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Q5VTU8

- AT5EL_HUMAN

UniProt

Q5VTU8 - AT5EL_HUMAN

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Protein

ATP synthase subunit epsilon-like protein, mitochondrial

Gene

ATP5EP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).By similarity

GO - Molecular functioni

  1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
  2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP synthesis coupled proton transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit epsilon-like protein, mitochondrial
Gene namesi
Name:ATP5EP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:34026. ATP5EP2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) Source: InterPro
  2. mitochondrion Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5151ATP synthase subunit epsilon-like protein, mitochondrialPRO_0000347182Add
BLAST

Proteomic databases

PaxDbiQ5VTU8.
PRIDEiQ5VTU8.

Expressioni

Gene expression databases

BgeeiQ5VTU8.
GenevestigatoriQ5VTU8.

Organism-specific databases

HPAiHPA042142.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000370414.

Structurei

3D structure databases

ProteinModelPortaliQ5VTU8.
SMRiQ5VTU8. Positions 2-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase epsilon family.Curated

Phylogenomic databases

eggNOGiNOG318665.
GeneTreeiENSGT00390000015470.
HOGENOMiHOG000214506.
HOVERGENiHBG050611.
InParanoidiQ5VTU8.
OrthoDBiEOG7GQXZP.
PhylomeDBiQ5VTU8.
TreeFamiTF300278.

Family and domain databases

Gene3Di1.10.1620.20. 1 hit.
InterProiIPR006721. ATPase_F1-cplx_esu_mt.
[Graphical view]
PfamiPF04627. ATP-synt_Eps. 1 hit.
[Graphical view]
SUPFAMiSSF48690. SSF48690. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5VTU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAYWRQAGL SYIRYSQICA KVVRDALKTE FKANAKKTSG NSVKIVKVKK

E
Length:51
Mass (Da):5,807
Last modified:December 7, 2004 - v1
Checksum:i3352CE8EC90F6DCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591024 Genomic DNA. Translation: CAH70632.1.
UniGeneiHs.574118.

Genome annotation databases

EnsembliENST00000381026; ENSP00000370414; ENSG00000180389.

Polymorphism databases

DMDMi74746994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591024 Genomic DNA. Translation: CAH70632.1 .
UniGenei Hs.574118.

3D structure databases

ProteinModelPortali Q5VTU8.
SMRi Q5VTU8. Positions 2-48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000370414.

Polymorphism databases

DMDMi 74746994.

Proteomic databases

PaxDbi Q5VTU8.
PRIDEi Q5VTU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381026 ; ENSP00000370414 ; ENSG00000180389 .

Organism-specific databases

GeneCardsi GC13P028519.
HGNCi HGNC:34026. ATP5EP2.
HPAi HPA042142.
neXtProti NX_Q5VTU8.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG318665.
GeneTreei ENSGT00390000015470.
HOGENOMi HOG000214506.
HOVERGENi HBG050611.
InParanoidi Q5VTU8.
OrthoDBi EOG7GQXZP.
PhylomeDBi Q5VTU8.
TreeFami TF300278.

Miscellaneous databases

ChiTaRSi ATP5EP2. human.
PROi Q5VTU8.

Gene expression databases

Bgeei Q5VTU8.
Genevestigatori Q5VTU8.

Family and domain databases

Gene3Di 1.10.1620.20. 1 hit.
InterProi IPR006721. ATPase_F1-cplx_esu_mt.
[Graphical view ]
Pfami PF04627. ATP-synt_Eps. 1 hit.
[Graphical view ]
SUPFAMi SSF48690. SSF48690. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAT5EL_HUMAN
AccessioniPrimary (citable) accession number: Q5VTU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Defined as a pseudogene by HGNC. However, proteomic data on a specific peptide from PubMed:17924679 suggest the existence of this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3