Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5VTU8

- AT5EL_HUMAN

UniProt

Q5VTU8 - AT5EL_HUMAN

Protein

ATP synthase subunit epsilon-like protein, mitochondrial

Gene

ATP5EP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits By similarity.By similarity

    GO - Molecular functioni

    1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
    2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP synthesis coupled proton transport Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit epsilon-like protein, mitochondrial
    Gene namesi
    Name:ATP5EP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:34026. ATP5EP2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) Source: InterPro
    2. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5151ATP synthase subunit epsilon-like protein, mitochondrialPRO_0000347182Add
    BLAST

    Proteomic databases

    PaxDbiQ5VTU8.
    PRIDEiQ5VTU8.

    Expressioni

    Gene expression databases

    BgeeiQ5VTU8.
    GenevestigatoriQ5VTU8.

    Organism-specific databases

    HPAiHPA042142.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000370414.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5VTU8.
    SMRiQ5VTU8. Positions 2-48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic ATPase epsilon family.Curated

    Phylogenomic databases

    eggNOGiNOG318665.
    HOGENOMiHOG000214506.
    HOVERGENiHBG050611.
    InParanoidiQ5VTU8.
    OrthoDBiEOG7GQXZP.
    PhylomeDBiQ5VTU8.
    TreeFamiTF300278.

    Family and domain databases

    Gene3Di1.10.1620.20. 1 hit.
    InterProiIPR006721. ATPase_F1-cplx_esu_mt.
    [Graphical view]
    PfamiPF04627. ATP-synt_Eps. 1 hit.
    [Graphical view]
    SUPFAMiSSF48690. SSF48690. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5VTU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAYWRQAGL SYIRYSQICA KVVRDALKTE FKANAKKTSG NSVKIVKVKK   50
    E 51
    Length:51
    Mass (Da):5,807
    Last modified:December 7, 2004 - v1
    Checksum:i3352CE8EC90F6DCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591024 Genomic DNA. Translation: CAH70632.1.
    UniGeneiHs.574118.

    Genome annotation databases

    EnsembliENST00000381026; ENSP00000370414; ENSG00000180389.

    Polymorphism databases

    DMDMi74746994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591024 Genomic DNA. Translation: CAH70632.1 .
    UniGenei Hs.574118.

    3D structure databases

    ProteinModelPortali Q5VTU8.
    SMRi Q5VTU8. Positions 2-48.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000370414.

    Polymorphism databases

    DMDMi 74746994.

    Proteomic databases

    PaxDbi Q5VTU8.
    PRIDEi Q5VTU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381026 ; ENSP00000370414 ; ENSG00000180389 .

    Organism-specific databases

    GeneCardsi GC13P028519.
    HGNCi HGNC:34026. ATP5EP2.
    HPAi HPA042142.
    neXtProti NX_Q5VTU8.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318665.
    HOGENOMi HOG000214506.
    HOVERGENi HBG050611.
    InParanoidi Q5VTU8.
    OrthoDBi EOG7GQXZP.
    PhylomeDBi Q5VTU8.
    TreeFami TF300278.

    Miscellaneous databases

    ChiTaRSi ATP5EP2. human.
    PROi Q5VTU8.

    Gene expression databases

    Bgeei Q5VTU8.
    Genevestigatori Q5VTU8.

    Family and domain databases

    Gene3Di 1.10.1620.20. 1 hit.
    InterProi IPR006721. ATPase_F1-cplx_esu_mt.
    [Graphical view ]
    Pfami PF04627. ATP-synt_Eps. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48690. SSF48690. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiAT5EL_HUMAN
    AccessioniPrimary (citable) accession number: Q5VTU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Defined as a pseudogene by HGNC. However, proteomic data on a specific peptide from PubMed:17924679 suggest the existence of this protein.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3