEHDSLKA 250 260 270 280 290 300 SLCVLALGLG RLLCWWWLAE LMAHLMYMHA IYSSIPLLET VSCWTLGGLA LAQVLFFYVK 310 320 330 340 350 360 YLVLFGVPAL LMRLDGLTPP ALPRCVSTMF SFTGMWRYFD VGLHNFLIRY VYIPVGGSQH 370 380 390 400 410 420 GLLGTLFSTA MTFAFVSYWH GGYDYLWCWA ALNWLGVTVE NGVRRLVETP CIQDSLARYF 430 440 450 460 470 480 SPQARRRFHA ALASCSTSML ILSNLVFLGG NEVGKTYWNR IFIQGWPWVT LSVLGFLYCY 490 SHVGIAWAQT YATD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes." Kawakami Y., Wang X., Shofuda T., Sumimoto H., Tupesis J., Fitzgerald E., Rosenberg S. J. Immunol. 166:2871-2877(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, GTP-BINDING, CHARACTERIZATION OF VARIANT GLU-448, VARIANT SER-450. Tissue: Melanoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5; 6 AND 7), VARIANT ARG-188. Tissue: Brain, Lung, Teratocarcinoma, Testis and Trachea.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain cortex.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-182. Tissue: Brain and Testis.
[7]	Rhodes S. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-335 (ISOFORM 2).
[8]	"Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal." Chamoun Z., Mann R.K., Nellen D., von Kessler D.P., Bellotto M., Beachy P.A., Basler K. Science 293:2080-2084(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 328-390 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001586 mRNA. Translation: BAA91772.1. AK297193 mRNA. Translation: BAH12521.1. AK298991 mRNA. Translation: BAH12917.1. AK302955 mRNA. Translation: BAH13854.1. AK316190 mRNA. Translation: BAH14561.1. AK316524 mRNA. Translation: BAH14895.1. CR936628 mRNA. Translation: CAI56771.1. AL590653 , AC096636, AL034351, AL035414, AL691441 Genomic DNA. Translation: CAH70523.1. AL034351 Genomic DNA. Translation: CAI23103.1. AL034351 , AC096636, AL035414, AL590653, AL691441 Genomic DNA. Translation: CAI23104.1. AL035414 , AC096636, AL034351, AL590653, AL691441 Genomic DNA. Translation: CAI22284.1. AL691441 , AC096636, AL034351, AL035414, AL590653 Genomic DNA. Translation: CAI17039.1. BX255872 Genomic DNA. No translation available. CH471100 Genomic DNA. Translation: EAW93427.1. CH471100 Genomic DNA. Translation: EAW93428.1. CH471100 Genomic DNA. Translation: EAW93430.1. BC117130 mRNA. Translation: AAI17131.1. AL049848 mRNA. Translation: CAB42852.1.
IPI	IPI00018902. IPI00163890. IPI00657747. IPI00922056. IPI00923457.
RefSeq	NP_001116306.1. NM_001122834.2. NP_001164035.1. NM_001170564.1. NP_001164051.1. NM_001170580.1. NP_001164058.1. NM_001170587.1. NP_001164059.1. NM_001170588.1. NP_060664.2. NM_018194.4.
UniGene	Hs.58650.
3D structure databases
ProteinModelPortal	Q5VTY9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000261458.
PTM databases
PhosphoSite	Q5VTY9.
Polymorphism databases
DMDM	74747010.
Proteomic databases
PRIDE	Q5VTY9.
Protocols and materials databases
DNASU	55733.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261458; ENSP00000261458; ENSG00000054392. ENST00000367010; ENSP00000355977; ENSG00000054392. ENST00000391905; ENSP00000375773; ENSG00000054392. ENST00000413764; ENSP00000416845; ENSG00000054392. ENST00000426968; ENSP00000413399; ENSG00000054392. ENST00000537898; ENSP00000442625; ENSG00000054392. ENST00000541565; ENSP00000444995; ENSG00000054392. ENST00000545154; ENSP00000438468; ENSG00000054392.
GeneID	55733.
KEGG	hsa:55733.
UCSC	uc001hhz.4. human.
Organism-specific databases
CTD	55733.
GeneCards	GC01P210501.
HGNC	HGNC:18270. HHAT.
HPA	HPA016462.
MIM	605743. gene.
neXtProt	NX_Q5VTY9.
PharmGKB	PA134926499.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1696.
HOGENOM	HOG000015758.
HOVERGEN	HBG106485.
OMA	IQSNETY.
OrthoDB	EOG41C6W6.
PhylomeDB	Q5VTY9.
Enzyme and pathway databases
Pathway_Interaction_DB	hedgehog_2pathway. Signaling events mediated by the Hedgehog family.
Gene expression databases
ArrayExpress	Q5VTY9.
Bgee	Q5VTY9.
CleanEx	HS_HHAT.
Genevestigator	Q5VTY9.
GermOnline	ENSG00000054392. Homo sapiens.
Family and domain databases
InterPro	IPR004299. MBOAT_fam. [Graphical view]
Pfam	PF03062. MBOAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55733.
NextBio	35480853.
SOURCE	Search...

Entry information

Entry name

HHAT_HUMAN

Accession

Primary (citable) accession number: Q5VTY9
Secondary accession number(s): B7Z4D5 , B7Z5I1, B7Z868, B7ZA75, D3DT91, F5H444, Q17RZ7, Q4G0K3, Q5CZ95, Q5TGI2, Q9NVH9, Q9Y3N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.